diff --git "a/assets/index-Cno3rxPp.js" "b/assets/index-Cno3rxPp.js"
new file mode 100644--- /dev/null
+++ "b/assets/index-Cno3rxPp.js"
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a.pendingProps}throw Error(s(156,a.tag))}function Ii(e){e.flags|=4}function Tc(e,a,o,f,p){if((a=(e.mode&32)!==0)&&(a=!1),a){if(e.flags|=16777216,(p&335544128)===p)if(e.stateNode.complete)e.flags|=8192;else if(v1())e.flags|=8192;else throw Nn=Ir,Xo}else e.flags&=-16777217}function K0(e,a){if(a.type!=="stylesheet"||(a.state.loading&4)!==0)e.flags&=-16777217;else if(e.flags|=16777216,!ld(a))if(v1())e.flags|=8192;else throw Nn=Ir,Xo}function Zr(e,a){a!==null&&(e.flags|=4),e.flags&16384&&(a=e.tag!==22?Su():536870912,e.lanes|=a,Ts|=a)}function ya(e,a){if(!It)switch(e.tailMode){case"hidden":a=e.tail;for(var o=null;a!==null;)a.alternate!==null&&(o=a),a=a.sibling;o===null?e.tail=null:o.sibling=null;break;case"collapsed":o=e.tail;for(var f=null;o!==null;)o.alternate!==null&&(f=o),o=o.sibling;f===null?a||e.tail===null?e.tail=null:e.tail.sibling=null:f.sibling=null}}function Zt(e){var a=e.alternate!==null&&e.alternate.child===e.child,o=0,f=0;if(a)for(var p=e.child;p!==null;)o|=p.lanes|p.childLanes,f|=p.subtreeFlags&65011712,f|=p.flags&65011712,p.return=e,p=p.sibling;else for(p=e.child;p!==null;)o|=p.lanes|p.childLanes,f|=p.subtreeFlags,f|=p.flags,p.return=e,p=p.sibling;return e.subtreeFlags|=f,e.childLanes=o,a}function Rg(e,a,o){var f=a.pendingProps;switch(Lo(a),a.tag){case 16:case 15:case 0:case 11:case 7:case 8:case 12:case 9:case 14:return Zt(a),null;case 1:return Zt(a),null;case 3:return o=a.stateNode,f=null,e!==null&&(f=e.memoizedState.cache),a.memoizedState.cache!==f&&(a.flags|=2048),Ti(le),Mt(),o.pendingContext&&(o.context=o.pendingContext,o.pendingContext=null),(e===null||e.child===null)&&(gs(a)?Ii(a):e===null||e.memoizedState.isDehydrated&&(a.flags&256)===0||(a.flags|=1024,zo())),Zt(a),null;case 26:var p=a.type,x=a.memoizedState;return 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b[0]=i,b[1]=t,b[2]=n,b[3]=s,b[4]=r,b[5]=c,b[6]=l,b[7]=d,b[8]=h,b[9]=u,b[10]=m,b[11]=g,b[12]=A,b[13]=v,b[14]=y,b[15]=w,b}function C2(i){return i[0]=1,i[1]=0,i[2]=0,i[3]=0,i[4]=0,i[5]=1,i[6]=0,i[7]=0,i[8]=0,i[9]=0,i[10]=1,i[11]=0,i[12]=0,i[13]=0,i[14]=0,i[15]=1,i}function We(i,t){if(i===t){var n=t[1],s=t[2],r=t[3],c=t[6],l=t[7],d=t[11];i[1]=t[4],i[2]=t[8],i[3]=t[12],i[4]=n,i[6]=t[9],i[7]=t[13],i[8]=s,i[9]=c,i[11]=t[14],i[12]=r,i[13]=l,i[14]=d}else i[0]=t[0],i[1]=t[4],i[2]=t[8],i[3]=t[12],i[4]=t[1],i[5]=t[5],i[6]=t[9],i[7]=t[13],i[8]=t[2],i[9]=t[6],i[10]=t[10],i[11]=t[14],i[12]=t[3],i[13]=t[7],i[14]=t[11],i[15]=t[15];return i}function Pe(i,t){var n=t[0],s=t[1],r=t[2],c=t[3],l=t[4],d=t[5],h=t[6],u=t[7],m=t[8],g=t[9],A=t[10],v=t[11],y=t[12],w=t[13],b=t[14],C=t[15],S=n*d-s*l,E=n*h-r*l,M=n*u-c*l,N=s*h-r*d,U=s*u-c*d,T=r*u-c*h,F=m*w-g*y,I=m*b-A*y,B=m*C-v*y,V=g*b-A*w,R=g*C-v*w,Y=A*C-v*b,P=S*Y-E*R+M*V+N*B-U*I+T*F;return P?(P=1/P,i[0]=(d*Y-h*R+u*V)*P,i[1]=(r*R-s*Y-c*V)*P,i[2]=(w*T-b*U+C*N)*P,i[3]=(A*U-g*T-v*N)*P,i[4]=(h*B-l*Y-u*I)*P,i[5]=(n*Y-r*B+c*I)*P,i[6]=(b*M-y*T-C*E)*P,i[7]=(m*T-A*M+v*E)*P,i[8]=(l*R-d*B+u*F)*P,i[9]=(s*B-n*R-c*F)*P,i[10]=(y*U-w*M+C*S)*P,i[11]=(g*M-m*U-v*S)*P,i[12]=(d*I-l*V-h*F)*P,i[13]=(n*V-s*I+r*F)*P,i[14]=(w*E-y*N-b*S)*P,i[15]=(m*N-g*E+A*S)*P,i):null}function qn(i,t,n){var s=t[0],r=t[1],c=t[2],l=t[3],d=t[4],h=t[5],u=t[6],m=t[7],g=t[8],A=t[9],v=t[10],y=t[11],w=t[12],b=t[13],C=t[14],S=t[15],E=n[0],M=n[1],N=n[2],U=n[3];return i[0]=E*s+M*d+N*g+U*w,i[1]=E*r+M*h+N*A+U*b,i[2]=E*c+M*u+N*v+U*C,i[3]=E*l+M*m+N*y+U*S,E=n[4],M=n[5],N=n[6],U=n[7],i[4]=E*s+M*d+N*g+U*w,i[5]=E*r+M*h+N*A+U*b,i[6]=E*c+M*u+N*v+U*C,i[7]=E*l+M*m+N*y+U*S,E=n[8],M=n[9],N=n[10],U=n[11],i[8]=E*s+M*d+N*g+U*w,i[9]=E*r+M*h+N*A+U*b,i[10]=E*c+M*u+N*v+U*C,i[11]=E*l+M*m+N*y+U*S,E=n[12],M=n[13],N=n[14],U=n[15],i[12]=E*s+M*d+N*g+U*w,i[13]=E*r+M*h+N*A+U*b,i[14]=E*c+M*u+N*v+U*C,i[15]=E*l+M*m+N*y+U*S,i}function Ps(i,t,n){var s=n[0],r=n[1],c=n[2],l,d,h,u,m,g,A,v,y,w,b,C;return t===i?(i[12]=t[0]*s+t[4]*r+t[8]*c+t[12],i[13]=t[1]*s+t[5]*r+t[9]*c+t[13],i[14]=t[2]*s+t[6]*r+t[10]*c+t[14],i[15]=t[3]*s+t[7]*r+t[11]*c+t[15]):(l=t[0],d=t[1],h=t[2],u=t[3],m=t[4],g=t[5],A=t[6],v=t[7],y=t[8],w=t[9],b=t[10],C=t[11],i[0]=l,i[1]=d,i[2]=h,i[3]=u,i[4]=m,i[5]=g,i[6]=A,i[7]=v,i[8]=y,i[9]=w,i[10]=b,i[11]=C,i[12]=l*s+m*r+y*c+t[12],i[13]=d*s+g*r+w*c+t[13],i[14]=h*s+A*r+b*c+t[14],i[15]=u*s+v*r+C*c+t[15]),i}function Bd(i,t,n){var s=n[0],r=n[1],c=n[2];return i[0]=t[0]*s,i[1]=t[1]*s,i[2]=t[2]*s,i[3]=t[3]*s,i[4]=t[4]*r,i[5]=t[5]*r,i[6]=t[6]*r,i[7]=t[7]*r,i[8]=t[8]*c,i[9]=t[9]*c,i[10]=t[10]*c,i[11]=t[11]*c,i[12]=t[12],i[13]=t[13],i[14]=t[14],i[15]=t[15],i}function Sl(i,t,n){var s=Math.sin(n),r=Math.cos(n),c=t[4],l=t[5],d=t[6],h=t[7],u=t[8],m=t[9],g=t[10],A=t[11];return t!==i&&(i[0]=t[0],i[1]=t[1],i[2]=t[2],i[3]=t[3],i[12]=t[12],i[13]=t[13],i[14]=t[14],i[15]=t[15]),i[4]=c*r+u*s,i[5]=l*r+m*s,i[6]=d*r+g*s,i[7]=h*r+A*s,i[8]=u*r-c*s,i[9]=m*r-l*s,i[10]=g*r-d*s,i[11]=A*r-h*s,i}function Ml(i,t,n){var s=Math.sin(n),r=Math.cos(n),c=t[0],l=t[1],d=t[2],h=t[3],u=t[4],m=t[5],g=t[6],A=t[7];return t!==i&&(i[8]=t[8],i[9]=t[9],i[10]=t[10],i[11]=t[11],i[12]=t[12],i[13]=t[13],i[14]=t[14],i[15]=t[15]),i[0]=c*r+u*s,i[1]=l*r+m*s,i[2]=d*r+g*s,i[3]=h*r+A*s,i[4]=u*r-c*s,i[5]=m*r-l*s,i[6]=g*r-d*s,i[7]=A*r-h*s,i}function ip(i,t,n){var s=n[0],r=n[1],c=n[2],l=Math.sqrt(s*s+r*r+c*c),d,h,u;return l<JA?null:(l=1/l,s*=l,r*=l,c*=l,d=Math.sin(t),h=Math.cos(t),u=1-h,i[0]=s*s*u+h,i[1]=r*s*u+c*d,i[2]=c*s*u-r*d,i[3]=0,i[4]=s*r*u-c*d,i[5]=r*r*u+h,i[6]=c*r*u+s*d,i[7]=0,i[8]=s*c*u+r*d,i[9]=r*c*u-s*d,i[10]=c*c*u+h,i[11]=0,i[12]=0,i[13]=0,i[14]=0,i[15]=1,i)}function np(i,t,n,s,r,c,l){var d=1/(t-n),h=1/(s-r),u=1/(c-l);return i[0]=-2*d,i[1]=0,i[2]=0,i[3]=0,i[4]=0,i[5]=-2*h,i[6]=0,i[7]=0,i[8]=0,i[9]=0,i[10]=2*u,i[11]=0,i[12]=(t+n)*d,i[13]=(r+s)*h,i[14]=(l+c)*u,i[15]=1,i}var El=np;function sp(i,t,n){return i[0]=t[0]*n,i[1]=t[1]*n,i[2]=t[2]*n,i[3]=t[3]*n,i[4]=t[4]*n,i[5]=t[5]*n,i[6]=t[6]*n,i[7]=t[7]*n,i[8]=t[8]*n,i[9]=t[9]*n,i[10]=t[10]*n,i[11]=t[11]*n,i[12]=t[12]*n,i[13]=t[13]*n,i[14]=t[14]*n,i[15]=t[15]*n,i}var S2=qn;function Gt(){var i=new xe(3);return xe!=Float32Array&&(i[0]=0,i[1]=0,i[2]=0),i}function gi(i){var t=new xe(3);return t[0]=i[0],t[1]=i[1],t[2]=i[2],t}function wn(i){var t=i[0],n=i[1],s=i[2];return Math.sqrt(t*t+n*n+s*s)}function lt(i,t,n){var s=new xe(3);return s[0]=i,s[1]=t,s[2]=n,s}function Id(i,t){return i[0]=t[0],i[1]=t[1],i[2]=t[2],i}function Qn(i,t,n){return i[0]=t[0]+n[0],i[1]=t[1]+n[1],i[2]=t[2]+n[2],i}function jt(i,t,n){return i[0]=t[0]-n[0],i[1]=t[1]-n[1],i[2]=t[2]-n[2],i}function Jh(i,t,n){return i[0]=Math.min(t[0],n[0]),i[1]=Math.min(t[1],n[1]),i[2]=Math.min(t[2],n[2]),i}function $h(i,t,n){return i[0]=Math.max(t[0],n[0]),i[1]=Math.max(t[1],n[1]),i[2]=Math.max(t[2],n[2]),i}function ap(i,t,n){return i[0]=t[0]*n,i[1]=t[1]*n,i[2]=t[2]*n,i}function rp(i,t){var n=t[0]-i[0],s=t[1]-i[1],r=t[2]-i[2];return Math.sqrt(n*n+s*s+r*r)}function lp(i,t){return i[0]=-t[0],i[1]=-t[1],i[2]=-t[2],i}function li(i,t){var n=t[0],s=t[1],r=t[2],c=n*n+s*s+r*r;return c>0&&(c=1/Math.sqrt(c)),i[0]=t[0]*c,i[1]=t[1]*c,i[2]=t[2]*c,i}function op(i,t){return i[0]*t[0]+i[1]*t[1]+i[2]*t[2]}function Ll(i,t,n){var s=t[0],r=t[1],c=t[2],l=n[0],d=n[1],h=n[2];return i[0]=r*h-c*d,i[1]=c*l-s*h,i[2]=s*d-r*l,i}function cp(i,t,n,s){var r=t[0],c=t[1],l=t[2];return i[0]=r+s*(n[0]-r),i[1]=c+s*(n[1]-c),i[2]=l+s*(n[2]-l),i}function Rd(i,t,n){var s=t[0],r=t[1],c=t[2];return i[0]=s*n[0]+r*n[3]+c*n[6],i[1]=s*n[1]+r*n[4]+c*n[7],i[2]=s*n[2]+r*n[5]+c*n[8],i}function Ch(i,t){var n=i[0],s=i[1],r=i[2],c=t[0],l=t[1],d=t[2],h=Math.sqrt((n*n+s*s+r*r)*(c*c+l*l+d*d)),u=h&&op(i,t)/h;return Math.acos(Math.min(Math.max(u,-1),1))}var Nd=jt,tr=wn;(function(){var i=Gt();return function(t,n,s,r,c,l){var d,h;for(n||(n=3),s||(s=0),r?h=Math.min(r*n+s,t.length):h=t.length,d=s;d<h;d+=n)i[0]=t[d],i[1]=t[d+1],i[2]=t[d+2],c(i,i,l),t[d]=i[0],t[d+1]=i[1],t[d+2]=i[2];return t}})();function ki(){var i=new xe(4);return xe!=Float32Array&&(i[0]=0,i[1]=0,i[2]=0,i[3]=0),i}function xn(i){var t=new xe(4);return t[0]=i[0],t[1]=i[1],t[2]=i[2],t[3]=i[3],t}function te(i,t,n,s){var r=new xe(4);return r[0]=i,r[1]=t,r[2]=n,r[3]=s,r}function Vd(i,t,n){return i[0]=t[0]+n[0],i[1]=t[1]+n[1],i[2]=t[2]+n[2],i[3]=t[3]+n[3],i}function hp(i,t,n){return i[0]=t[0]-n[0],i[1]=t[1]-n[1],i[2]=t[2]-n[2],i[3]=t[3]-n[3],i}function up(i,t,n){return i[0]=t[0]*n,i[1]=t[1]*n,i[2]=t[2]*n,i[3]=t[3]*n,i}function De(i,t,n){var s=t[0],r=t[1],c=t[2],l=t[3];return i[0]=n[0]*s+n[4]*r+n[8]*c+n[12]*l,i[1]=n[1]*s+n[5]*r+n[9]*c+n[13]*l,i[2]=n[2]*s+n[6]*r+n[10]*c+n[14]*l,i[3]=n[3]*s+n[7]*r+n[11]*c+n[15]*l,i}var fp=hp;(function(){var i=ki();return function(t,n,s,r,c,l){var d,h;for(n||(n=4),s||(s=0),r?h=Math.min(r*n+s,t.length):h=t.length,d=s;d<h;d+=n)i[0]=t[d],i[1]=t[d+1],i[2]=t[d+2],i[3]=t[d+3],c(i,i,l),t[d]=i[0],t[d+1]=i[1],t[d+2]=i[2],t[d+3]=i[3];return t}})();function dp(){var i=new xe(2);return xe!=Float32Array&&(i[0]=0,i[1]=0),i}function Ld(i,t){var n=new xe(2);return n[0]=i,n[1]=t,n}function mp(i,t,n){return i[0]=t[0]*n,i[1]=t[1]*n,i}function Od(i){var t=i[0],n=i[1];return Math.sqrt(t*t+n*n)}function gp(i,t){var n=t[0],s=t[1],r=n*n+s*s;return r>0&&(r=1/Math.sqrt(r)),i[0]=t[0]*r,i[1]=t[1]*r,i}(function(){var i=dp();return function(t,n,s,r,c,l){var d,h;for(n||(n=2),s||(s=0),r?h=Math.min(r*n+s,t.length):h=t.length,d=s;d<h;d+=n)i[0]=t[d],i[1]=t[d+1],c(i,i,l),t[d]=i[0],t[d+1]=i[1];return t}})();var jn=256,Ol=[],Dl;for(;jn--;)Ol[jn]=(jn+256).toString(16).substring(1);function qh(){var 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n+(t&2)},Np=function(i){var t=i.length;return(i[t-4]|i[t-3]<<8|i[t-2]<<16|i[t-1]<<24)>>>0},Vp=function(i,t){return((i[0]&15)!=8||i[0]>>4>7||(i[0]<<8|i[1])%31)&&Fe(6,"invalid zlib data"),(i[1]>>5&1)==1&&Fe(6,"invalid zlib data: "+(i[1]&32?"need":"unexpected")+" dictionary"),(i[1]>>3&4)+2},Dh=(function(){function i(t,n){typeof t=="function"&&(n=t,t={}),this.ondata=n;var s=t&&t.dictionary&&t.dictionary.subarray(-32768);this.s={i:0,b:s?s.length:0},this.o=new ve(32768),this.p=new ve(0),s&&this.o.set(s)}return i.prototype.e=function(t){if(this.ondata||Fe(5),this.d&&Fe(4),!this.p.length)this.p=t;else if(t.length){var n=new ve(this.p.length+t.length);n.set(this.p),n.set(t,this.p.length),this.p=n}},i.prototype.c=function(t){this.s.i=+(this.d=t||!1);var n=this.s.b,s=Ql(this.p,this.s,this.o);this.ondata(zl(s,n,this.s.b),this.d),this.o=zl(s,this.s.b-32768),this.s.b=this.o.length,this.p=zl(this.p,this.s.p/8|0),this.s.p&=7},i.prototype.push=function(t,n){this.e(t),this.c(n)},i})();function Lp(i,t){return Ql(i,{i:2},t,t)}var Op=(function(){function i(t,n){this.v=1,this.r=0,Dh.call(this,t,n)}return i.prototype.push=function(t,n){if(Dh.prototype.e.call(this,t),this.r+=t.length,this.v){var s=this.p.subarray(this.v-1),r=s.length>3?V2(s):4;if(r>s.length){if(!n)return}else this.v>1&&this.onmember&&this.onmember(this.r-s.length);this.p=s.subarray(r),this.v=0}Dh.prototype.c.call(this,n),this.s.f&&!this.s.l&&!n&&(this.v=N2(this.s.p)+9,this.s={i:0},this.o=new ve(0),this.push(new ve(0),n))},i})();function zp(i,t){var n=V2(i);return n+8>i.length&&Fe(6,"invalid gzip data"),Ql(i.subarray(n,-8),{i:2},new ve(Np(i)),t)}function Pp(i,t){return Ql(i.subarray(Vp(i),-4),{i:2},t,t)}function kp(i,t){return i[0]==31&&i[1]==139&&i[2]==8?zp(i,t):(i[0]&15)!=8||i[0]>>4>7||(i[0]<<8|i[1])%31?Lp(i,t):Pp(i,t)}var Yp=typeof TextDecoder<"u"&&new TextDecoder,Gp=0;try{Yp.decode(Rp,{stream:!0}),Gp=1}catch{}class L2{esize;ecode;edata;littleEndian;constructor(t,n,s,r){if(t%16!=0)throw new Error("This does not appear to be a NIFTI extension");this.esize=t,this.ecode=n,this.edata=s,this.littleEndian=r}toArrayBuffer(){let t=new Uint8Array(this.esize),n=new Uint8Array(this.edata);t.set(n,8);let s=new DataView(t.buffer);return s.setInt32(0,this.esize,this.littleEndian),s.setInt32(4,this.ecode,this.littleEndian),t.buffer}}class rt{static crcTable=null;static GUNZIP_MAGIC_COOKIE1=31;static GUNZIP_MAGIC_COOKIE2=139;static getStringAt(t,n,s){var r="",c,l;for(c=n;c<s;c+=1)l=t.getUint8(c),l!==0&&(r+=String.fromCharCode(l));return r}static getByteAt=function(t,n){return t.getUint8(n)};static getShortAt=function(t,n,s){return t.getInt16(n,s)};static getIntAt(t,n,s){return t.getInt32(n,s)}static getFloatAt(t,n,s){return t.getFloat32(n,s)}static getDoubleAt(t,n,s){return t.getFloat64(n,s)}static getInt64At(t,n,s){const r=t.getUint32(n,s),c=t.getInt32(n+4,s);let l;return s?l=c*2**32+r:l=r*2**32+c,c<0&&(l+=-1*2**32*2**32),l}static getUint64At(t,n,s){const r=t.getUint32(n+(s?0:4),s),c=t.getUint32(n+(s?4:0),s);return s?c*2**32+r:r*2**32+c}static getExtensionsAt(t,n,s,r){let c=[],l=n;for(;l<r;){let d=s,h=rt.getIntAt(t,l,s);if(!h)break;if(h+l>r&&(d=!d,h=rt.getIntAt(t,l,d),h+l>r))throw new Error("This does not appear to be a valid NIFTI extension");if(h%16!=0)throw new Error("This does not appear to be a NIFTI extension");let u=rt.getIntAt(t,l+4,d),m=t.buffer.slice(l+8,l+h),g=new L2(h,u,m,d);c.push(g),l+=h}return c}static toArrayBuffer(t){var n,s,r;for(n=new ArrayBuffer(t.length),s=new Uint8Array(n),r=0;r<t.length;r+=1)s[r]=t[r];return n}static isString(t){return typeof t=="string"||t instanceof String}static formatNumber(t,n=void 0){let s;return rt.isString(t)?s=Number(t):s=t,n?s=s.toPrecision(5):s=s.toPrecision(7),parseFloat(s)}static makeCRCTable(){let t,n=[];for(var s=0;s<256;s++){t=s;for(var r=0;r<8;r++)t=t&1?3988292384^t>>>1:t>>>1;n[s]=t}return n}static crc32(t){rt.crcTable||(rt.crcTable=rt.makeCRCTable());const n=rt.crcTable;let s=-1;for(var r=0;r<t.byteLength;r++)s=s>>>8^n[(s^t.getUint8(r))&255];return(s^-1)>>>0}}class ut{littleEndian=!1;dim_info=0;dims=[];intent_p1=0;intent_p2=0;intent_p3=0;intent_code=0;datatypeCode=0;numBitsPerVoxel=0;slice_start=0;slice_end=0;slice_code=0;pixDims=[];vox_offset=0;scl_slope=1;scl_inter=0;xyzt_units=0;cal_max=0;cal_min=0;slice_duration=0;toffset=0;description="";aux_file="";intent_name="";qform_code=0;sform_code=0;quatern_a=0;quatern_b=0;quatern_c=0;quatern_d=0;qoffset_x=0;qoffset_y=0;qoffset_z=0;affine=[[1,0,0,0],[0,1,0,0],[0,0,1,0],[0,0,0,1]];qfac=1;quatern_R;magic="0";isHDR=!1;extensionFlag=[0,0,0,0];extensionSize=0;extensionCode=0;extensions=[];static TYPE_NONE=0;static TYPE_BINARY=1;static TYPE_UINT8=2;static TYPE_INT16=4;static TYPE_INT32=8;static TYPE_FLOAT32=16;static TYPE_COMPLEX64=32;static TYPE_FLOAT64=64;static TYPE_RGB24=128;static TYPE_INT8=256;static TYPE_UINT16=512;static TYPE_UINT32=768;static TYPE_INT64=1024;static TYPE_UINT64=1280;static TYPE_FLOAT128=1536;static TYPE_COMPLEX128=1792;static TYPE_COMPLEX256=2048;static XFORM_UNKNOWN=0;static XFORM_SCANNER_ANAT=1;static XFORM_ALIGNED_ANAT=2;static XFORM_TALAIRACH=3;static XFORM_MNI_152=4;static SPATIAL_UNITS_MASK=7;static TEMPORAL_UNITS_MASK=56;static UNITS_UNKNOWN=0;static UNITS_METER=1;static UNITS_MM=2;static UNITS_MICRON=3;static UNITS_SEC=8;static UNITS_MSEC=16;static UNITS_USEC=24;static UNITS_HZ=32;static UNITS_PPM=40;static UNITS_RADS=48;static MAGIC_COOKIE=348;static STANDARD_HEADER_SIZE=348;static MAGIC_NUMBER_LOCATION=344;static MAGIC_NUMBER=[110,43,49];static MAGIC_NUMBER2=[110,105,49];static EXTENSION_HEADER_SIZE=8;readHeader(t){var n=new DataView(t),s=rt.getIntAt(n,0,this.littleEndian),r,c,l,d;if(s!==ut.MAGIC_COOKIE&&(this.littleEndian=!0,s=rt.getIntAt(n,0,this.littleEndian)),s!==ut.MAGIC_COOKIE)throw new Error("This does not appear to be a NIFTI file!");for(this.dim_info=rt.getByteAt(n,39),r=0;r<8;r+=1)d=40+r*2,this.dims[r]=rt.getShortAt(n,d,this.littleEndian);for(this.intent_p1=rt.getFloatAt(n,56,this.littleEndian),this.intent_p2=rt.getFloatAt(n,60,this.littleEndian),this.intent_p3=rt.getFloatAt(n,64,this.littleEndian),this.intent_code=rt.getShortAt(n,68,this.littleEndian),this.datatypeCode=rt.getShortAt(n,70,this.littleEndian),this.numBitsPerVoxel=rt.getShortAt(n,72,this.littleEndian),this.slice_start=rt.getShortAt(n,74,this.littleEndian),r=0;r<8;r+=1)d=76+r*4,this.pixDims[r]=rt.getFloatAt(n,d,this.littleEndian);if(this.vox_offset=rt.getFloatAt(n,108,this.littleEndian),this.scl_slope=rt.getFloatAt(n,112,this.littleEndian),this.scl_inter=rt.getFloatAt(n,116,this.littleEndian),this.slice_end=rt.getShortAt(n,120,this.littleEndian),this.slice_code=rt.getByteAt(n,122),this.xyzt_units=rt.getByteAt(n,123),this.cal_max=rt.getFloatAt(n,124,this.littleEndian),this.cal_min=rt.getFloatAt(n,128,this.littleEndian),this.slice_duration=rt.getFloatAt(n,132,this.littleEndian),this.toffset=rt.getFloatAt(n,136,this.littleEndian),this.description=rt.getStringAt(n,148,228),this.aux_file=rt.getStringAt(n,228,252),this.qform_code=rt.getShortAt(n,252,this.littleEndian),this.sform_code=rt.getShortAt(n,254,this.littleEndian),this.quatern_b=rt.getFloatAt(n,256,this.littleEndian),this.quatern_c=rt.getFloatAt(n,260,this.littleEndian),this.quatern_d=rt.getFloatAt(n,264,this.littleEndian),this.quatern_a=Math.sqrt(1-(Math.pow(this.quatern_b,2)+Math.pow(this.quatern_c,2)+Math.pow(this.quatern_d,2))),this.qoffset_x=rt.getFloatAt(n,268,this.littleEndian),this.qoffset_y=rt.getFloatAt(n,272,this.littleEndian),this.qoffset_z=rt.getFloatAt(n,276,this.littleEndian),this.qform_code<1&&this.sform_code<1&&(this.affine[0][0]=this.pixDims[1],this.affine[1][1]=this.pixDims[2],this.affine[2][2]=this.pixDims[3]),this.qform_code>0&&this.sform_code<this.qform_code){const h=this.quatern_a,u=this.quatern_b,m=this.quatern_c,g=this.quatern_d;for(this.qfac=this.pixDims[0]===0?1:this.pixDims[0],this.quatern_R=[[h*h+u*u-m*m-g*g,2*u*m-2*h*g,2*u*g+2*h*m],[2*u*m+2*h*g,h*h+m*m-u*u-g*g,2*m*g-2*h*u],[2*u*g-2*h*m,2*m*g+2*h*u,h*h+g*g-m*m-u*u]],c=0;c<3;c+=1)for(l=0;l<3;l+=1)this.affine[c][l]=this.quatern_R[c][l]*this.pixDims[l+1],l===2&&(this.affine[c][l]*=this.qfac);this.affine[0][3]=this.qoffset_x,this.affine[1][3]=this.qoffset_y,this.affine[2][3]=this.qoffset_z}else if(this.sform_code>0)for(c=0;c<3;c+=1)for(l=0;l<4;l+=1)d=280+(c*4+l)*4,this.affine[c][l]=rt.getFloatAt(n,d,this.littleEndian);if(this.affine[3][0]=0,this.affine[3][1]=0,this.affine[3][2]=0,this.affine[3][3]=1,this.intent_name=rt.getStringAt(n,328,344),this.magic=rt.getStringAt(n,344,348),this.isHDR=this.magic===String.fromCharCode.apply(null,ut.MAGIC_NUMBER2),n.byteLength>ut.MAGIC_COOKIE){this.extensionFlag[0]=rt.getByteAt(n,348),this.extensionFlag[1]=rt.getByteAt(n,349),this.extensionFlag[2]=rt.getByteAt(n,350),this.extensionFlag[3]=rt.getByteAt(n,351);let h=!0;!this.isHDR&&this.vox_offset<=352&&(h=!1),n.byteLength<=368&&(h=!1),h&&this.extensionFlag[0]&&(this.extensions=rt.getExtensionsAt(n,this.getExtensionLocation(),this.littleEndian,this.vox_offset),this.extensionSize=this.extensions[0].esize,this.extensionCode=this.extensions[0].ecode)}}toFormattedString(){var t=rt.formatNumber,n="";return n+="Dim Info = "+this.dim_info+`
+`,n+="Image Dimensions (1-8): "+this.dims[0]+", "+this.dims[1]+", "+this.dims[2]+", "+this.dims[3]+", "+this.dims[4]+", "+this.dims[5]+", "+this.dims[6]+", "+this.dims[7]+`
+`,n+="Intent Parameters (1-3): "+this.intent_p1+", "+this.intent_p2+", "+this.intent_p3+`
+`,n+="Intent Code = "+this.intent_code+`
+`,n+="Datatype = "+this.datatypeCode+" ("+this.getDatatypeCodeString(this.datatypeCode)+`)
+`,n+="Bits Per Voxel = "+this.numBitsPerVoxel+`
+`,n+="Slice Start = "+this.slice_start+`
+`,n+="Voxel Dimensions (1-8): "+t(this.pixDims[0])+", "+t(this.pixDims[1])+", "+t(this.pixDims[2])+", "+t(this.pixDims[3])+", "+t(this.pixDims[4])+", "+t(this.pixDims[5])+", "+t(this.pixDims[6])+", "+t(this.pixDims[7])+`
+`,n+="Image Offset = "+this.vox_offset+`
+`,n+="Data Scale:  Slope = "+t(this.scl_slope)+"  Intercept = "+t(this.scl_inter)+`
+`,n+="Slice End = "+this.slice_end+`
+`,n+="Slice Code = "+this.slice_code+`
+`,n+="Units Code = "+this.xyzt_units+" ("+this.getUnitsCodeString(ut.SPATIAL_UNITS_MASK&this.xyzt_units)+", "+this.getUnitsCodeString(ut.TEMPORAL_UNITS_MASK&this.xyzt_units)+`)
+`,n+="Display Range:  Max = "+t(this.cal_max)+"  Min = "+t(this.cal_min)+`
+`,n+="Slice Duration = "+this.slice_duration+`
+`,n+="Time Axis Shift = "+this.toffset+`
+`,n+='Description: "'+this.description+`"
+`,n+='Auxiliary File: "'+this.aux_file+`"
+`,n+="Q-Form Code = "+this.qform_code+" ("+this.getTransformCodeString(this.qform_code)+`)
+`,n+="S-Form Code = "+this.sform_code+" ("+this.getTransformCodeString(this.sform_code)+`)
+`,n+="Quaternion Parameters:  b = "+t(this.quatern_b)+"  c = "+t(this.quatern_c)+"  d = "+t(this.quatern_d)+`
+`,n+="Quaternion Offsets:  x = "+this.qoffset_x+"  y = "+this.qoffset_y+"  z = "+this.qoffset_z+`
+`,n+="S-Form Parameters X: "+t(this.affine[0][0])+", "+t(this.affine[0][1])+", "+t(this.affine[0][2])+", "+t(this.affine[0][3])+`
+`,n+="S-Form Parameters Y: "+t(this.affine[1][0])+", "+t(this.affine[1][1])+", "+t(this.affine[1][2])+", "+t(this.affine[1][3])+`
+`,n+="S-Form Parameters Z: "+t(this.affine[2][0])+", "+t(this.affine[2][1])+", "+t(this.affine[2][2])+", "+t(this.affine[2][3])+`
+`,n+='Intent Name: "'+this.intent_name+`"
+`,this.extensionFlag[0]&&(n+="Extension: Size = "+this.extensionSize+"  Code = "+this.extensionCode+`
+`),n}getDatatypeCodeString=function(t){return t===ut.TYPE_UINT8?"1-Byte Unsigned Integer":t===ut.TYPE_INT16?"2-Byte Signed Integer":t===ut.TYPE_INT32?"4-Byte Signed Integer":t===ut.TYPE_FLOAT32?"4-Byte Float":t===ut.TYPE_FLOAT64?"8-Byte Float":t===ut.TYPE_RGB24?"RGB":t===ut.TYPE_INT8?"1-Byte Signed Integer":t===ut.TYPE_UINT16?"2-Byte Unsigned Integer":t===ut.TYPE_UINT32?"4-Byte Unsigned Integer":t===ut.TYPE_INT64?"8-Byte Signed Integer":t===ut.TYPE_UINT64?"8-Byte Unsigned Integer":"Unknown"};getTransformCodeString=function(t){return t===ut.XFORM_SCANNER_ANAT?"Scanner":t===ut.XFORM_ALIGNED_ANAT?"Aligned":t===ut.XFORM_TALAIRACH?"Talairach":t===ut.XFORM_MNI_152?"MNI":"Unknown"};getUnitsCodeString=function(t){return t===ut.UNITS_METER?"Meters":t===ut.UNITS_MM?"Millimeters":t===ut.UNITS_MICRON?"Microns":t===ut.UNITS_SEC?"Seconds":t===ut.UNITS_MSEC?"Milliseconds":t===ut.UNITS_USEC?"Microseconds":t===ut.UNITS_HZ?"Hz":t===ut.UNITS_PPM?"PPM":t===ut.UNITS_RADS?"Rads":"Unknown"};getQformMat(){return this.convertNiftiQFormToNiftiSForm(this.quatern_b,this.quatern_c,this.quatern_d,this.qoffset_x,this.qoffset_y,this.qoffset_z,this.pixDims[1],this.pixDims[2],this.pixDims[3],this.pixDims[0])}convertNiftiQFormToNiftiSForm(t,n,s,r,c,l,d,h,u,m){var g=[[0,0,0,0],[0,0,0,0],[0,0,0,0],[0,0,0,0]],A,v=t,y=n,w=s,b,C,S;return g[3][0]=g[3][1]=g[3][2]=0,g[3][3]=1,A=1-(v*v+y*y+w*w),A<1e-7?(A=1/Math.sqrt(v*v+y*y+w*w),v*=A,y*=A,w*=A,A=0):A=Math.sqrt(A),b=d>0?d:1,C=h>0?h:1,S=u>0?u:1,m<0&&(S=-S),g[0][0]=(A*A+v*v-y*y-w*w)*b,g[0][1]=2*(v*y-A*w)*C,g[0][2]=2*(v*w+A*y)*S,g[1][0]=2*(v*y+A*w)*b,g[1][1]=(A*A+y*y-v*v-w*w)*C,g[1][2]=2*(y*w-A*v)*S,g[2][0]=2*(v*w-A*y)*b,g[2][1]=2*(y*w+A*v)*C,g[2][2]=(A*A+w*w-y*y-v*v)*S,g[0][3]=r,g[1][3]=c,g[2][3]=l,g}convertNiftiSFormToNEMA(t){var n,s,r,c,l,d,h,u,m,g,A,v,y,w,b,C,S,E,M,N,U,T,F,I,B,V,R,Y,P,X,L,H,W,at;if(b=0,R=[[0,0,0],[0,0,0],[0,0,0]],Y=[[0,0,0],[0,0,0],[0,0,0]],n=t[0][0],s=t[0][1],r=t[0][2],c=t[1][0],l=t[1][1],d=t[1][2],h=t[2][0],u=t[2][1],m=t[2][2],g=Math.sqrt(n*n+c*c+h*h),g===0||(n/=g,c/=g,h/=g,g=Math.sqrt(s*s+l*l+u*u),g===0))return null;if(s/=g,l/=g,u/=g,g=n*s+c*l+h*u,Math.abs(g)>1e-4){if(s-=g*n,l-=g*c,u-=g*h,g=Math.sqrt(s*s+l*l+u*u),g===0)return null;s/=g,l/=g,u/=g}if(g=Math.sqrt(r*r+d*d+m*m),g===0?(r=c*u-h*l,d=h*s-u*n,m=n*l-c*s):(r/=g,d/=g,m/=g),g=n*r+c*d+h*m,Math.abs(g)>1e-4){if(r-=g*n,d-=g*c,m-=g*h,g=Math.sqrt(r*r+d*d+m*m),g===0)return null;r/=g,d/=g,m/=g}if(g=s*r+l*d+u*m,Math.abs(g)>1e-4){if(r-=g*s,d-=g*l,m-=g*u,g=Math.sqrt(r*r+d*d+m*m),g===0)return null;r/=g,d/=g,m/=g}if(R[0][0]=n,R[0][1]=s,R[0][2]=r,R[1][0]=c,R[1][1]=l,R[1][2]=d,R[2][0]=h,R[2][1]=u,R[2][2]=m,A=this.nifti_mat33_determ(R),A===0)return null;for(V=-666,M=T=F=I=1,N=2,U=3,y=1;y<=3;y+=1)for(w=1;w<=3;w+=1)if(y!==w){for(b=1;b<=3;b+=1)if(!(y===b||w===b))for(Y[0][0]=Y[0][1]=Y[0][2]=Y[1][0]=Y[1][1]=Y[1][2]=Y[2][0]=Y[2][1]=Y[2][2]=0,C=-1;C<=1;C+=2)for(S=-1;S<=1;S+=2)for(E=-1;E<=1;E+=2)Y[0][y-1]=C,Y[1][w-1]=S,Y[2][b-1]=E,v=this.nifti_mat33_determ(Y),v*A>0&&(B=this.nifti_mat33_mul(Y,R),g=B[0][0]+B[1][1]+B[2][2],g>V&&(V=g,M=y,N=w,U=b,T=C,F=S,I=E))}switch(P=X=L=H=W=at="",M*T){case 1:P="X",H="+";break;case-1:P="X",H="-";break;case 2:P="Y",H="+";break;case-2:P="Y",H="-";break;case 3:P="Z",H="+";break;case-3:P="Z",H="-";break}switch(N*F){case 1:X="X",W="+";break;case-1:X="X",W="-";break;case 2:X="Y",W="+";break;case-2:X="Y",W="-";break;case 3:X="Z",W="+";break;case-3:X="Z",W="-";break}switch(U*I){case 1:L="X",at="+";break;case-1:L="X",at="-";break;case 2:L="Y",at="+";break;case-2:L="Y",at="-";break;case 3:L="Z",at="+";break;case-3:L="Z",at="-";break}return P+X+L+H+W+at}nifti_mat33_mul=function(t,n){var s=[[0,0,0],[0,0,0],[0,0,0]],r,c;for(r=0;r<3;r+=1)for(c=0;c<3;c+=1)s[r][c]=t[r][0]*n[0][c]+t[r][1]*n[1][c]+t[r][2]*n[2][c];return s};nifti_mat33_determ=function(t){var n,s,r,c,l,d,h,u,m;return n=t[0][0],s=t[0][1],r=t[0][2],c=t[1][0],l=t[1][1],d=t[1][2],h=t[2][0],u=t[2][1],m=t[2][2],n*l*m-n*u*d-c*s*m+c*u*r+h*s*d-h*l*r};getExtensionLocation(){return ut.MAGIC_COOKIE+4}getExtensionSize(t){return rt.getIntAt(t,this.getExtensionLocation(),this.littleEndian)}getExtensionCode(t){return rt.getIntAt(t,this.getExtensionLocation()+4,this.littleEndian)}addExtension(t,n=-1){n==-1?this.extensions.push(t):this.extensions.splice(n,0,t),this.vox_offset+=t.esize}removeExtension(t){let n=this.extensions[t];n&&(this.vox_offset-=n.esize),this.extensions.splice(t,1)}toArrayBuffer(t=!1){let r=352;if(t)for(let h of this.extensions)r+=h.esize;let c=new Uint8Array(r),l=new DataView(c.buffer);l.setInt32(0,348,this.littleEndian),l.setUint8(39,this.dim_info);for(let h=0;h<8;h++)l.setUint16(40+2*h,this.dims[h],this.littleEndian);l.setFloat32(56,this.intent_p1,this.littleEndian),l.setFloat32(60,this.intent_p2,this.littleEndian),l.setFloat32(64,this.intent_p3,this.littleEndian),l.setInt16(68,this.intent_code,this.littleEndian),l.setInt16(70,this.datatypeCode,this.littleEndian),l.setInt16(72,this.numBitsPerVoxel,this.littleEndian),l.setInt16(74,this.slice_start,this.littleEndian);for(let h=0;h<8;h++)l.setFloat32(76+4*h,this.pixDims[h],this.littleEndian);l.setFloat32(108,this.vox_offset,this.littleEndian),l.setFloat32(112,this.scl_slope,this.littleEndian),l.setFloat32(116,this.scl_inter,this.littleEndian),l.setInt16(120,this.slice_end,this.littleEndian),l.setUint8(122,this.slice_code),l.setUint8(123,this.xyzt_units),l.setFloat32(124,this.cal_max,this.littleEndian),l.setFloat32(128,this.cal_min,this.littleEndian),l.setFloat32(132,this.slice_duration,this.littleEndian),l.setFloat32(136,this.toffset,this.littleEndian),c.set(new TextEncoder().encode(this.description),148),c.set(new TextEncoder().encode(this.aux_file),228),l.setInt16(252,this.qform_code,this.littleEndian),l.setInt16(254,this.sform_code,this.littleEndian),l.setFloat32(256,this.quatern_b,this.littleEndian),l.setFloat32(260,this.quatern_c,this.littleEndian),l.setFloat32(264,this.quatern_d,this.littleEndian),l.setFloat32(268,this.qoffset_x,this.littleEndian),l.setFloat32(272,this.qoffset_y,this.littleEndian),l.setFloat32(276,this.qoffset_z,this.littleEndian);const d=this.affine.flat();for(let h=0;h<12;h++)l.setFloat32(280+4*h,d[h],this.littleEndian);if(c.set(new TextEncoder().encode(this.intent_name),328),c.set(new TextEncoder().encode(this.magic),344),t){c.set(Uint8Array.from([1,0,0,0]),348);let h=this.getExtensionLocation();for(const u of this.extensions)l.setInt32(h,u.esize,u.littleEndian),l.setInt32(h+4,u.ecode,u.littleEndian),c.set(new Uint8Array(u.edata),h+8),h+=u.esize}else c.set(new Uint8Array(4).fill(0),348);return c.buffer}}class Me{littleEndian=!1;dim_info=0;dims=[];intent_p1=0;intent_p2=0;intent_p3=0;intent_code=0;datatypeCode=0;numBitsPerVoxel=0;slice_start=0;slice_end=0;slice_code=0;pixDims=[];vox_offset=0;scl_slope=1;scl_inter=0;xyzt_units=0;cal_max=0;cal_min=0;slice_duration=0;toffset=0;description="";aux_file="";intent_name="";qform_code=0;sform_code=0;quatern_b=0;quatern_c=0;quatern_d=0;qoffset_x=0;qoffset_y=0;qoffset_z=0;affine=[[1,0,0,0],[0,1,0,0],[0,0,1,0],[0,0,0,1]];magic="0";extensionFlag=[0,0,0,0];extensions=[];extensionSize=0;extensionCode=0;static MAGIC_COOKIE=540;static MAGIC_NUMBER_LOCATION=4;static MAGIC_NUMBER=[110,43,50,0,13,10,26,10];static MAGIC_NUMBER2=[110,105,50,0,13,10,26,10];readHeader(t){var n=new DataView(t),s=rt.getIntAt(n,0,this.littleEndian),r,c,l,d;if(s!==Me.MAGIC_COOKIE&&(this.littleEndian=!0,s=rt.getIntAt(n,0,this.littleEndian)),s!==Me.MAGIC_COOKIE)throw new Error("This does not appear to be a NIFTI file!");for(this.magic=rt.getStringAt(n,4,12),this.datatypeCode=rt.getShortAt(n,12,this.littleEndian),this.numBitsPerVoxel=rt.getShortAt(n,14,this.littleEndian),r=0;r<8;r+=1)d=16+r*8,this.dims[r]=rt.getInt64At(n,d,this.littleEndian);for(this.intent_p1=rt.getDoubleAt(n,80,this.littleEndian),this.intent_p2=rt.getDoubleAt(n,88,this.littleEndian),this.intent_p3=rt.getDoubleAt(n,96,this.littleEndian),r=0;r<8;r+=1)d=104+r*8,this.pixDims[r]=rt.getDoubleAt(n,d,this.littleEndian);for(this.vox_offset=rt.getInt64At(n,168,this.littleEndian),this.scl_slope=rt.getDoubleAt(n,176,this.littleEndian),this.scl_inter=rt.getDoubleAt(n,184,this.littleEndian),this.cal_max=rt.getDoubleAt(n,192,this.littleEndian),this.cal_min=rt.getDoubleAt(n,200,this.littleEndian),this.slice_duration=rt.getDoubleAt(n,208,this.littleEndian),this.toffset=rt.getDoubleAt(n,216,this.littleEndian),this.slice_start=rt.getInt64At(n,224,this.littleEndian),this.slice_end=rt.getInt64At(n,232,this.littleEndian),this.description=rt.getStringAt(n,240,320),this.aux_file=rt.getStringAt(n,320,344),this.qform_code=rt.getIntAt(n,344,this.littleEndian),this.sform_code=rt.getIntAt(n,348,this.littleEndian),this.quatern_b=rt.getDoubleAt(n,352,this.littleEndian),this.quatern_c=rt.getDoubleAt(n,360,this.littleEndian),this.quatern_d=rt.getDoubleAt(n,368,this.littleEndian),this.qoffset_x=rt.getDoubleAt(n,376,this.littleEndian),this.qoffset_y=rt.getDoubleAt(n,384,this.littleEndian),this.qoffset_z=rt.getDoubleAt(n,392,this.littleEndian),c=0;c<3;c+=1)for(l=0;l<4;l+=1)d=400+(c*4+l)*8,this.affine[c][l]=rt.getDoubleAt(n,d,this.littleEndian);this.affine[3][0]=0,this.affine[3][1]=0,this.affine[3][2]=0,this.affine[3][3]=1,this.slice_code=rt.getIntAt(n,496,this.littleEndian),this.xyzt_units=rt.getIntAt(n,500,this.littleEndian),this.intent_code=rt.getIntAt(n,504,this.littleEndian),this.intent_name=rt.getStringAt(n,508,524),this.dim_info=rt.getByteAt(n,524),n.byteLength>Me.MAGIC_COOKIE&&(this.extensionFlag[0]=rt.getByteAt(n,540),this.extensionFlag[1]=rt.getByteAt(n,541),this.extensionFlag[2]=rt.getByteAt(n,542),this.extensionFlag[3]=rt.getByteAt(n,543),this.extensionFlag[0]&&(this.extensions=rt.getExtensionsAt(n,this.getExtensionLocation(),this.littleEndian,this.vox_offset),this.extensionSize=this.extensions[0].esize,this.extensionCode=this.extensions[0].ecode))}toFormattedString(){var t=rt.formatNumber,n="";return n+="Datatype = "+ +this.datatypeCode+" ("+this.getDatatypeCodeString(this.datatypeCode)+`)
+`,n+="Bits Per Voxel =  = "+this.numBitsPerVoxel+`
+`,n+="Image Dimensions (1-8): "+this.dims[0]+", "+this.dims[1]+", "+this.dims[2]+", "+this.dims[3]+", "+this.dims[4]+", "+this.dims[5]+", "+this.dims[6]+", "+this.dims[7]+`
+`,n+="Intent Parameters (1-3): "+this.intent_p1+", "+this.intent_p2+", "+this.intent_p3+`
+`,n+="Voxel Dimensions (1-8): "+t(this.pixDims[0])+", "+t(this.pixDims[1])+", "+t(this.pixDims[2])+", "+t(this.pixDims[3])+", "+t(this.pixDims[4])+", "+t(this.pixDims[5])+", "+t(this.pixDims[6])+", "+t(this.pixDims[7])+`
+`,n+="Image Offset = "+this.vox_offset+`
+`,n+="Data Scale:  Slope = "+t(this.scl_slope)+"  Intercept = "+t(this.scl_inter)+`
+`,n+="Display Range:  Max = "+t(this.cal_max)+"  Min = "+t(this.cal_min)+`
+`,n+="Slice Duration = "+this.slice_duration+`
+`,n+="Time Axis Shift = "+this.toffset+`
+`,n+="Slice Start = "+this.slice_start+`
+`,n+="Slice End = "+this.slice_end+`
+`,n+='Description: "'+this.description+`"
+`,n+='Auxiliary File: "'+this.aux_file+`"
+`,n+="Q-Form Code = "+this.qform_code+" ("+this.getTransformCodeString(this.qform_code)+`)
+`,n+="S-Form Code = "+this.sform_code+" ("+this.getTransformCodeString(this.sform_code)+`)
+`,n+="Quaternion Parameters:  b = "+t(this.quatern_b)+"  c = "+t(this.quatern_c)+"  d = "+t(this.quatern_d)+`
+`,n+="Quaternion Offsets:  x = "+this.qoffset_x+"  y = "+this.qoffset_y+"  z = "+this.qoffset_z+`
+`,n+="S-Form Parameters X: "+t(this.affine[0][0])+", "+t(this.affine[0][1])+", "+t(this.affine[0][2])+", "+t(this.affine[0][3])+`
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+`,n+="Dim Info = "+this.dim_info+`
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ts",{});const t=Object.keys(kl).filter(n=>!n.startsWith("$")).sort(new Intl.Collator("en").compare);for(const n of t)this.cluts[n]=kl[n]}addColormap(i,t){this.cluts[i]=t}colormaps(){return Object.keys(this.cluts)}colorMaps(){return this.colormaps()}colormapFromKey(i){let t=this.cluts[i];return t!==void 0||(t=this.cluts[i.toLowerCase()],t!==void 0)?t:(i.length>0&&k.warn("No color map named "+i),{min:0,max:0,R:[0,255],G:[0,255],B:[0,255],A:[0,255],I:[0,255]})}colormap(i="",t=!1){const n=this.colormapFromKey(i);return this.makeLut(n.R,n.G,n.B,n.A,n.I,t)}makeLabelLut(i,t=255,n=1/0){if(i.R===void 0||i.G===void 0||i.B===void 0)throw new Error(`Invalid colormap table: ${i}`);const s=i.R.length,r=i.I??[...Array(s).keys()];let c=!1;for(let A=0;A<r.length;A++)r[A]>n&&(c=!0,r[A]=n);if(c&&k.warn("Some colormap indices clamped to match label range."),s!==i.G.length||s!==i.B.length||s!==r.length)throw new Error(`colormap does not make sense: ${i} Rs ${i.R.length} Gs ${i.G.length} Bs ${i.B.length} Is ${r.length}`);let l=new Uint8ClampedArray(s).fill(t);l[0]=0,i.A!==void 0&&(l=Uint8ClampedArray.from(i.A));const d=Math.min(...r),h=Math.max(...r),u=h-d+1,m=new Uint8ClampedArray(u*4).fill(0);for(let A=0;A<s;A++){let v=(r[A]-d)*4;m[v++]=i.R[A],m[v++]=i.G[A],m[v++]=i.B[A],m[v++]=l[A]}const g={lut:m,min:d,max:h};if(i.labels){const A=i.labels.length;if(A===u)g.labels=i.labels;else if(A===s){g.labels=Array(u).fill("?");for(let v=0;v<s;v++){const y=r[v];g.labels[y]=i.labels[v]}}}return g}async makeLabelLutFromUrl(i,t=255,n=1/0){const r=await(await fetch(i)).json();return this.makeLabelLut(r,t,n)}makeDrawLut(i){let t=typeof i=="object"?i:kl[i];t===void 0&&(k.warn("colormap undefined ",i),t=this.colormapFromKey(""));const n=this.makeLabelLut(t,255);if(n.labels===void 0&&(n.labels=[]),n.labels.length<256){const l=n.labels.length;for(let d=l;d<256;d++)n.labels.push(d.toString())}const s=new Uint8ClampedArray(256*4);let r=0;for(let l=0;l<256;l++)s[r++]=255,s[r++]=0,s[r++]=0,s[r++]=255;s[3]=0;const c=Math.min(n.lut.length,256*4);if(c>0)for(let l=0;l<c;l++)s[l]=n.lut[l];return{lut:s,labels:n.labels}}makeLut(i,t,n,s,r,c){const l=i.length,d=[...i],h=[...t],u=[...n];if(!r){r=new Array(l);for(let v=0;v<l;v++)r[v]=v/(l-1)*255}s||(s=new Array(l).fill(64),s[0]=0);let m=Uint8ClampedArray.from(s),g=Uint8ClampedArray.from(r);if(c)for(let v=0;v<l;v++)d[v]=i[l-1-v],h[v]=t[l-1-v],u[v]=n[l-1-v],m[v]=255-s[l-1-v],g[v]=255-r[l-1-v];const A=new Uint8ClampedArray(256*4);if(typeof g>"u"){g=new Uint8ClampedArray(l).fill(0);for(let v=0;v<l;v++)g[v]=Math.round(v*255/(l-1))}typeof m>"u"&&(m=new Uint8ClampedArray(l).fill(64),m[0]=0);for(let v=0;v<l-1;v++){const y=g[v];let w=g[v+1];v===0&&y!==0&&k.warn("colormap issue: indices expected to start with 0 not ",y),v===g.length-2&&w!==255&&(k.warn("padding colormap: indices expected end with 255 not ",w),w=255);const b=w-y;let C=y*4;for(let S=y;S<=w;S++){const E=(S-y)/b;A[C++]=d[v]+E*(d[v+1]-d[v]),A[C++]=h[v]+E*(h[v+1]-h[v]),A[C++]=u[v]+E*(u[v+1]-u[v]),A[C++]=m[v]+E*(m[v+1]-m[v])}}if(this.gamma===1)return A;for(let v=0;v<1020;v++)v%4!==3&&(A[v]=Math.pow(A[v]/255,1/this.gamma)*255);return A}},Pt=new h4,Xn=class{static getClusterBoundaryU8(i,t){const n=new Array(i.length).fill(!1),s=new Array(i.length).fill(!1);for(let l=0;l<i.length;l++)i[l]>0&&(s[l]=!0);const r=t.length/3;let c=0;for(let l=0;l<r;l++){const d=t[c],h=t[c+1],u=t[c+2];c+=3,!(s[d]===s[h]&&s[d]===s[u]&&s[h]===s[u])&&(n[d]=!0,n[h]=!0,n[u]=!0)}return n}static async gzip(i){const t=new CompressionStream("gzip"),n=t.writable.getWriter();n.write(i).catch(console.error);const s=n.close().catch(console.error),r=new Response(t.readable),c=new Uint8Array(await r.arrayBuffer());return await s,c}static createMZ3(i,t,n=!1,s=null){const c=s instanceof Uint8Array&&s.length===i.length/3*4,l=c?7:3,d=t.length/3,h=i.length/3,u=0,m=16,g=d*3*4,A=h*3*4,v=c?s.length:0,y=m+g+A+v,w=new ArrayBuffer(y),b=new DataView(w);b.setUint16(0,23117,!0),b.setUint16(2,l,!0),b.setUint32(4,d,!0),b.setUint32(8,h,!0),b.setUint32(12,u,!0);let C=m;if(new Uint32Array(w,C,t.length).set(t),C+=g,new Float32Array(w,C,i.length).set(i),c&&(C+=A,new Uint8Array(w,C,s.length).set(s)),n)throw new Error("Call async createMZ3Async() for compression");return w}static async createMZ3Async(i,t,n=!1,s=null){const r=this.createMZ3(i,t,n,s);return n?await this.gzip(new Uint8Array(r)):r}static createOBJ(i,t){let n="";for(let c=0;c<i.length;c+=3)n+=`v ${i[c]} ${i[c+1]} ${i[c+2]}
+`;for(let c=0;c<t.length;c+=3)n+=`f ${t[c]+1} ${t[c+1]+1} ${t[c+2]+1}
+`;return new TextEncoder().encode(n).buffer}static createSTL(i,t){const n=t.length/3,s=84+n*50,r=new ArrayBuffer(s),c=new DataView(r);for(let d=0;d<80;d++)c.setUint8(d,0);c.setUint32(80,n,!0);let l=84;for(let d=0;d<t.length;d+=3){const h=t[d]*3,u=t[d+1]*3,m=t[d+2]*3;c.setFloat32(l,0,!0),c.setFloat32(l+4,0,!0),c.setFloat32(l+8,0,!0),l+=12,c.setFloat32(l,i[h],!0),c.setFloat32(l+4,i[h+1],!0),c.setFloat32(l+8,i[h+2],!0),l+=12,c.setFloat32(l,i[u],!0),c.setFloat32(l+4,i[u+1],!0),c.setFloat32(l+8,i[u+2],!0),l+=12,c.setFloat32(l,i[m],!0),c.setFloat32(l+4,i[m+1],!0),c.setFloat32(l+8,i[m+2],!0),l+=12,c.setUint16(l,0,!0),l+=2}return r}static downloadArrayBuffer(i,t){const n=new Blob([i],{type:"application/octet-stream"}),s=URL.createObjectURL(n),r=document.createElement("a");r.href=s,r.download=t,document.body.appendChild(r),r.style.display="none",r.click(),setTimeout(()=>{document.body.removeChild(r),URL.revokeObjectURL(s)},0)}static async saveMesh(i,t,n=".mz3",s=!1){let r=new ArrayBuffer(0);return/\.obj$/i.test(n)?r=this.createOBJ(i,t):/\.stl$/i.test(n)?r=this.createSTL(i,t):(/\.mz3$/i.test(n)||(n+=".mz3"),r=await this.createMZ3Async(i,t,s)),n.length>4&&this.downloadArrayBuffer(r,n),r}static getClusterBoundary(i,t){const n=new Uint32Array(i.buffer),s=new Array(n.length).fill(!1),r=t.length/3;let c=0;for(let l=0;l<r;l++){const d=t[c],h=t[c+1],u=t[c+2];c+=3,!(n[d]===n[h]&&n[d]===n[u]&&n[h]===n[u])&&(s[d]=!0,s[h]=!0,s[u]=!0)}return s}static getExtents(i){if(!ArrayBuffer.isView(i)&&!Array.isArray(i)||i.length<3)return{mxDx:0,extentsMin:0,extentsMax:0};let t=0;const n=lt(i[0],i[1],i[2]),s=lt(i[0],i[1],i[2]);for(let l=0;l<i.length;l+=3){const d=lt(i[l],i[l+1],i[l+2]);t=Math.max(t,tr(d)),Jh(n,n,d),$h(s,s,d)}const r=[n[0],n[1],n[2]],c=[s[0],s[1],s[2]];return{mxDx:t,extentsMin:r,extentsMax:c}}static generateNormals(i,t){const n=[];let s;const r=i.length;let c,l,d,h,u,m,g,A,v;const y=new Float32Array(r),w=t.length;for(s=0;s<w;s+=3){g=t[s]*3,A=t[s+1]*3,v=t[s+2]*3;const b=[i[g],i[g+1],i[g+2]],C=[i[A],i[A+1],i[A+2]],S=[i[v],i[v+1],i[v+2]];c=C[0]-b[0],l=C[1]-b[1],d=C[2]-b[2],h=S[0]-b[0],u=S[1]-b[1],m=S[2]-b[2],n[0]=u*d-m*l,n[1]=m*c-h*d,n[2]=h*l-u*c,y[g]+=n[0],y[g+1]+=n[1],y[g+2]+=n[2],y[A]+=n[0],y[A+1]+=n[1],y[A+2]+=n[2],y[v]+=n[0],y[v+1]+=n[1],y[v+2]+=n[2]}for(s=0;s<r;s+=3){n[0]=-1*y[s],n[1]=-1*y[s+1],n[2]=-1*y[s+2];let b=n[0]*n[0]+n[1]*n[1]+n[2]*n[2];b>0&&(b=1/Math.sqrt(b),n[0]*=b,n[1]*=b,n[2]*=b),y[s]=n[0],y[s+1]=n[1],y[s+2]=n[2]}return y}},yt,ze,Yl,Qh,Qa,Q2=class{constructor(i){ks(this,yt),ks(this,ze,0),ks(this,Yl,[]),ks(this,Qh,[]),ks(this,Qa),pn(this,yt,new DataView(i)),this.read()}async extract(i){const t=new Uint8Array(dt(this,yt).buffer.slice(i.startsAt,i.startsAt+i.compressedSize));if(i.compressionMethod===0)return t;if(i.compressionMethod===8){const n=new DecompressionStream("deflate-raw"),s=n.writable.getWriter();s.write(t).catch(console.error);const r=s.close().catch(console.error),c=new Response(n.readable),l=new Uint8Array(await c.arrayBuffer());return await r,l}throw new Error(`Unsupported compression method: ${i.compressionMethod}`)}read(){for(;!dt(this,Qa)&&dt(this,ze)<dt(this,yt).byteLength;){const i=dt(this,yt).getUint32(dt(this,ze),!0);if(i===67324752){const t=this.readLocalFile(dt(this,ze));t.extract=this.extract.bind(this,t),dt(this,Yl).push(t);const n=(t.generalPurpose&8)!==0;if(t.startsAt=dt(this,ze)+30+t.fileNameLength+t.extraLength,t.compressedSize===0&&n){let s=t.startsAt;for(;s+20<=dt(this,yt).byteLength;){if(dt(this,yt).getUint32(s,!0)===134695760&&dt(this,yt).getUint16(s+16,!0)===19280){s+=4;break}s++}t.crc=dt(this,yt).getUint32(s,!0),t.compressedSize=dt(this,yt).getUint32(s+4,!0),t.uncompressedSize=dt(this,yt).getUint32(s+8,!0),pn(this,ze,s+12)}else pn(this,ze,t.startsAt+t.compressedSize)}else if(i===33639248){const t=this.readCentralDirectory(dt(this,ze));dt(this,Qh).push(t),pn(this,ze,dt(this,ze)+(46+t.fileNameLength+t.extraLength+t.fileCommentLength))}else if(i===101010256){pn(this,Qa,this.readEndCentralDirectory(dt(this,ze)));break}else if(i===101075792){pn(this,Qa,this.readEndCentralDirectory64(dt(this,ze)));break}else{console.error(`Unexpected ZIP signature 0x${i.toString(16).padStart(8,"0")} at index ${dt(this,ze)}`);break}}}readLocalFile(i){let t=dt(this,yt).getUint32(i+18,!0),n=dt(this,yt).getUint32(i+22,!0);const s=dt(this,yt).getUint16(i+26,!0),r=dt(this,yt).getUint16(i+28,!0),c=i+30+s;if(this.readString(c,r),t===4294967295&&n===4294967295){let l=c,d=!1;for(;l<c+r-4;){const h=dt(this,yt).getUint16(l,!0),u=dt(this,yt).getUint16(l+2,!0);if(l+=4,h===1)if(u>=16){n=Number(dt(this,yt).getBigUint64(l,!0)),l+=8,t=Number(dt(this,yt).getBigUint64(l,!0)),d=!0;break}else throw new Error(`ZIP64 extra field found but is too small (expected at least 16 bytes, got ${u}).`);l+=u}if(!d)throw new Error("ZIP64 format missing extra field with signature 0x0001.")}return{signature:this.readString(i,4),version:dt(this,yt).getUint16(i+4,!0),generalPurpose:dt(this,yt).getUint16(i+6,!0),compressionMethod:dt(this,yt).getUint16(i+8,!0),lastModifiedTime:dt(this,yt).getUint16(i+10,!0),lastModifiedDate:dt(this,yt).getUint16(i+12,!0),crc:dt(this,yt).getUint32(i+14,!0),compressedSize:t,uncompressedSize:n,fileNameLength:s,extraLength:r,fileName:this.readString(i+30,s),extra:this.readString(i+30+s,r)}}readCentralDirectory(i){return{versionCreated:dt(this,yt).getUint16(i+4,!0),versionNeeded:dt(this,yt).getUint16(i+6,!0),fileNameLength:dt(this,yt).getUint16(i+28,!0),extraLength:dt(this,yt).getUint16(i+30,!0),fileCommentLength:dt(this,yt).getUint16(i+32,!0),diskNumber:dt(this,yt).getUint16(i+34,!0),internalAttributes:dt(this,yt).getUint16(i+36,!0),externalAttributes:dt(this,yt).getUint32(i+38,!0),offset:dt(this,yt).getUint32(i+42,!0),comments:this.readString(i+46,dt(this,yt).getUint16(i+32,!0))}}readEndCentralDirectory(i){const t=dt(this,yt).getUint16(i+20,!0);return{numberOfDisks:dt(this,yt).getUint16(i+4,!0),centralDirectoryStartDisk:dt(this,yt).getUint16(i+6,!0),numberCentralDirectoryRecordsOnThisDisk:dt(this,yt).getUint16(i+8,!0),numberCentralDirectoryRecords:dt(this,yt).getUint16(i+10,!0),centralDirectorySize:dt(this,yt).getUint32(i+12,!0),centralDirectoryOffset:dt(this,yt).getUint32(i+16,!0),commentLength:t,comment:this.readString(i+22,t)}}readEndCentralDirectory64(i){const t=Number(dt(this,yt).getBigUint64(i+0,!0));return{numberOfDisks:dt(this,yt).getUint32(i+16,!0),centralDirectoryStartDisk:dt(this,yt).getUint32(i+20,!0),numberCentralDirectoryRecordsOnThisDisk:Number(dt(this,yt).getBigUint64(i+24,!0)),numberCentralDirectoryRecords:Number(dt(this,yt).getBigUint64(i+32,!0)),centralDirectorySize:Number(dt(this,yt).getBigUint64(i+40,!0)),centralDirectoryOffset:Number(dt(this,yt).getBigUint64(i+48,!0)),commentLength:t,comment:""}}readString(i,t){return Array.from({length:t},(n,s)=>String.fromCharCode(dt(this,yt).getUint8(i+s))).join("")}get entries(){return dt(this,Yl)}};yt=new WeakMap;ze=new WeakMap;Yl=new WeakMap;Qh=new WeakMap;Qa=new WeakMap;var At=class Ys{static arrayBufferToBase64(t){const n=new Uint8Array(t);return Ys.uint8tob64(n)}static async decompress(t){const n=t[0]===31&&t[1]===139&&t[2]===8?"gzip":t[0]===120&&(t[1]===1||t[1]===94||t[1]===156||t[1]===218)?"deflate":"deflate-raw",s=new DecompressionStream(n),r=s.writable.getWriter();r.write(t).catch(console.error);const c=r.close().catch(console.error),l=new Response(s.readable),d=new Uint8Array(await l.arrayBuffer());return await c,d}static async decompressToBuffer(t){const n=await Ys.decompress(t);return n.buffer.slice(n.byteOffset,n.byteOffset+n.byteLength)}static async readMatV4(t,n=!1){let s=t.byteLength;if(s<40)throw new Error("File too small to be MAT v4: bytes = "+t.byteLength);let r=new DataView(t),c=r.getUint16(0,!0),l=t;if(c===35615||c===8075){const y=await this.decompress(new Uint8Array(t));r=new DataView(y.buffer),c=r.getUint16(0,!0),l=y.buffer,s=l.byteLength}const d=new TextDecoder("utf-8"),h=new Uint8Array(l);let u=0;const m={};function g(y){return Math.floor(y/10)%10}function A(y,w,b){const C=new Uint8Array(h.subarray(w,b));return y===1?new Float32Array(C.buffer):y===2?new Int32Array(C.buffer):y===3?new Int16Array(C.buffer):y===4?new Uint16Array(C.buffer):y===5?new Uint8Array(C.buffer):new Float64Array(C.buffer)}function v(){const y=r.getUint32(u,!0),w=r.getUint32(u+4,!0),b=r.getUint32(u+8,!0),C=r.getUint32(u+12,!0),S=r.getUint32(u+16,!0);if(u+=20,C!==0)throw new Error("Matlab V4 reader does not support imaginary numbers");const E=w*b;if(E<1)throw new Error("mrows * ncols must be greater than one");const M=new Uint8Array(h.subarray(u,u+S));let N=d.decode(M).trim().replaceAll("\0","");n&&(N=N.replaceAll(".","_"));const U=g(y);let T=8;if(U>=1&&U<=2)T=4;else if(U>=3&&U<=4)T=2;else if(U===5)T=1;else if(U!==0)throw new Error("impossible Matlab v4 datatype");if(u+=S,y>50)throw new Error("Does not appear to be little-endian V4 Matlab file");const F=u+E*T;m[N]=A(U,u,F),u=F}for(;u+20<s;)v();return m}static b64toUint8(t){const n=atob(t),s=n.length,r=new Uint8Array(s);for(let c=0;c<s;c++)r[c]=n.charCodeAt(c);return r}static uint8tob64(t){let n="";const s="ABCDEFGHIJKLMNOPQRSTUVWXYZabcdefghijklmnopqrstuvwxyz0123456789+/",r=t.byteLength,c=r%3,l=r-c;let d,h,u,m,g;for(let A=0;A<l;A=A+3)g=t[A]<<16|t[A+1]<<8|t[A+2],d=(g&16515072)>>18,h=(g&258048)>>12,u=(g&4032)>>6,m=g&63,n+=s[d]+s[h]+s[u]+s[m];return c===1?(g=t[l],d=(g&252)>>2,h=(g&3)<<4,n+=s[d]+s[h]+"=="):c===2&&(g=t[l]<<8|t[l+1],d=(g&64512)>>10,h=(g&1008)>>4,u=(g&15)<<2,n+=s[d]+s[h]+s[u]+"="),n}static download(t,n,s){const r=document.createElement("a"),c=Array.isArray(t)?t:[t],l=new Blob(c,{type:s});r.href=URL.createObjectURL(l),r.download=n,r.click()}static readFileAsync(t){return new Promise((n,s)=>{const r=new FileReader;r.onload=()=>{n(r.result)},r.onerror=s,r.readAsArrayBuffer(t)})}static blobToBase64(t){return new Promise(n=>{const s=new FileReader;s.onloadend=()=>n(s.result),s.readAsDataURL(t)})}static async decompressBase64String(t){const n=atob(t),s=new ArrayBuffer(n.length),r=new Uint8Array(s);for(let c=0;c<n.length;c++)r[c]=n.charCodeAt(c);return Ys.decompressArrayBuffer(r)}static async compressToBase64String(t){const n=await Ys.compressStringToArrayBuffer(t);return Ys.uint8tob64(new Uint8Array(n))}static strToU8(t,n){if(n){const h=new Uint8Array(t.length);for(let u=0;u<t.length;++u)h[u]=t.charCodeAt(u);return h}const s=t.length,r=(h,u,m)=>((m==null||m>h.length)&&(m=h.length),new Uint8Array(h.subarray(u,m)));let c=new Uint8Array(t.length+(t.length>>1)),l=0;const d=h=>{c[l++]=h};for(let h=0;h<s;++h){if(l+5>c.length){const m=new Uint8Array(l+8+(s-h<<1));m.set(c),c=m}let u=t.charCodeAt(h);u<128||n?d(u):u<2048?(d(192|u>>6),d(128|u&63)):(u>55295&&u<57344,u=65536+(u&1047552)|t.charCodeAt(++h)&1023,d(240|u>>18),d(128|u>>12&63),d(128|u>>6&63),d(128|u&63))}return r(c,0,l)}static async compress(t,n="gzip"){const s=new CompressionStream(n),r=s.writable.getWriter();r.write(t).catch(console.error);const c=r.close().catch(console.error),d=await new Response(s.readable).arrayBuffer();return await c,d}static async compressStringToArrayBuffer(t){const n=this.strToU8(t);return await this.compress(n)}static isArrayBufferCompressed(t){if(t&&t.byteLength){const n=new Uint8Array(t);return(n[0]<<8|n[1])===8075}else return!1}static strFromU8(t,n){if(n){let s="";for(let r=0;r<t.length;r+=16384)s+=String.fromCharCode.apply(null,t.subarray(r,r+16384));return s}else{const s=(d,h,u)=>((h==null||h<0)&&(h=0),(u==null||u>d.length)&&(u=d.length),new Uint8Array(d.subarray(h,u))),r=d=>{for(let h="",u=0;;){let m=d[u++];const g=(m>127)+(m>223)+(m>239);if(u+g>d.length)return{s:h,r:s(d,u-1)};g?g===3?(m=((m&15)<<18|(d[u++]&63)<<12|(d[u++]&63)<<6|d[u++]&63)-65536,h+=String.fromCharCode(55296|m>>10,56320|m&1023)):g&1?h+=String.fromCharCode((m&31)<<6|d[u++]&63):h+=String.fromCharCode((m&15)<<12|(d[u++]&63)<<6|d[u++]&63):h+=String.fromCharCode(m)}},{s:c,r:l}=r(t);if(l.length)throw new Error("Unexpected trailing bytes in UTF-8 decoding");return c}}static async decompressArrayBuffer(t){const n=await this.decompress(new Uint8Array(t));return this.strFromU8(n)}static arraysAreEqual(t,n){return vp(t,n)}static range(t,n,s){return Array.from({length:(n-t)/s+1},(r,c)=>t+c*s)}static sph2cartDeg(t,n){const s=-n*(Math.PI/180),r=(t-90)%360*(Math.PI/180),c=[Math.cos(s)*Math.cos(r),Math.cos(s)*Math.sin(r),Math.sin(s)],l=Math.sqrt(c[0]*c[0]+c[1]*c[1]+c[2]*c[2]);return l<=0||(c[0]/=l,c[1]/=l,c[2]/=l),c}static vox2mm(t,n){const s=re(n);We(s,s);const r=te(t[0],t[1],t[2],1);return De(r,r,s),lt(r[0],r[1],r[2])}},Ya=k,$t=class me{static readTRACT(t){const n=t.byteLength;if(n<20)throw new Error("File too small to be niml.tract: bytes = "+n);const s=new DataView(t),r=new Uint8Array(t);let c=0;function l(){for(;c<n&&r[c]!==60;)c++;const w=c;for(;c<n&&r[c]!==62;)c++;return c++,c-w<1?"":new TextDecoder().decode(t.slice(w,c-1)).trim()}let d=l();function h(w){const b=d.indexOf(w);if(b<0)return 0;const C=d.indexOf('"',b)+1,S=d.indexOf('"',C),E=d.slice(C,S);return parseInt(E)}const u=h("N_tracts=");(!d.startsWith("<network")||u<1)&&k.warn("This is not a valid niml.tract file "+d);let m=0;const g=[];g.push(m);const A=[],v=[];for(let w=0;w<u;w++){d=l();const b=h("ni_dimen="),C=h("Bundle_Tag="),S=d.includes("binary.lsbfirst");for(let E=0;E<b;E++){c+=4;const M=s.getUint32(c,S)/3;c+=4;for(let N=0;N<M;N++)A.push(s.getFloat32(c,S)),c+=4,A.push(-s.getFloat32(c,S)),c+=4,A.push(s.getFloat32(c,S)),c+=4;m+=M,g.push(m),v.push(C)}d=l()}const y=[];return y.push({id:"tract",vals:Float32Array.from(v)}),{pts:new Float32Array(A),offsetPt0:new Uint32Array(g),dps:y}}static async readTT(t){let n=new Uint32Array(0),s=new Float32Array(0);const r=await At.readMatV4(t);if(!("trans_to_mni"in r))throw new Error("TT format file must have 'trans_to_mni'");if(!("voxel_size"in r))throw new Error("TT format file must have 'voxel_size'");if(!("track"in r))throw new Error("TT format file must have 'track'");let c=Ut();const l=r.trans_to_mni;c=oi(l[0],l[1],l[2],l[3],l[4],l[5],l[6],l[7],l[8],l[9],l[10],l[11],l[12],l[13],l[14],l[15]),We(c,c);function d(h){const u=new DataView(h.buffer),m=[];let g=0,A=0;for(;A<h.length;){m.push(A);const w=u.getUint32(A,!0);A=A+w+13,g+=w}n=new Uint32Array(m.length+1),s=new Float32Array(g);let v=0;for(let w=0;w<m.length;w++){n[w]=v/3;let b=m[w];const C=u.getUint32(b,!0)/3;let S=u.getInt32(b+4,!0),E=u.getInt32(b+8,!0),M=u.getInt32(b+12,!0);b+=16,s[v++]=S,s[v++]=E,s[v++]=M;for(let N=2;N<=C;N++)S=S+u.getInt8(b++),E=E+u.getInt8(b++),M=M+u.getInt8(b++),s[v++]=S,s[v++]=E,s[v++]=M}for(let w=0;w<v;w++)s[w]=s[w]/32;let y=0;for(let w=0;w<v/3;w++){const b=te(s[y],s[y+1],s[y+2],1);De(b,b,c),s[y++]=b[0],s[y++]=b[1],s[y++]=b[2]}n[m.length]=v/3}return d(r.track),{pts:s,offsetPt0:n}}static assembleDpgFromMap(t,n){if(!Array.isArray(n)||n.length===0)throw new Error('assembleDpgFromMap: "groups" is empty or missing; cannot assemble dpg.');for(let h=0;h<n.length;h++){const u=String(n[h].id);if(!t[u])throw new Error(`assembleDpgFromMap: missing dpgMap entry for group "${u}".`);if(!Array.isArray(t[u]))throw new Error(`assembleDpgFromMap: dpgMap["${u}"] is not an array.`)}const s=String(n[0].id),r=t[s],c=[],l=new Set;for(const h of r){if(!h||typeof h.id!="string")throw new Error(`assembleDpgFromMap: invalid entry in group "${s}".`);if(l.has(h.id))throw new Error(`assembleDpgFromMap: duplicate tag "${h.id}" in group "${s}".`);l.add(h.id),c.push(h.id)}if(l.size===0)throw new Error(`assembleDpgFromMap: no tags found in group "${s}".`);for(let h=1;h<n.length;h++){const u=String(n[h].id),m=t[u],g=new Map;for(const A of m){if(!A||typeof A.id!="string")throw new Error(`assembleDpgFromMap: invalid entry in group "${u}".`);g.set(A.id,(g.get(A.id)||0)+1)}for(const[A,v]of g.entries())if(v>1)throw new Error(`assembleDpgFromMap: multiple entries for tag "${A}" in group "${u}".`);if(g.size!==l.size)throw new Error(`assembleDpgFromMap: tag coverage mismatch for group "${u}". Expected ${l.size} tags but found ${g.size}.`);for(const A of l)if(!g.has(A))throw new Error(`assembleDpgFromMap: group "${u}" missing tag "${A}".`)}const d=[];for(const h of c){const u=[];let m=0;for(let v=0;v<n.length;v++){const y=String(n[v].id),b=t[y].filter(S=>S.id===h);if(b.length===0)throw new Error(`assembleDpgFromMap: missing tag "${h}" for group "${y}".`);if(b.length>1)throw new Error(`assembleDpgFromMap: multiple entries for tag "${h}" in group "${y}".`);const C=b[0];if(C.vals instanceof Float32Array)u.push(C.vals),m+=C.vals.length;else try{const S=Float32Array.from(C.vals);u.push(S),m+=S.length}catch{throw new Error(`assembleDpgFromMap: invalid vals for tag "${h}" in group "${y}".`)}}const g=new Float32Array(m);let A=0;for(const v of u)g.set(v,A),A+=v.length;d.push({id:h,vals:g})}return d}static async readTRX(t){function n(w){const b=(w&31744)>>10,C=w&1023;return(w>>15?-1:1)*(b?b===31?C?NaN:1/0:Math.pow(2,b-15)*(1+C/1024):6103515625e-14*(C/1024))}let s=0,r=0,c=new Float32Array([]);const l=[],d={},h=[],u=[],m=[];let g=[],A=!1;const v=new Q2(t);for(let w=0;w<v.entries.length;w++){const b=v.entries[w];if(b.uncompressedSize===0)continue;const C=b.fileName.split("/"),S=C.slice(-1)[0];if(S.startsWith("."))continue;const E=C.slice(-3)[0],M=C.slice(-2)[0],N=S.split(".")[0],U=await b.extract();if(S.includes("header.json")){const I=new TextDecoder().decode(U);g=JSON.parse(I);continue}let T=0,F=[];if(S.endsWith(".uint64")||S.endsWith(".int64")){T=U.length/8,F=new Uint32Array(T);const I=new Uint32Array(U.buffer);let B=0;for(let V=0;V<T;V++)F[V]=I[B],I[B+1]!==0&&(A=!0),B+=2}else if(S.endsWith(".uint32"))F=new Uint32Array(U.buffer);else if(S.endsWith(".uint16"))F=new Uint16Array(U.buffer);else if(S.endsWith(".uint8"))F=new Uint8Array(U.buffer);else if(S.endsWith(".int32"))F=new Int32Array(U.buffer);else if(S.endsWith(".int16"))F=new Int16Array(U.buffer);else if(S.endsWith(".int8"))F=new Int8Array(U.buffer);else if(S.endsWith(".float64"))F=new Float64Array(U.buffer);else if(S.endsWith(".float32"))F=new Float32Array(U.buffer);else if(S.endsWith(".float16")){T=U.length/2,F=new Float32Array(T);const I=new Uint16Array(U.buffer),B=new Float32Array(65536);for(let V=0;V<65536;V++)B[V]=n(V);for(let V=0;V<T;V++)F[V]=B[I[V]]}else continue;if(T=F.length,M.includes("groups")){h.push({id:N,vals:Float32Array.from(F.slice())});continue}if(E.includes("dpg")){const I=String(M);d[I]||(d[I]=[]),d[I].push({id:N,vals:Float32Array.from(F.slice())});continue}if(M.includes("dpv")){m.push({id:N,vals:Float32Array.from(F.slice())});continue}if(M.includes("dps")){u.push({id:N,vals:Float32Array.from(F.slice())});continue}if(S.startsWith("offsets.")){s=T;for(let I=0;I<T;I++)l[I]=F[I]}S.startsWith("positions.3.")&&(r=T,c=new Float32Array(F))}if(s===0||r===0)throw new Error("Failure reading TRX format (no offsets or points).");if(A)throw new Error("Too many vertices: JavaScript does not support 64 bit integers");let y=[];return h.length>0&&d&&Object.keys(d).length>0&&(y=this.assembleDpgFromMap(d,h)),l[s]=r/3,{pts:c,offsetPt0:new Uint32Array(l),dpg:y,dps:u,dpv:m,groups:h,header:g}}static readTXT(t,n=0){const r=new TextDecoder("utf-8").decode(t).split(/\r?\n|\r/).filter(l=>l.trim().length>0);n<=0&&(n=r.length);const c=new Float32Array(n);for(let l=0;l<n&&l<r.length;l++){const d=parseFloat(r[l].trim());c[l]=Number.isFinite(d)?d:0}return c}static readTSF(t,n=0){const s=new Float32Array(n),r=t.byteLength;if(r<20)throw new Error("File too small to be TSF: bytes = "+r);const c=new Uint8Array(t);let l=0;function d(){for(;l<r&&c[l]===10;)l++;const A=l;for(;l<r&&c[l]!==10;)l++;return l++,l-A<1?"":new TextDecoder().decode(t.slice(A,l-1))}let h=d();if(!h.includes("mrtrix track scalars"))throw new Error("Not a valid TSF file");let u=-1;for(;l<r&&!h.includes("END");)if(h=d(),h.toLowerCase().startsWith("file:")&&(u=parseInt(h.split(" ").pop())),h.toLowerCase().startsWith("datatype:")&&!h.endsWith("Float32LE"))throw new Error("Only supports TSF files with Float32LE");if(u<20)throw new Error("Not a valid TSF file (missing file offset)");l=u;const m=new DataView(t);let g=0;for(;l+4<=r&&g<n;){const A=m.getFloat32(l,!0);if(l+=4,isFinite(A))s[g++]=A;else if(!isNaN(A))break}return s}static readTCK(t){const n=t.byteLength;if(n<20)throw new Error("File too small to be TCK: bytes = "+n);const s=new Uint8Array(t);let r=0;function c(){for(;r<n&&s[r]===10;)r++;const y=r;for(;r<n&&s[r]!==10;)r++;return r++,r-y<1?"":new TextDecoder().decode(t.slice(y,r-1))}let l=c();if(!l.includes("mrtrix tracks"))throw new Error("Not a valid TCK file");let d=-1;for(;r<n&&!l.includes("END");)l=c(),l.toLowerCase().startsWith("file:")&&(d=parseInt(l.split(" ").pop()));if(d<20)throw new Error("Not a valid TCK file (missing file offset)");r=d;const h=new DataView(t);let u=0,m=new Uint32Array(n/16),g=0,A=0,v=new Float32Array(n/4);for(m[0]=0;r+12<n;){const y=h.getFloat32(r,!0);r+=4;const w=h.getFloat32(r,!0);r+=4;const b=h.getFloat32(r,!0);if(r+=4,isFinite(y))v[A++]=y,v[A++]=w,v[A++]=b,u++;else if(m[g++]=u,!isNaN(y))break}return v=v.slice(0,A),m=m.slice(0,g),{pts:v,offsetPt0:m}}static async readTRK(t){let n=new DataView(t),s=n.getUint32(0,!0);if(s!==1128354388){let V;if(s===4247762216)throw new Error("zstd TRK decompression is not supported");V=await At.decompress(new Uint8Array(t)),t=V.buffer,n=new DataView(t),s=n.getUint32(0,!0)}const r=n.getUint32(992,!0),c=n.getUint32(996,!0);if(r>2||c!==1e3||s!==1128354388)throw new Error("Not a valid TRK file");const l=n.getInt16(36,!0),d=[];for(let V=0;V<l;V++){const R=new Uint8Array(t.slice(38+V*20,58+V*20)),Y=new TextDecoder().decode(R).split("\0").shift();d.push({id:Y.trim(),vals:[]})}const h=n.getFloat32(12,!0),u=n.getFloat32(16,!0),m=n.getFloat32(20,!0),g=oi(1/h,0,0,-.5,0,1/u,0,-.5,0,0,1/m,-.5,0,0,0,1),A=n.getInt16(238,!0),v=[];for(let V=0;V<A;V++){const R=new Uint8Array(t.slice(240+V*20,260+V*20)),Y=new TextDecoder().decode(R).split("\0").shift();v.push({id:Y.trim(),vals:[]})}const y=Ut();for(let V=0;V<16;V++)y[V]=n.getFloat32(440+V*4,!0);y[15]===0&&(k.warn("TRK vox_to_ras not set"),C2(y));const w=Ut();S2(w,g,y);let b=null,C=null;b=new Int32Array(t.slice(c)),C=new Float32Array(b.buffer);const S=b.length;if(S<1)throw new Error("Empty TRK file.");let E=0,M=0,N=new Uint32Array(b.length/4),U=0,T=new Float32Array(b.length),F=0;for(;E<S;){const V=b[E];E=E+1,N[U++]=M;for(let R=0;R<V;R++){const Y=C[E+0],P=C[E+1],X=C[E+2];if(E+=3,T[F++]=Y*w[0]+P*w[1]+X*w[2]+w[3],T[F++]=Y*w[4]+P*w[5]+X*w[6]+w[7],T[F++]=Y*w[8]+P*w[9]+X*w[10]+w[11],l>0)for(let L=0;L<l;L++)d[L].vals.push(C[E]),E++;M++}if(A>0)for(let R=0;R<A;R++)v[R].vals.push(C[E]),E++}const I=[];for(let V=0;V<v.length;V++)I.push({id:v[V].id,vals:Float32Array.from(v[V].vals)});const B=[];for(let V=0;V<d.length;V++)B.push({id:d[V].id,vals:Float32Array.from(d[V].vals)});return N[U++]=M,T=T.slice(0,F),N=N.slice(0,U),{pts:T,offsetPt0:N,dps:I,dpv:B}}static readTxtVTK(t){const r=new TextDecoder("utf-8").decode(t).split(`
+`);if(r.length<7||!r[0].startsWith("# vtk DataFile"))throw new Error("Invalid VTK image");if(!r[2].startsWith("ASCII"))throw new Error("Not ASCII VTK mesh");let l=3;for(;r[l].length<1;)l++;if(!r[l].includes("POLYDATA"))throw new Error("Not ASCII VTK polydata");for(l++;r[l].length<1;)l++;if(!r[l].startsWith("POINTS"))throw new Error("Not VTK POINTS");let d=r[l].trim().split(/\s+/);const h=parseInt(d[1]),u=h*3,m=new Float32Array(h*3);let g=0;for(;g<h*3;){l++;const w=r[l].trim().trim().split(/\s+/);for(let b=0;b<w.length&&!(g>=u);b++)m[g]=parseFloat(w[b]),g++}const A=[];for(l++;r[l].length<1;)l++;if(r[l].startsWith("METADATA")){for(;r[l].length>1;)l++;l++}if(d=r[l].trim().split(/\s+/),l++,d[0].includes("LINES")){const y=parseInt(d[1]);if(y<1)throw new Error("Corrupted VTK ASCII");let w=r[l].trim();const b=[];let C=[];if(w.startsWith("OFFSETS")){l++;let S=0;for(;S<y;){w=r[l].trim(),l++;const E=w.trim().split(/\s+/);for(let M=0;M<E.length&&(b[S]=parseInt(E[M]),S++,!(S>=y));M++);}C=Array.from(m)}else{let S=function(){w=r[l].trim();const U=w.trim().split(/\s+/);M=[];for(let T=0;T<U.length;T++)M.push(parseInt(U[T]));N=0,l++},E=0;b[0]=0;let M=[],N=0;S();for(let U=0;U<y;U++){N>=M.length&&S();const T=M[N++];E+=T,b[U+1]=E;for(let F=0;F<T;F++){N>=M.length&&S();const I=M[N++]*3;C.push(m[I+0]),C.push(m[I+1]),C.push(m[I+2])}}}return{pts:Float32Array.from(C),offsetPt0:Uint32Array.from(b)}}else if(d[0].includes("TRIANGLE_STRIPS")){const y=parseInt(d[1]);for(let w=0;w<y;w++){const b=r[l].trim();l++;const C=b.trim().split(/\s+/),S=parseInt(C[0])-2;let E=1;for(let M=0;M<S;M++)M%2?(A.push(parseInt(C[E+2])),A.push(parseInt(C[E+1])),A.push(parseInt(C[E]))):(A.push(parseInt(C[E])),A.push(parseInt(C[E+1])),A.push(parseInt(C[E+2]))),E+=1}}else if(d[0].includes("POLYGONS")){const y=parseInt(d[1]);for(let w=0;w<y;w++){const b=r[l].trim();l++;const C=b.trim().split(/\s+/),S=parseInt(C[0])-2,E=parseInt(C[1]);let M=parseInt(C[2]);for(let N=0;N<S;N++){const U=parseInt(C[3+N]);A.push(E),A.push(M),A.push(U),M=U}}}else throw new Error("Unsupported ASCII VTK datatype "+d[0]);const v=new Uint32Array(A);return{positions:m,indices:v}}static async readLayer(t="",n,s,r=.5,c="warm",l="winter",d=!1,h=null,u=null,m=0){const g={...w4,colormapInvert:!1,colormapType:0,isTransparentBelowCalMin:!0,isAdditiveBlend:!1,colorbarVisible:!0,colormapLabel:null},A=/(?:\.([^.]+))?$/;let v=A.exec(t)[1];v=v.toUpperCase(),v==="GZ"&&(v=A.exec(t.slice(0,-3))[1],v=v.toUpperCase());const y=s.vertexCount/3;if(s.offsetPt0){const C=t.split("/");let S="Unknown";if(C.length>1&&C.pop()&&(S=S.split(".").slice(0,-1).join(".")),v==="TXT"){const T=s.offsetPt0.length-1,F=me.readTXT(n,T);if(F.length!==T)throw new Error(`TXT file has ${F.length} items, expected one per streamline (${T}).`);s.dps||(s.dps=[]);const I=F.reduce((V,R)=>Math.min(V,R)),B=F.reduce((V,R)=>Math.max(V,R));return s.dps.push({id:S,vals:Float32Array.from(F.slice()),global_min:I,global_max:B,cal_min:I,cal_max:B}),g}if(v!=="TSF")throw new Error("readLayer for streamlines only supports TSF and TXT files.");const E=s.pts.length/3,M=me.readTSF(n,E);s.dpv||(s.dpv=[]);const N=M.reduce((T,F)=>Math.min(T,F)),U=M.reduce((T,F)=>Math.max(T,F));return s.dpv.push({id:S,vals:Float32Array.from(M.slice()),global_min:N,global_max:U,cal_min:N,cal_max:U}),g}if(y<3){k.error("n_vert < 3 in layer");return}if(v==="MZ3"){const C=await me.readMZ3(n,y);g.values=C.scalars,"colormapLabel"in C&&(g.colormapLabel=C.colormapLabel)}else if(v==="ANNOT"){const C=me.readANNOT(n,y,!0);C instanceof Uint32Array?g.values=C:(g.values=C.scalars,g.colormapLabel=C.colormapLabel)}else if(v==="CRV"||v==="CURV"||v==="THICKNESS"||v==="AREA")g.values=me.readCURV(n,y),g.isTransparentBelowCalMin=!1;else if(v==="GII"){const C=await me.readGII(n,y);g.values=C.scalars,g.colormapLabel=C.colormapLabel}else if(v==="MGH"||v==="MGZ"){const C=await me.readMGH(n,y,!0);"scalars"in C?(g.values=C.scalars,g.colormapLabel=C.colormapLabel):g.values=C}else if(v==="NII")g.values=await me.readNII(n,s.pts,s.anatomicalStructurePrimary);else if(v==="SMP")g.values=await me.readSMP(n,y);else if(v==="STC")g.values=me.readSTC(n,y);else if(me.isCurv(n))g.values=me.readCURV(n,y),g.isTransparentBelowCalMin=!1;else return k.warn("Unknown layer overlay format "+t),g;if(!g.values){k.error("no values in layer");return}g.nFrame4D=g.values.length/y,g.frame4D=0,g.outlineBorder=m;let w=g.values[0],b=g.values[0];for(let C=0;C<g.values.length;C++)w=Math.min(w,g.values[C]),b=Math.max(b,g.values[C]);return g.global_min=w,g.global_max=b,g.cal_min=h||0,h||(g.cal_min=w),g.cal_max=u||0,u||(g.cal_max=b),g.cal_minNeg=NaN,g.cal_maxNeg=NaN,g.opacity=r,g.colormap=c,g.colormapNegative=l,g.useNegativeCmap=d,g}static async readSMP(t,n){const s=t.byteLength;let r=new DataView(t),c=r.getUint16(0,!0);if(c>5){const g=await At.decompress(new Uint8Array(t));r=new DataView(g.buffer),c=r.getUint16(0,!0),t=g.buffer}c>5&&k.error("Unsupported or invalid BrainVoyager SMP version "+c);const l=r.getUint32(2,!0);l!==n&&k.error("SMP file has "+l+" vertices, background mesh has "+n);const d=r.getUint16(6,!0),h=new Float32Array(l*d);let u=9;function m(){const g=u;for(;u<s&&r.getUint8(u)!==0;)u++;return u++,new TextDecoder().decode(t.slice(g,u-1))}m();for(let g=0;g<d;g++){const A={};A.mapType=r.getUint32(u,!0),u+=4,c>=3&&A.mapType===3&&(A.nLags=r.getUint32(u,!0),u+=4,A.mnLag=r.getUint32(u,!0),u+=4,A.mxLag=r.getUint32(u,!0),u+=4,A.ccOverlay=r.getUint32(u,!0),u+=4),A.clusterSize=r.getUint32(u,!0),u+=4,A.clusterCheck=r.getUint8(u),u+=1,A.critThresh=r.getFloat32(u,!0),u+=4,A.maxThresh=r.getFloat32(u,!0),u+=4,c>=4&&(A.includeValuesGreaterThreshMax=r.getUint32(u,!0),u+=4),A.df1=r.getUint32(u,!0),u+=4,A.df2=r.getUint32(u,!0),u+=4,c>=5?(A.posNegFlag=r.getUint32(u,!0),u+=4):A.posNegFlag=3,A.cortexBonferroni=r.getUint32(u,!0),u+=4,A.posMinRGB=[0,0,0],A.posMaxRGB=[0,0,0],A.negMinRGB=[0,0,0],A.negMaxRGB=[0,0,0],c>=2&&(A.posMinRGB[0]=r.getUint8(u),u++,A.posMinRGB[1]=r.getUint8(u),u++,A.posMinRGB[2]=r.getUint8(u),u++,A.posMaxRGB[0]=r.getUint8(u),u++,A.posMaxRGB[1]=r.getUint8(u),u++,A.posMaxRGB[2]=r.getUint8(u),u++,c>=4&&(A.negMinRGB[0]=r.getUint8(u),u++,A.negMinRGB[1]=r.getUint8(u),u++,A.negMinRGB[2]=r.getUint8(u),u++,A.negMaxRGB[0]=r.getUint8(u),u++,A.negMaxRGB[1]=r.getUint8(u),u++,A.negMaxRGB[2]=r.getUint8(u),u++),A.enableSMPColor=r.getUint8(u),u++,c>=4&&(A.lut=m()),A.colorAlpha=r.getFloat32(u,!0),u+=4),A.name=m();const v=new Float32Array(t,u,l);h.set(v,g*l),u+=l*4}return h}static readSTC(t,n){const s=new DataView(t),r=s.getInt32(8,!1);if(r!==n)throw new Error("Overlay has "+r+" vertices, expected "+n);let c=12+r*4;const l=s.getUint32(c,!1);c+=4;const d=new Float32Array(l*r);for(let h=0;h<l*r;h++)d[h]=s.getFloat32(c,!1),c+=4;return d}static isCurv(t){const n=new DataView(t),s=n.getUint8(0),r=n.getUint8(1),c=n.getUint8(2);return s!==255||r!==255||c!==255?(Ya.debug("Unable to recognize file type: does not appear to be FreeSurfer format."),!1):!0}static readCURV(t,n){const s=new DataView(t),r=s.getUint8(0),c=s.getUint8(1),l=s.getUint8(2),d=s.getUint32(3,!1),h=s.getUint32(11,!1);if((r!==255||c!==255||l!==255)&&Ya.debug("Unable to recognize file type: does not appear to be FreeSurfer format."),n!==d)throw new Error("CURV file has different number of vertices ( "+d+")than mesh ("+n+")");if(t.byteLength<15+4*d*h)throw new Error("CURV file smaller than specified");const u=new Float32Array(h*d);let m=15;for(let y=0;y<h*d;y++)u[y]=s.getFloat32(m,!1),m+=4;let g=u[0],A=u[0];for(let y=0;y<u.length;y++)g=Math.min(g,u[y]),A=Math.max(A,u[y]);const v=1/(A-g);for(let y=0;y<u.length;y++)u[y]=1-(u[y]-g)*v;return u}static readANNOT(t,n,s=!1){const r=new DataView(t),c=r.getUint32(0,!1),l=this.decimateLayerVertices(c,n);if(n!==l)throw new Error("ANNOT file has different number of vertices than mesh");if(t.byteLength<4+8*c)throw new Error("ANNOT file smaller than specified");let d=0;const h=new Uint32Array(c);for(let E=0;E<c;E++){const M=r.getUint32(d+=4,!1);h[M]=r.getUint32(d+=4,!1)}if(!s)return h;let u=0;try{u=r.getInt32(d+=4,!1)}catch{return h}if(u!==1||r.getInt32(d+=4,!1)>0)return h;const A=r.getInt32(d+=4,!1),v=r.getInt32(d+=4,!1);d+=v;const y=r.getInt32(d+=4,!1);if(y<1)return h;const w={R:Array(A).fill(0),G:Array(A).fill(0),B:Array(A).fill(0),A:Array(A).fill(0),I:Array(A).fill(0),labels:Array(A).fill("")};for(let E=0;E<y;E++){const M=r.getInt32(d+=4,!1),N=r.getInt32(d+=4,!1);d+=4;let U="";for(let V=0;V<N;V++){const R=r.getUint8(d++);if(R===0)break;U+=String.fromCharCode(R)}d-=4;const T=r.getInt32(d+=4,!1),F=r.getInt32(d+=4,!1),I=r.getInt32(d+=4,!1),B=r.getInt32(d+=4,!1);if(M<0||M>=A){k.warn("annot entry out of range");continue}w.R[M]=T,w.G[M]=F,w.B[M]=I,w.A[M]=B,w.I[M]=(B<<24)+(I<<16)+(F<<8)+T,w.labels[M]=U}const b=new Float32Array(c);b.fill(-1);let C=0;for(let E=0;E<n;E++){const M=h[E];for(let N=0;N<A;N++)if(w.I[N]===M){b[E]=N;break}b[E]<0&&(C++,b[E]=0)}C>0&&k.error(`annot vertex colors do not match ${C} of ${c} vertices.`);for(let E=0;E<A;E++)w.I[E]=E;const S=Pt.makeLabelLut(w);return{scalars:b,colormapLabel:S}}static readNV(t){const n=t.byteLength,s=new Uint8Array(t);let r=0;function c(){for(;r<n&&s[r]===10;)r++;const A=r;for(;r<n&&s[r]!==10;)r++;return r++,r-A<1?"":new TextDecoder().decode(t.slice(A,r-1))}let l=0,d=0,h=0,u=0,m,g;for(;r<n;){const A=c();if(A.startsWith("#"))continue;const v=A.trim().split(/\s+/);if(l<1){l=parseInt(v[0]),m=new Float32Array(l*3);continue}if(h<l*3){m[h]=parseFloat(v[0]),m[h+1]=parseFloat(v[1]),m[h+2]=parseFloat(v[2]),h+=3;continue}if(d<1){d=parseInt(v[0]),g=new Uint32Array(d*3);continue}if(u>=d*3)break;g[u+2]=parseInt(v[0])-1,g[u+1]=parseInt(v[1])-1,g[u+0]=parseInt(v[2])-1,u+=3}return{positions:m,indices:g}}static readASC(t){const n=t.byteLength,s=new Uint8Array(t);let r=0;function c(){for(;r<n&&s[r]===10;)r++;const v=r;for(;r<n&&s[r]!==10;)r++;return r++,r-v<1?"":new TextDecoder().decode(t.slice(v,r-1))}let l=c();l.startsWith("#!ascii")||k.warn("Invalid ASC mesh"),l=c();let d=l.trim().split(/\s+/);const h=parseInt(d[0]),u=parseInt(d[1]),m=new Float32Array(h*3);let g=0;for(let v=0;v<h;v++)l=c(),d=l.trim().split(/\s+/),m[g]=parseFloat(d[0]),m[g+1]=parseFloat(d[1]),m[g+2]=parseFloat(d[2]),g+=3;const A=new Uint32Array(u*3);g=0;for(let v=0;v<u;v++)l=c(),d=l.trim().split(/\s+/),A[g]=parseInt(d[0]),A[g+1]=parseInt(d[1]),A[g+2]=parseInt(d[2]),g+=3;return{positions:m,indices:A}}static readVTK(t){const n=t.byteLength;if(n<20)throw new Error("File too small to be VTK: bytes = "+t.byteLength);const s=new Uint8Array(t);let r=0;function c(w=!0){if(w)for(;r<n&&s[r]===10;)r++;const b=r;for(;r<n&&s[r]!==10;)r++;return r++,r-b<1?"":new TextDecoder().decode(t.slice(b,r-1))}let l=c();if(!l.startsWith("# vtk DataFile"))throw new Error("Invalid VTK mesh");if(l=c(!1),l=c(),l.startsWith("ASCII"))return me.readTxtVTK(t);if(!l.startsWith("BINARY"))throw new Error("Invalid VTK image, expected ASCII or BINARY "+l);if(l=c(),!l.includes("POLYDATA"))throw new Error("Only able to read VTK POLYDATA "+l);l=c(),(!l.includes("POINTS")||!l.includes("double")&&!l.includes("float"))&&k.warn("Only able to read VTK float or double POINTS"+l);const d=l.includes("double");let h=l.trim().split(/\s+/);const m=parseInt(h[1])*3,g=new Float32Array(m),A=new DataView(t);if(d)for(let w=0;w<m;w++)g[w]=A.getFloat64(r,!1),r+=8;else for(let w=0;w<m;w++)g[w]=A.getFloat32(r,!1),r+=4;l=c(),h=l.trim().split(/\s+/);const v=[];if(h[0].includes("LINES")){const w=parseInt(h[1]),b=r;if(l=c(),l.startsWith("OFFSETS")){let M=!1;l.includes("int64")&&(M=!0);const N=new Uint32Array(w);if(M){let T=!1;for(let F=0;F<w;F++){let I=A.getInt32(r,!1);I!==0&&(T=!0),r+=4,I=A.getInt32(r,!1),r+=4,N[F]=I}T&&k.warn("int32 overflow: JavaScript does not support int64")}else for(let T=0;T<w;T++){const F=A.getInt32(r,!1);r+=4,N[T]=F}return{pts:g,offsetPt0:N}}r=b;let C=0;const S=[],E=[];S.push(C);for(let M=0;M<w;M++){const N=A.getInt32(r,!1);r+=4,C+=N,S.push(C);for(let U=0;U<N;U++){const T=A.getInt32(r,!1)*3;r+=4,E.push(g[T+0]),E.push(g[T+1]),E.push(g[T+2])}}return{pts:Float32Array.from(E),offsetPt0:Uint32Array.from(S)}}else if(h[0].includes("TRIANGLE_STRIPS")){const w=parseInt(h[1]);for(let b=0;b<w;b++){const C=A.getInt32(r,!1)-2;r+=4;for(let S=0;S<C;S++)S%2?(v.push(A.getInt32(r+8,!1)),v.push(A.getInt32(r+4,!1)),v.push(A.getInt32(r,!1))):(v.push(A.getInt32(r,!1)),v.push(A.getInt32(r+4,!1)),v.push(A.getInt32(r+8,!1))),r+=4;r+=8}}else if(h[0].includes("POLYGONS")){const w=parseInt(h[1]),b=r,C=c();if(C.startsWith("OFFSETS")){let S=C.includes("int64");const E=new Uint32Array(w);let M=!1;for(let F=0;F<w;F++)S&&(A.getInt32(r,!1)!==0&&(M=!0),r+=4),E[F]=A.getInt32(r,!1),r+=4;if(!Number.isSafeInteger(w)||w>=2147483648||M)throw new Error("values exceed 2GB limit");const N=c();if(!N.startsWith("CONNECTIVITY"))throw new Error("Expected CONNECTIVITY after OFFSETS");S=N.includes("int64");const U=E[w-1],T=new Uint32Array(U);for(let F=0;F<U;F++)S&&(r+=4),T[F]=A.getInt32(r,!1),r+=4;for(let F=0;F<w;F++){const I=F===0?0:E[F-1],B=E[F];for(let V=1;V<B-I-1;V++)v.push(T[I]),v.push(T[I+V]),v.push(T[I+V+1])}}else{r=b;for(let S=0;S<w;S++){const E=A.getInt32(r,!1)-2;if(S===0&&E>65535)throw new Error("Invalid VTK binary polygons using little-endian data (MRtrix)");r+=4;const M=A.getInt32(r,!1);r+=4;let N=A.getInt32(r,!1);r+=4;for(let U=0;U<E;U++){const T=A.getInt32(r,!1);r+=4,v.push(M,N,T),N=T}}}}else throw new Error("Unsupported binary VTK datatype "+h[0]);const y=new Uint32Array(v);return{positions:g,indices:y}}static readWRL(t){const n=new TextDecoder("utf-8").decode(t),s=/coord\s+Coordinate\s*\{\s*point\s*\[([\s\S]*?)\]/,r=/coordIndex\s*\[([\s\S]*?)\]/,c=/color\s+Color\s*\{\s*color\s*\[([\s\S]*?)\]/,l=s.exec(n),d=r.exec(n),h=c.exec(n);if(!l||!d)throw new Error("Invalid WRL file: Could not find vertices or indices.");const u=new Float32Array(l[1].trim().split(/[\s,]+/).map(Number));let m=null;if(h){m=new Float32Array(h[1].trim().split(/[\s,]+/).map(Number));const A=u.length/3;m.length!==A*3&&(console.warn(`Unexpected color count: expected ${A*3}, got ${m.length}`),m=null)}const g=new Uint32Array(d[1].trim().split(/[\s,]+/).map(Number).filter(A=>A!==-1));return{positions:u,indices:g,colors:m}}static readDFS(t){const n=new DataView(t),s=n.getUint32(0,!0),r=n.getUint16(4,!0);(s!==1599292996||r!==17740)&&k.warn("Not a little-endian brainsuite DFS mesh");const c=n.getUint32(12,!0),l=n.getUint32(24,!0),d=n.getUint32(28,!0),h=n.getUint32(48,!0);let u=c;const m=new Uint32Array(t,u,l*3);u+=l*3*4;const g=new Float32Array(t,u,d*3);for(let v=0;v<d*3;v+=3){const y=g[v];g[v]=g[v+1],g[v+1]=y}let A;return h>=0&&(A=new Float32Array(t,h,d*3)),{positions:g,indices:m,colors:A}}static async readMZ3(t,n=0){if(t.byteLength<20)throw new Error("File too small to be mz3: bytes = "+t.byteLength);let s=new DataView(t),r=t,c=s.getUint16(0,!0);if(c===35615||c===8075){const I=await At.decompress(new Uint8Array(t));s=new DataView(I.buffer),c=s.getUint16(0,!0),r=I.buffer}const l=s.getUint16(2,!0),d=s.getUint32(4,!0);let h=s.getUint32(8,!0);const u=s.getUint32(12,!0);if(Ya.debug("MZ3 magic %d attr %d face %d vert %d skip %d",c,l,d,h,u),c!==23117)throw new Error("Invalid MZ3 file");const m=(l&1)!==0,g=(l&2)!==0,A=(l&4)!==0;let v=(l&8)!==0;const y=(l&16)!==0,w=(l&32)!==0,b=(l&64)!==0;if(Ya.debug(`isFace=${m} isVert=${g} isRGBA=${A} isSCALAR=${v} isDOUBLE=${y} isAOMAP=${w} isLOOKUP=${b}`),l>127)throw new Error("Unsupported future version of MZ3 file");let C=4;y&&(C=8);let S=0;if(n>0&&!m&&d<1&&!A&&(v=!0),v){const I=n||h,B=16+u+(m?d*12:0)+(g?I*12:0)+(A?I*4:0),V=Math.floor((r.byteLength-B)/C);h!==n&&V%n===0&&(h=n),S=Math.floor(V/h),S<1&&(k.warn("Corrupt MZ3: file reports NSCALAR but not enough bytes"),v=!1)}if(h<3&&n<3)throw new Error("Not a mesh MZ3 file (maybe scalar)");n>0&&n!==h&&k.warn("Layer has "+h+"vertices, but background mesh has "+n);let E=16+u;const M=new DataView(r);let N=null;if(m){N=new Uint32Array(d*3);for(let I=0;I<d*3;I++)N[I]=M.getUint32(E,!0),E+=4}let U=null;if(g){U=new Float32Array(h*3);for(let I=0;I<h*3;I++)U[I]=M.getFloat32(E,!0),E+=4}let T=null;if(A){T=new Float32Array(h*3);for(let I=0;I<h;I++){for(let B=0;B<3;B++)T[I*3+B]=M.getUint8(E++)/255;E++}}let F=new Float32Array;if(v&&S>0)if(y){const I=new Float64Array(S*h);for(let B=0;B<S*h;B++)I[B]=M.getFloat64(E,!0),E+=8;F=Float32Array.from(I)}else{F=new Float32Array(S*h);for(let I=0;I<S*h;I++)F[I]=M.getFloat32(E,!0),E+=4}if(n>0&&b&&v){const I=new TextDecoder("utf-8"),B=new Uint8Array(r,16,u),V=I.decode(B),R=JSON.parse(V),Y=Pt.makeLabelLut(R);return{scalars:F,colormapLabel:Y}}if(n>0&&A&&v){let I=F[0];for(let R=0;R<h;R++)I=Math.max(I,F[R]);const B={R:[],G:[],B:[],A:[],I:[],labels:[]};for(let R=0;R<=I;R++)for(let Y=0;Y<h;Y++)if(R===F[Y]){const P=Y*3;B.I.push(R),B.R.push(T[P]*255),B.G.push(T[P+1]*255),B.B.push(T[P+2]*255),B.A.push(255),B.labels.push(`${R}`);break}const V=Pt.makeLabelLut(B);return{scalars:F,colormapLabel:V}}return n>0?{scalars:F}:{positions:U,indices:N,scalars:F,colors:T}}static readPLY(t){const n=t.byteLength,s=new Uint8Array(t);let r=0;function c(){for(;r<n&&s[r]===10;)r++;const F=r;for(;r<n&&s[r]!==10;)r++;return r++,r-F<1?"":new TextDecoder().decode(t.slice(F,r-1))}let l=c();if(!l.startsWith("ply"))throw new Error("Not a valid PLY file");l=c();const d=l.includes("ascii");function h(F){if(F==="char"||F==="uchar"||F==="int8"||F==="uint8")return 1;if(F==="short"||F==="ushort"||F==="int16"||F==="uint16")return 2;if(F==="int"||F==="uint"||F==="int32"||F==="uint32"||F==="float"||F==="float32")return 4;if(F==="double")return 8;throw new Error("Unknown data type: "+F)}const u=l.includes("binary_little_endian");let m=0,g=!1,A=0,v=0,y=0,w=0,b=0,C=0,S=0;for(;r<n&&!l.startsWith("end_header");){if(l=c(),l.startsWith("comment"))continue;let F=l.split(/\s/);if(l.startsWith("element vertex"))for(m=parseInt(F[F.length-1]),l=c(),F=l.split(/\s/);l.startsWith("property");){const I=F[1];F[2]==="x"&&I.startsWith("double")?g=!0:F[2]==="x"&&!I.startsWith("float")&&k.error("Error: expect ply xyz to be float or double: "+l),A+=h(I),l=c(),F=l.split(/\s/)}if(l.startsWith("element face"))for(S=parseInt(F[F.length-1]),l=c(),F=l.split(/\s/);l.startsWith("property");){if(F[1]==="list")y=h(F[2]),w=h(F[3]),v+=y+3*w;else{const I=h(F[1]);v+=I,w===0&&(b+=I,C++)}l=c(),F=l.split(/\s/)}}if(d){S<1&&k.error(`Malformed ply format: faces ${S} `);const F=new Float32Array(m*3);let I=0;for(let R=0;R<m;R++){l=c();const Y=l.split(/\s/);F[I]=parseFloat(Y[0]),F[I+1]=parseFloat(Y[1]),F[I+2]=parseFloat(Y[2]),I+=3}let B=new Uint32Array(S*3),V=0;for(let R=0;R<S;R++){l=c();const Y=l.split(/\s/),P=parseInt(Y[C])-2;if(P<1)break;if(V+P*3>B.length){const H=new Uint32Array(B.length+B.length);H.set(B),B=H.slice()}const X=parseInt(Y[C+1]);let L=parseInt(Y[C+2]);for(let H=0;H<P;H++){const W=parseInt(Y[C+3+H]);B[V+0]=X,B[V+1]=L,B[V+2]=W,L=W,V+=3}}return B.length!==V&&(B=B.slice(0,V)),{positions:F,indices:B}}(A<12||y<1||w<1||S<1)&&k.warn(`Malformed ply format: stride ${A} count ${y} iBytes ${w} iStrideBytes ${v} iPadBytes ${b} faces ${S}`);const E=new DataView(t);let M;if(r%4===0&&A===12&&u)M=new Float32Array(t,r,m*3),r+=m*A;else{M=new Float32Array(m*3);let F=0;for(let I=0;I<m;I++)g?(M[F]=E.getFloat64(r,u),M[F+1]=E.getFloat64(r+8,u),M[F+2]=E.getFloat64(r+16,u)):(M[F]=E.getFloat32(r,u),M[F+1]=E.getFloat32(r+4,u),M[F+2]=E.getFloat32(r+8,u)),F+=3,r+=A}const N=new Uint32Array(S*3);let U=!0,T=0;if(y===1&&w===4&&v===13)for(let F=0;F<S;F++){const I=E.getUint8(r);r+=y,I!==3&&(U=!1),N[T]=E.getUint32(r,u),r+=4,N[T+1]=E.getUint32(r,u),r+=4,N[T+2]=E.getUint32(r,u),r+=4,T+=3}else{let F=r;for(let I=0;I<S;I++){r=F+b;let B=0;y===1?B=E.getUint8(r):y===2?B=E.getUint16(r,u):y===4&&(B=E.getUint32(r,u)),r+=y,B!==3&&(U=!1);for(let V=0;V<3;V++)w===1?N[T]=E.getUint8(r):w===2?N[T]=E.getUint16(r,u):w===4&&(N[T]=E.getUint32(r,u)),T++,r+=w;F+=v}}return U||k.warn("Only able to read PLY meshes limited to triangles."),{positions:M,indices:N}}static readICO(t){const r=new TextDecoder("utf-8").decode(t).split(`
+`);let c=r[0].trim().split(/\s+/);c.length>1&&k.warn("This is not a valid FreeSurfer ICO/TRI mesh.");const l=parseInt(c[0]),d=new Float32Array(l*3);let h=1;for(let g=0;g<l;g++){const A=r[h].trim().split(/\s+/);h++;let v=parseInt(A[0])-1;const y=parseFloat(A[1]),w=parseFloat(A[2]),b=parseFloat(A[3]);if(v<0||v>=l){k.error("ICO vertices corrupted");break}v*=3,d[v]=y,d[v+1]=w,d[v+2]=b}c=r[h].trim().split(/\s+/),h++;const u=parseInt(c[0]),m=new Uint32Array(u*3);for(let g=0;g<u;g++){const A=r[h].trim().split(/\s+/);h++;let v=parseInt(A[0])-1;const y=parseInt(A[1])-1,w=parseInt(A[2])-1,b=parseInt(A[3])-1;if(v<0||v>=u){k.error("ICO indices corrupted");break}v*=3,m[v]=y,m[v+1]=w,m[v+2]=b}for(let g=0;g<m.length;g+=3){const A=m[g];m[g]=m[g+1],m[g+1]=A}return{positions:d,indices:m}}static readGEO(t,n=!1){const c=new TextDecoder("utf-8").decode(t).split(`
+`),l=c[0].trim().split(/\s+/),d=parseInt(l[0]);let h=parseInt(l[1]),u=parseInt(l[2]);const m=parseInt(l[3]);(d>1||m!==u*3)&&k.warn("Multi-part BYU/GEO header or not a triangular mesh.");const g=[];h*=3;let A=0,v=2;for(;A<h;){const S=c[v].trim().split(/\s+/);v++;for(let E=0;E<S.length&&(g.push(parseFloat(S[E])),A++,!(A>=h));E++);}const y=[];u*=3;let w=0;for(;w<u;){const S=c[v].trim().split(/\s+/);v++;for(let E=0;E<S.length&&(y.push(Math.abs(parseInt(S[E]))-1),w++,!(w>=u));E++);}if(n)for(let S=0;S<y.length;S+=3){const E=y[S];y[S]=y[S+1],y[S+1]=E}const b=new Float32Array(g),C=new Uint32Array(y);return{positions:b,indices:C}}static readOFF(t){const r=new TextDecoder("utf-8").decode(t).split(`
+`),c=[],l=[];let d=0;r[d].includes("OFF")?d++:k.warn("File does not start with OFF");let h=r[d].trim().split(/\s+/);const u=parseInt(h[0]),m=parseInt(h[1]);d++;for(let v=0;v<u;v++)h=r[d].trim().split(/\s+/),c.push(parseFloat(h[0])),c.push(parseFloat(h[1])),c.push(parseFloat(h[2])),d++;for(let v=0;v<m;v++)h=r[d].trim().split(/\s+/),parseInt(h[0])!==3&&k.warn("Only able to read OFF files with triangular meshes"),l.push(parseInt(h[1])),l.push(parseInt(h[2])),l.push(parseInt(h[3])),d++;const g=new Float32Array(c),A=new Uint32Array(l);return{positions:g,indices:A}}static readOBJMNI(t){const r=new TextDecoder("utf-8").decode(t).trim().split(/\s*,\s*|\s+/);(r.length<1||r[0]!=="P")&&k.warn("This is not a valid MNI OBJ mesh.");let c=6;const l=parseInt(r[c++]),d=l*3,h=new Float32Array(d);for(let y=0;y<d;y++)h[y]=parseFloat(r[c++]);c+=d;const u=parseInt(r[c++]),m=parseInt(r[c++]);(u<1||m<0||m>2)&&k.warn("This is not a valid MNI OBJ mesh.");let g=1;m===1?g=u:m===1&&(g=l),c+=g*4,c+=u;const A=u*3,v=new Uint32Array(A);for(let y=0;y<A;y++)v[y]=parseInt(r[c++]);return{positions:h,indices:v}}static async readOBJ(t){const n=new Uint8Array(t,0,2);n[0]===31&&n[1]===139&&(t=await At.decompressToBuffer(new Uint8Array(t)));const r=new TextDecoder("utf-8").decode(t);if(r[0]==="P")return this.readOBJMNI(t);const c=r.split(`
+`),l=c.length,d=[],h=[];for(let v=0;v<l;v++){const y=c[v];if(y[0]==="v"&&y[1]===" "){const w=y.trim().split(/\s+/);d.push(parseFloat(w[1])),d.push(parseFloat(w[2])),d.push(parseFloat(w[3]))}if(y[0]==="f"){const w=y.trim().split(/\s+/),b=w.length-3;if(b<1)break;let C=w[1].split("/");const S=parseInt(C[0])-1;C=w[2].split("/");let E=parseInt(C[0])-1;for(let M=0;M<b;M++){C=w[3+M].split("/");const N=parseInt(C[0])-1;h.push(S),h.push(E),h.push(N),E=N}}}const u=new Float32Array(d),m=new Uint32Array(h);let g=m[0],A=m[0];for(let v=1;v<m.length;v++)m[v]<g&&(g=m[v]),m[v]>A&&(A=m[v]);if(A-g+1>u.length/3)throw new Error("Not a valid OBJ file");for(let v=0;v<m.length;v++)m[v]-=g;return{positions:u,indices:m}}static readFreeSurfer(t){const n=new Uint8Array(t);if(n[0]===35&&n[1]===33&&n[2]===97)return me.readASC(t);const s=new DataView(t),r=s.getUint32(0,!1),c=s.getUint32(4,!1);(r!==4294966883||c!==1919246708)&&Ya.debug("Unable to recognize file type: does not appear to be FreeSurfer format.");let l=0;for(;s.getUint8(l)!==10;)l++;l+=2;let d=s.getUint32(l,!1);l+=4;let h=s.getUint32(l,!1);l+=4,d*=3;const u=new Float32Array(d);for(let v=0;v<d;v++)u[v]=s.getFloat32(l,!1),l+=4;h*=3;const m=new Uint32Array(h);for(let v=0;v<h;v++)m[v]=s.getUint32(l,!1),l+=4;const g=s.getUint32(l,!1);l+=4;let A=g===20;if(!A){const v=s.getUint32(l,!1);l+=4;const y=s.getUint32(l,!1);l+=4,A=g===2&&v===0&&y===20}if(!A)k.warn("Unknown FreeSurfer Mesh extension code.");else{const y=new TextDecoder().decode(t.slice(l)).trim().split(`
+`);for(let w=0;w<y.length;w++){if(!y[w].startsWith("cras"))continue;const C=y[w].split("=")[1].trim().split(" ").map(Number),S=Math.floor(u.length/3);let E=0;for(let M=0;M<S;M++)u[E]+=C[0],E++,u[E]+=C[1],E++,u[E]+=C[2],E++}}return{positions:u,indices:m}}static async readSRF(t){const n=new Uint8Array(t);if(n[0]===35&&n[1]===33&&n[2]===97)return me.readASC(t);n[0]===31&&n[1]===139&&(t=(await At.decompress(new Uint8Array(t))).buffer);const s=new DataView(t),r=s.getFloat32(0,!0),c=s.getUint32(8,!0),l=s.getUint32(12,!0),d=s.getFloat32(16,!0),h=s.getFloat32(20,!0),u=s.getFloat32(24,!0),m=new Float32Array(c*3);let g=28,A=1;for(let U=0;U<c;U++)m[A]=-s.getFloat32(g,!0)+d,A+=3,g+=4;A=2;for(let U=0;U<c;U++)m[A]=-s.getFloat32(g,!0)+h,A+=3,g+=4;A=0;for(let U=0;U<c;U++)m[A]=-s.getFloat32(g,!0)+u,A+=3,g+=4;g=28+24*c;const v=s.getFloat32(g,!0),y=s.getFloat32(g+4,!0),w=s.getFloat32(g+8,!0),b=s.getFloat32(g+16,!0),C=s.getFloat32(g+20,!0),S=s.getFloat32(g+24,!0);g+=32;const E=new Float32Array(c*3),M=new Uint32Array(t,g,c);A=0;for(let U=0;U<c;U++){const T=M[U];T>1056964608&&(E[A+0]=(T>>16&255)/255,E[A+1]=(T>>8&255)/255,E[A+2]=(T&255)/255),T===0&&(E[A+0]=v,E[A+1]=y,E[A+2]=w),T===1&&(E[A+0]=b,E[A+1]=C,E[A+2]=S),A+=3}g+=c*4;for(let U=0;U<c;U++){const T=s.getUint32(g,!0);g+=4+4*T}const N=new Uint32Array(l*3);for(let U=0;U<l*3;U++)N[U]=s.getInt32(g,!0),g+=4;return r!==4&&k.warn("Not valid SRF"),{positions:m,indices:N,colors:E}}static readTxtSTL(t){const r=new TextDecoder("utf-8").decode(t).split(`
+`);if(!r[0].startsWith("solid"))throw new Error("Not a valid STL file");const c=[];for(let u=1;u<r.length;u++){if(!r[u].includes("vertex"))continue;const m=r[u].trim().split(/\s+/);for(let g=1;g<m.length;g++)c.push(parseFloat(m[g]))}const l=Math.floor(c.length/3);if(l*3!==c.length)throw new Error("Unable to parse ASCII STL file.");const d=new Float32Array(c),h=new Uint32Array(l);for(let u=0;u<l;u++)h[u]=u;return{positions:d,indices:h}}static readSTL(t){if(t.byteLength<134)throw new Error("File too small to be STL: bytes = "+t.byteLength);const n=new DataView(t);if(n.getUint32(0,!0)===1768714099)return me.readTxtSTL(t);const r=n.getUint32(80,!0),c=3*r;if(t.byteLength<84+r*50)throw new Error("STL file too small to store triangles = "+r);const l=new Uint32Array(c),d=new Float32Array(c*3);let h=96,u=0;for(let m=0;m<r;m++){for(let g=0;g<9;g++)d[u]=n.getFloat32(h,!0),u+=1,h+=4;h+=14}for(let m=0;m<c;m++)l[m]=m;return{positions:d,indices:l}}static decimateLayerVertices(t,n){if(t%n===0)return t;const s=12,r=Math.round(Math.log((t-2)/(s-2))/Math.log(4)),c=Math.round(Math.log((n-2)/(s-2))/Math.log(4)),l=Math.pow(4,r)*(s-2)+2,d=Math.pow(4,c)*(s-2)+2;return l!==t||d!==n?t:n}static async readNII2(t,n=0,s=""){let r=new Float32Array;const c=t.byteLength;let l=!0;const d=new DataView(t);let h=d.getUint16(0,l);if(h===469893120&&(l=!1,h=d.getUint16(0,l)),h!==540)throw new Error("Not a valid NIfTI-2 dataset");const u=Number(d.getBigInt64(168,l)),m=d.getFloat64(176,l),g=d.getFloat64(184,l);(m!==1||g!==0)&&k.warn("ignoring scale slope and intercept");const A=d.getUint32(504,l),v=d.getUint16(12,l);if(v!==2&&v!==4&&v!==8&&v!==16)throw new Error("Unsupported NIfTI datatype "+v);let y=1;const w=[1,1,1,1,1,1,1,1];for(let b=1;b<8;b++)w[b]=Math.max(Number(d.getBigInt64(16+b*8,l)),1),y*=w[b];if(A>=3e3&&A<=3099&&u>580){let b=function(){for(;I<c&&F[I]===10;)I++;const L=I;for(;I<c&&F[I]!==10;)I++;return I++,I-L<1?"":new TextDecoder().decode(t.slice(L,I-1)).trim()},C=function(){let L=b();if(!L.startsWith("<")||L.endsWith(">"))return L;for(;I<c&&!L.endsWith(">");)L+=b();return L},S=function(L,H=!1){const W=B.indexOf(L);if(W<0)return 1;const at=B.indexOf('"',W)+1,ct=B.indexOf('"',at),G=B.slice(at,ct);return H?G:parseInt(G)},E=0,M=0,N=0,U="",T=new Uint32Array;const F=new Uint8Array(t);let I=552,B;const V=w[5],R=new Float32Array(n*V);for(;I<c&&(B=C(),!B.includes("</CIFTI>"));)if(B.includes("<BrainModel")){const L=S("SurfaceNumberOfVertices="),H=S("BrainStructure=",!0).toUpperCase();if(L%n!==0)continue;let W=!1;if(s.includes("CORTEX")&&H.includes("CORTEX")&&(W=!0),!W||(W=!1,s.includes("LEFT")&&H.includes("LEFT")&&(W=!0),s.includes("RIGHT")&&H.includes("RIGHT")&&(W=!0),!W))continue;if(N=L,E=S("IndexOffset="),M=S("IndexCount="),U=H,B.includes("<VertexIndices>")||(B=C()),!B.startsWith("<VertexIndices>")||!B.endsWith("</VertexIndices>"))return k.warn("Unable to find CIfTI <VertexIndices>"),R;B=B.slice(15,-16);const at=B.trim().split(/\s+/);at.length<M&&k.error("Error parsing VertexIndices"),T=new Uint32Array(M);for(let ct=0;ct<M;ct++)T[ct]=parseInt(at[ct])}if(N===0||T.length===0)return k.warn("Unable to find CIfTI structure that matches the mesh."),R;if(v!==16)return k.warn("Only able to read float32 CIfTI (only known datatype)."),R;const Y=new Float32Array(M*V),P=u+V*E*4;for(let L=0;L<M*V;L++)Y[L]=d.getFloat32(P+L*4,l);let X=0;for(let L=0;L<M;L++)for(let H=0;H<V;H++)R[T[L]+H*n]=Y[X],X++;return k.debug("CIfTI diagnostics",N,U,E,M,E,s),R}if(y=this.decimateLayerVertices(y,n),y%n!==0)throw new Error("Vertices in layer ("+y+") is not a multiple of number of vertices ("+n+")");if(l)v===16?r=new Float32Array(t,u,y):v===8?r=new Int32Array(t,u,y):v===4&&(r=new Int16Array(t,u,y));else if(v===16){r=new Float32Array(y);for(let b=0;b<y;b++)r[b]=d.getFloat32(u+b*4,l)}else if(v===8){r=new Int32Array(y);for(let b=0;b<y;b++)r[b]=d.getInt32(u+b*4,l)}else if(v===4){r=new Int16Array(y);for(let b=0;b<y;b++)r[b]=d.getInt16(u+b*2,l)}return v===2&&(r=new Uint8Array(t,u,y)),r}static async readNII(t,n,s=""){const r=n.length/3;let c=new Float32Array,l=!0,d=new DataView(t),h=d.getUint16(0,l);if(h===540||h===469893120)return me.readNII2(t,r,s);if(h===23553&&(l=!1,h=d.getUint16(0,l)),h!==348){const M=await At.decompress(new Uint8Array(t));if(d=new DataView(M.buffer),t=M.buffer,h=d.getUint16(0,l),h===540||h===469893120)return me.readNII2(t,r,s);h===23553&&(l=!1,h=d.getUint16(0,l))}h!==348&&k.error("Not a valid NIfTI image.");const u=d.getFloat32(108,l),m=d.getFloat32(112,l),g=d.getFloat32(116,l),A=d.getUint16(252,l),v=d.getUint16(254,l),y=d.getUint16(70,l);if(y!==2&&y!==4&&y!==8&&y!==16)throw new Error("Unsupported NIfTI datatype "+y);const w=Ut();for(let M=0;M<12;M++)w[M]=d.getFloat32(280+M*4,l);let b=1;const C=new Array(8);for(let M=0;M<8;M++)C[M]=d.getUint16(40+M*2,l),!(M<1)&&(b*=C[M]||1);let S=!1,E=this.decimateLayerVertices(b,r);if(E%r!==0)if(C[0]>=3&&C[1]>1&&C[2]>1&&C[3]>1)S=!0,E=C[1]*C[2]*C[3];else throw new Error("Voxels in layer ("+b+") is not a multiple of number of vertices ("+r+")");if(b=E,l)y===16?c=new Float32Array(t,u,b):y===8?c=new Int32Array(t,u,b):y===4&&(c=new Int16Array(t,u,b));else if(y===16){c=new Float32Array(b);for(let M=0;M<b;M++)c[M]=d.getFloat32(u+M*4,l)}else if(y===8){c=new Int32Array(b);for(let M=0;M<b;M++)c[M]=d.getInt32(u+M*4,l)}else if(y===4){c=new Int16Array(b);for(let M=0;M<b;M++)c[M]=d.getInt16(u+M*2,l)}if(y===2&&(c=new Uint8Array(t,u,b)),m!==1||g!==0){const M=new Float32Array(b);for(let N=0;N<b;N++)M[N]=c[N]*m+g;c=M}for(let M=0;M<b;M++)isNaN(c[M])&&(c[M]=0);if(S){let M=function(X,L){const H=[0,0,0];return H[0]=L[0]*X[0]+L[1]*X[1]+L[2]*X[2]+L[3],H[1]=L[4]*X[0]+L[5]*X[1]+L[6]*X[2]+L[7],H[2]=L[8]*X[0]+L[9]*X[1]+L[10]*X[2]+L[11],H};const N=new Float32Array(b);k.warn("Sampling voxel intensities at mesh vertices (assumes precise alignment)."),(A>v||v<=0)&&k.warn(`Requires valid sform (sform_code = ${v})`);const U=Ut();Pe(U,w);const T=C[1],F=C[2],I=C[3],B=T*F;let V=0,R=0,Y=0;for(;R<r;){const X=[n[V],n[V+1],n[V+2]],L=M(X,U);V+=3,R+=1;const H=Math.floor(L[0]),W=Math.floor(L[1]),at=Math.floor(L[2]),ct=Math.ceil(L[0]),G=Math.ceil(L[1]),j=Math.ceil(L[2]);if(H<0||ct>=T||W<0||G>=F||at<0||j>=I)continue;const $=H+W*T+at*B,et=new Float32Array(8);et[0]=c[$],et[1]=c[$+1],et[2]=c[$+T],et[3]=c[$+T+1],et[4]=c[$+B],et[5]=c[$+B+1],et[6]=c[$+B+T],et[7]=c[$+B+T+1];let ot=et[0],mt=ot;for(let vt=1;vt<8;vt++)ot=Math.max(ot,et[vt]),mt=Math.min(mt,et[vt]);Math.abs(mt)>ot&&(ot=mt),N[R-1]=ot,Y++}const P=Y/r;P<.1&&k.warn(`${Y} of ${r} vertices in range (${(P*100).toFixed(1)}%)`),c=N}return c}static async readMGH(t,n=0,s=!1){let r=new DataView(t),c=t;if(r.getUint8(0)===31&&r.getUint8(1)===139){const T=await At.decompress(new Uint8Array(t));c=new ArrayBuffer(T.byteLength),new Uint8Array(c).set(new Uint8Array(T)),r=new DataView(T.buffer)}const l=r.getInt32(0,!1),d=Math.max(1,r.getInt32(4,!1)),h=Math.max(1,r.getInt32(8,!1)),u=Math.max(1,r.getInt32(12,!1)),m=Math.max(1,r.getInt32(16,!1)),g=r.getInt32(20,!1);let A=284;const v=!1;(l!==1||g<0||g>4)&&k.warn("Not a valid MGH file");let y=d*h*u*m,w=[];if(y=this.decimateLayerVertices(y,n),y%n!==0)return k.warn("Vertices in layer ("+y+") is not a multiple of number of vertices ("+n+")"),w;if(g===3){w=new Float32Array(y);for(let T=0;T<y;T++)w[T]=r.getFloat32(A+T*4,v)}else if(g===1){w=new Int32Array(y);for(let T=0;T<y;T++)w[T]=r.getInt32(A+T*4,v)}else if(g===4){w=new Int16Array(y);for(let T=0;T<y;T++)w[T]=r.getInt16(A+T*2,v)}else g===0&&(w=new Uint8Array(t,A,y));if(!s)return w;let b=4;g===4&&(b=2),g===0&&(b=1),A+=b*y,A+=16;const C=1,S=2,E=20,M=30,N=c.byteLength;let U;for(;A<N-8;){const T=r.getInt32(A+=4,v);let F=0;switch(T){case M:F=r.getInt32(A+=4,v)-1;break;case E:case S:F=0;break;case C:F=0;{let I=r.getInt32(A+=4,v);if(I>0)return k.warn("unsupported CTABreadFromBinaryV1"),w;if(I=-I,I!==2)return k.warn("CTABreadFromBinary: unknown version"),w;const B=r.getInt32(A+=4,v);if(B<0)return k.warn("CTABreadFromBinaryV2: nentries was ",B),w;const V=r.getInt32(A+=4,v);A+=V;const R=r.getInt32(A+=4,v);if(R<0)return w;const Y={R:[],G:[],B:[],A:[],I:[],labels:[]};for(let P=0;P<R;P++){const X=r.getInt32(A+=4,v),L=r.getInt32(A+=4,v);let H=A+4,W="";for(let $=0;$<L;$++){const et=r.getUint8(H++);if(et===0)break;W+=String.fromCharCode(et)}A+=L;const at=r.getInt32(A+=4,v),ct=r.getInt32(A+=4,v),G=r.getInt32(A+=4,v),j=255-r.getInt32(A+=4,v);Y.I.push(X),Y.R.push(at),Y.G.push(ct),Y.B.push(G),Y.A.push(j),Y.labels.push(W)}U=Pt.makeLabelLut(Y)}break;default:F=r.getInt32(A+=8,v)}A+=F}return{scalars:w,colormapLabel:U}}static readX3D(t){const n=t.byteLength;if(n<20)throw new Error("File too small to be X3D: bytes = "+n);const s=new Uint8Array(t);let r=0;function c(){for(;r<n&&s[r]!==60;)r++;const E=r;for(;r<n&&s[r]!==62;)r++;const M=r;return new TextDecoder().decode(t.slice(E,M+1)).trim()}let l=c();function d(E){const M=l.indexOf(E+"=");if(M<0)return"";const N=l[M+E.length+1],U=l.indexOf(N,M)+1,T=l.indexOf(N,U);return l.slice(U,T)}function h(E){const M=l.indexOf(E+"=");if(M<0)return 1;const N=l[M+E.length+1],U=l.indexOf(N,M)+1,T=l.indexOf(N,U);let F=l.slice(U,T).trim();F=F.replace(/,\s*$/,"");const I=F.trim().split(/\s*,\s*|\s+/);if(I.length<2)return parseFloat(F);let B=new Array(I.length),V=0;for(let R=0;R<I.length;R++){const Y=parseFloat(I[R]);isFinite(Y)&&(B[V]=Y,V++)}return B=B.slice(0,V),B}l.includes("xml version")||k.warn("Not a X3D image");let u=[],m=[],g=[],A=[],v=[0,0,0,0],y=[0,0,0,0],w=[255,255,255,255],b=[255,255,255,255];const C={};function S(){if(!l.endsWith("/>"))if(l.startsWith("<Appearance>"))for(;r<n&&!l.endsWith("</Appearance>");)l+=c();else for(;r<n&&!l.endsWith("/>");)l+=c();const E=d("USE");if(E.length>1){E in C?w=C[E]:k.warn("Unable to find DEF for "+E);return}const M=h("diffuseColor");if(M.length<3)return;w[0]=Math.round(M[0]*255),w[1]=Math.round(M[1]*255),w[2]=Math.round(M[2]*255);const N=d("DEF");N.length<1||(C[N]=w)}for(;r<n;)if(l=c(),w=b.slice(),l.startsWith("<Transform")&&(v=h("translation"),y=h("rotation")),l.startsWith("<Appearance")&&(S(),b=w.slice()),l.startsWith("<Shape")){let E=1,M=1,N=[],U=[];for(;r<n&&(l=c(),l.startsWith("<Appearance")&&S(),!l.startsWith("</Shape"));){if(l.startsWith("<Sphere")&&(E=h("radius"),M=-1),l.startsWith("<Cylinder")&&(E=h("radius"),M=h("height")),l.startsWith("<IndexedFaceSet")&&(M=-2,N=h("coordIndex")),l.startsWith("<IndexedTriangleSet")&&(M=-7,N=h("index")),l.startsWith("<IndexedTriangleStripSet")&&(M=-3,N=h("index")),l.startsWith("<Coordinate")){U=h("point");const T=U.length%3;T!==0&&(U=U.slice(0,-T))}l.startsWith("<Color")&&(A=h("color")),l.startsWith("<Box")&&(M=-4,k.warn("Unsupported x3d shape: Box")),l.startsWith("<Cone")&&(M=-5,k.warn("Unsupported x3d shape: Cone")),l.startsWith("<ElevationGrid")&&(M=-6,k.warn("Unsupported x3d shape: ElevationGrid"))}if(!(M<-3&&M!==-7))if(M<-1){if(N.length<1||U.length<3||U.length===void 0){k.warn("Indexed mesh must specify indices and points");break}const T=Math.floor(u.length/3);let F=2;if(M===-7)m=[...m,...N];else if(M===-2){let V=0;for(;F<N.length;)N[F]>=0?(m.push(N[V]+T),m.push(N[F-1]+T),m.push(N[F-0]+T),F+=1):(F+=3,V=F-2)}else for(;F<N.length;)N[F]>=0?(m.push(N[F-2]+T),m.push(N[F-1]+T),m.push(N[F-0]+T),F+=1):F+=3;u=[...u,...U];const I=Math.floor(U.length/3),B=Array(I).fill(w).flat();if(A.length===I*3){let V=0,R=0;for(let Y=0;Y<I;Y++){for(let P=0;P<3;P++)B[R]=Math.round(A[V]*255),V++,R++;R++}}g=[...g,...B]}else if(M<0)Wn.makeColoredSphere(u,m,g,E,v,w);else{const T=Ut();ip(T,y[3],[y[0],y[1],y[2]]);const F=te(0,-M*.5,0,1),I=te(0,+M*.5,0,1);De(F,F,T),De(I,I,T),Vd(F,F,v),Vd(I,I,v);const B=lt(F[0],F[1],F[2]),V=lt(I[0],I[1],I[2]);Wn.makeColoredCylinder(u,m,g,B,V,E,w)}}return{positions:Float32Array.from(u),indices:Uint32Array.from(m),rgba255:Uint8Array.from(g)}}static async readGII(t,n=0){let s=t.byteLength;if(s<20)throw new Error("File too small to be GII: bytes = "+s);let r=new TextDecoder("ascii").decode(t);if(r[0].charCodeAt(0)===31){const R=await At.decompress(new Uint8Array(t));t=R.buffer,r=new TextDecoder("ascii").decode(R.buffer)}let c=0;function l(){let R=!0,Y=c;for(;R;){for(;c<s&&r[c]!=="<";)c++;for(Y=c;c<s&&r[c]!==">";)c++;if(R=r[c-1]==="/",Y+1<s&&r[Y+1]==="/"&&(c+=1,R=!0),c>=s)break}const P=new TextDecoder().decode(t.slice(Y+1,c)).trim(),X=P.split(" ")[0].trim(),L=c;let H=c,W=c;if(r[Y+1]!=="?"&&r[Y+1]!=="!"){const at="</"+X+">";H=r.indexOf(at,L),W=H+at.length-1}return{name:P,startPos:Y,contentStartPos:L,contentEndPos:H,endPos:W}}let d=l();if(!d.name.startsWith("?xml"))throw new Error("readGII: Invalid XML file");for(;!d.name.startsWith("GIFTI")&&d.endPos<s;)d=l();if(!d.name.startsWith("GIFTI")||d.contentStartPos===d.contentEndPos)throw new Error("readGII: XML file does not include GIFTI tag");s=d.contentEndPos;let h=new Float32Array,u=new Uint32Array,m=new Float32Array,g="",A=!1,v=!1,y=!1,w=!1,b=[1,1,1];const C=[0,0,0];let S=0,E=!1,M=!1,N=0,U=!1;d.endPos=d.contentStartPos;let T="";function F(R,Y=!1){const P=T.indexOf(R);if(P<0)return 1;const X=T.indexOf('"',P)+1,L=T.indexOf('"',X),H=T.slice(X,L);return Y?parseFloat(H):parseInt(H)}function I(R){const Y=T.indexOf(R);if(Y<0)return"";const P=Y+R.length,X=T.indexOf("]",P);return T.slice(P,X)}const B={R:[],G:[],B:[],A:[],I:[],labels:[]};for(;d.endPos<s&&d.name.length>1;){if(d=l(),d.name.startsWith("Label Key")&&(T=d.name,B.I.push(F("Key=")),B.R.push(Math.round(255*F("Red=",!0))),B.G.push(Math.round(255*F("Green=",!0))),B.B.push(Math.round(255*F("Blue=",!0))),B.A.push(Math.round(255*F("Alpha",!0))),T=new TextDecoder().decode(t.slice(d.contentStartPos+1,d.contentEndPos)).trim(),B.labels.push(I("<![CDATA["))),d.name.trim()==="Data"){if(y)continue;T=new TextDecoder().decode(t.slice(d.contentStartPos+1,d.contentEndPos)).trim();let R;if(M){const Y=b[0]*b[1]*b[2],P=T.split(/\s+/);if(Y!==P.length)throw new Error("Unable to parse ASCII GIfTI");if(S===2&&(S=8),S===32&&(S=16),S===8){R=new Int32Array(Y);for(let X=0;X<Y;X++)R[X]=parseInt(P[X])}if(S===16){R=new Float32Array(Y);for(let X=0;X<Y;X++)R[X]=parseFloat(P[X])}}else if(typeof Buffer>"u"){let Y=function(P){const X=atob(P),L=X.length,H=new Uint8Array(L);for(let W=0;W<L;W++)H[W]=X.charCodeAt(W);return H};if(E){const P=Y(T.slice());R=await At.decompress(new Uint8Array(P))}else R=Y(T.slice())}else if(E){const Y=Buffer.from(T.slice(),"base64");R=await At.decompress(new Uint8Array(Y))}else R=Buffer.from(T.slice(),"base64");if(v){if(S!==16&&k.warn("expect positions as FLOAT32"),h=new Float32Array(R.buffer),w){const Y=h.slice(),P=Y.length/3;let X=0;for(let L=0;L<P;L++)for(let H=0;H<3;H++)h[X]=Y[H*P+L],X++}}else if(A){if(S!==8&&k.warn("expect indices as INT32"),u=new Uint32Array(R.buffer),w){const Y=u.slice(),P=Y.length/3;let X=0;for(let L=0;L<P;L++)for(let H=0;H<3;H++)u[X]=Y[H*P+L],X++}}else{let Y=function(X,L){const H=X.length,W=new Float32Array(H+L.length);return W.set(X),W.set(L,H),W};N=b[0]*b[1]*b[2],n!==0&&N%n!==0&&k.warn("Number of vertices in scalar overlay ("+N+") does not match mesh ("+n+")");let P;if(S===2){const X=new Uint8Array(R.buffer);P=Float32Array.from(X)}else if(S===8){const X=new Int32Array(R.buffer);P=Float32Array.from(X)}else if(S===16)P=new Float32Array(R.buffer);else if(S===32){const X=new Float64Array(R.buffer);P=Float32Array.from(X)}else throw new Error(`Invalid dataType: ${S}`);m=Y(m,P)}continue}if(d.name.trim()==="DataSpace"&&(T=new TextDecoder().decode(t.slice(d.contentStartPos+1,d.contentEndPos)).trim(),T.includes("NIFTI_XFORM_SCANNER_ANAT")&&(U=!0)),d.name.trim()==="MD"&&(T=new TextDecoder().decode(t.slice(d.contentStartPos+1,d.contentEndPos)).trim(),T.includes("AnatomicalStructurePrimary")&&T.includes("CDATA[")&&(g=I("<Value><![CDATA[").toUpperCase()),T.includes("VolGeom")&&T.includes("CDATA["))){let R=-1;if(T.includes("VolGeomC_R")&&(R=0),T.includes("VolGeomC_A")&&(R=1),T.includes("VolGeomC_S")&&(R=2),R<0)continue;C[R]=parseFloat(I("<Value><![CDATA["))}d.name.startsWith("DataArray")&&(T=d.name,b=[1,1,1],E=T.includes('Encoding="GZipBase64Binary"'),M=T.includes('Encoding="ASCII"'),A=T.includes('Intent="NIFTI_INTENT_TRIANGLE"'),v=T.includes('Intent="NIFTI_INTENT_POINTSET"'),y=T.includes('Intent="NIFTI_INTENT_VECTOR"'),w=T.includes('ArrayIndexingOrder="ColumnMajorOrder"'),T.includes('DataType="NIFTI_TYPE_UINT8"')&&(S=2),T.includes('DataType="NIFTI_TYPE_INT32"')&&(S=8),T.includes('DataType="NIFTI_TYPE_FLOAT32"')&&(S=16),T.includes('DataType="NIFTI_TYPE_FLOAT64"')&&(S=32),b[0]=F("Dim0="),b[1]=F("Dim1="),b[2]=F("Dim2="))}let V;if(B.I.length>1&&(B.A.some(Y=>Y>0)||B.A.fill(255),V=Pt.makeLabelLut(B)),n>0)return{scalars:m,colormapLabel:V,anatomicalStructurePrimary:g};if(h.length>2&&!U&&(C[0]!==0||C[1]!==0||C[2]!==0)){N=Math.floor(h.length/3);let R=0;for(let Y=0;Y<N;Y++)h[R]+=C[0],R++,h[R]+=C[1],R++,h[R]+=C[2],R++}return{positions:h,indices:u,scalars:m,colormapLabel:V,anatomicalStructurePrimary:g}}},pu=class{constructor(i,t,n,s,r){z(this,"text"),z(this,"style"),z(this,"points"),z(this,"anchor"),z(this,"onClick"),this.text=i,this.style=t,this.points=n,this.anchor=s||0,this.onClick=r}},Zh=()=>{const i=new ArrayBuffer(2);return new DataView(i).setInt16(0,256,!0),new Int16Array(i)[0]===256},Z2=(i=>(i[i.UNKNOWN=0]="UNKNOWN",i[i.NII=1]="NII",i[i.DCM=2]="DCM",i[i.DCM_MANIFEST=3]="DCM_MANIFEST",i[i.MIH=4]="MIH",i[i.MIF=5]="MIF",i[i.NHDR=6]="NHDR",i[i.NRRD=7]="NRRD",i[i.MHD=8]="MHD",i[i.MHA=9]="MHA",i[i.MGH=10]="MGH",i[i.MGZ=11]="MGZ",i[i.V=12]="V",i[i.V16=13]="V16",i[i.VMR=14]="VMR",i[i.HEAD=15]="HEAD",i[i.DCM_FOLDER=16]="DCM_FOLDER",i[i.SRC=17]="SRC",i[i.FIB=18]="FIB",i[i.BMP=19]="BMP",i[i.ZARR=20]="ZARR",i[i.NPY=21]="NPY",i[i.NPZ=22]="NPZ",i[i.HDR=23]="HDR",i))(Z2||{}),bt=Object.freeze({...Z2,parse:i=>{let t=0;switch(i.toUpperCase()){case"":case"DCM":t=2;break;case"TXT":t=3;break;case"FZ":case"GQI":case"QSDR":case"FIB":t=18;break;case"HDR":case"NII":t=1;break;case"MIH":t=4;break;case"MIF":t=5;break;case"NHDR":t=6;break;case"NRRD":t=7;break;case"MHD":t=8;break;case"MHA":t=9;break;case"MGH":t=10;break;case"MGZ":t=11;break;case"NPY":t=21;break;case"NPZ":t=22;break;case"SRC":t=17;break;case"V":t=12;break;case"V16":t=13;break;case"VMR":t=14;break;case"HEAD":t=15;break;case"PNG":case"BMP":case"GIF":case"JPG":case"JPEG":t=19;break;case"ZARR":t=20;break}return t}}),Gl=(i,t="",n="",s="gray",r=1,c=NaN,l=NaN,d=!0,h=.02,u=!1,m=!1,g="",A=0,v=bt.UNKNOWN,y=NaN,w=NaN,b=!0,C=!1,S=null)=>({url:i,urlImageData:t,name:n,colormap:s,colorMap:s,opacity:r,cal_min:c,cal_max:l,trustCalMinMax:d,percentileFrac:h,ignoreZeroVoxels:u,useQFormNotSForm:m,colormapNegative:g,imageType:v,cal_minNeg:y,cal_maxNeg:w,colorbarVisible:b,frame4D:A,alphaThreshold:C,colormapLabel:S});function i2(i,t=80){i=i.replace(/[`$]/g,"");const n=[],s=Math.min(t,i.length);for(let r=0;r<s;r++){const c=i.charCodeAt(r);n.push(c&255)}return n}function Kl(i,t=!1,n=!1){let c=!0;n&&(c=i.littleEndian);const l=new Uint8Array(348),d=new DataView(l.buffer);d.setInt32(0,348,c),d.setUint8(38,114),d.setUint8(39,i.dim_info);for(let u=0;u<8;u++)d.setUint16(40+2*u,i.dims[u],c);d.setFloat32(56,i.intent_p1,c),d.setFloat32(60,i.intent_p2,c),d.setFloat32(64,i.intent_p3,c),d.setInt16(68,i.intent_code,c),t?(d.setInt16(70,2,c),d.setInt16(72,8,c)):(d.setInt16(70,i.datatypeCode,c),d.setInt16(72,i.numBitsPerVoxel,c)),d.setInt16(74,i.slice_start,c);for(let u=0;u<8;u++)d.setFloat32(76+4*u,i.pixDims[u],c);t?(d.setFloat32(108,352,c),d.setFloat32(112,1,c),d.setFloat32(116,0,c)):(d.setFloat32(108,i.vox_offset,c),d.setFloat32(112,i.scl_slope,c),d.setFloat32(116,i.scl_inter,c)),d.setInt16(120,i.slice_end,c),d.setUint8(122,i.slice_code),i.xyzt_units===0?d.setUint8(123,10):d.setUint8(123,i.xyzt_units),t?(d.setFloat32(124,0,c),d.setFloat32(128,0,c)):(d.setFloat32(124,i.cal_max,c),d.setFloat32(128,i.cal_min,c)),d.setFloat32(132,i.slice_duration,c),d.setFloat32(136,i.toffset,c),l.set(i2(i.description),148),l.set(i2(i.aux_file),228),d.setInt16(252,i.qform_code,c),i.sform_code<1||i.sform_code<1?d.setInt16(254,1,c):d.setInt16(254,i.sform_code,c),d.setFloat32(256,i.quatern_b,c),d.setFloat32(260,i.quatern_c,c),d.setFloat32(264,i.quatern_d,c),d.setFloat32(268,i.qoffset_x,c),d.setFloat32(272,i.qoffset_y,c),d.setFloat32(276,i.qoffset_z,c);const h=i.affine.flat();for(let u=0;u<12;u++)d.setFloat32(280+4*u,h[u],c);return d.setInt32(344,3222382,!0),l}function u4(i,t=!0){const n=Math.round(i.length/3),s=lt(0,0,0),r=Gt(),c=Gt();let l=0,d=1;t&&(d=2);for(let g=0;g<d;g++){l=0;for(let v=0;v<n;v++){const y=lt(i[v*3],i[v*3+1],i[v*3+2]);v===0&&(Id(r,y),Id(c,y)),Jh(r,r,y),$h(c,c,y),jt(y,y,s);const w=tr(y);l=Math.max(l,w)}if(g+1>=d)break;let A=!0;for(let v=0;v<3;++v)r[v]>s[v]&&(A=!1),c[v]<s[v]&&(A=!1);if(A)break;cp(s,r,c,.5),k.debug("origin moved inside volume: ",s)}const h=[r[0],r[1],r[2]],u=[c[0],c[1],c[2]];return{min:h,max:u,furthestVertexFromOrigin:l,origin:s}}function n2(i){const t=[!1,!1,!1,!1],n=[!1,!1,!1,!1];for(let s=0;s<4;s++)for(let r=0;r<4;r++)if(isNaN(i[s][r]))return!1;for(let s=0;s<3;s++)for(let r=0;r<3;r++)i[s][r]!==0&&(t[s]=!0,n[r]=!0);for(let s=0;s<3;s++)if(!t[s]||!n[s])return!1;return!0}async function Fh(i){const t=i.getReader(),{done:n,value:s}=await t.read();if(n)return t.releaseLock(),new ReadableStream({start(l){l.close()}});if(!s||s.length<2)return t.releaseLock(),new ReadableStream({start(l){s&&l.enqueue(s),l.close()}});const r=s[0]===31&&s[1]===139,c=new ReadableStream({async start(l){try{for(l.enqueue(s);;){const{done:d,value:h}=await t.read();if(d){l.close(),t.releaseLock();break}l.enqueue(h)}}catch(d){l.error(d),t.releaseLock()}}});return r?c.pipeThrough(new DecompressionStream("gzip")):c}function W2(i=[256,256,256],t=[1,1,1],n=[1,0,0,-128,0,1,0,-128,0,0,1,-128,0,0,0,1],s=2){const r=new ut;r.littleEndian=!0,r.dims=[3,1,1,1,0,0,0,0],r.dims[0]=Math.max(3,i.length);for(let l=0;l<i.length;l++)r.dims[l+1]=i[l];r.pixDims=[1,1,1,1,1,0,0,0];for(let l=0;l<i.length;l++)r.pixDims[l+1]=t[l];if(n.length===16){let l=0;for(let d=0;d<4;d++)for(let h=0;h<4;h++)r.affine[d][h]=n[l],l++}let c=8;return s===256||s===2?c=8:s===512||s===4?c=16:s===16||s===768||s===8||s===2304?c=32:s===64?c=64:k.warn("Unsupported NIfTI datatypeCode for header creation: "+s),r.datatypeCode=s,r.numBitsPerVoxel=c,r.scl_inter=0,r.scl_slope=1,r.sform_code=2,r.magic="n+1",r.vox_offset=352,r}function f4(i=[256,256,256],t=[1,1,1],n=[1,0,0,-128,0,1,0,-128,0,0,1,-128,0,0,0,1],s=2,r=new Uint8Array){const c=W2(i,t,n,s),l=Kl(c,!1);c.vox_offset=Math.max(352,l.length);const d=Kl(c,!1);if(r.length<1)return d;const h=Math.max(0,c.vox_offset-d.length),u=new Uint8Array(h),m=new Uint8Array(r.buffer,r.byteOffset,r.byteLength),g=c.vox_offset+m.length,A=new Uint8Array(g);return A.set(d,0),A.set(u,d.length),A.set(m,c.vox_offset),A}function _2(i,t=null){if(!i.hdr)throw new Error("NVImage header is not defined for toUint8Array");if(!i.img&&t===null)throw new Error("NVImage image data is not defined for toUint8Array");const n=t!==null,s=JSON.parse(JSON.stringify(i.hdr)),r=i.extensions&&i.extensions.length>0,c=new Uint8Array(4);c[0]=r?1:0;let l=new Uint8Array(0);if(r){const b=[];let C=0;for(const E of i.extensions){const M=new Uint8Array(E.edata),N=new Uint8Array(8+M.length),U=new DataView(N.buffer);U.setInt32(0,E.esize,!0),U.setInt32(4,E.ecode,!0),N.set(M,8),b.push(N),C+=N.length}l=new Uint8Array(C);let S=0;for(const E of b)l.set(E,S),S+=E.length}const d=348;s.vox_offset=Math.max(352,d+c.length+l.length),n&&(s.datatypeCode=2,s.numBitsPerVoxel=8,s.scl_slope=1,s.scl_inter=0);const h=Kl(s,n);let u;if(n){const b=t,C=i.permRAS;if(C&&(C[0]!==1||C[1]!==2||C[2]!==3)){k.debug("Reorienting drawing bytes back to native space for saving...");const S=i.hdr.dims,E=S[1]*S[2]*S[3],M=i.dimsRAS?i.dimsRAS[1]*i.dimsRAS[2]*i.dimsRAS[3]:E;if(b.length!==M)console.warn(`Drawing length (${b.length}) does not match expected RAS voxel count (${M}). Cannot reorient drawing reliably.`),u=b;else if(!i.img2RASstep||!i.img2RASstart||!i.dimsRAS)console.warn("Missing RAS transformation info (img2RASstep, img2RASstart, dimsRAS). Cannot reorient drawing reliably."),u=b;else{const N=i.img2RASstep,U=i.img2RASstart,T=i.dimsRAS,F=new Uint8Array(E);F.fill(0);const I=b;let B=0;for(let V=0;V<T[3];V++){const R=U[2]+V*N[2];for(let Y=0;Y<T[2];Y++){const P=U[1]+Y*N[1];for(let X=0;X<T[1];X++){const H=U[0]+X*N[0]+P+R;H>=0&&H<E?F[H]=I[B]:B<I.length&&console.warn(`Calculated native index ${H} is out of bounds [0..${E-1}] during drawing reorientation.`),B++}}}u=F}}else u=b}else{if(!i.img)throw new Error("NVImage image data is null when trying to save non-drawing.");u=new Uint8Array(i.img.buffer,i.img.byteOffset,i.img.byteLength)}const m=h.length+c.length+l.length,g=Math.max(0,s.vox_offset-m),A=new Uint8Array(g),v=s.vox_offset+u.length,y=new Uint8Array(v);let w=0;return y.set(h,w),w+=h.length,y.set(c,w),w+=c.length,y.set(l,w),w+=l.length,y.set(A,w),w+=A.length,y.set(u,s.vox_offset),y}async function J2(i,t,n=null){const s=_2(i,n);if(t.toLowerCase().endsWith(".gz"))try{const c=await At.compress(s,"gzip");return new Uint8Array(c)}catch(c){return k.error("Compression failed:",c),k.warn("Returning uncompressed data due to compression error."),s}else return s}async function d4(i,t="",n=null){const s=await J2(i,t,n);if(!t)return k.debug("saveToDisk: empty file name, returning data as Uint8Array rather than triggering download"),s;try{const r=new Blob([s.buffer],{type:"application/octet-stream"}),c=URL.createObjectURL(r),l=document.createElement("a");l.setAttribute("href",c),l.setAttribute("download",t),l.style.visibility="hidden",document.body.appendChild(l),l.click(),document.body.removeChild(l),setTimeout(()=>URL.revokeObjectURL(c),100)}catch(r){k.error("Failed to trigger download:",r)}return s}function $2(i,t,n,s,r=0,c=!1){if(!i.hdr)throw new Error("getValue: NVImage header is not defined.");if(!c&&!i.img)throw new Error("getValue: NVImage image data is not defined.");if(c&&!i.imaginary)return k.warn("getValue: Attempted to read imaginary data, but none exists."),[0];const l=i.hdr.dims[1],d=i.hdr.dims[2],h=i.hdr.dims[3],u=i.permRAS.slice();if(u[0]!==1||u[1]!==2||u[2]!==3){const S=te(t,n,s,1);De(S,S,i.toRASvox),t=S[0],n=S[1],s=S[2]}t=Math.max(0,Math.min(Math.round(t),l-1)),n=Math.max(0,Math.min(Math.round(n),d-1)),s=Math.max(0,Math.min(Math.round(s),h-1)),r=Math.max(0,r);let m=t+n*l+s*l*d;if(i.hdr.datatypeCode===2304)return i.img?(m*=4,m+3>=i.img.length?(k.warn(`getValue: Calculated index ${m} out of bounds for RGBA data.`),[0]):[i.img[m],i.img[m+1],i.img[m+2],i.img[m+3]]):[0];if(i.hdr.datatypeCode===128)return i.img?(m*=3,m+2>=i.img.length?(k.warn(`getValue: Calculated index ${m} out of bounds for RGB data.`),[0]):[i.img[m],i.img[m+1],i.img[m+2]]):[0];const g=l*d*h,A=r*g,v=m+A,y=c?i.imaginary:i.img;if(v<0||v>=y.length)return[0];const w=y[v],b=isNaN(i.hdr.scl_slope)||i.hdr.scl_slope===0?1:i.hdr.scl_slope,C=isNaN(i.hdr.scl_inter)?0:i.hdr.scl_inter;return[b*w+C]}function m4(i,t,n,s,r=0,c=!1){const l=$2(i,t,n,s,r,c);return l.length<3?l[0]:l[0]*.2126+l[1]*.7152+l[2]*.0722}function g4(i,t=[-1,0,0],n=[0,0,0],s="same"){const r=[new Uint8Array,[0,0,0]];if(!i.hdr||!i.img||!i.dimsRAS||!i.img2RASstep||!i.img2RASstart)return k.error("getVolumeData: Missing required NVImage properties (hdr, img, dimsRAS, img2RASstep/start)."),r;if(t=t.slice(0,3),n=n.slice(0,3),Math.min(...t)<0||Math.min(...n)<0)return k.warn("getVolumeData: Invalid start or end coordinates provided."),r;const c=i.dimsRAS.slice(1,4);for(let b=0;b<3;b++)if(t[b]=Math.max(0,Math.min(Math.round(t[b]),c[b]-1)),n[b]=Math.max(0,Math.min(Math.round(n[b]),c[b]-1)),n[b]<t[b]){const C=n[b];n[b]=t[b],t[b]=C}const l=[n[0]-t[0]+1,n[1]-t[1]+1,n[2]-t[2]+1],d=l[0]*l[1]*l[2];if(d<=0)return k.warn("getVolumeData: Calculated slab size is zero or negative."),r;let h=i.img.constructor;s==="uint8"?h=Uint8Array:s==="int16"?h=Int16Array:s==="uint16"?h=Uint16Array:s==="float32"||s==="scaled"||s==="normalized"||s==="windowed"?h=Float32Array:s==="float64"?h=Float64Array:s!=="same"&&k.warn(`getVolumeData: Unsupported dataType '${s}'. Using 'same'.`);let u;try{u=new h(d)}catch(b){return k.error(`getVolumeData: Failed to create output array for dataType '${s}'.`,b),r}const m=i.img2RASstep,g=i.img2RASstart,A=i.img;let v=0;for(let b=t[2];b<=n[2];b++){const C=g[2]+b*m[2];for(let S=t[1];S<=n[1];S++){const E=g[1]+S*m[1];for(let M=t[0];M<=n[0];M++){const U=g[0]+M*m[0]+E+C;let T=0;U>=0&&U<A.length&&(T=A[U]),u[v++]=T}}}const y=isNaN(i.hdr.scl_slope)||i.hdr.scl_slope===0?1:i.hdr.scl_slope,w=isNaN(i.hdr.scl_inter)?0:i.hdr.scl_inter;if(s==="scaled"||s==="normalized"||s==="windowed"){u instanceof Float32Array||(k.warn(`getVolumeData: Converting output to Float32 for scaling type '${s}'.`),u=Float32Array.from(u));for(let b=0;b<u.length;b++)u[b]=u[b]*y+w}if(s==="normalized"||s==="windowed"){let b=i.cal_min,C=i.cal_max;s==="normalized"&&(b=i.global_min,C=i.global_max);const S=C-b,E=S===0?0:1/S;for(let M=0;M<u.length;M++)u[M]=(u[M]-b)*E,u[M]=Math.max(0,Math.min(u[M],1))}return[u,l]}function A4(i,t=[-1,0,0],n=[0,0,0],s=new Uint8Array){if(!i.hdr||!i.img||!i.dimsRAS||!i.img2RASstep||!i.img2RASstart){k.error("setVolumeData: Missing required NVImage properties (hdr, img, dimsRAS, img2RASstep/start).");return}if(s.length<1){k.warn("setVolumeData: Input slabData is empty.");return}if(t=t.slice(0,3),n=n.slice(0,3),Math.min(...t)<0||Math.min(...n)<0){k.warn("setVolumeData: Invalid start or end coordinates provided.");return}const r=i.dimsRAS.slice(1,4);for(let g=0;g<3;g++)if(t[g]=Math.max(0,Math.min(Math.round(t[g]),r[g]-1)),n[g]=Math.max(0,Math.min(Math.round(n[g]),r[g]-1)),n[g]<t[g]){const A=n[g];n[g]=t[g],t[g]=A}const c=[n[0]-t[0]+1,n[1]-t[1]+1,n[2]-t[2]+1],l=c[0]*c[1]*c[2];if(l<=0){k.warn("setVolumeData: Calculated slab size is zero or negative.");return}if(s.length<l){k.error(`setVolumeData: Input slabData length (${s.length}) is less than the calculated slab size (${l}).`);return}const d=i.img2RASstep,h=i.img2RASstart,u=i.img;let m=0;for(let g=t[2];g<=n[2];g++){const A=h[2]+g*d[2];for(let v=t[1];v<=n[1];v++){const y=h[1]+v*d[1];for(let w=t[0];w<=n[0];w++){const C=h[0]+w*d[0]+y+A;C>=0&&C<u.length&&(u[C]=s[m]),m++}}}}var tm={};_l(tm,{isFreeSurferLabelImage:()=>im,optimizeFreeSurferLabels:()=>em,readMgh:()=>p4});function s2(i,t,n,s=1){const r=t+n;let c=t;const l=[];for(;c+12<=r;){const d=i.getInt32(c,!1),h=i.getInt32(c+8,!1);if(c+=12,h<=0||c+h>r)break;if(d!==s){c+=h;continue}let u=h,m=c;if(s===1){if(c+4>r)break;u=i.getInt32(c,!1),m+=4}if(u>1&&m+u<=r){const g=new Uint8Array(i.buffer,m,u),A=new TextDecoder("utf-8").decode(g.slice(0,-1));l.push(A)}c+=h}return l.join(`
+
+`)}function em(i,t){if(i.intent_code=1002,i.datatypeCode!==16&&i.datatypeCode!==8)return t;let n=new Float32Array(t);if(i.datatypeCode===8&&(n=new Int32Array(t)),Zh()){const l=new Uint32Array(t);for(let d=0;d<l.length;d++){const h=l[d];l[d]=(h&255)<<24|(h&65280)<<8|(h&16711680)>>>8|(h&4278190080)>>>24}}i.littleEndian=Zh();let s=!0,r=1/0,c=-1/0;for(let l=0;l<n.length;l++){const d=n[l];Number.isFinite(d)&&(Number.isInteger(d)||(s=!1),d<r&&(r=d),d>c&&(c=d))}if(!s||r<0||c>2147483647)return k.warn(`FreeSurfer Labels must be integers in INT32 range. range ${r}..${c}`),t;if(c>32767){i.datatypeCode=8;const l=new Int32Array(n.length);for(let d=0;d<n.length;d++)l[d]=Math.trunc(n[d]);return l.buffer}else if(c>255){i.datatypeCode=4,i.numBitsPerVoxel=16;const l=new Int16Array(n.length);for(let d=0;d<n.length;d++)l[d]=Math.trunc(n[d]);return l.buffer}else{i.datatypeCode=2,i.numBitsPerVoxel=8;const l=new Uint8Array(n.length);for(let d=0;d<n.length;d++)l[d]=Math.trunc(n[d]);return l.buffer}}function im(i,t,n){const s=i.byteLength-t.vox_offset;if(s<n)return k.error(`MGH image data size mismatch: expected ${n}, found ${s}`),!1;if(s===n)return!1;const r=t.vox_offset+n+20,c=i.byteLength-r;return c<=12?!1:s2(new DataView(i),r,c).toLowerCase().endsWith("lut.txt")?!0:s2(new DataView(i),r,c,3).includes("mri_label2vol")}async function p4(i,t){i.hdr||(k.debug("readMgh called before nvImage.hdr was initialized. Creating default."),i.hdr=new ut);const n=i.hdr;n.littleEndian=!1;let s=t,r=new DataView(s);if(s.byteLength>=2&&r.getUint8(0)===31&&r.getUint8(1)===139)try{s=await At.decompressToBuffer(new Uint8Array(t)),r=new DataView(s)}catch(H){return k.error("Failed to decompress MGZ file.",H),null}if(s.byteLength<284)return k.error("File too small to be a valid MGH/MGZ header."),null;const c=r.getInt32(0,!1),l=r.getInt32(4,!1),d=r.getInt32(8,!1),h=r.getInt32(12,!1),u=r.getInt32(16,!1),m=r.getInt32(20,!1),g=r.getFloat32(30,!1),A=r.getFloat32(34,!1),v=r.getFloat32(38,!1),y=r.getFloat32(42,!1),w=r.getFloat32(46,!1),b=r.getFloat32(50,!1),C=r.getFloat32(54,!1),S=r.getFloat32(58,!1),E=r.getFloat32(62,!1),M=r.getFloat32(66,!1),N=r.getFloat32(70,!1),U=r.getFloat32(74,!1),T=r.getFloat32(78,!1),F=r.getFloat32(82,!1),I=r.getFloat32(86,!1);if(c!==1&&k.warn(`Unexpected MGH version: ${c}.`),l<=0||d<=0||h<=0)return k.error(`Invalid MGH dimensions: ${l}x${d}x${h}`),null;switch(m){case 0:n.numBitsPerVoxel=8,n.datatypeCode=2;break;case 4:n.numBitsPerVoxel=16,n.datatypeCode=4;break;case 1:n.numBitsPerVoxel=32,n.datatypeCode=8;break;case 3:n.numBitsPerVoxel=32,n.datatypeCode=16;break;default:return k.error(`Unsupported MGH data type: ${m}`),null}n.dims[1]=l,n.dims[2]=d,n.dims[3]=h,n.dims[4]=Math.max(1,u),n.dims[0]=n.dims[4]>1?4:3,n.pixDims[1]=Math.abs(g),n.pixDims[2]=Math.abs(A),n.pixDims[3]=Math.abs(v),n.pixDims[4]=0,n.sform_code=1,n.qform_code=0,n.sform_code=1;const B=oi(y*n.pixDims[1],C*n.pixDims[2],M*n.pixDims[3],0,w*n.pixDims[1],S*n.pixDims[2],N*n.pixDims[3],0,b*n.pixDims[1],E*n.pixDims[2],U*n.pixDims[3],0,0,0,0,1),V=[n.dims[1]/2,n.dims[2]/2,n.dims[3]/2,1],R=[0,0,0,0];for(let H=0;H<3;H++){R[H]=0;for(let W=0;W<3;W++)R[H]=R[H]+B[W+H*4]*V[W]}n.affine=[[B[0],B[1],B[2],T-R[0]],[B[4],B[5],B[6],F-R[1]],[B[8],B[9],B[10],I-R[2]],[0,0,0,1]],n.vox_offset=284,n.magic="n+1";const Y=n.numBitsPerVoxel/8,X=l*d*h*n.dims[4]*Y,L=s.slice(n.vox_offset,n.vox_offset+X);return im(s,n,X)?em(n,L):L}var nm={};_l(nm,{readNifti:()=>v4});async function v4(i,t,n){let s=t,r=null;try{if(su(s)&&(k.debug(`Decompressing NIfTI file: ${i.name}`),s=await Kp(s),k.debug(`Decompression complete for: ${i.name}`)),!s||s.byteLength===0)throw new Error("Buffer became invalid after decompression attempt.");if(i.hdr=await Ka(s,n!=null),Qp(i.hdr)&&(i.extensions=i.hdr.extensions),i.hdr===null)throw new Error(`Failed to read NIfTI header: ${i.name}`);if(i.hdr.cal_min===0&&i.hdr.cal_max===255&&i.hdr.datatypeCode!==2&&(k.debug(`Resetting suspicious cal_min/max (0/255) for non-uint8 NIfTI: ${i.name}`),i.hdr.cal_min=0,i.hdr.cal_max=0),r=n?Yd(i.hdr,n):Yd(i.hdr,s),r===null)throw new Error(`nifti-reader-js readImage returned null for ${i.name}`);return r}catch(c){return k.error(`Error processing NIfTI file ${i.name}:`,c),i.hdr=null,null}}var sm={};_l(sm,{readNrrd:()=>x4});async function x4(i,t,n=null){i.hdr||(k.warn("readNrrd called before nvImage.hdr was initialized. Creating default."),i.hdr=new ut);const s=i.hdr;s.pixDims=[1,1,1,1,1,0,0,0];const r=t.byteLength;let c=null;const l=new Uint8Array(t);for(let U=1;U<r;U++)if(l[U-1]===10&&l[U]===10){const T=t.slice(0,U-1);c=new TextDecoder().decode(T),s.vox_offset=U+1;break}if(c===null)return k.error("readNrrd: could not extract txt"),null;const d=c.split(`
+`);if(!d[0].startsWith("NRRD"))return k.error("Invalid NRRD image (magic signature missing)"),null;const h=d.length;let u=!1,m=!1,g=!1;const A=vn(NaN,0,0,0,1,0,0,0,1),v=lt(0,0,0);let y=Hh();for(let U=1;U<h;U++){let T=d[U];if((T.length===0||T[0]==="#")&&(T.startsWith("#")||T.trim().length===0))continue;T=T.toLowerCase();const F=T.split(":");if(F.length<2)continue;const I=F[0].trim();let B=F[1].trim();switch(B=B.replaceAll(")"," "),B=B.replaceAll("("," "),B=B.trim(),I){case"data file":g=!0;break;case"encoding":if(B.includes("raw"))u=!1;else if(B.includes("gz"))u=!0;else return k.error("Unsupported NRRD encoding"),null;break;case"type":switch(B){case"uchar":case"unsigned char":case"uint8":case"uint8_t":s.numBitsPerVoxel=8,s.datatypeCode=2;break;case"signed char":case"int8":case"int8_t":s.numBitsPerVoxel=8,s.datatypeCode=256;break;case"short":case"short int":case"signed short":case"signed short int":case"int16":case"int16_t":s.numBitsPerVoxel=16,s.datatypeCode=4;break;case"ushort":case"unsigned short":case"unsigned short int":case"uint16":case"uint16_t":s.numBitsPerVoxel=16,s.datatypeCode=512;break;case"int":case"signed int":case"int32":case"int32_t":s.numBitsPerVoxel=32,s.datatypeCode=8;break;case"uint":case"unsigned int":case"uint32":case"uint32_t":s.numBitsPerVoxel=32,s.datatypeCode=768;break;case"float":s.numBitsPerVoxel=32,s.datatypeCode=16;break;case"double":s.numBitsPerVoxel=64,s.datatypeCode=64;break;default:return k.error("Unsupported NRRD data type: "+B),null}break;case"spacings":{const V=B.split(/[ ,]+/);for(let R=0;R<V.length;R++)s.pixDims[R+1]=parseFloat(V[R])}break;case"sizes":{const V=B.split(/[ ,]+/);s.dims[0]=V.length;for(let R=0;R<V.length;R++)s.dims[R+1]=parseInt(V[R])}break;case"endian":B.includes("little")?s.littleEndian=!0:B.includes("big")&&(s.littleEndian=!1);break;case"space directions":{const V=B.split(/[ ,]+/);if(V.length===9)for(let R=0;R<9;R++)A[R]=parseFloat(V[R])}break;case"space origin":{const V=B.split(/[ ,]+/);V.length===3&&(v[0]=parseFloat(V[0]),v[1]=parseFloat(V[1]),v[2]=parseFloat(V[2]))}break;case"space units":B.includes("microns")&&(m=!0);break;case"space":B.includes("right-anterior-superior")||B.includes("ras")?y=vn(1,0,0,0,1,0,0,0,1):B.includes("left-anterior-superior")||B.includes("las")?y=vn(-1,0,0,0,1,0,0,0,1):B.includes("left-posterior-superior")||B.includes("lps")?y=vn(-1,0,0,0,-1,0,0,0,1):k.warn("Unsupported NRRD space value:",B);break;default:k.warn("Unknown:",I);break}}if(!isNaN(A[0])){s.sform_code=2,m&&(sp(A,A,.001),v[0]*=.001,v[1]*=.001,v[2]*=.001),y[0]<0&&(v[0]=-v[0]),y[4]<0&&(v[1]=-v[1]),y[8]<0&&(v[2]=-v[2]),b2(A,y,A);const U=oi(A[0],A[3],A[6],v[0],A[1],A[4],A[7],v[1],A[2],A[5],A[8],v[2],0,0,0,1);if(!i.vox2mm)return null;const T=i.vox2mm([0,0,0],U),F=i.vox2mm([1,0,0],U);jt(F,F,T);const I=i.vox2mm([0,1,0],U);jt(I,I,T);const B=i.vox2mm([0,0,1],U);jt(B,B,T),s.pixDims[1]=wn(F),s.pixDims[2]=wn(I),s.pixDims[3]=wn(B),s.affine=[[U[0],U[1],U[2],U[3]],[U[4],U[5],U[6],U[7]],[U[8],U[9],U[10],U[11]],[0,0,0,1]]}let w=null;const b=g?n:t,C=g?0:s.vox_offset;if(g&&!b)return k.warn("Missing data: NRRD header describes detached data file but only one URL provided"),null;if(!b||C>=b.byteLength)return k.error(`NRRD data offset (${C}) invalid for buffer length (${b?.byteLength??0})`),null;let S=b.slice(C);if(u)try{k.debug("Decompressing NRRD data..."),S=await At.decompressToBuffer(new Uint8Array(S)),k.debug("Decompression complete.")}catch(U){return k.error("Failed to decompress NRRD data.",U),null}const E=s.numBitsPerVoxel/8,N=s.dims.slice(1,s.dims[0]+1).reduce((U,T)=>U*Math.max(1,T),1)*E;return S.byteLength<N?(k.error(`NRRD image data size mismatch: expected ${N}, found ${S.byteLength}`),null):(S.byteLength>N&&(k.warn(`NRRD has extra ${S.byteLength-N} bytes after expected image data. Truncating.`),S=S.slice(0,N)),w=S,s.datatypeCode?s.numBitsPerVoxel?w:(k.error("NRRD parsing failed to set numBitsPerVoxel."),null):(k.error("NRRD parsing failed to set datatypeCode."),null))}var Ue=class Hl{constructor(t=null,n="",s="gray",r=1,c=null,l=NaN,d=NaN,h=!0,u=.02,m=!1,g=!1,A="",v=0,y=bt.UNKNOWN,w=NaN,b=NaN,C=!0,S=null,E=0){z(this,"name"),z(this,"id"),z(this,"url"),z(this,"headers"),z(this,"_colormap"),z(this,"_opacity"),z(this,"percentileFrac"),z(this,"ignoreZeroVoxels"),z(this,"trustCalMinMax"),z(this,"colormapNegative"),z(this,"colormapLabel"),z(this,"colormapInvert"),z(this,"nFrame4D"),z(this,"frame4D"),z(this,"nTotalFrame4D"),z(this,"cal_minNeg"),z(this,"cal_maxNeg"),z(this,"colorbarVisible",!0),z(this,"modulationImage",null),z(this,"modulateAlpha",0),z(this,"series",[]),z(this,"nVox3D"),z(this,"oblique_angle"),z(this,"maxShearDeg"),z(this,"useQFormNotSForm"),z(this,"colormapType"),z(this,"pixDims"),z(this,"matRAS"),z(this,"pixDimsRAS"),z(this,"obliqueRAS"),z(this,"dimsRAS"),z(this,"permRAS"),z(this,"img2RASstep"),z(this,"img2RASstart"),z(this,"toRAS"),z(this,"toRASvox"),z(this,"frac2mm"),z(this,"frac2mmOrtho"),z(this,"extentsMinOrtho"),z(this,"extentsMaxOrtho"),z(this,"mm2ortho"),z(this,"hdr",null),z(this,"extensions"),z(this,"imageType"),z(this,"img"),z(this,"imaginary"),z(this,"v1"),z(this,"fileObject"),z(this,"dims"),z(this,"onColormapChange",()=>{}),z(this,"onOpacityChange",()=>{}),z(this,"mm000"),z(this,"mm100"),z(this,"mm010"),z(this,"mm001"),z(this,"cal_min"),z(this,"cal_max"),z(this,"robust_min"),z(this,"robust_max"),z(this,"global_min"),z(this,"global_max"),z(this,"urlImgData"),z(this,"isManifest"),z(this,"limitFrames4D"),this.init(t,n,s,r,c,l,d,h,u,m,g,A,v,y,w,b,C,S,E)}init(t=null,n="",s="",r=1,c=null,l=NaN,d=NaN,h=!0,u=.02,m=!1,g=!1,A="",v=0,y=bt.UNKNOWN,w=NaN,b=NaN,C=!0,S=null,E=0,M=null){const N=s==="";if(N&&(s="gray"),this.name=n,this.imageType=y,this.id=qh(),this._colormap=s,this._opacity=r>1?1:r,this.percentileFrac=u,this.ignoreZeroVoxels=m,this.trustCalMinMax=h,this.colormapNegative=A,this.colormapLabel=S,this.frame4D=v,this.cal_minNeg=w,this.cal_maxNeg=b,this.colorbarVisible=C,this.colormapType=E,this.useQFormNotSForm=g,!t)return;if(N&&this.hdr&&this.hdr.intent_code===1002&&(s="random",this._colormap=s),this.hdr&&typeof this.hdr.magic=="number"&&(this.hdr.magic="n+1"),this.nFrame4D=1,this.hdr)for(let I=4;I<7;I++)this.hdr.dims[I]>1&&(this.nFrame4D*=this.hdr.dims[I]);if(this.frame4D=Math.min(this.frame4D,this.nFrame4D-1),this.nTotalFrame4D=this.nFrame4D,!this.hdr||!M)return;this.nVox3D=this.hdr.dims[1]*this.hdr.dims[2]*this.hdr.dims[3];const U=this.nVox3D*(this.hdr.numBitsPerVoxel/8),T=M.byteLength/U;T!==this.nFrame4D&&(T>0&&T*U===M.byteLength?k.debug("Loading the first "+T+" of "+this.nFrame4D+" volumes"):k.warn("This header does not match voxel data",this.hdr,M.byteLength),this.nFrame4D=T),(this.hdr.intent_code===1007||this.hdr.intent_code===2003)&&this.nFrame4D===3&&this.hdr.datatypeCode===16&&(M=this.float32V1asRGBA(new Float32Array(M)).buffer),(this.hdr.pixDims[1]===0||this.hdr.pixDims[2]===0||this.hdr.pixDims[3]===0)&&k.error("pixDims not plausible",this.hdr),(isNaN(this.hdr.scl_slope)||this.hdr.scl_slope===0)&&(this.hdr.scl_slope=1),isNaN(this.hdr.scl_inter)&&(this.hdr.scl_inter=0);let F=n2(this.hdr.affine);if(g||!F||this.hdr.qform_code>this.hdr.sform_code){k.debug("spatial transform based on QForm");const I=this.hdr.quatern_b,B=this.hdr.quatern_c,V=this.hdr.quatern_d,R=Math.sqrt(1-(Math.pow(I,2)+Math.pow(B,2)+Math.pow(V,2))),Y=this.hdr.pixDims[0]===0?1:this.hdr.pixDims[0],P=[[R*R+I*I-B*B-V*V,2*I*B-2*R*V,2*I*V+2*R*B],[2*I*B+2*R*V,R*R+B*B-I*I-V*V,2*B*V-2*R*I],[2*I*V-2*R*B,2*B*V+2*R*I,R*R+V*V-B*B-I*I]],X=this.hdr.affine;for(let L=0;L<3;L+=1)for(let H=0;H<3;H+=1)X[L][H]=P[L][H]*this.hdr.pixDims[H+1],H===2&&(X[L][H]*=Y);X[0][3]=this.hdr.qoffset_x,X[1][3]=this.hdr.qoffset_y,X[2][3]=this.hdr.qoffset_z,this.hdr.affine=X}if(F=n2(this.hdr.affine),!F){k.debug("Defective NIfTI: spatial transform does not make sense");let I=this.hdr.pixDims[1],B=this.hdr.pixDims[2],V=this.hdr.pixDims[3];(isNaN(I)||I===0)&&(I=1),(isNaN(B)||B===0)&&(B=1),(isNaN(V)||V===0)&&(V=1),this.hdr.pixDims[1]=I,this.hdr.pixDims[2]=B,this.hdr.pixDims[3]=V;const R=[[I,0,0,0],[0,B,0,0],[0,0,V,0],[0,0,0,1]];this.hdr.affine=R}if(this.hdr.datatypeCode!==128&&this.hdr.datatypeCode!==2304&&this.hdr.littleEndian!==Zh()&&this.hdr.numBitsPerVoxel>8){if(this.hdr.numBitsPerVoxel===16){const I=new Uint16Array(M);for(let B=0;B<I.length;B++){const V=I[B];I[B]=((V&255)<<8|V>>8&255)<<16>>16}}else if(this.hdr.numBitsPerVoxel===32){const I=new Uint32Array(M);for(let B=0;B<I.length;B++){const V=I[B];I[B]=(V&255)<<24|(V&65280)<<8|V>>8&65280|V>>24&255}}else if(this.hdr.numBitsPerVoxel===64){const I=this.hdr.numBitsPerVoxel/8,B=new Uint8Array(M);for(let V=0;V<B.length;V+=I){let R=I-1;for(let Y=0;Y<R;Y++){const P=B[V+Y];B[V+Y]=B[V+R],B[V+R]=P,R--}}}}switch(this.hdr.datatypeCode){case 2:this.img=new Uint8Array(M);break;case 4:this.img=new Int16Array(M);break;case 16:this.img=new Float32Array(M);break;case 64:this.img=new Float64Array(M);break;case 128:this.img=new Uint8Array(M);break;case 512:this.img=new Uint16Array(M);break;case 2304:this.img=new Uint8Array(M);break;case 256:{const I=new Int8Array(M),B=I.length;this.img=new Int16Array(B);for(let V=0;V<B;V++)this.img[V]=I[V];this.hdr.datatypeCode=4,this.hdr.numBitsPerVoxel=16;break}case 1:{const I=this.hdr.dims[1]*this.hdr.dims[2]*Math.max(1,this.hdr.dims[3])*Math.max(1,this.hdr.dims[4]),B=new Uint8Array(M);this.img=new Uint8Array(I);const V=new Uint8Array(8);for(let Y=0;Y<8;Y++)V[Y]=Math.pow(2,Y);let R=-1;for(let Y=0;Y<I;Y++){const P=Y%8;P===0&&R++,(B[R]&V[P])!==0&&(this.img[Y]=1)}this.hdr.datatypeCode=2,this.hdr.numBitsPerVoxel=8;break}case 768:{const I=new Uint32Array(M),B=I.length;this.img=new Float64Array(B);for(let V=0;V<B-1;V++)this.img[V]=I[V];this.hdr.datatypeCode=64;break}case 8:{const I=new Int32Array(M),B=I.length;this.img=new Float64Array(B);for(let V=0;V<B-1;V++)this.img[V]=I[V];this.hdr.datatypeCode=64;break}case 1024:{const I=new BigInt64Array(M),B=I.length;this.img=new Float64Array(B);for(let V=0;V<B-1;V++)this.img[V]=Number(I[V]);this.hdr.datatypeCode=64;break}case 32:{const I=new Float32Array(M),B=Math.floor(I.length/2);this.imaginary=new Float32Array(B),this.img=new Float32Array(B);let V=0;for(let R=0;R<B-1;R++)this.img[R]=I[V],this.imaginary[R]=I[V+1],V+=2;this.hdr.datatypeCode=16;break}default:throw new Error("datatype "+this.hdr.datatypeCode+" not supported")}this.calculateRAS(),isNaN(l)||(this.hdr.cal_min=l),isNaN(d)||(this.hdr.cal_max=d),this.calMinMax()}static async new(t=null,n="",s="",r=1,c=null,l=NaN,d=NaN,h=!0,u=.02,m=!1,g=!1,A="",v=0,y=bt.UNKNOWN,w=NaN,b=NaN,C=!0,S=null,E=0,M){const N=new Hl,U=/(?:\.([^.]+))?$/;let T=U.exec(n)[1]||"";T=T.toUpperCase(),T==="GZ"&&(T=U.exec(n.slice(0,-3))[1],T=T.toUpperCase());let F=null;if(y===bt.UNKNOWN&&(y=bt.parse(T)),t instanceof ArrayBuffer&&t.byteLength>=2&&y===bt.DCM){const I=new Uint8Array(t);(I[0]===92&&I[1]===1||I[1]===92&&I[0]===1)&&(y=bt.NII)}switch(N.imageType=y,y){case bt.DCM_FOLDER:case bt.DCM_MANIFEST:case bt.DCM:return;case bt.FIB:[F,N.v1]=await N.readFIB(t);break;case bt.MIH:case bt.MIF:F=await N.readMIF(t,c);break;case bt.NHDR:case bt.NRRD:if(F=await sm.readNrrd(N,t),F===null)throw new Error(`Failed to parse NHDR/NRRD file ${n}`);break;case bt.MHD:case bt.MHA:F=await N.readMHA(t,c);break;case bt.MGH:case bt.MGZ:if(F=await tm.readMgh(N,t),F===null)throw new Error(`Failed to parse MGH/MGZ file ${n}`);break;case bt.SRC:F=await N.readSRC(t);break;case bt.V:F=N.readECAT(t);break;case bt.V16:F=N.readV16(t);break;case bt.VMR:F=N.readVMR(t);break;case bt.HEAD:F=await N.readHEAD(t,c);break;case bt.BMP:F=await N.readBMP(t);break;case bt.NPY:F=await N.readNPY(t);break;case bt.NPZ:F=await N.readNPZ(t);break;case bt.ZARR:F=await N.readZARR(t,M);break;case bt.NII:if(F=await nm.readNifti(N,t,c),F===null)throw new Error(`Failed to parse NIfTI file ${n}.`);break;default:throw new Error("Image type not supported")}return N.init(t,n,s,r,c,l,d,h,u,m,g,A,v,y,w,b,C,S,E,F),N}computeObliqueAngle(t){const n=re(t);We(n,t);const s=Math.sqrt(n[0]*n[0]+n[1]*n[1]+n[2]*n[2]),r=Math.max(Math.max(Math.abs(n[0]),Math.abs(n[1])),Math.abs(n[2]))/s,c=Math.sqrt(n[4]*n[4]+n[5]*n[5]+n[6]*n[6]),l=Math.max(Math.max(Math.abs(n[4]),Math.abs(n[5])),Math.abs(n[6]))/c,d=Math.sqrt(n[8]*n[8]+n[9]*n[9]+n[10]*n[10]),h=Math.max(Math.max(Math.abs(n[8]),Math.abs(n[9])),Math.abs(n[10]))/d,u=Math.min(Math.min(r,l),h);let m=Math.abs(Math.acos(u)*180/3.141592653);return m>.01?k.warn("Warning voxels not aligned with world space: "+m+` degrees from plumb.
+`):m=0,m}float32V1asRGBA(t){t.length!==this.nVox3D*3&&k.warn("float32V1asRGBA() expects "+this.nVox3D*3+"voxels, got ",+t.length);const n=t.slice();this.hdr.datatypeCode=2304,this.nFrame4D=1;for(let h=4;h<7;h++)this.hdr.dims[h]=1;this.hdr.dims[0]=3;const s=new Uint8Array(this.nVox3D*4);let r=1;for(let h=0;h<this.nVox3D*3;h++)isNaN(n[h])||(r=Math.max(r,Math.abs(n[h])));const c=255/r,l=this.nVox3D*2;let d=0;for(let h=0;h<this.nVox3D;h++){const u=n[h],m=n[h+this.nVox3D],g=n[h+l];s[d]=Math.abs(u*c),s[d+1]=Math.abs(m*c),s[d+2]=Math.abs(g*c);const A=+(u>0)*1,v=+(m>0)*2,y=+(g>0)*4;let w=248+A+v+y;Math.abs(u)+Math.abs(m)+Math.abs(g)<.1&&(w=0),s[d+3]=w,d+=4}return s}loadImgV1(t=!1,n=!1,s=!1){let r=this.v1;if(!r&&this.nFrame4D===3&&this.img.constructor===Float32Array&&(r=this.img.slice()),!r)return k.warn("Image does not have V1 data"),!1;if(t)for(let c=0;c<this.nVox3D;c++)r[c]=-r[c];if(n)for(let c=this.nVox3D;c<2*this.nVox3D;c++)r[c]=-r[c];if(s)for(let c=2*this.nVox3D;c<3*this.nVox3D;c++)r[c]=-r[c];return this.img=this.float32V1asRGBA(r),!0}calculateOblique(){if(!this.matRAS)throw new Error("matRAS not defined");if(this.pixDimsRAS===void 0)throw new Error("pixDimsRAS not defined");if(!this.dimsRAS)throw new Error("dimsRAS not defined");this.oblique_angle=this.computeObliqueAngle(this.matRAS);const t=this.vox2mm([0,0,0],this.matRAS),n=this.vox2mm([1/this.pixDimsRAS[1],0,0],this.matRAS),s=this.vox2mm([0,1/this.pixDimsRAS[2],0],this.matRAS),r=this.vox2mm([0,0,1/this.pixDimsRAS[3]],this.matRAS);jt(n,n,t),jt(s,s,t),jt(r,r,t);const c=oi(n[0],n[1],n[2],0,s[0],s[1],s[2],0,r[0],r[1],r[2],0,0,0,0,1);this.obliqueRAS=re(c);const l=Math.abs(90-Ch(n,s)*(180/Math.PI)),d=Math.abs(90-Ch(n,r)*(180/Math.PI)),h=Math.abs(90-Ch(s,r)*(180/Math.PI));this.maxShearDeg=Math.max(Math.max(l,d),h),this.maxShearDeg>.1&&k.warn("Warning: voxels are rhomboidal, maximum shear is %f degrees.",this.maxShearDeg);const u=te(this.dimsRAS[1],this.dimsRAS[2],this.dimsRAS[3],1),m=re(this.matRAS);We(m,m);const g=te(-.5,-.5,-.5,0);Ps(m,m,lt(g[0],g[1],g[2])),m[0]*=u[0],m[1]*=u[0],m[2]*=u[0],m[4]*=u[1],m[5]*=u[1],m[6]*=u[1],m[8]*=u[2],m[9]*=u[2],m[10]*=u[2],this.frac2mm=re(m);const A=this.pixDimsRAS[1],v=this.pixDimsRAS[2],y=this.pixDimsRAS[3],w=re(m);w[0]=A*u[0],w[1]=0,w[2]=0,w[4]=0,w[5]=v*u[1],w[6]=0,w[8]=0,w[9]=0,w[10]=y*u[2];const b=this.mm2vox([0,0,0],!0);w[12]=(-b[0]-.5)*A,w[13]=(-b[1]-.5)*v,w[14]=(-b[2]-.5)*y,this.frac2mmOrtho=re(w),this.extentsMinOrtho=[w[12],w[13],w[14]],this.extentsMaxOrtho=[w[0]+w[12],w[5]+w[13],w[10]+w[14]],this.mm2ortho=Ut(),Pe(this.mm2ortho,c)}THD_daxes_to_NIFTI(t,n,s){const r=this.hdr;if(r===null)throw new Error("HDR is not set");r.sform_code=2;const c="xxyyzzg";let l=-1,d=-1,h=-1;const u=["x","y","z"];u[0]=c[s[0]],u[1]=c[s[1]],u[2]=c[s[2]];const m=t.slice(0,3),g=n.slice(0,3);for(let A=0;A<3;A++)u[A]==="x"?l=A:u[A]==="y"?d=A:h=A;l<0||d<0||h<0||l===d||l===h||d===h||(r.pixDims[1]=Math.abs(m[0]),r.pixDims[2]=Math.abs(m[1]),r.pixDims[3]=Math.abs(m[2]),r.affine=[[1,0,0,0],[0,1,0,0],[0,0,1,0],[0,0,0,1]],r.affine[0][l]=-m[l],r.affine[1][d]=-m[d],r.affine[2][h]=m[h],r.affine[0][3]=-g[l],r.affine[1][3]=-g[d],r.affine[2][3]=g[h])}SetPixDimFromSForm(){if(!this.hdr)throw new Error("hdr not defined");const t=this.hdr.affine,n=oi(t[0][0],t[0][1],t[0][2],t[0][3],t[1][0],t[1][1],t[1][2],t[1][3],t[2][0],t[2][1],t[2][2],t[2][3],t[3][0],t[3][1],t[3][2],t[3][3]),s=this.vox2mm([0,0,0],n),r=this.vox2mm([1,0,0],n);jt(r,r,s);const c=this.vox2mm([0,1,0],n);jt(c,c,s);const l=this.vox2mm([0,0,1],n);jt(l,l,s),this.hdr.pixDims[1]=wn(r),this.hdr.pixDims[2]=wn(c),this.hdr.pixDims[3]=wn(l)}readECAT(t){this.hdr=new ut;const n=this.hdr;n.dims=[3,1,1,1,0,0,0,0],n.pixDims=[1,1,1,1,1,0,0,0];const s=new DataView(t),r=s.getInt32(0,!1),c=s.getInt16(50,!1);if(r!==1296127058||c<1||c>14)throw new Error("Not a valid ECAT file");let l=512,d=0;const h=[];let u=new Float32Array;for(;;){const m=s.getInt32(l,!1),g=s.getInt32(l+12,!1);if(m+g!==31)break;let A=l+20,v=0,y=0;for(;v<31&&(y=s.getInt32(A,!1),A+=16,y!==0);){v++;let w=y*512;const b=w-512,C=s.getUint16(b,!1);n.dims[1]=s.getUint16(b+4,!1),n.dims[2]=s.getUint16(b+6,!1),n.dims[3]=s.getUint16(b+8,!1);const S=s.getFloat32(b+26,!1);n.pixDims[1]=s.getFloat32(b+34,!1)*10,n.pixDims[2]=s.getFloat32(b+38,!1)*10,n.pixDims[3]=s.getFloat32(b+42,!1)*10,n.pixDims[4]=s.getUint32(b+46,!1)/1e3,h.push(n.pixDims[4]);const E=n.dims[1]*n.dims[2]*n.dims[3],M=new Float32Array(E);if(C===1)for(let U=0;U<E;U++)M[U]=s.getUint8(w)*S,w++;else if(C===6)for(let U=0;U<E;U++)M[U]=s.getUint16(w,!1)*S,w+=2;else if(C===7)for(let U=0;U<E;U++)M[U]=s.getUint32(w,!1)*S,w+=4;else k.warn("Unknown ECAT data type "+C);const N=u.slice(0);u=new Float32Array(N.length+M.length),u.set(N),u.set(M,N.length),d++}if(y===0)break;l+=512}if(n.dims[4]=d,n.pixDims[4]=h[0],d>1){n.dims[0]=4;let m=!1;for(let g=0;g<d;g++)h[g]!==h[0]&&(m=!0);m&&k.warn("Frame durations vary")}return n.sform_code=1,n.affine=[[-n.pixDims[1],0,0,(n.dims[1]-2)*.5*n.pixDims[1]],[0,-n.pixDims[2],0,(n.dims[2]-2)*.5*n.pixDims[2]],[0,0,-n.pixDims[3],(n.dims[3]-2)*.5*n.pixDims[3]],[0,0,0,1]],n.numBitsPerVoxel=32,n.datatypeCode=16,u.buffer}readV16(t){this.hdr=new ut;const n=this.hdr;n.dims=[3,1,1,1,0,0,0,0],n.pixDims=[1,1,1,1,1,0,0,0];const s=new DataView(t);return n.dims[1]=s.getUint16(0,!0),n.dims[2]=s.getUint16(2,!0),n.dims[3]=s.getUint16(4,!0),2*n.dims[1]*n.dims[2]*n.dims[3]+6!==t.byteLength&&k.warn("This does not look like a valid BrainVoyager V16 file"),n.numBitsPerVoxel=16,n.datatypeCode=512,k.warn("Warning: V16 files have no spatial transforms"),n.affine=[[0,0,-n.pixDims[1],(n.dims[1]-2)*.5*n.pixDims[1]],[-n.pixDims[2],0,0,(n.dims[2]-2)*.5*n.pixDims[2]],[0,-n.pixDims[3],0,(n.dims[3]-2)*.5*n.pixDims[3]],[0,0,0,1]],n.littleEndian=!0,t.slice(6)}async readNPY(t){function n(M){return{"|b1":1,"<i1":1,"<u1":1,"<i2":2,"<u2":2,"<i4":4,"<u4":4,"<f4":4,"<f8":8}[M]??1}function s(M){return{"|b1":2,"<i1":256,"<u1":2,"<i2":4,"<u2":512,"<i4":8,"<u4":768,"<f4":16,"<f8":64}[M]??16}const r=new DataView(t),c=[r.getUint8(0),r.getUint8(1),r.getUint8(2),r.getUint8(3),r.getUint8(4),r.getUint8(5)],l=[147,78,85,77,80,89];if(!c.every((M,N)=>M===l[N]))throw new Error("Not a valid NPY file: Magic number mismatch");const d=r.getUint16(8,!0),h=new TextDecoder("utf-8").decode(t.slice(10,10+d)),u=h.match(/'shape': \((.*?)\)/);if(!u)throw new Error("Invalid NPY header: Shape not found");const m=u[1].split(",").map(M=>M.trim()).filter(M=>M!=="").map(Number),g=h.match(/'descr': '([^']+)'/);if(!g)throw new Error("Invalid NPY header: Data type not found");const A=g[1],v=m.reduce((M,N)=>M*N,1),y=10+d,w=t.slice(y,y+v*n(A)),b=m.length>0?m[m.length-1]:1,C=m.length>1?m[m.length-2]:1,S=m.length>2?m[m.length-3]:1;this.hdr=new ut;const E=this.hdr;return E.dims=[3,b,C,S,0,0,0,0],E.pixDims=[1,1,1,1,1,0,0,0],E.affine=[[E.pixDims[1],0,0,-(E.dims[1]-2)*.5*E.pixDims[1]],[0,-E.pixDims[2],0,(E.dims[2]-2)*.5*E.pixDims[2]],[0,0,-E.pixDims[3],(E.dims[3]-2)*.5*E.pixDims[3]],[0,0,0,1]],E.numBitsPerVoxel=n(A)*8,E.datatypeCode=s(A),w}async readNPZ(t){const n=new Q2(t);for(let s=0;s<n.entries.length;s++){const r=n.entries[s];if(r.fileName.toLowerCase().endsWith(".npy")){const c=await r.extract();return await this.readNPY(c.buffer)}}}async imageDataFromArrayBuffer(t){return new Promise((n,s)=>{const r=new Blob([t]),c=URL.createObjectURL(r),l=new Image;l.crossOrigin="Anonymous",l.src=c,l.onload=()=>{URL.revokeObjectURL(c);const d=document.createElement("canvas");d.width=l.width,d.height=l.height;const h=d.getContext("2d");if(!h){s(new Error("Failed to get 2D context"));return}h.drawImage(l,0,0),n(h.getImageData(0,0,l.width,l.height))},l.onerror=d=>{URL.revokeObjectURL(c),s(d)}})}async readBMP(t){const n=await this.imageDataFromArrayBuffer(t),{width:s,height:r,data:c}=n;this.hdr=new ut;const l=this.hdr;l.dims=[3,s,r,1,0,0,0,0],l.pixDims=[1,1,1,1,1,0,0,0],l.affine=[[l.pixDims[1],0,0,-(l.dims[1]-2)*.5*l.pixDims[1]],[0,-l.pixDims[2],0,(l.dims[2]-2)*.5*l.pixDims[2]],[0,0,-l.pixDims[3],(l.dims[3]-2)*.5*l.pixDims[3]],[0,0,0,1]],l.numBitsPerVoxel=8,l.datatypeCode=2304;let d=!0;for(let h=0;h<c.length;h+=4)if(c[h]!==c[h+1]||c[h]!==c[h+2]){d=!1;break}if(d){l.datatypeCode=2;const h=new Uint8Array(s*r);for(let u=0,m=0;u<c.length;u+=4,m++)h[m]=c[u];return h.buffer}return c.buffer}async readZARR(t,n){let{width:s,height:r,depth:c=1,data:l}=n??{},d=s*r*c*3,h=d===l.length;if(h||(d=s*r*c,c===3&&(h=!0,c=1)),d!==l.length)throw new Error(`Expected RGB ${s}×${r}×${c}×3 =  ${d}, but ZARR length ${l.length}`);this.hdr=new ut;const u=this.hdr;if(u.dims=[3,s,r,c,1,1,1,1],u.pixDims=[1,1,1,1,0,0,0,0],u.affine=[[u.pixDims[1],0,0,-(u.dims[1]-2)*.5*u.pixDims[1]],[0,-u.pixDims[2],0,(u.dims[2]-2)*.5*u.pixDims[2]],[0,0,-u.pixDims[3],(u.dims[3]-2)*.5*u.pixDims[3]],[0,0,0,1]],!h){if(u.numBitsPerVoxel=8,u.datatypeCode=2,l instanceof Uint8Array){const y=new ArrayBuffer(l.length);return new Uint8Array(y).set(l),y}return l}u.numBitsPerVoxel=24,u.datatypeCode=128;function m(y,w,b,C){const S=w*b,E=new Uint8Array(S*C*3),M=new Array(C);for(let T=0;T<C;T++)M[T]=S*3*T;let N=0,U=0;for(let T=0;T<S;T++){for(let F=0;F<C;F++)E[M[F]+U]=y[N++],E[M[F]+U+1]=y[N++],E[M[F]+U+2]=y[N++];U+=3}return E}const g=m(l,u.dims[1],u.dims[2],u.dims[3]),A=new ArrayBuffer(g.length);return new Uint8Array(A).set(g),A}readVMR(t){this.hdr=new ut;const n=this.hdr;n.dims=[3,1,1,1,0,0,0,0],n.pixDims=[1,1,1,1,1,0,0,0];const s=new DataView(t),r=s.getUint16(0,!0);r!==4&&k.warn("Not a valid version 4 VMR image"),n.dims[1]=s.getUint16(2,!0),n.dims[2]=s.getUint16(4,!0),n.dims[3]=s.getUint16(6,!0);const c=n.dims[1]*n.dims[2]*n.dims[3];if(r>=4){let l=8+c;const d=s.getUint32(l+88,!0);if(l=l+92,d>0){const h=t.byteLength;for(let u=0;u<d;u++){for(;l<h&&s.getUint8(l)!==0;)l++;for(l++,l+=4;l<h&&s.getUint8(l)!==0;)l++;l++;const m=s.getUint32(l,!0);l+=4;for(let g=0;g<m;g++)l+=4}}n.pixDims[1]=s.getFloat32(l+2,!0),n.pixDims[2]=s.getFloat32(l+6,!0),n.pixDims[3]=s.getFloat32(l+10,!0)}return k.warn("Warning: VMR spatial transform not implemented"),n.affine=[[0,0,-n.pixDims[1],(n.dims[1]-2)*.5*n.pixDims[1]],[-n.pixDims[2],0,0,(n.dims[2]-2)*.5*n.pixDims[2]],[0,-n.pixDims[3],0,(n.dims[3]-2)*.5*n.pixDims[3]],[0,0,0,1]],k.debug(n),n.numBitsPerVoxel=8,n.datatypeCode=2,t.slice(8,8+c)}async readFIB(t){this.hdr=new ut;const n=this.hdr;n.littleEndian=!1,n.dims=[3,1,1,1,0,0,0,0],n.pixDims=[1,1,1,1,1,0,0,0];const s=await At.readMatV4(t,!0);if(!("dimension"in s)||!("dti_fa"in s))throw new Error("Not a valid DSIstudio FIB file");const r="index0"in s&&"index1"in s&&"index2"in s&&"odf_vertices"in s;n.numBitsPerVoxel=32,n.datatypeCode=16,n.dims[1]=s.dimension[0],n.dims[2]=s.dimension[1],n.dims[3]=s.dimension[2],n.dims[4]=1,n.pixDims[1]=s.voxel_size[0],n.pixDims[2]=s.voxel_size[1],n.pixDims[3]=s.voxel_size[2],n.sform_code=1;const c=(n.dims[1]-1)*.5*n.pixDims[1],l=(n.dims[2]-1)*.5*n.pixDims[2],d=(n.dims[3]-1)*.5*n.pixDims[3];n.affine=[[n.pixDims[1],0,0,-c],[0,-n.pixDims[2],0,l],[0,0,n.pixDims[2],-d],[0,0,0,1]],n.littleEndian=!0;const h=n.dims[1]*n.dims[2]*n.dims[3],u=h*Math.ceil(n.numBitsPerVoxel/8),m=u*n.dims[4],g=new Uint8Array(new ArrayBuffer(h*4*3));if(r){const w=n.dims[1]*n.dims[2]*n.dims[3],b=new Float32Array(w),C=new Float32Array(w),S=new Float32Array(w),E=s.index0,M=s.odf_vertices;for(let N=0;N<w;N++){const U=E[N]*3;b[N]=M[U+0],C[N]=M[U+1],S[N]=-M[U+2]}g.set(new Uint8Array(b.buffer,b.byteOffset,b.byteLength),0*u),g.set(new Uint8Array(C.buffer,C.byteOffset,C.byteLength),1*u),g.set(new Uint8Array(S.buffer,S.byteOffset,S.byteLength),2*u)}"report"in s&&(n.description=new TextDecoder().decode(s.report.subarray(0,Math.min(79,s.report.byteLength))));const A=new Uint8Array(new ArrayBuffer(m)),v=Float32Array.from(s.dti_fa);if("mask"in s){let w=1;"dti_fa_slope"in s&&(w=s.dti_fa_slope[0]);let b=1;"dti_fa_inter"in s&&(b=s.dti_fa_inter[0]);const C=n.dims[1]*n.dims[2]*n.dims[3],S=s.mask,E=new Float32Array(C);let M=0;for(let N=0;N<C;N++)S[N]!==0&&(E[N]=v[M]*w+b,M++);return[E.buffer,new Float32Array(g.buffer)]}const y=new Uint8Array(v.buffer,v.byteOffset,v.byteLength);return A.set(y,0),[A.buffer,new Float32Array(g.buffer)]}async readSRC(t){this.hdr=new ut;const n=this.hdr;n.littleEndian=!1,n.dims=[3,1,1,1,0,0,0,0],n.pixDims=[1,1,1,1,1,0,0,0];const s=await At.readMatV4(t);if(!("dimension"in s)||!("image0"in s))throw new Error("Not a valid DSIstudio SRC file");let r=0,c=0;for(const[v,y]of Object.entries(s))if(v.startsWith("image")){if(r===0?c=y.length:c!==y.length&&(c=-1),y.constructor!==Uint16Array)throw new Error("DSIstudio SRC files always use Uint16 datatype");r++}if(c<1||r<1)throw new Error("SRC file not valid DSI Studio data. The image(s) should have the same length");n.numBitsPerVoxel=16,n.datatypeCode=512,n.dims[1]=s.dimension[0],n.dims[2]=s.dimension[1],n.dims[3]=s.dimension[2],n.dims[4]=r,n.dims[4]>1&&(n.dims[0]=4),n.pixDims[1]=s.voxel_size[0],n.pixDims[2]=s.voxel_size[1],n.pixDims[3]=s.voxel_size[2],n.sform_code=1;const l=(n.dims[1]-1)*.5*n.pixDims[1],d=(n.dims[2]-1)*.5*n.pixDims[2],h=(n.dims[3]-1)*.5*n.pixDims[3];n.affine=[[n.pixDims[1],0,0,-l],[0,-n.pixDims[2],0,d],[0,0,n.pixDims[2],-h],[0,0,0,1]],n.littleEndian=!0;const u=n.dims[1]*n.dims[2]*n.dims[3]*(n.numBitsPerVoxel/8),m=u*n.dims[4],g=new Uint8Array(new ArrayBuffer(m));let A=0;for(let v=0;v<r;v++){const y=s[`image${v}`],w=new Uint8Array(y.buffer,y.byteOffset,y.byteLength);g.set(w,A),A+=u}return"report"in s&&(n.description=new TextDecoder().decode(s.report.subarray(0,Math.min(79,s.report.byteLength)))),g.buffer}async readHEAD(t,n){this.hdr=new ut;const s=this.hdr;s.dims[0]=3,s.pixDims=[1,1,1,1,1,0,0,0];let r=[0,0,0],c=[0,0,0],l=[1,1,1];const h=new TextDecoder().decode(t).split(/\r?\n/),u=(t.byteLength+8)%16,m=t.byteLength+(16-u);k.debug(t.byteLength,"len",m);const g=new ArrayBuffer(m);new Uint8Array(g).set(new Uint8Array(t));const A=new L2(m+8,42,g,!0);s.addExtension(A),s.extensionCode=42,s.extensionFlag[0]=1,s.extensionSize=m+8;const v=h.length;let y=0,w=!1;for(;y<v;){let C=h[y];if(y++,!C.startsWith("type"))continue;const S=C.includes("integer-attribute"),E=C.includes("float-attribute");if(C=h[y],y++,!C.startsWith("name"))continue;let M=C.split("= ");const N=M[1];C=h[y],y++,M=C.split("= ");let U=parseInt(M[1]);if(!(U<1)){if(C=h[y],y++,M=C.trim().split(/\s+/),E||S){for(;M.length<U;){C=h[y],y++;const T=C.trim().split(/\s+/);M.push(...T)}for(let T=0;T<U;T++)M[T]=parseFloat(M[T])}switch(N){case"BYTEORDER_STRING":M[0].includes("LSB_FIRST")?s.littleEndian=!0:M[0].includes("MSB_FIRST")&&(s.littleEndian=!1);break;case"BRICK_TYPES":{s.dims[4]=U;const T=parseInt(M[0]);T===0?(s.numBitsPerVoxel=8,s.datatypeCode=2):T===1?(s.numBitsPerVoxel=16,s.datatypeCode=4):T===3?(s.numBitsPerVoxel=32,s.datatypeCode=16):k.warn("Unknown BRICK_TYPES ",T)}break;case"IJK_TO_DICOM_REAL":if(U<12)break;w=!0,s.sform_code=2,s.affine=[[-M[0],-M[1],-M[2],-M[3]],[-M[4],-M[5],-M[6],-M[7]],[M[8],M[9],M[10],M[11]],[0,0,0,1]];break;case"DATASET_DIMENSIONS":U=Math.max(U,3);for(let T=0;T<U;T++)s.dims[T+1]=M[T];break;case"ORIENT_SPECIFIC":r=M;break;case"ORIGIN":c=M;break;case"DELTA":l=M;break;case"TAXIS_FLOATS":s.pixDims[4]=M[0];break;default:k.warn("Unknown:",N)}}}w?this.SetPixDimFromSForm():this.THD_daxes_to_NIFTI(l,c,r);const b=s.numBitsPerVoxel/8*s.dims[1]*s.dims[2]*s.dims[3]*s.dims[4];if(!n)throw new Error("pairedImgData not set");return n.byteLength<b?await At.decompressToBuffer(new Uint8Array(n)):n.slice(0)}async readMHA(t,n){const s=t.byteLength;if(s<20)throw new Error("File too small to be VTK: bytes = "+t.byteLength);const r=new Uint8Array(t);let c=0;function l(w){return w===10||w===13}function d(){for(;c<s&&l(r[c]);)c++;const w=c;for(;c<s&&!l(r[c]);)c++;return c-w<2?"":new TextDecoder().decode(t.slice(w,c))}let h=d();this.hdr=new ut;const u=this.hdr;u.pixDims=[1,1,1,1,1,0,0,0],u.dims=[1,1,1,1,1,1,1,1],u.littleEndian=!0;let m=!1,g=!1;const A=vn(NaN,0,0,0,1,0,0,0,1),v=lt(0,0,0);for(;h!=="";){let w=h.split(" ");if(w.length>2&&(w=w.slice(2)),h.startsWith("BinaryDataByteOrderMSB")&&w[0].includes("False")&&(u.littleEndian=!0),h.startsWith("BinaryDataByteOrderMSB")&&w[0].includes("True")&&(u.littleEndian=!1),h.startsWith("CompressedData")&&w[0].includes("True")&&(m=!0),h.startsWith("TransformMatrix"))for(let b=0;b<9;b++)A[b]=parseFloat(w[b]);if(h.startsWith("Offset"))for(let b=0;b<Math.min(w.length,3);b++)v[b]=parseFloat(w[b]);if(h.startsWith("ElementSpacing"))for(let b=0;b<w.length;b++)u.pixDims[b+1]=parseFloat(w[b]);if(h.startsWith("DimSize")){u.dims[0]=w.length;for(let b=0;b<w.length;b++)u.dims[b+1]=parseInt(w[b])}if(h.startsWith("ElementType"))switch(w[0]){case"MET_UCHAR":u.numBitsPerVoxel=8,u.datatypeCode=2;break;case"MET_CHAR":u.numBitsPerVoxel=8,u.datatypeCode=256;break;case"MET_SHORT":u.numBitsPerVoxel=16,u.datatypeCode=4;break;case"MET_USHORT":u.numBitsPerVoxel=16,u.datatypeCode=512;break;case"MET_INT":u.numBitsPerVoxel=32,u.datatypeCode=8;break;case"MET_UINT":u.numBitsPerVoxel=32,u.datatypeCode=768;break;case"MET_FLOAT":u.numBitsPerVoxel=32,u.datatypeCode=16;break;case"MET_DOUBLE":u.numBitsPerVoxel=64,u.datatypeCode=64;break;default:throw new Error("Unsupported MHA data type: "+w[0])}if(h.startsWith("ObjectType")&&!w[0].includes("Image")&&k.warn("Only able to read ObjectType = Image, not "+h),h.startsWith("ElementDataFile")){w[0]!=="LOCAL"&&(g=!0);break}h=d()}const y=vn(u.pixDims[1],0,0,0,u.pixDims[2],0,0,0,u.pixDims[3]);for(b2(A,A,y),u.affine=[[-A[0],-A[3],-A[6],-v[0]],[-A[1],-A[4],-A[7],-v[1]],[A[2],A[5],A[8],v[2]],[0,0,0,1]];r[c]===10;)c++;return u.vox_offset=c,g&&n?m?await At.decompressToBuffer(new Uint8Array(n.slice(0))):n.slice(0):m?await At.decompressToBuffer(new Uint8Array(t.slice(u.vox_offset))):t.slice(u.vox_offset)}async readMIF(t,n){this.hdr=new ut;const s=this.hdr;s.pixDims=[1,1,1,1,1,0,0,0],s.dims=[1,1,1,1,1,1,1,1];let r=t.byteLength;if(r<20)throw new Error("File too small to be MIF: bytes = "+r);let c=new Uint8Array(t);c[0]===31&&c[1]===139&&(k.debug("MIF with GZ decompression"),t=await At.decompressToBuffer(new Uint8Array(t)),r=t.byteLength,c=new Uint8Array(t));let l=0;function d(){for(;l<r&&c[l]===10;)l++;const R=l;for(;l<r&&c[l]!==10;)l++;return l++,l-R<1?"":new TextDecoder().decode(t.slice(R,l-1))}let h=d();if(!h.startsWith("mrtrix image"))throw new Error("Not a valid MIF file");const u=[];let m=!1,g=0,A=0,v=!1;for(h=d();l<r&&!h.startsWith("END");){let R=h.split(":");if(h=d(),R.length<2)break;const Y=R[0];R=R[1].split(",");for(let P=0;P<R.length;P++)R[P]=R[P].trim();switch(Y){case"dim":s.dims[0]=R.length;for(let P=0;P<R.length;P++)s.dims[P+1]=parseInt(R[P]);break;case"vox":for(let P=0;P<R.length;P++)s.pixDims[P+1]=parseFloat(R[P]),isNaN(s.pixDims[P+1])&&(s.pixDims[P+1]=0);break;case"layout":for(let P=0;P<R.length;P++)u.push(parseInt(R[P]));break;case"datatype":{const P=R[0];P.startsWith("Bit")?(m=!0,s.datatypeCode=2):P.startsWith("Int8")?s.datatypeCode=256:P.startsWith("UInt8")?s.datatypeCode=2:P.startsWith("Int16")?s.datatypeCode=4:P.startsWith("UInt16")?s.datatypeCode=512:P.startsWith("Int32")?s.datatypeCode=8:P.startsWith("UInt32")?s.datatypeCode=768:P.startsWith("Float32")?s.datatypeCode=16:P.startsWith("Float64")?s.datatypeCode=64:k.warn("Unsupported datatype "+P),P.includes("8")?s.numBitsPerVoxel=8:P.includes("16")?s.numBitsPerVoxel=16:P.includes("32")?s.numBitsPerVoxel=32:P.includes("64")&&(s.numBitsPerVoxel=64),s.littleEndian=!0,P.endsWith("LE")&&(s.littleEndian=!0),P.endsWith("BE")&&(s.littleEndian=!1)}break;case"transform":if(g>2||R.length!==4)break;s.affine[g][0]=parseFloat(R[0]),s.affine[g][1]=parseFloat(R[1]),s.affine[g][2]=parseFloat(R[2]),s.affine[g][3]=parseFloat(R[3]),g++;break;case"comments":s.description=R[0].substring(0,Math.min(79,R[0].length));break;case"RepetitionTime":A=parseFloat(R[0]);break;case"file":v=!R[0].startsWith(". "),v||(R=R[0].split(" "),s.vox_offset=parseInt(R[1]));break}}const y=s.dims[0];y>5&&k.warn("reader only designed for a maximum of 5 dimensions (XYZTD)");let w=1;for(let R=0;R<y;R++)w*=Math.max(s.dims[R+1],1);for(let R=0;R<3;R++)for(let Y=0;Y<3;Y++)s.affine[R][Y]*=s.pixDims[Y+1];k.debug("mif affine:"+s.affine[0]),A>0&&(s.pixDims[4]=A),v&&!n&&k.warn("MIH header provided without paired image data");let b;if(n&&v)b=n.slice(0);else if(m){s.numBitsPerVoxel=8;const R=new Uint8Array(w),Y=t.slice(s.vox_offset,s.vox_offset+Math.ceil(w/8)),P=new Uint8Array(Y);let X=0;for(let L=0;L<w;L++){const H=L%8;R[L]=P[X]>>7-H&1,H===7&&X++}b=R.buffer}else b=t.slice(s.vox_offset,s.vox_offset+w*(s.numBitsPerVoxel/8));u.length!==s.dims[0]&&k.warn("dims does not match layout");let C=1;const S=[1,1,1,1,1],E=[!1,!1,!1,!1,!1];for(let R=0;R<u.length;R++)for(let Y=0;Y<u.length;Y++)Math.abs(u[Y])===R&&(S[Y]=C,(u[Y]<0||Object.is(u[Y],-0))&&(E[Y]=!0),C*=s.dims[Y+1]);let M=At.range(0,s.dims[1]-1,1);E[0]&&(M=At.range(s.dims[1]-1,0,-1));for(let R=0;R<s.dims[1];R++)M[R]*=S[0];let N=At.range(0,s.dims[2]-1,1);E[1]&&(N=At.range(s.dims[2]-1,0,-1));for(let R=0;R<s.dims[2];R++)N[R]*=S[1];let U=At.range(0,s.dims[3]-1,1);E[2]&&(U=At.range(s.dims[3]-1,0,-1));for(let R=0;R<s.dims[3];R++)U[R]*=S[2];let T=At.range(0,s.dims[4]-1,1);E[3]&&(T=At.range(s.dims[4]-1,0,-1));for(let R=0;R<s.dims[4];R++)T[R]*=S[3];let F=At.range(0,s.dims[5]-1,1);E[4]&&(F=At.range(s.dims[5]-1,0,-1));for(let R=0;R<s.dims[5];R++)F[R]*=S[4];let I=0,B,V;switch(s.datatypeCode){case 256:B=new Int8Array(b),V=new Int8Array(w);break;case 2:B=new Uint8Array(b),V=new Uint8Array(w);break;case 4:B=new Int16Array(b),V=new Int16Array(w);break;case 512:B=new Uint16Array(b),V=new Uint16Array(w);break;case 8:B=new Int32Array(b),V=new Int32Array(w);break;case 768:B=new Uint32Array(b),V=new Uint32Array(w);break;case 16:B=new Float32Array(b),V=new Float32Array(w);break;case 64:B=new Float64Array(b),V=new Float64Array(w);break;default:throw new Error("unknown datatypeCode")}for(let R=0;R<s.dims[5];R++)for(let Y=0;Y<s.dims[4];Y++)for(let P=0;P<s.dims[3];P++)for(let X=0;X<s.dims[2];X++)for(let L=0;L<s.dims[1];L++)V[I]=B[M[L]+N[X]+U[P]+T[Y]+F[R]],I++;return V.buffer}calculateRAS(){if(!this.hdr)throw new Error("hdr not set");const t=this.hdr.affine,n=this.hdr,s=vn(Math.abs(t[0][0]),Math.abs(t[0][1]),Math.abs(t[0][2]),Math.abs(t[1][0]),Math.abs(t[1][1]),Math.abs(t[1][2]),Math.abs(t[2][0]),Math.abs(t[2][1]),Math.abs(t[2][2])),r=[1,1,1];s[3]>s[0]&&(r[0]=2),s[6]>s[0]&&s[6]>s[3]&&(r[0]=3),r[1]=1,r[0]===1?s[4]>s[7]?r[1]=2:r[1]=3:r[0]===2?s[1]>s[7]?r[1]=1:r[1]=3:s[1]>s[4]?r[1]=1:r[1]=2,r[2]=6-r[1]-r[0];let c=[1,2,3];c[r[0]-1]=1,c[r[1]-1]=2,c[r[2]-1]=3;let l=oi(t[0][0],t[0][1],t[0][2],t[0][3],t[1][0],t[1][1],t[1][2],t[1][3],t[2][0],t[2][1],t[2][2],t[2][3],0,0,0,1);this.mm000=this.vox2mm([-.5,-.5,-.5],l),this.mm100=this.vox2mm([n.dims[1]-.5,-.5,-.5],l),this.mm010=this.vox2mm([-.5,n.dims[2]-.5,-.5],l),this.mm001=this.vox2mm([-.5,-.5,n.dims[3]-.5],l);const d=Ut();ep(d,l);for(let b=0;b<3;b++)for(let C=0;C<3;C++)d[b*4+C]=l[b*4+c[C]-1];const h=[0,0,0];d[0]<0&&(h[0]=1),d[5]<0&&(h[1]=1),d[10]<0&&(h[2]=1),this.dimsRAS=[n.dims[0],n.dims[c[0]],n.dims[c[1]],n.dims[c[2]]],this.pixDimsRAS=[n.pixDims[0],n.pixDims[c[0]],n.pixDims[c[1]],n.pixDims[c[2]]],this.permRAS=c.slice();for(let b=0;b<3;b++)h[b]===1&&(this.permRAS[b]=-this.permRAS[b]);if(this.arrayEquals(c,[1,2,3])&&this.arrayEquals(h,[0,0,0])){this.toRAS=Ut(),this.matRAS=re(l),this.calculateOblique(),this.img2RASstep=[1,this.dimsRAS[1],this.dimsRAS[1]*this.dimsRAS[2]],this.img2RASstart=[0,0,0];return}C2(l),l[0]=1-h[0]*2,l[5]=1-h[1]*2,l[10]=1-h[2]*2,l[3]=(n.dims[c[0]]-1)*h[0],l[7]=(n.dims[c[1]]-1)*h[1],l[11]=(n.dims[c[2]]-1)*h[2];const u=Ut();Pe(u,l),qn(u,u,d),this.matRAS=re(u),l=oi(0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1),l[c[0]-1+0]=-h[0]*2+1,l[c[1]-1+4]=-h[1]*2+1,l[c[2]-1+8]=-h[2]*2+1,l[3]=h[0],l[7]=h[1],l[11]=h[2],this.toRAS=re(l),l[3]=0,l[7]=0,l[11]=0,l[12]=0,(this.permRAS[0]===-1||this.permRAS[1]===-1||this.permRAS[2]===-1)&&(l[12]=n.dims[1]-1),l[13]=0,(this.permRAS[0]===-2||this.permRAS[1]===-2||this.permRAS[2]===-2)&&(l[13]=n.dims[2]-1),l[14]=0,(this.permRAS[0]===-3||this.permRAS[1]===-3||this.permRAS[2]===-3)&&(l[14]=n.dims[3]-1),this.toRASvox=re(l),k.debug(this.hdr.dims),k.debug(this.dimsRAS);const m=this.hdr;c=this.permRAS;const g=[Math.abs(c[0]),Math.abs(c[1]),Math.abs(c[2])],A=[m.dims[g[0]],m.dims[g[1]],m.dims[g[2]]],v=[1,m.dims[1],m.dims[1]*m.dims[2]],y=[v[g[0]-1],v[g[1]-1],v[g[2]-1]],w=[0,0,0];for(let b=0;b<3;b++)c[b]<0&&(w[b]=y[b]*(A[b]-1),y[b]=-y[b]);this.img2RASstep=y,this.img2RASstart=w,this.calculateOblique()}async hdr2RAS(t=1){if(!this.permRAS)throw new Error("permRAS undefined");if(!this.hdr)throw new Error("hdr undefined");const n=Kl({...this.hdr,vox_offset:352},!1),s=await Ka(n.buffer,!0);t===1?(s.dims[0]=3,s.dims[4]=1):t>1&&(s.dims[0]=4,s.dims[4]=t);const r=this.permRAS.slice();if(r[0]===1&&r[1]===2&&r[2]===3)return s;s.qform_code=0;for(let l=1;l<4;l++)s.dims[l]=this.dimsRAS[l];for(let l=0;l<this.pixDimsRAS.length;l++)s.pixDims[l]=this.pixDimsRAS[l];let c=0;for(let l=0;l<4;l++)for(let d=0;d<4;d++)s.affine[l][d]=this.matRAS[c],c++;return s}img2RAS(t=0){if(!this.permRAS)throw new Error("permRAS undefined");if(!this.img)throw new Error("img undefined");if(!this.hdr)throw new Error("hdr undefined");const n=this.permRAS.slice();if(n[0]===1&&n[1]===2&&n[2]===3)return this.img;const s=this.hdr,r=s.dims[1]*s.dims[2]*s.dims[3];let c=t*r;(c+r>this.img.length||c<0)&&(c=0,k.warn(`img2RAS nVolume (${t}) out of bounds (${t}+1)×${r} > ${this.img.length}`));const l=this.img.slice(0,r),d=[Math.abs(n[0]),Math.abs(n[1]),Math.abs(n[2])],h=[s.dims[d[0]],s.dims[d[1]],s.dims[d[2]]],u=[1,s.dims[1],s.dims[1]*s.dims[2]],m=[u[d[0]-1],u[d[1]-1],u[d[2]-1]],g=[0,0,0];for(let v=0;v<3;v++)n[v]<0&&(g[v]=m[v]*(h[v]-1),m[v]=-m[v]);let A=0;for(let v=0;v<h[2];v++){const y=g[2]+v*m[2];for(let w=0;w<h[1];w++){const b=g[1]+w*m[1];for(let C=0;C<h[0];C++){const S=g[0]+C*m[0];l[A]=this.img[S+b+y+c],A++}}}return l}vox2mm(t,n){const s=re(n);We(s,s);const r=te(t[0],t[1],t[2],1);return De(r,r,s),lt(r[0],r[1],r[2])}mm2vox(t,n=!1){if(!this.matRAS)throw new Error("matRAS undefined");const s=re(this.matRAS),r=re(s);We(r,s),Pe(r,r);const c=te(t[0],t[1],t[2],1);De(c,c,r);const l=lt(c[0],c[1],c[2]);return n?l:[Math.round(l[0]),Math.round(l[1]),Math.round(l[2])]}arrayEquals(t,n){return Array.isArray(t)&&Array.isArray(n)&&t.length===n.length&&t.every((s,r)=>s===n[r])}setColormap(t){this._colormap=t,this.calMinMax(),this.onColormapChange&&this.onColormapChange(this)}setColormapLabel(t){this.colormapLabel=Pt.makeLabelLut(t)}async setColormapLabelFromUrl(t){this.colormapLabel=await Pt.makeLabelLutFromUrl(t)}get colormap(){return this._colormap}get colorMap(){return this._colormap}set colormap(t){this.setColormap(t)}set colorMap(t){this.setColormap(t)}get opacity(){return this._opacity}set opacity(t){this._opacity=t,this.onOpacityChange&&this.onOpacityChange(this)}calMinMax(t=Number.POSITIVE_INFINITY,n=!0){if(!this.hdr)throw new Error("hdr undefined");if(!this.img)throw new Error("img undefined");let s=Number.POSITIVE_INFINITY,r=Number.NEGATIVE_INFINITY,c=0,l=0,d=this.hdr.dims[1]*this.hdr.dims[2]*this.hdr.dims[3];const h=Math.floor(this.img.length/d);t>=h&&(t=this.frame4D),t=Math.min(t,h-1);const u=t*d;let m=[];if(n){const Y=[Math.floor(.25*this.hdr.dims[1]),Math.floor(.25*this.hdr.dims[2]),Math.floor(.25*this.hdr.dims[3])],P=[this.hdr.dims[1]-2*Y[0],this.hdr.dims[2]-2*Y[1],this.hdr.dims[3]-2*Y[2]],X=[P[0]+Y[0],P[1]+Y[1],P[2]+Y[2]];d=P[0]*P[1]*P[2],m=new this.img.constructor(d);let L=-1,H=0;for(let W=0;W<this.hdr.dims[3];W++)for(let at=0;at<this.hdr.dims[2];at++)for(let ct=0;ct<this.hdr.dims[1];ct++)L++,!(ct<Y[0]||at<Y[1]||W<Y[2])&&(ct>=X[0]||at>=X[1]||W>=X[2]||(m[H]=this.img[L+u],H++))}else{m=new this.img.constructor(d);for(let R=0;R<d;R++)m[R]=this.img[R+u]}const g=m.constructor!==Float64Array&&m.constructor!==Float32Array&&this.ignoreZeroVoxels;if(g)for(let R=0;R<d;R++)s=Math.min(m[R],s),r=Math.max(m[R],r),m[R]===0&&c++;else for(let R=0;R<d;R++){if(isNaN(m[R])){l++;continue}m[R]===0&&(c++,this.ignoreZeroVoxels)||(s=Math.min(m[R],s),r=Math.max(m[R],r))}this.ignoreZeroVoxels&&s===r&&c>0&&(s=0);const A=this.intensityRaw2Scaled(s),v=this.intensityRaw2Scaled(r),y=Pt.colormapFromKey(this._colormap);let w=0,b=0;if(y.min!==void 0&&(w=y.min),y.max!==void 0&&(b=y.max),w===b&&this.trustCalMinMax&&isFinite(this.hdr.cal_min)&&isFinite(this.hdr.cal_max)&&this.hdr.cal_max>this.hdr.cal_min)return this.cal_min=this.hdr.cal_min,this.cal_max=this.hdr.cal_max,this.robust_min=this.cal_min,this.robust_max=this.cal_max,this.global_min=A,this.global_max=v,[this.hdr.cal_min,this.hdr.cal_max,this.hdr.cal_min,this.hdr.cal_max];if(w!==b)return this.cal_min=w,this.cal_max=b,this.robust_min=this.cal_min,this.robust_max=this.cal_max,[w,b,w,b];const C=100*c/(d-0);let S=!1;C>60&&!this.ignoreZeroVoxels&&(k.warn(`${Math.round(C)}% of voxels are zero: ignoring zeros for cal_max`),S=!0,this.ignoreZeroVoxels=!0),this.ignoreZeroVoxels||(c=0),c+=l;const E=Math.round((d-0-c)*this.percentileFrac);if(E<1||s===r)return n?this.calMinMax(t,!1):(k.debug("no variability in image intensity?"),this.cal_min=A,this.cal_max=v,this.robust_min=this.cal_min,this.robust_max=this.cal_max,this.global_min=A,this.global_max=v,[A,v,A,v]);const M=1001,N=(M-1)/(r-s),U=new Array(M);for(let R=0;R<M;R++)U[R]=0;if(g)for(let R=0;R<d;R++)U[Math.round((m[R]-s)*N)]++;else if(this.ignoreZeroVoxels)for(let R=0;R<d;R++)m[R]!==0&&(isNaN(m[R])||U[Math.round((m[R]-s)*N)]++);else for(let R=0;R<d;R++)isNaN(m[R])||U[Math.round((m[R]-s)*N)]++;let T=0,F=0;for(;T<E;)T+=U[F],F++;F--,T=0;let I=M;for(;T<E;)I--,T+=U[I];if(F===I){let R=-1;for(;R!==0;)F>0&&(F--,U[F]>0&&(R=0)),R!==0&&I<M-1&&(I++,U[I]>0&&(R=0)),F===0&&I===M-1&&(R=0)}let B=this.intensityRaw2Scaled(F/N+s),V=this.intensityRaw2Scaled(I/N+s);return this.hdr.cal_min<this.hdr.cal_max&&this.hdr.cal_min>=A&&this.hdr.cal_max<=v&&(B=this.hdr.cal_min,V=this.hdr.cal_max),S&&(B=Math.min(B,0)),this.cal_min=B,this.cal_max=V,this.hdr.intent_code===1002&&(this.cal_min=A,this.cal_max=v),this.robust_min=this.cal_min,this.robust_max=this.cal_max,this.global_min=A,this.global_max=v,[B,V,A,v]}intensityRaw2Scaled(t){if(!this.hdr)throw new Error("hdr undefined");return this.hdr.scl_slope===0&&(this.hdr.scl_slope=1),t*this.hdr.scl_slope+this.hdr.scl_inter}intensityScaled2Raw(t){if(!this.hdr)throw new Error("hdr undefined");return this.hdr.scl_slope===0&&(this.hdr.scl_slope=1),(t-this.hdr.scl_inter)/this.hdr.scl_slope}async saveToUint8Array(t,n=null){return J2(this,t,n)}async saveToDisk(t="",n=null){return d4(this,t,n)}static async fetchDicomData(t,n={}){if(t==="")throw Error("url must not be empty");let r=/^(?:[a-z+]+:)?\/\//i.test(t)?t:new URL(t,window.location.href);/(?:.([^.]+))?$/.exec(r.pathname)||(r=new URL("niivue-manifest.txt",t));let d=await fetch(r,{headers:n});if(!d.ok)throw Error(d.statusText);const u=(await d.text()).split(`
+`),g=/(.*\/).*/.exec(r)[0],A=[];for(const v of u){const y=new URL(v,g);if(d=await fetch(y,{headers:n}),!d.ok)throw Error(d.statusText);const w=await d.arrayBuffer();A.push({name:v,data:w})}return A}static async readFirstDecompressedBytes(t,n){const s=t.getReader(),r=new Op,c=[];let l=0,d=!1,h,u;const m=new Promise((A,v)=>{h=A,u=v});function g(){const A=new Uint8Array(l);let v=0;for(const y of c)A.set(y,v),v+=y.length;h(A)}return r.ondata=A=>{c.push(A),l+=A.length,l>=n&&(d=!0,s.cancel().catch(()=>{}),g())},(async()=>{try{for(;!d;){const{done:A,value:v}=await s.read();if(A){d=!0,r.push(new Uint8Array,!0);return}r.push(v,!1)}}catch(A){u(A)}})().catch(()=>{}),m}static extractFilenameFromUrl(t){const s=new URL(t).searchParams.get("response-content-disposition");if(s){const r=s.match(/filename\*?=(?:UTF-8'')?"?([^";]+)"?/);if(r)return decodeURIComponent(r[1])}return t.split("/").pop().split("?")[0]}static async loadInitialVolumesGz(t="",n={},s=NaN){if(isNaN(s))return null;const r=await fetch(t,{headers:n,cache:"force-cache"});let c=352,l=await this.readFirstDecompressedBytes(r.body,c);const d=new DataView(l.buffer,l.byteOffset,l.byteLength),h=d.getUint16(0,!0),u=h===348;if(!u&&!(h===23553)||(l.length>111&&(c=d.getFloat32(108,u)),c>l.length&&(l=await this.readFirstDecompressedBytes(r.body,c)),!(l[0]===92&&l[1]===1||l[1]===92&&l[0]===1)))return null;const A=await Ka(l.buffer);if(!A)throw new Error("Could not read NIfTI header");const v=A.numBitsPerVoxel/8,y=[1,2,3].reduce((M,N)=>M*(A.dims[N]>1?A.dims[N]:1),1),w=[4,5,6].reduce((M,N)=>M*(A.dims[N]>1?A.dims[N]:1),1),b=Math.max(Math.min(s,w),1),C=A.vox_offset+b*y*v;if(b===w)return null;const S=await fetch(t,{headers:n,cache:"force-cache"});return(await this.readFirstDecompressedBytes(S.body,C)).buffer.slice(0,C)}static async loadInitialVolumes(t="",n={},s=NaN){if(isNaN(s))return null;const c=(await fetch(t,{headers:n,cache:"force-cache"})).body.getReader(),{value:l,done:d}=await c.read();let h=l;if(d||!h||h.length<2)throw new Error("Not enough data to determine compression");const u=new DataView(h.buffer,h.byteOffset,h.byteLength),m=u.getUint16(0,!0);if(m===35615)return await c.cancel(),this.loadInitialVolumesGz(t,n,s);const A=m===348;if(!A&&!(m===23553))return await c.cancel(),null;let y=352;for(h.length>111&&(y=u.getFloat32(108,A));h.length<y;){let F=function(V,R){const Y=new Uint8Array(V.length+R.length);return Y.set(V,0),Y.set(R,V.length),Y};const{value:I,done:B}=await c.read();if(B||!I)break;h=F(h,I)}const w=await Ka(h.buffer);if(!w)throw new Error("Could not read NIfTI header");const b=w.numBitsPerVoxel/8,C=[1,2,3].reduce((F,I)=>F*(w.dims[I]>1?w.dims[I]:1),1),S=[4,5,6].reduce((F,I)=>F*(w.dims[I]>1?w.dims[I]:1),1),E=Math.max(Math.min(s,S),1),M=w.vox_offset+E*C*b,N=new Uint8Array(M),U=Math.min(h.length,M);N.set(h.subarray(0,U),0);let T=U;for(;T<M;){const{value:F,done:I}=await c.read();if(I||!F)return await c.cancel(),null;const B=Math.min(F.length,M-T);N.set(F.subarray(0,B),T),T+=B}return await c.cancel(),N.buffer}static async loadFromUrl({url:t="",urlImgData:n="",headers:s={},name:r="",colormap:c="",opacity:l=1,cal_min:d=NaN,cal_max:h=NaN,trustCalMinMax:u=!0,percentileFrac:m=.02,ignoreZeroVoxels:g=!1,useQFormNotSForm:A=!1,colormapNegative:v="",frame4D:y=0,isManifest:w=!1,limitFrames4D:b=NaN,imageType:C=bt.UNKNOWN,colorbarVisible:S=!0,buffer:E=new ArrayBuffer(0)}={}){if(t==="")throw Error("url must not be empty");let M=null,N=null,U=null;if(t instanceof Uint8Array&&(t=t.slice().buffer),E.byteLength>0&&(t=E),t instanceof ArrayBuffer)if(N=t,r!=="")t=r;else{const V=new Uint8Array(N);t=V[0]===31&&V[1]===139?"array.nii.gz":"array.nii"}function T(V){const R=V.match(/\.([^.]+)(?:\.gz|\.bz2|\.xz)?$/);return R?R[1]:""}let F="";if(r===""?F=T(t):F=T(r),C===bt.UNKNOWN&&(C=bt.parse(F)),C===bt.UNKNOWN&&typeof t=="string"){const V=await fetch(t,{});if(V.redirected){const R=this.extractFilenameFromUrl(V.url);R&&R.length>0&&r===""&&(r=R,F=T(r),C=bt.parse(F))}}if(C===bt.ZARR){const V=new URL(t).searchParams,R=V.get("z"),Y=V.get("y"),P=V.get("x"),X=R?Ja(parseInt(R),parseInt(R)+1):null,L=Y?Ja(parseInt(Y),parseInt(Y)+1):null,H=P?Ja(parseInt(P),parseInt(P)+1):null,W=t.split("?")[0],at=new _p(W),ct=p5(at);let G;try{G=await yn(ct.resolve(t),{kind:"array"})}catch{G=await yn(ct,{kind:"array"})}let j;if(G.shape.length===4){const Rt=G.shape[2],Mt=G.shape[1],_t=G.shape[0];X&&X[0]>=Rt&&(X[0]=Rt-1),L&&L[0]>=Mt&&(L[0]=Mt-1),H&&H[0]>=_t&&(H[0]=_t-1),j=await $d(G,[H,L,X,null])}else j=await $d(G,[H,L,X]);N=j.data;const[$,et,ot,mt]=j.shape;U={data:N,width:et,height:$,depth:ot,channels:mt}}const I=C===bt.DCM||bt.NII;if(!N&&I&&(N=await this.loadInitialVolumes(t,s,b)),!N)if(w)N=await Hl.fetchDicomData(t,s),C=bt.DCM_MANIFEST;else{const V=await fetch(t,{headers:s});if(!V.ok)throw Error(V.statusText);if(!V.body)throw new Error("No readable stream available");const R=await Fh(V.body),Y=[],P=R.getReader();for(;;){const{done:W,value:at}=await P.read();if(W)break;Y.push(at)}const X=Y.reduce((W,at)=>W+at.length,0);N=new ArrayBuffer(X);const L=new Uint8Array(N);let H=0;for(const W of Y)L.set(W,H),H+=W.length}F.toUpperCase()==="HEAD"&&n===""&&(n=t.substring(0,t.lastIndexOf("HEAD"))+"BRIK"),F.toUpperCase()==="HDR"&&n===""&&(n=t.substring(0,t.lastIndexOf("HDR"))+"IMG");let B=null;if(n)try{let V=await fetch(n,{headers:s});if(V.status===404&&(n.includes("BRIK")||n.includes("IMG"))&&(V=await fetch(`${n}.gz`,{headers:s})),V.ok&&V.body){const R=await Fh(V.body),Y=[],P=R.getReader();for(;;){const{done:W,value:at}=await P.read();if(W)break;Y.push(at)}const X=Y.reduce((W,at)=>W+at.length,0);B=new ArrayBuffer(X);const L=new Uint8Array(B);let H=0;for(const W of Y)L.set(W,H),H+=W.length}}catch(V){console.error("Error loading paired image data:",V)}if(!N)throw new Error("Unable to load buffer properly from volume");if(!r){let V;try{V=new URL(t).pathname.split("/")}catch{V=t.split("/")}r=V.slice(-1)[0],r.indexOf("?")>-1&&(r=r.slice(0,r.indexOf("?")))}return M=await this.new(N,r,c,l,B,d,h,u,m,g,A,v,y,C,NaN,NaN,!0,null,0,U),M.url=t,M.colorbarVisible=S,M}static async readFileAsync(t,n=NaN){let s=t.stream();if(!isNaN(n)){let g=0;const A=new TransformStream({transform(v,y){if(g>=n){y.terminate();return}const w=n-g;v.length>w?(y.enqueue(v.slice(0,w)),y.terminate()):y.enqueue(v),g+=v.length}});s=s.pipeThrough(A)}const r=await Fh(s),c=[],l=r.getReader();for(;;){const{done:g,value:A}=await l.read();if(g)break;c.push(A)}const d=c.reduce((g,A)=>g+A.length,0),h=new ArrayBuffer(d),u=new Uint8Array(h);let m=0;for(const g of c)u.set(g,m),m+=g.length;return h}static async loadFromFile({file:t,name:n="",colormap:s="",opacity:r=1,urlImgData:c=null,cal_min:l=NaN,cal_max:d=NaN,trustCalMinMax:h=!0,percentileFrac:u=.02,ignoreZeroVoxels:m=!1,useQFormNotSForm:g=!1,colormapNegative:A="",frame4D:v=0,limitFrames4D:y=NaN,imageType:w=bt.UNKNOWN}){let b=null,C=[];try{if(Array.isArray(t))C=await Promise.all(t.map(E=>this.readFileAsync(E)));else{if(isNaN(y))C=await this.readFileAsync(t);else{const E=await this.readFileAsync(t,512),M=new Uint8Array(E);if(!(M[0]===92&&M[1]===1||M[1]===92&&M[0]===1))C=await this.readFileAsync(t);else{const U=await Ka(E);if(!U)throw new Error("could not read nifti header");const T=U.numBitsPerVoxel/8,F=[1,2,3].reduce((R,Y)=>R*(U.dims[Y]>1?U.dims[Y]:1),1),I=[4,5,6].reduce((R,Y)=>R*(U.dims[Y]>1?U.dims[Y]:1),1),B=Math.max(Math.min(y,I),1),V=U.vox_offset+B*F*T;C=await this.readFileAsync(t,V)}}n=t.name}let S=null;c&&(S=await this.readFileAsync(c)),b=await this.new(C,n,s,r,S,l,d,h,u,m,g,A,v,w,NaN,NaN,!0,null,0,null),b.fileObject=t}catch(S){throw k.error(S),new Error("could not build NVImage")}if(b===null)throw new Error("could not build NVImage");return b}static createNiftiArray(t=[256,256,256],n=[1,1,1],s=[1,0,0,-128,0,1,0,-128,0,0,1,-128,0,0,0,1],r=2,c=new Uint8Array){return f4(t,n,s,r,c)}static createNiftiHeader(t=[256,256,256],n=[1,1,1],s=[1,0,0,-128,0,1,0,-128,0,0,1,-128,0,0,0,1],r=2){return W2(t,n,s,r)}getVolumeData(t=[-1,0,0],n=[0,0,0],s="same"){return g4(this,t,n,s)}setVolumeData(t=[-1,0,0],n=[0,0,0],s=new Uint8Array){A4(this,t,n,s)}static async loadFromBase64({base64:t,name:n="",colormap:s="",opacity:r=1,cal_min:c=NaN,cal_max:l=NaN,trustCalMinMax:d=!0,percentileFrac:h=.02,ignoreZeroVoxels:u=!1,useQFormNotSForm:m=!1,colormapNegative:g="",frame4D:A=0,imageType:v=bt.UNKNOWN,cal_minNeg:y=NaN,cal_maxNeg:w=NaN,colorbarVisible:b=!0,colormapLabel:C=null}){function S(M){const N=window.atob(M),U=N.length,T=new Uint8Array(U);for(let F=0;F<U;F++)T[F]=N.charCodeAt(F);return T.buffer}let E=null;try{const M=S(t);E=await this.new(M,n,s,r,null,c,l,d,h,u,m,g,A,v,y,w,b,C,0,null)}catch(M){k.debug(M)}if(E===null)throw new Error("could not load NVImage");return E}clone(){const t=new Hl;return t.id=qh(),t.hdr=Object.assign({},this.hdr),t.img=this.img.slice(),t.calculateRAS(),t.calMinMax(),t}zeroImage(){this.img.fill(0)}getImageMetadata(){if(!this.hdr)throw new Error("hdr undefined");const t=this.id,n=this.hdr.datatypeCode,s=this.hdr.dims,r=s[1],c=s[2],l=s[3],d=Math.max(1,s[4]),h=this.hdr.pixDims,u=h[1],m=h[2],g=h[3],A=h[4],v=Math.floor(this.hdr.numBitsPerVoxel/8);return{id:t,datatypeCode:n,nx:r,ny:c,nz:l,nt:d,dx:u,dy:m,dz:g,dt:A,bpv:v}}static zerosLike(t,n="same"){const s=t.clone();return s.zeroImage(),n==="uint8"&&(s.img=Uint8Array.from(s.img),s.hdr.datatypeCode=2,s.hdr.numBitsPerVoxel=8),n==="float32"&&(s.img=Float32Array.from(s.img),s.hdr.datatypeCode=16,s.hdr.numBitsPerVoxel=32),s}getValue(t,n,s,r=0,c=!1){return m4(this,t,n,s,r,c)}getValues(t,n,s,r=0,c=!1){return $2(this,t,n,s,r,c)}applyOptionsUpdate(t){this.hdr.cal_min=t.cal_min,this.hdr.cal_max=t.cal_max,Object.assign(this,t)}getImageOptions(){return Gl("","",this.name,this._colormap,this.opacity,this.hdr.cal_min,this.hdr.cal_max,this.trustCalMinMax,this.percentileFrac,this.ignoreZeroVoxels,this.useQFormNotSForm,this.colormapNegative,this.frame4D,this.imageType,this.colormapType)}toUint8Array(t=null){return _2(this,t)}convertVox2Frac(t){return lt((t[0]+.5)/this.dimsRAS[1],(t[1]+.5)/this.dimsRAS[2],(t[2]+.5)/this.dimsRAS[3])}convertFrac2Vox(t){return lt(Math.round(t[0]*this.dims[1]-.5),Math.round(t[1]*this.dims[2]-.5),Math.round(t[2]*this.dims[3]-.5))}convertFrac2MM(t,n=!1){const s=te(t[0],t[1],t[2],1);return n?De(s,s,this.frac2mm):De(s,s,this.frac2mmOrtho),s}convertMM2Frac(t,n=!1){const s=te(t[0],t[1],t[2],1),r=this.dimsRAS,c=lt(0,0,0);if(typeof r>"u")return c;if(!n){const d=re(this.frac2mmOrtho);return Pe(d,d),De(s,s,d),c[0]=s[0],c[1]=s[1],c[2]=s[2],c}if(r[1]<1||r[2]<1||r[3]<1)return c;const l=re(this.matRAS);return Pe(l,l),We(l,l),De(s,s,l),c[0]=(s[0]+.5)/r[1],c[1]=(s[1]+.5)/r[2],c[2]=(s[2]+.5)/r[3],c}},am=(i=>(i[i.none=0]="none",i[i.contrast=1]="contrast",i[i.measurement=2]="measurement",i[i.pan=3]="pan",i[i.slicer3D=4]="slicer3D",i[i.callbackOnly=5]="callbackOnly",i[i.roiSelection=6]="roiSelection",i[i.angle=7]="angle",i[i.crosshair=8]="crosshair",i[i.windowing=9]="windowing",i))(am||{}),mi={textHeight:-1,fontSizeScaling:.4,fontMinPx:13,colorbarHeight:.05,colorbarWidth:-1,showColorbarBorder:!0,crosshairWidth:1,crosshairWidthUnit:"voxels",crosshairGap:0,rulerWidth:4,show3Dcrosshair:!1,backColor:[0,0,0,1],crosshairColor:[1,0,0,1],fontColor:[.5,.5,.5,1],selectionBoxColor:[1,1,1,.5],clipPlaneColor:[.7,0,.7,.5],isClipPlanesCutaway:!1,paqdUniforms:[.3,.5,.5,1],rulerColor:[1,0,0,.8],colorbarMargin:.05,trustCalMinMax:!0,clipPlaneHotKey:"KeyC",cycleClipPlaneHotKey:"KeyP",viewModeHotKey:"KeyV",doubleTouchTimeout:500,longTouchTimeout:1e3,keyDebounceTime:50,isNearestInterpolation:!1,isResizeCanvas:!0,atlasOutline:0,atlasActiveIndex:0,isRuler:!1,isColorbar:!1,isOrientCube:!1,tileMargin:0,multiplanarPadPixels:0,multiplanarForceRender:!1,multiplanarEqualSize:!1,multiplanarShowRender:2,isRadiologicalConvention:!1,meshThicknessOn2D:1/0,dragMode:1,dragModePrimary:8,mouseEventConfig:void 0,touchEventConfig:void 0,yoke3Dto2DZoom:!1,isDepthPickMesh:!1,isCornerOrientationText:!1,isOrientationTextVisible:!0,showAllOrientationMarkers:!1,heroImageFraction:0,heroSliceType:4,sagittalNoseLeft:!1,isSliceMM:!1,isV1SliceShader:!1,forceDevicePixelRatio:0,logLevel:"info",loadingText:"loading ...",isForceMouseClickToVoxelCenters:!1,dragAndDropEnabled:!0,drawingEnabled:!1,penValue:1,penType:0,floodFillNeighbors:6,isFilledPen:!1,thumbnail:"",maxDrawUndoBitmaps:8,sliceType:3,meshXRay:0,isAntiAlias:null,limitFrames4D:NaN,isAdditiveBlend:!1,showLegend:!0,legendBackgroundColor:[.3,.3,.3,.5],legendTextColor:[1,1,1,1],multiplanarLayout:0,renderOverlayBlend:1,sliceMosaicString:"",centerMosaic:!1,penSize:1,interactive:!0,clickToSegment:!1,clickToSegmentRadius:3,clickToSegmentBright:!0,clickToSegmentAutoIntensity:!1,clickToSegmentIntensityMax:NaN,clickToSegmentIntensityMin:NaN,clickToSegmentPercent:0,clickToSegmentMaxDistanceMM:Number.POSITIVE_INFINITY,clickToSegmentIs2D:!1,selectionBoxLineThickness:4,selectionBoxIsOutline:!1,scrollRequiresFocus:!1,showMeasureUnits:!0,measureTextJustify:"center",measureTextColor:[1,0,0,1],measureLineColor:[1,0,0,1],measureTextHeight:.06,isAlphaClipDark:!1,gradientOrder:1,gradientOpacity:0,renderSilhouette:0,gradientAmount:0,invertScrollDirection:!1,is2DSliceShader:!1,bounds:null,showBoundsBorder:!1,boundsBorderColor:[1,1,1,1]},Za={gamma:1,azimuth:110,elevation:10,crosshairPos:lt(.5,.5,.5),clipPlanes:[[0,0,0,0]],clipPlaneDepthAziElevs:[[2,0,0]],volScaleMultiplier:1,pan2Dxyzmm:te(0,0,0,1)};function y4(i,t){const n={};for(const s in i){const r=i[s],c=t[s],l=Array.isArray(r)&&Array.isArray(c);(l&&r.some((d,h)=>d!==c[h])||!l&&r!==c)&&(n[s]=r)}return n}var Bh=class An{constructor(){z(this,"data",{title:"Untitled document",imageOptionsArray:[],meshOptionsArray:[],opts:{...mi},previewImageDataURL:"",labels:[],encodedImageBlobs:[],encodedDrawingBlob:""}),z(this,"scene"),z(this,"volumes",[]),z(this,"meshDataObjects"),z(this,"meshes",[]),z(this,"drawBitmap",null),z(this,"imageOptionsMap",new Map),z(this,"meshOptionsMap",new Map),z(this,"completedMeasurements",[]),z(this,"completedAngles",[]),z(this,"_optsProxy",null),z(this,"_optsChangeCallback",null),this.scene={onAzimuthElevationChange:()=>{},onZoom3DChange:()=>{},sceneData:{...Za,pan2Dxyzmm:te(0,0,0,1),crosshairPos:lt(.5,.5,.5)},get renderAzimuth(){return this.sceneData.azimuth},set renderAzimuth(t){this.sceneData.azimuth=t,this.onAzimuthElevationChange&&this.onAzimuthElevationChange(this.sceneData.azimuth,this.sceneData.elevation)},get renderElevation(){return this.sceneData.elevation},set renderElevation(t){this.sceneData.elevation=t,this.onAzimuthElevationChange&&this.onAzimuthElevationChange(this.sceneData.azimuth,this.sceneData.elevation)},get volScaleMultiplier(){return this.sceneData.volScaleMultiplier},set volScaleMultiplier(t){this.sceneData.volScaleMultiplier=t,this.onZoom3DChange(t)},get crosshairPos(){return this.sceneData.crosshairPos},set crosshairPos(t){this.sceneData.crosshairPos=t},get clipPlane(){return this.sceneData.clipPlanes[0]??[]},set clipPlane(t){this.sceneData.clipPlanes[0]=t},get clipPlanes(){return this.sceneData.clipPlanes},set clipPlanes(t){this.sceneData.clipPlanes=t},get clipPlaneDepthAziElevs(){return this.sceneData.clipPlaneDepthAziElevs},set clipPlaneDepthAziElevs(t){this.sceneData.clipPlaneDepthAziElevs=t},get pan2Dxyzmm(){return this.sceneData.pan2Dxyzmm},set pan2Dxyzmm(t){this.sceneData.pan2Dxyzmm=t},get gamma(){return this.sceneData.gamma},set gamma(t){this.sceneData.gamma=t}}}get title(){return this.data.title}get previewImageDataURL(){return this.data.previewImageDataURL}set previewImageDataURL(t){this.data.previewImageDataURL=t}set title(t){this.data.title=t}get imageOptionsArray(){return this.data.imageOptionsArray}get encodedImageBlobs(){return this.data.encodedImageBlobs}get encodedDrawingBlob(){return this.data.encodedDrawingBlob}get opts(){return this._optsProxy||this._createOptsProxy(),this._optsProxy}set opts(t){this.data.opts={...t},this._optsProxy=null}get labels(){return this.data.labels}set labels(t){this.data.labels=t}get customData(){return this.data.customData}set customData(t){this.data.customData=t}hasImage(t){return this.volumes.find(n=>n.id===t.id)!==void 0}hasImageFromUrl(t){return this.data.imageOptionsArray.find(n=>n.url===t)!==void 0}addImageOptions(t,n){if(!this.hasImage(t)&&!n.name)if(n.url){const r=/^(?:[a-z+]+:)?\/\//i.test(n.url)?new URL(n.url):new URL(n.url,window.location.href);n.name=r.pathname.split("/").pop(),n.name.toLowerCase().endsWith(".gz")&&(n.name=n.name.slice(0,-3)),n.name.toLowerCase().endsWith(".nii")||(n.name+=".nii")}else n.name="untitled.nii";n.imageType=bt.NII,this.data.imageOptionsArray.push(n),this.imageOptionsMap.set(t.id,this.data.imageOptionsArray.length-1)}removeImage(t){if(this.imageOptionsMap.has(t.id)){const n=this.imageOptionsMap.get(t.id);this.data.imageOptionsArray.length>n&&this.data.imageOptionsArray.splice(n,1),this.imageOptionsMap.delete(t.id)}this.volumes=this.volumes.filter(n=>n.id!==t.id)}async fetchLinkedData(){if(this.data.encodedImageBlobs=[],!!this.imageOptionsArray?.length){for(const t of this.imageOptionsArray)if(t.url)try{const n=await fetch(t.url);if(!n.ok){console.warn("Failed to fetch image:",t.url);continue}const s=await n.arrayBuffer(),r=new Uint8Array(s),c=At.uint8tob64(r);this.data.encodedImageBlobs.push(c),console.info("fetch linked data fetched from ",t.url)}catch(n){console.warn(`Failed to fetch/encode image from ${t.url}:`,n)}}}getImageOptions(t){return this.imageOptionsMap.has(t.id)?this.data.imageOptionsArray[this.imageOptionsMap.get(t.id)]:null}json(t=!0,n=!0){const s={encodedImageBlobs:[],previewImageDataURL:this.data.previewImageDataURL,imageOptionsMap:new Map},r=[];s.sceneData={...this.scene.sceneData},delete s.sceneData.clipPlane,delete s.sceneData.clipPlaneDepthAziElev,delete s.sceneData.clipThick,delete s.sceneData.clipVolumeLow,delete s.sceneData.clipVolumeHigh,s.opts=y4(this.opts,mi),this.opts.meshThicknessOn2D===1/0&&(s.opts.meshThicknessOn2D="infinity"),this.opts.meshThicknessOn2D===1/0&&(s.opts.meshThicknessOn2D="infinity"),s.labels=[...this.data.labels];for(const l of s.labels)delete l.onClick;if(s.customData=this.customData,s.completedMeasurements=[...this.completedMeasurements],s.completedAngles=[...this.completedAngles],this.volumes.length)for(let l=0;l<this.volumes.length;l++){const d=this.volumes[l];let h=this.getImageOptions(d);if(h===null?(k.warn("no options found for image, using options from the volume directly"),h={name:d?.name??"",colormap:d?._colormap??"gray",opacity:d?._opacity??1,pairedImgData:null,cal_min:d?.cal_min??NaN,cal_max:d?.cal_max??NaN,trustCalMinMax:d?.trustCalMinMax??!0,percentileFrac:d?.percentileFrac??.02,ignoreZeroVoxels:d?.ignoreZeroVoxels??!1,useQFormNotSForm:d?.useQFormNotSForm??!1,colormapNegative:d?.colormapNegative??"",colormapLabel:d?.colormapLabel??null,imageType:d?.imageType??bt.NII,frame4D:d?.frame4D??0,limitFrames4D:d?.limitFrames4D??NaN,url:d?.url??"",urlImageData:d?.urlImgData??"",alphaThreshold:!1,cal_minNeg:d?.cal_minNeg??NaN,cal_maxNeg:d?.cal_maxNeg??NaN,colorbarVisible:d?.colorbarVisible??!0}):"imageType"in h||(h.imageType=bt.NII),h.colormap=d.colormap,h.colormapLabel=d.colormapLabel,h.opacity=d.opacity,h.cal_max=d.cal_max??NaN,h.cal_min=d.cal_min??NaN,r.push(h),t){const u=At.uint8tob64(d.toUint8Array());s.encodedImageBlobs.push(u)}s.imageOptionsMap.set(d.id,l)}s.imageOptionsArray=[...r];const c=[];s.connectomes=[];for(const l of this.meshes){if(l.type==="connectome"){s.connectomes.push(JSON.stringify(l.json()));continue}const d={pts:l.pts,tris:l.tris,name:l.name,rgba255:Uint8Array.from(l.rgba255),opacity:l.opacity,connectome:l.connectome,dpg:l.dpg,dps:l.dps,dpv:l.dpv,meshShaderIndex:l.meshShaderIndex,layers:l.layers.map(h=>({values:h.values,nFrame4D:h.nFrame4D,frame4D:0,outlineBorder:h.outlineBorder,global_min:h.global_min,global_max:h.global_max,cal_min:h.cal_min,cal_max:h.cal_max,opacity:h.opacity,colormap:h.colormap,colormapNegative:h.colormapNegative,colormapLabel:h.colormapLabel,useNegativeCmap:h.useNegativeCmap})),hasConnectome:l.hasConnectome,edgeColormap:l.edgeColormap,edgeColormapNegative:l.edgeColormapNegative,edgeMax:l.edgeMax,edgeMin:l.edgeMin,edges:l.edges&&Array.isArray(l.edges)?[...l.edges]:[],extentsMax:l.extentsMax,extentsMin:l.extentsMin,furthestVertexFromOrigin:l.furthestVertexFromOrigin,nodeColormap:l.nodeColormap,nodeColormapNegative:l.nodeColormapNegative,nodeMaxColor:l.nodeMaxColor,nodeMinColor:l.nodeMinColor,nodeScale:l.nodeScale,legendLineThickness:l.legendLineThickness,offsetPt0:l.offsetPt0,nodes:l.nodes};l.offsetPt0&&l.offsetPt0.length>0&&(d.offsetPt0=l.offsetPt0,d.fiberGroupColormap=l.fiberGroupColormap,d.fiberColor=l.fiberColor,d.fiberDither=l.fiberDither,d.fiberRadius=l.fiberRadius,d.colormap=l.colormap),c.push(d)}return s.meshesString=JSON.stringify(Sp(c)),n&&this.drawBitmap&&(s.encodedDrawingBlob=At.uint8tob64(this.drawBitmap)),s}async download(t,n,s={embedImages:!0}){const r=this.json(s.embedImages),c=JSON.stringify(r),l=n?"application/gzip":"application/json",d=n?await At.compressStringToArrayBuffer(c):c;At.download(d,t,l)}static deserializeMeshDataObjects(t){if(!t.data.meshesString||t.data.meshesString==="[]"){t.meshDataObjects=[];return}if(t.data.meshesString){t.meshDataObjects=yp(JSON.parse(t.data.meshesString));for(const n of t.meshDataObjects)for(const s of n.layers)"colorMap"in s&&(s.colormap=s.colorMap,delete s.colorMap),"colorMapNegative"in s&&(s.colormapNegative=s.colorMapNegative,delete s.colorMapNegative)}}static async loadFromUrl(t){const s=await(await fetch(t)).arrayBuffer();let r;if(At.isArrayBufferCompressed(s)){const c=await At.decompressArrayBuffer(s);r=JSON.parse(c)}else{const c=new TextDecoder;r=JSON.parse(c.decode(s))}return An.loadFromJSON(r)}static async loadFromFile(t){const n=await At.readFileAsync(t);let s;const r=new An;return At.isArrayBufferCompressed(n)?s=await At.decompressArrayBuffer(n):s=new TextDecoder().decode(n),r.data=JSON.parse(s),r.data.opts.meshThicknessOn2D==="infinity"&&(r.data.opts.meshThicknessOn2D=1/0),r.scene.sceneData={...Za,...r.data.sceneData},An.deserializeMeshDataObjects(r),r}static loadFromJSON(t){const n=new An;Object.assign(n.data,{...t,imageOptionsArray:t.imageOptionsArray??[],encodedImageBlobs:t.encodedImageBlobs??[],labels:t.labels??[],meshOptionsArray:t.meshOptionsArray??[],connectomes:t.connectomes??[],encodedDrawingBlob:t.encodedDrawingBlob??"",previewImageDataURL:t.previewImageDataURL??"",customData:t.customData??"",title:t.title??"untitled"}),n.data.opts={...mi,...t.opts||{}},n.data.opts.meshThicknessOn2D==="infinity"&&(n.data.opts.meshThicknessOn2D=1/0),n.scene.sceneData={...Za,...t.sceneData||{}};const s=t.sceneData||{};return s.clipPlane&&!s.clipPlanes&&(n.scene.sceneData.clipPlanes=[s.clipPlane]),s.clipPlaneDepthAziElev&&!s.clipPlaneDepthAziElevs&&(n.scene.sceneData.clipPlaneDepthAziElevs=[s.clipPlaneDepthAziElev]),t.completedMeasurements&&(n.completedMeasurements=t.completedMeasurements.map(r=>({...r,startMM:gi(r.startMM),endMM:gi(r.endMM)}))),t.completedAngles&&(n.completedAngles=t.completedAngles.map(r=>({...r,firstLineMM:{start:gi(r.firstLineMM.start),end:gi(r.firstLineMM.end)},secondLineMM:{start:gi(r.secondLineMM.start),end:gi(r.secondLineMM.end)}}))),n.data.meshesString&&An.deserializeMeshDataObjects(n),n}static oldloadFromJSON(t){const n=new An;return n.data=t,n.data.opts.meshThicknessOn2D==="infinity"&&(n.data.opts.meshThicknessOn2D=1/0),n.scene.sceneData={...Za,...t.sceneData},An.deserializeMeshDataObjects(n),n}setOptsChangeCallback(t){this._optsChangeCallback=t,this._optsProxy=null}removeOptsChangeCallback(){this._optsChangeCallback=null,this._optsProxy=null}_createOptsProxy(){const t=this.data.opts;this._optsProxy=new Proxy(t,{set:(n,s,r)=>{const c=n[s];return c!==r&&(n[s]=r,this._optsChangeCallback&&typeof s=="string"&&s in mi&&this._optsChangeCallback(s,r,c)),!0},get:(n,s)=>n[s]})}},w4={colormap:"gray",opacity:0,nFrame4D:0,frame4D:0,outlineBorder:0,cal_min:0,cal_max:0,cal_minNeg:0,cal_maxNeg:0,colormapType:0,values:new Array,useNegativeCmap:!1,showLegend:!0},Gs=class yi{constructor(t,n,s="",r=new Uint8Array([255,255,255,255]),c=1,l=!0,d,h=null,u=null,m=null,g=null,A=null,v=!0,y=""){z(this,"id"),z(this,"name"),z(this,"anatomicalStructurePrimary"),z(this,"colorbarVisible"),z(this,"furthestVertexFromOrigin"),z(this,"extentsMin"),z(this,"extentsMax"),z(this,"opacity"),z(this,"visible"),z(this,"meshShaderIndex",0),z(this,"offsetPt0",null),z(this,"colormapInvert",!1),z(this,"fiberGroupColormap",null),z(this,"indexBuffer"),z(this,"vertexBuffer"),z(this,"vao"),z(this,"vaoFiber"),z(this,"pts"),z(this,"tris"),z(this,"layers"),z(this,"type","mesh"),z(this,"data_type"),z(this,"rgba255"),z(this,"fiberLength"),z(this,"fiberLengths"),z(this,"fiberDensity"),z(this,"fiberDither",.1),z(this,"fiberColor","Global"),z(this,"fiberDecimationStride",1),z(this,"fiberSides",5),z(this,"fiberRadius",0),z(this,"fiberOcclusion",0),z(this,"f32PerVertex",5),z(this,"dpsThreshold",NaN),z(this,"fiberMask"),z(this,"colormap"),z(this,"dpg"),z(this,"dps"),z(this,"dpv"),z(this,"groups"),z(this,"hasConnectome",!1),z(this,"connectome"),z(this,"indexCount"),z(this,"vertexCount",1),z(this,"nodeScale",4),z(this,"edgeScale",1),z(this,"legendLineThickness",0),z(this,"showLegend",!0),z(this,"nodeColormap","warm"),z(this,"edgeColormap","warm"),z(this,"nodeColormapNegative"),z(this,"edgeColormapNegative"),z(this,"nodeMinColor"),z(this,"nodeMaxColor"),z(this,"edgeMin"),z(this,"edgeMax"),z(this,"nodes"),z(this,"edges"),z(this,"points"),this.anatomicalStructurePrimary=y,this.name=s,this.colorbarVisible=v,this.id=qh();const w=Xn.getExtents(t);if(this.furthestVertexFromOrigin=w.mxDx,this.extentsMin=w.extentsMin,this.extentsMax=w.extentsMax,this.opacity=c>1?1:c,this.visible=l,this.meshShaderIndex=0,this.indexBuffer=d.createBuffer(),this.vertexBuffer=d.createBuffer(),this.vao=d.createVertexArray(),d.bindVertexArray(this.vao),d.bindBuffer(d.ELEMENT_ARRAY_BUFFER,this.indexBuffer),d.bindBuffer(d.ARRAY_BUFFER,this.vertexBuffer),d.enableVertexAttribArray(0),d.enableVertexAttribArray(1),this.f32PerVertex!==7?(d.vertexAttribPointer(0,3,d.FLOAT,!1,20,0),d.vertexAttribPointer(1,4,d.BYTE,!0,20,12),d.enableVertexAttribArray(2),d.vertexAttribPointer(2,4,d.UNSIGNED_BYTE,!0,20,16)):(d.vertexAttribPointer(0,3,d.FLOAT,!1,28,0),d.vertexAttribPointer(1,3,d.FLOAT,!1,28,12),d.enableVertexAttribArray(2),d.vertexAttribPointer(2,4,d.UNSIGNED_BYTE,!0,28,24)),d.bindVertexArray(null),this.vaoFiber=d.createVertexArray(),this.offsetPt0=null,this.hasConnectome=!1,this.colormapInvert=!1,this.fiberGroupColormap=null,this.pts=t,this.layers=[],this.type="mesh",this.tris=n,r[3]<1){this.rgba255=r,this.fiberLength=2,this.fiberDither=.1,this.fiberColor="Global",this.fiberDecimationStride=1,this.fiberMask=[],this.colormap=h,this.dpg=u,this.dps=m,this.dpv=g,this.groups=A,u&&this.initValuesArray(u),m&&this.initValuesArray(m),g&&this.initValuesArray(g),A&&this.initValuesArray(A),this.offsetPt0=new Uint32Array(n),this.tris=new Uint32Array(0),this.updateFibers(d),d.bindVertexArray(this.vaoFiber),d.bindBuffer(d.ELEMENT_ARRAY_BUFFER,this.indexBuffer),d.bindBuffer(d.ARRAY_BUFFER,this.vertexBuffer),d.enableVertexAttribArray(0),d.vertexAttribPointer(0,3,d.FLOAT,!1,16,0),d.enableVertexAttribArray(1),d.vertexAttribPointer(1,4,d.UNSIGNED_BYTE,!0,16,12),d.bindVertexArray(null);return}if(h){this.connectome=h,this.hasConnectome=!0;const C=Object.keys(h);for(let S=0,E=C.length;S<E;S++)this[C[S]]=h[C[S]]}this.rgba255=r,this.updateMesh(d)}initValuesArray(t){for(let n=0;n<t.length;n++){const s=t[n].vals.reduce((c,l)=>Math.min(c,l)),r=t[n].vals.reduce((c,l)=>Math.max(c,l));t[n].global_min=s,t[n].global_max=r,t[n].cal_min=s,t[n].cal_max=r}return t}linesToCylinders(t,n,s){function r(I){return lt(I[0],I[1],I[2])}const c=Math.pow(2,32)-1,l=s.length;let d=0,h=0;for(let I=0;I<l;I++){if(s[I]===c){h++;continue}d++}const u=this.fiberSides,m=u*d,g=this.f32PerVertex;if(g!==5)throw Error("fiberSides > 1 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F=0;y=0;for(let I=1;I<l;I++){if(s[I]===c){y+=u;continue}if(s[I-1]===c)continue;let B=y,V=y+u;const R=V,Y=V+u;for(let P=0;P<u;P++)T[F++]=B,T[F++]=V++,V===Y&&(V=Y-u),T[F++]=V,T[F++]=B++,B===R&&(B=R-u),T[F++]=V,T[F++]=B;y+=u}t.bindBuffer(t.ELEMENT_ARRAY_BUFFER,this.indexBuffer),t.bufferData(t.ELEMENT_ARRAY_BUFFER,Uint32Array.from(T),t.STATIC_DRAW),t.bindBuffer(t.ARRAY_BUFFER,this.vertexBuffer),t.bufferData(t.ARRAY_BUFFER,v,t.STATIC_DRAW),this.indexCount=U}createFiberDensityMap(){if(this.fiberDensity)return;const t=this.pts,n=t.length/3;let s=0;for(let S=0;S<3;S++){const E=this.extentsMax[S]-this.extentsMin[S];s=Math.max(s,E)}if(this.fiberDensity=new Float32Array(n),s===0)return;const r=64,l=s/(r-1)/2,d=(r-1)/s;let h=new Float32Array(r*r*r);const u=[this.extentsMin[0]-l,this.extentsMin[1]-l,this.extentsMin[2]-l],m=[0,0,0],g=-1,A=r*r;let v=0;for(let S=0;S<n;S++){m[0]=Math.round((t[v++]-u[0])*d),m[1]=Math.round((t[v++]-u[1])*d),m[2]=Math.round((t[v++]-u[2])*d);const E=m[0]+m[1]*r+m[2]*A;E!==g&&h[E]++}function y(S,E){let M=S.slice(),N=-1;const U=E-1;for(let F=0;F<E;F++)for(let I=0;I<E;I++)for(let B=0;B<E;B++)N++,!(B<1||B>=U)&&(S[N]=M[N-1]+M[N]+M[N]+M[N+1]);N=-1,M=S.slice();for(let F=0;F<E;F++)for(let I=0;I<E;I++)for(let B=0;B<E;B++)N++,!(I<1||I>=U)&&(S[N]=M[N-E]+M[N]+M[N]+M[N+E]);const T=E*E;N=-1,M=S.slice();for(let F=0;F<E;F++)for(let I=0;I<E;I++)for(let B=0;B<E;B++)N++,!(F<1||F>=U)&&(S[N]=M[N-T]+M[N]+M[N]+M[T]);return S}h=y(h,r),h=y(h,r);let w=0,b=1/0;const C=r*r*r;for(let S=0;S<C;S++)h[S]<=0||(w=Math.max(w,h[S]),b=Math.min(b,h[S]));if(!(w<=1||w<=b)){v=0;for(let S=0;S<C;S++)h[S]=Math.max(0,h[S]-b);w-=b;for(let S=0;S<n;S++){m[0]=Math.round((t[v++]-u[0])*d),m[1]=Math.round((t[v++]-u[1])*d),m[2]=Math.round((t[v++]-u[2])*d);const E=m[0]+m[1]*r+m[2]*A;this.fiberDensity[S]=h[E]/w}}}updateFibers(t){if(!this.offsetPt0||!this.fiberLength)return;const n=this.pts,s=this.offsetPt0,r=s.length-1,c=n.length/3;if(!this.fiberLengths){this.fiberLengths=new Uint32Array(r);for(let U=0;U<r;U++){const T=s[U]*3,F=(s[U+1]-1)*3;let I=0;for(let B=T;B<F;B+=3){const V=lt(n[B+0]-n[B+3],n[B+1]-n[B+4],n[B+2]-n[B+5]);I+=tr(V)}this.fiberLengths[U]=I}}const l=new Float32Array(c*4),d=new Uint32Array(l.buffer);let h=0,u=0;for(let U=0;U<c;U++)l[u+0]=n[h+0],l[u+1]=n[h+1],l[u+2]=n[h+2],h+=3,u+=4;const m=this.fiberDither,g=m*.5;function A(U,T,F){const B=255*(m*Math.random()-g);return U=Math.max(Math.min(U+B,255),0),T=Math.max(Math.min(T+B,255),0),F=Math.max(Math.min(F+B,255),0),U+(T<<8)+(F<<16)}function v(U,T,F,I,B,V,R){const Y=lt(Math.abs(U-I),Math.abs(T-B),Math.abs(F-V));li(Y,Y);const P=R-g;for(let X=0;X<3;X++)Y[X]=255*Math.max(Math.min(Math.abs(Y[X])+P,1),0);return Y[0]+(Y[1]<<8)+(Y[2]<<16)}const y=this.fiberColor.toLowerCase();let w=null,b=null;if(y.startsWith("dps")&&this.dps&&this.dps.length>0){const U=parseInt(y.substring(3));U<this.dps.length&&this.dps[U].vals.length===r&&(w=this.dps[U].vals)}if(y.startsWith("dpv")&&this.dpv&&this.dpv.length>0){const U=parseInt(y.substring(3));U<this.dpv.length&&this.dpv[U].vals.length===c&&(b=this.dpv[U])}const C=new Int16Array(r);if(this.groups&&this.fiberGroupColormap!==null||y.startsWith("dpg")&&this.dpg.length>0){const U=new Uint8ClampedArray(this.groups.length*4),T=new Array(this.groups.length).fill(!1);if(this.fiberGroupColormap){const F=this.fiberGroupColormap;F.A===void 0&&(F.A=Array.from(new Uint8ClampedArray(F.I.length).fill(255)));for(let I=0;I<F.I.length;I++){let B=F.I[I];B<0||B>=this.groups.length||F.A[I]<1||(T[B]=!0,B*=4,U[B]=F.R[I],U[B+1]=F.G[I],U[B+2]=F.B[I],U[B+3]=255)}}else if(y.startsWith("dpg")&&this.dpg.length>0){const F=parseInt(y.substring(3)),I=F<this.dpg.length?this.dpg[F]:this.dpg[0],B=Pt.colormap(this.colormap,this.colormapInvert),V=I.cal_min,R=I.cal_max,Y=this.groups.length;for(let P=0;P<Y;P++){const X=I.vals[P];if(X<V)continue;let L=Math.round(255*Math.min(Math.max((X-V)/(R-V),0),1));T[P]=!0;const H=P*4;L*=4,U[H]=B[L+0],U[H+1]=B[L+1],U[H+2]=B[L+2],U[H+3]=255}}C.fill(-1);for(let F=0;F<this.groups.length;F++)if(T[F])for(let I=0;I<this.groups[F].vals.length;I++)C[this.groups[F].vals[I]]=F;for(let F=0;F<r;F++){if(C[F]<0)continue;const I=C[F]%256*4,B=A(U[I],U[I+1],U[I+2]),V=s[F],R=s[F+1]-1,Y=V*4+3,P=R*4+3;for(let X=Y;X<=P;X+=4)d[X]=B}}else if(b){const U=Pt.colormap(this.colormap,this.colormapInvert),T=b.cal_min,F=b.cal_max;let I=3;for(let B=0;B<c;B++){let V=Math.min(Math.max((b.vals[B]-T)/(F-T),0),1);V=Math.round(Math.max(Math.min(255,V*255)))*4;const R=U[V]+(U[V+1]<<8)+(U[V+2]<<16);d[I]=R,I+=4}}else if(w){const U=Pt.colormap(this.colormap,this.colormapInvert);let T=w[0],F=w[0];for(let I=0;I<r;I++)T=Math.min(T,w[I]),F=Math.max(F,w[I]);F===T&&(T-=1);for(let I=0;I<r;I++){let B=(w[I]-T)/(F-T);B=Math.round(Math.max(Math.min(255,B*255)))*4;const V=U[B]+(U[B+1]<<8)+(U[B+2]<<16),R=s[I],Y=s[I+1]-1,P=R*4+3,X=Y*4+3;for(let L=P;L<=X;L+=4)d[L]=V}}else if(y.includes("fixed"))if(m===0){const U=this.rgba255[0]+(this.rgba255[1]<<8)+(this.rgba255[2]<<16);let T=3;for(let F=0;F<c;F++)d[T]=U,T+=4}else for(let U=0;U<r;U++){const T=A(this.rgba255[0],this.rgba255[1],this.rgba255[2]),F=s[U],I=s[U+1]-1,B=F*4+3,V=I*4+3;for(let R=B;R<=V;R+=4)d[R]=T}else if(y.includes("local"))for(let U=0;U<r;U++){const T=s[U],F=s[U+1]-1;let I=T*3;const B=F*3,V=m*Math.random();let R=v(n[I],n[I+1],n[I+2],n[I+4],n[I+5],n[I+6],V),Y=T*4+3;for(;I<B;)d[Y]=R,Y+=4,I+=3,R=v(n[I-3],n[I-2],n[I-1],n[I+3],n[I+4],n[I+5],V);d[Y]=d[Y-4]}else for(let U=0;U<r;U++){const T=s[U],F=s[U+1]-1,I=T*3,B=F*3,V=v(n[I],n[I+1],n[I+2],n[B],n[B+1],n[B+2],m*Math.random()),R=T*4+3,Y=F*4+3;for(let P=R;P<=Y;P+=4)d[P]=V}if(this.fiberOcclusion>0){let U=function(T,F){const I=F*(T&255),B=F*(T>>8&255),V=F*(T>>16&255);return I+(B<<8)+(V<<16)};this.createFiberDensityMap();for(let T=0;T<r;T++){const F=s[T],I=s[T+1]-1,B=F*4+3,V=I*4+3;let R=F;const Y=Math.min(this.fiberOcclusion,.99);for(let P=B;P<=V;P+=4){let X=this.fiberDensity[R++];if(X<=0)continue;X=X/((1/Y-2)*(1-X)+1);const L=1-Math.min(X,.9);let H=d[P];H=U(H,L),d[P]=H}}}if(Number.isFinite(this.dpsThreshold)&&this.dps&&(w||this.dps[0].vals.length===r&&(w=this.dps[0].vals),w))for(let U=0;U<r;U++)w[U]<this.dpsThreshold&&(C[U]=-1);const S=this.fiberLength,E=Math.pow(2,32)-1,M=[];let N=-1;for(let U=0;U<r;U++)if(!(C[U]<0)&&!(this.fiberLengths[U]<S)&&(N++,N%this.fiberDecimationStride===0)){for(let T=s[U];T<s[U+1];T++)M.push(T);M.push(E)}this.fiberSides>2&&this.fiberRadius>0?this.linesToCylinders(t,l,M):(this.indexCount=M.length,t.bindBuffer(t.ARRAY_BUFFER,this.vertexBuffer),t.bufferData(t.ARRAY_BUFFER,Uint32Array.from(d),t.STATIC_DRAW),t.bindBuffer(t.ELEMENT_ARRAY_BUFFER,this.indexBuffer),t.bufferData(t.ELEMENT_ARRAY_BUFFER,Uint32Array.from(M),t.STATIC_DRAW))}indexNearestXYZmm(t,n,s){const r=this.pts,c=this.pts.length/3;let l=0,d=1/0,h=0;for(let u=0;u<c;u++){const m=Math.pow(r[l]-t,2)+Math.pow(r[l+1]-n,2)+Math.pow(r[l+2]-s,2);m<d&&(d=m,h=u),l+=3}return d=Math.sqrt(d),[h,d]}unloadMesh(t){if(t.bindBuffer(t.ARRAY_BUFFER,null),t.bindBuffer(t.ELEMENT_ARRAY_BUFFER,null),t.bindVertexArray(null),t.deleteBuffer(this.vertexBuffer),t.deleteBuffer(this.indexBuffer),t.deleteVertexArray(this.vao),t.deleteVertexArray(this.vaoFiber),this.offsetPt0=null,this.tris=null,this.pts=null,this.layers&&this.layers.length>0)for(let n=0;n<this.layers.length;n++)this.layers[n].values=null;if(this.dpg&&this.dpg.length>0)for(let n=0;n<this.dpg.length;n++)this.dpg[n].vals=null;if(this.dps&&this.dps.length>0)for(let n=0;n<this.dps.length;n++)this.dps[n].vals=null}scalars2RGBA(t,n,s,r=!1){const c=s.length;if(4*c<t.length)return k.error(`colormap2RGBA incorrectly specified ${c}*4 != ${t.length}`),t;const l=Math.round(n.opacity*255);let d=n.cal_min,h=n.cal_max,u=Pt.colormap(n.colormap,this.colormapInvert),m=1;if(r){if(!n.useNegativeCmap)return t;m=-1,u=Pt.colormap(n.colormapNegative,n.colormapInvert),d=n.cal_min,h=n.cal_max,isFinite(n.cal_minNeg)&&isFinite(n.cal_minNeg)&&(d=-n.cal_minNeg,h=-n.cal_maxNeg)}let g=d;n.isTransparentBelowCalMin||(g=Number.NEGATIVE_INFINITY);const A=n.colormapType===2;n.colormapType!==0&&(d=Math.min(d,0));const v=255/(h-d);for(let y=0;y<c;y++){let w=s[y]*m;if(isNaN(w))continue;let b=l;if(w<g)if(w>0&&A)b=Math.round(n.opacity*255*Math.pow(w/g,2));else continue;if(w=(w-d)*v,w<0&&n.isTransparentBelowCalMin)continue;w=Math.min(255,Math.max(0,Math.round(w)))*4;const C=y*4;t[C+0]=u[w+0],t[C+1]=u[w+1],t[C+2]=u[w+2],t[C+3]=b}return t}blendColormap(t,n,s,r,c,l,d=!1){const h=this.pts.length/3,u=Math.min(s.opacity,1);function m(E,M,N){return E*(1-N)+M*N}function g(E,M){return Math.min(E+M,255)}const A=d?-1:1,v=Math.min(Math.max(s.frame4D,0),s.nFrame4D-1),y=h*v;let w=r;s.isTransparentBelowCalMin||(w=Number.NEGATIVE_INFINITY),s.colormapType!==0&&(r=Math.min(r,0));const b=255/(c-r);let C=new Array(h).fill(!1);if(s.outlineBorder!==0){const E=new Uint8Array(h).fill(0);for(let M=0;M<h;M++)A*s.values[M+y]>=w&&(E[M]=1);C=Xn.getClusterBoundaryU8(E,this.tris);for(let M=0;M<h;M++)A*s.values[M+y]<w&&(C[M]=!1)}const S=new Float32Array(256).fill(u);if(w>r&&s.colormapType===2){let E=Math.round((w-r)*b);E=Math.max(E,1);for(let M=1;M<E;M++)S[M]=u*Math.pow(M/E,2);S[0]=0,w=r+Number.EPSILON}for(let E=0;E<h;E++){const M=A*s.values[E+y];if(M<w)continue;let N=Math.round((M-r)*b);if(N<0&&s.isTransparentBelowCalMin)continue;N=Math.max(0,N),N=Math.min(255,N);let U=S[N];N*=4;let T=E*28+24;if(this.f32PerVertex!==7&&(T=E*20+16),s.isAdditiveBlend){const F=E*4;n[F+0]=g(n[F+0],l[N+0]),n[F+1]=g(n[F+1],l[N+1]),n[F+2]=g(n[F+2],l[N+2]),n[F+3]=g(n[F+3],255)}else{if(C[E]&&(U=s.outlineBorder,s.outlineBorder<0)){t[T+0]=0,t[T+1]=0,t[T+2]=0;continue}t[T+0]=m(t[T+0],l[N+0],U),t[T+1]=m(t[T+1],l[N+1],U),t[T+2]=m(t[T+2],l[N+2],U)}}}updateMesh(t){if(this.offsetPt0){this.updateFibers(t);return}if(this.hasConnectome)return;if(!this.pts||!this.tris||!this.rgba255){k.warn("underspecified mesh");return}function n(u,m,g){return u*(1-g)+m*g}const s=this.generatePosNormClr(this.pts,this.tris,this.rgba255),r=this.pts.length/3,c=new Uint8Array(s.buffer);let l=0;const d=new Uint8Array(r*4);let h=this.tris;if(this.layers&&this.layers.length>0)for(let u=0;u<this.layers.length;u++){const m=this.layers[u],g=m.opacity;if(g<=0||m.cal_min>m.cal_max)continue;if(m.outlineBorder===void 0&&(m.outlineBorder=0),m.isAdditiveBlend===void 0&&(m.isAdditiveBlend=!1),m.colormapLabel&&m.colormapLabel.R&&!m.colormapLabel.lut&&(m.colormapLabel=Pt.makeLabelLut(m.colormapLabel,255,m.global_max)),m.colormapLabel&&m.colormapLabel.lut){const v=m.colormapLabel;let y=0;m.colormapLabel.min&&(y=m.colormapLabel.min);let w=v.lut;const b=Math.floor(w.length/4);if(m.atlasValues&&b>0&&b===m.atlasValues.length&&m.colormap){const U=m.atlasValues;let T=!1,F=!0;for(let I=0;I<b;I++)isNaN(U[I])?T=!0:F=!1;if(F){k.debug("invisible mesh: all atlasValues are NaN.");return}if(T){k.debug("some vertices have NaN atlasValues (mesh will be decimated).");const I=new Array(r).fill(!1);for(let P=0;P<r;P++){const X=Math.round(m.values[P])-y;isNaN(U[X])&&(I[P]=!0)}const B=new Array(h.length).fill(!1);for(let P=0;P<h.length;P++)I[h[P]]&&(B[P]=!0);const V=this.tris;let R=0;for(let P=0;P<V.length;P+=3)!B[P]&&!B[P+1]&&!B[P+2]&&R++;R===0&&k.debug("invisible mesh: all triangles of a vertex with a NaN atlasValue."),h=new Uint32Array(R*3);let Y=0;for(let P=0;P<V.length;P+=3)!B[P]&&!B[P+1]&&!B[P+2]&&(h[Y++]=V[P],h[Y++]=V[P+1],h[Y++]=V[P+2])}w.fill(0),w=this.scalars2RGBA(w,m,U),m.useNegativeCmap&&(w=this.scalars2RGBA(w,m,U,!0))}else m.atlasValues&&k.warn(`Expected ${b} atlasValues but got ${m.atlasValues.length} for mesh layer`);if(m.showLegend&&b===m.colormapLabel.labels.length){m.labels=[];for(let U=0;U<b;U++){const T=Array.from(w.slice(U*4,U*4+4)).map(R=>R/255),F=m.colormapLabel.labels[U],I=[0,0,0];let B=0;for(let R=0;R<r;R++)if(m.values[R]===U){const Y=R*3;I[0]+=this.pts[Y],I[1]+=this.pts[Y+1],I[2]+=this.pts[Y+2],B++}if(B>0&&(I[0]/=B,I[1]/=B,I[2]/=B),T[3]===0||!F||F.startsWith("_"))continue;T[3]=1;const V=new pu(F,{textColor:T,bulletScale:1,bulletColor:T,lineWidth:0,lineColor:T,textScale:1,textAlignment:"left",lineTerminator:"none"},I);m.labels.push(V),k.debug("label for mesh layer:",V)}}else delete m.labels;const C=Math.min(Math.max(m.frame4D,0),m.nFrame4D-1),S=r*C,E=new Uint8Array(r*4);let M=0;for(let U=0;U<r;U++){const T=m.values[U+S]-y,F=4*Math.min(Math.max(T,0),b-1);E[M+0]=w[F+0],E[M+1]=w[F+1],E[M+2]=w[F+2],E[M+3]=Math.round(w[F+3]/255*m.opacity*255),M+=4}let N=new Array(r).fill(!1);m.outlineBorder!==0&&(N=Xn.getClusterBoundary(E,this.tris)),M=0;for(let U=0;U<r;U++){let T=U*28+24;this.f32PerVertex!==7&&(T=U*20+16);let F=E[M+3]/255;if(N[U]&&(F=m.outlineBorder,m.outlineBorder<0)){c[T+0]=0,c[T+1]=0,c[T+2]=0,M+=4;continue}c[T+0]=n(c[T+0],E[M+0],F),c[T+1]=n(c[T+1],E[M+1],F),c[T+2]=n(c[T+2],E[M+2],F),M+=4}continue}if(m.values instanceof Uint8Array){const v=new Uint8Array(m.values.buffer);let y=new Array(r).fill(!0);m.outlineBorder!==0&&(y=Xn.getClusterBoundary(v,this.tris));let w=0;for(let b=0;b<m.values.length;b++){let C=b*28+24;this.f32PerVertex!==7&&(C=b*20+16);let S=g;if(y[b]&&(S=m.outlineBorder,m.outlineBorder<0)){c[C+0]=0,c[C+1]=0,c[C+2]=0,w+=4;continue}c[C+0]=n(c[C+0],v[w+0],S),c[C+1]=n(c[C+1],v[w+1],S),c[C+2]=n(c[C+2],v[w+2],S),w+=4}continue}m.useNegativeCmap&&(m.cal_min=Math.max(Number.EPSILON,m.cal_min),m.cal_max=Math.max(m.cal_min+1e-6,m.cal_max)),m.isTransparentBelowCalMin===void 0&&(m.isTransparentBelowCalMin=!0);const A=Pt.colormap(m.colormap,m.colormapInvert);if(m.isAdditiveBlend&&l++,this.blendColormap(c,d,m,m.cal_min,m.cal_max,A),m.useNegativeCmap){const v=Pt.colormap(m.colormapNegative,m.colormapInvert);let y=m.cal_min,w=m.cal_max;isFinite(m.cal_minNeg)&&isFinite(m.cal_minNeg)&&(y=-m.cal_minNeg,w=-m.cal_maxNeg),this.blendColormap(c,d,m,y,w,v,!0)}}if(l>0)for(let u=0;u<r;u++){let m=function(y,w){return Math.min(y*w*.00392156862745098,255)},g=u*28+24;this.f32PerVertex!==7&&(g=u*20+16);const A=u*4,v=Math.min(l,d[A+3]/255);v<=0||(c[g+0]=m(c[g+0],d[A+0]),c[g+1]=m(c[g+1],d[A+1]),c[g+2]=m(c[g+2],d[A+2]),c[g+0]=n(c[g+0],d[A+0],v),c[g+1]=n(c[g+1],d[A+1],v),c[g+2]=n(c[g+2],d[A+2],v))}t.bindBuffer(t.ELEMENT_ARRAY_BUFFER,this.indexBuffer),t.bufferData(t.ELEMENT_ARRAY_BUFFER,Uint32Array.from(h),t.STATIC_DRAW),t.bindBuffer(t.ARRAY_BUFFER,this.vertexBuffer),t.bufferData(t.ARRAY_BUFFER,c,t.STATIC_DRAW),this.indexCount=h.length,this.vertexCount=this.pts.length}reverseFaces(t){if(this.offsetPt0||this.hasConnectome)return;const n=this.tris||[];for(let s=0;s<n.length;s+=3){const r=n[s];n[s]=n[s+1],n[s+1]=r}this.updateMesh(t)}hierarchicalOrder(){const s=this.tris.length/3,r=Math.log(s/20)/Math.log(4);if(s!==Math.pow(4,r)*20)return NaN;if(this.pts.length/3!==Math.pow(4,r)*10+2)return NaN;for(let l=0;l<15;l+=3)if(this.tris[l]!==0)return NaN;for(let l=15;l<24;l+=3)if(this.tris[l]!==3)return NaN;for(let l=24;l<30;l+=3)if(this.tris[l]!==4)return NaN;return r}decimateFaces(t,n){let s=this.tris;const r=12,c=20;for(let l=t-1;l>=n;l--){const d=Math.pow(4,l+1)*(r-2)+2,h=Math.pow(4,l)*(r-2)+2,u=s.length/3,m=Math.pow(4,l)*c;k.info(`order ${l+1} -> ${l} vertices ${d} -> ${h} faces ${u} -> ${m}`);const g=Array.from({length:d},(v,y)=>y+1);for(let v=0;v<u;v++){const y=s[3*v],w=s[3*v+1],b=s[3*v+2];g[y-1]=Math.min(g[y-1],w,b)}const A=new Uint32Array(m*3);for(let v=0;v<m;v++)A[3*v]=g[s[3*v]-1],A[3*v+1]=g[s[3*v+1]-1],A[3*v+2]=g[s[3*v+2]-1];s=A}this.tris=new Uint32Array(s)}decimateHierarchicalMesh(t,n=4){const s=this.hierarchicalOrder();if(isNaN(s))return k.warn("Unable to decimate mesh: it does not have a hierarchical structure"),!1;if(n>=s)return k.warn(`Unable to decimate mesh: input order (${s}) must be larger than downsampled order (${n})`),!1;const r=this.pts.length/3,l=Math.pow(4,n)*(12-2)+2;if(this.pts=new Float32Array(this.pts.slice(0,l*3)),this.decimateFaces(s,n),this.layers&&this.layers.length>0)for(let d=0;d<this.layers.length;d++){const h=this.layers[d];h.values instanceof Float32Array||h.values.length!==r?h.values=new Float32Array(h.values.slice(0,l)):k.warn("decimation logic needs to be updated")}return this.updateMesh(t),!0}async setLayerProperty(t,n,s,r){const c=this.layers[t];if(!c||!(n in c)){k.warn("mesh does not have property ",n," for layer ",c);return}if(n==="colormapLabel")if(typeof s=="object")c[n]=Pt.makeLabelLut(s,255,c.global_max);else if(typeof s=="string"){const l=await Pt.makeLabelLutFromUrl(s);c[n]=l,this.updateMesh(r);return}else k.error("colormapLabel requires a string or object");else c[n]=s;this.updateMesh(r)}setProperty(t,n,s){if(!(t in this)){console.warn("Mesh does not have property:",t,this);return}this[t]=n,this.updateMesh(s)}generatePosNormClr(t,n,s){(t.length<3||s.length<4)&&(k.error("Catastrophic failure generatePosNormClr()"),k.debug("this",this),k.debug("pts",t),k.debug("rgba",s));const r=Xn.generateNormals(t,n),c=t.length/3,l=c===s.length/4,d=this.f32PerVertex,h=new Float32Array(c*d),u=new Uint8Array(h.buffer);let m=0,g=0,A=0,v=(d-1)*4;for(let y=0;y<c;y++)h[A+0]=t[m+0],h[A+1]=t[m+1],h[A+2]=t[m+2],d!==7?(u[v-4]=r[m+0]*127,u[v-3]=r[m+1]*127,u[v-2]=r[m+2]*127):(h[A+3]=r[m+0],h[A+4]=r[m+1],h[A+5]=r[m+2]),u[v]=s[g+0],u[v+1]=s[g+1],u[v+2]=s[g+2],u[v+3]=s[g+3],l&&(g+=4),m+=3,A+=d,v+=d*4;return h}static async readMesh(t,n,s,r=1,c=new Uint8Array([255,255,255,255]),l=!0){let d=new Uint32Array([]),h=new Float32Array([]),u="",m;const g=/(?:\.([^.]+))?$/;let A=g.exec(n)[1];if(A=A.toUpperCase(),A==="GZ"&&(A=g.exec(n.slice(0,-3))[1],A=A.toUpperCase()),A==="JCON"&&k.error("you should never see this message: load using nvconnectome not nvmesh"),A==="JSON"&&k.error("you should never see this message: load using nvconnectome not nvmesh"),c[3]=Math.max(1,c[3]),A==="TCK"||A==="TRK"||A==="TT"||A==="TRX"||A==="TRACT"){if(A==="TCK"?m=$t.readTCK(t):A==="TRACT"?m=$t.readTRACT(t):A==="TT"?m=await $t.readTT(t):A==="TRX"?m=await $t.readTRX(t):m=await $t.readTRK(t),typeof m>"u"){const b=new Float32Array([0,0,0,0,0,0]),C=new Uint32Array([0]);m={pts:b,offsetPt0:C},k.error("Creating empty tracts")}return c[3]=0,new yi(m.pts,m.offsetPt0,n,c,r,l,s,"inferno",m.dpg||null,m.dps||null,m.dpv||null,m.groups)}if(A==="GII")m=await $t.readGII(t);else if(A==="MZ3")m=await $t.readMZ3(t),"positions"in m||k.warn("MZ3 does not have positions (statistical overlay?)");else if(A==="ASC")m=$t.readASC(t);else if(A==="DFS")m=$t.readDFS(t);else if(A==="BYU"||A==="G")m=$t.readGEO(t);else if(A==="GEO")m=$t.readGEO(t,!0);else if(A==="ICO"||A==="TRI")m=$t.readICO(t);else if(A==="OFF")m=$t.readOFF(t);else if(A==="NV")m=$t.readNV(t);else if(A==="OBJ")m=await $t.readOBJ(t);else if(A==="PLY")m=$t.readPLY(t);else if(A==="WRL")m=$t.readWRL(t);else if(A==="X3D")m=$t.readX3D(t);else if(A==="FIB"||A==="VTK"){if(m=$t.readVTK(t),"offsetPt0"in m)return c[3]=0,new yi(m.pts,m.offsetPt0,n,c,r,l,s,"inferno")}else A==="SRF"?m=await $t.readSRF(t):A==="STL"?m=$t.readSTL(t):m=$t.readFreeSurfer(t);if(m.anatomicalStructurePrimary&&(u=m.anatomicalStructurePrimary),m instanceof Float32Array)throw new Error("fatal: unknown mesh type loaded");if(!("positions"in m))throw new Error("positions not loaded");if(!m.indices)throw new Error("indices not loaded");if(h=m.positions,d=m.indices,"rgba255"in m&&m.rgba255.length>0&&(c=m.rgba255),"colors"in m&&m.colors&&m.colors.length===h.length){const b=h.length/3;c=new Uint8Array(b*4);let C=0,S=0;for(let E=0;E<b;E++)c[S++]=m.colors[C]*255,c[S++]=m.colors[C+1]*255,c[S++]=m.colors[C+2]*255,c[S++]=255,C+=3}const v=h.length/3;if(d.length/3<1||v<3)throw new Error("Mesh should have at least one triangle and three vertices");c[3]=Math.max(1,c[3]);const w=new yi(h,d,n,c,r,l,s,null,null,null,null,null,!0,u);if("scalars"in m&&m.scalars.length>0){const b=await $t.readLayer(n,t,w,r,"gray");typeof b>"u"?k.warn("readLayer() failed to convert scalars"):(w.layers.push(b),w.updateMesh(s))}return w}static async loadLayer(t,n){let s=new Uint8Array().buffer;function r(y){const w=window.atob(y),b=w.length,C=new Uint8Array(b);for(let S=0;S<b;S++)C[S]=w.charCodeAt(S);return C.buffer}if(t.base64!==void 0)s=r(t.base64);else{if(!t.url)throw new Error("layer: missing url");const y=await fetch(t.url,{headers:t.headers});if(!y.ok)throw Error(y.statusText);s=await y.arrayBuffer()}let c,l=[];if(t.name&&t.name!=="")c=t.name;else{if(!t.url)throw new Error("layer: missing url");try{l=new URL(t.url).pathname.split("/")}catch{l=t.url.split("/")}finally{c=l.slice(-1)[0]}}c.indexOf("?")>-1&&(c=c.slice(0,c.indexOf("?")));let d=.5;"opacity"in t&&(d=t.opacity);let h="warm";"colormap"in t&&(h=t.colormap);let u="winter";"colormapNegative"in t&&(u=t.colormapNegative);let m=!1;"useNegativeCmap"in t&&(m=t.useNegativeCmap);let g=null;"cal_min"in t&&(g=t.cal_min);let A=null;"cal_max"in t&&(A=t.cal_max);const v=await $t.readLayer(c,s,n,d,h,u,m,g,A);v&&n.layers.push(v)}static async loadFromUrl({url:t="",headers:n={},gl:s,name:r="",opacity:c=1,rgba255:l=[255,255,255,255],visible:d=!0,layers:h=[],buffer:u=new ArrayBuffer(0)}={}){let m=t.split("/");if(r===""){try{m=new URL(t).pathname.split("/")}catch{m=t.split("/")}r=m.slice(-1)[0],r.indexOf("?")>-1&&(r=r.slice(0,r.indexOf("?")))}if(t==="")throw Error("url must not be empty");if(!s)throw Error("gl context is null");let g;if(u.byteLength>0)g=u;else{const v=await fetch(t,{headers:n});if(!v.ok)throw Error(v.statusText);g=await v.arrayBuffer()}const A=await this.readMesh(g,r,s,c,new Uint8Array(l),d);if(!h||h.length<1)return A;for(let v=0;v<h.length;v++)await yi.loadLayer(h[v],A);return A.updateMesh(s),A}static async readFileAsync(t){return new Promise((n,s)=>{const r=new FileReader;r.onload=()=>{n(r.result)},r.onerror=s,r.readAsArrayBuffer(t)})}static async loadFromFile({file:t,gl:n,name:s="",opacity:r=1,rgba255:c=[255,255,255,255],visible:l=!0,layers:d=[]}={}){if(!t)throw new Error("file must be set");if(!n)throw new Error("rendering context must be set");const h=await yi.readFileAsync(t),u=await yi.readMesh(h,s,n,r,new Uint8Array(c),l);if(!d||d.length<1)return u;for(let m=0;m<d.length;m++)await yi.loadLayer(d[m],u);return u.updateMesh(n),u}async loadFromBase64({base64:t,gl:n,name:s="",opacity:r=1,rgba255:c=[255,255,255,255],visible:l=!0,layers:d=[]}={}){if(!t)throw new Error("base64 must bet set");if(!n)throw new Error("rendering context must be set");function h(g){const A=window.atob(g),v=A.length,y=new Uint8Array(v);for(let w=0;w<v;w++)y[w]=A.charCodeAt(w);return y.buffer}const u=h(t),m=await yi.readMesh(u,s,n,r,new Uint8Array(c),l);if(!d||d.length<1)return m;for(let g=0;g<d.length;g++)await yi.loadLayer(d[g],m);return 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",a2="data:image/png;base64,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c=Pt.colormap(this.nodeColormap,this.colormapInvert),l=Pt.colormap(this.nodeColormapNegative,this.colormapInvert),d="nodeColormapNegative"in this;let h=this.legendLineThickness?this.legendLineThickness:0;this.showLegend===!1&&(h=0);for(let u=0;u<t.length;u++){let m=t[u].colorValue,g=!1;if(d&&m<0&&(g=!0,m=-m),s<r){if(m<s){k.warn("color value lower than min");continue}m=(m-s)/(r-s)}else m=1;m=Math.round(Math.max(Math.min(255,m*255)))*4;let A=[c[m],c[m+1],c[m+2],255];g&&(A=[l[m],l[m+1],l[m+2],255]),A=A.map(v=>v/255),k.debug("adding label for ",t[u]),t[u].label=new pu(t[u].name,{textColor:A,bulletScale:t[u].sizeValue/n,bulletColor:A,lineWidth:h,lineColor:A,textScale:1,textAlignment:"left",lineTerminator:"none"},[t[u].x,t[u].y,t[u].z]),k.debug("label for node:",t[u].label)}}}addConnectomeNode(t){if(k.debug("adding node",t),!this.nodes)throw new Error("nodes not defined");this.nodes.push(t),this.updateLabels(),this.nodesChanged.dispatchEvent(new CustomEvent("nodeAdded",{detail:{node:t}}))}deleteConnectomeNode(t){const n=this.nodes.indexOf(t),s=this.edges;s&&(this.edges=s.filter(r=>r.first!==n&&r.second!==n)),this.nodes=this.nodes.filter(r=>r!==t),this.updateLabels(),this.updateConnectome(this.gl),this.nodesChanged.dispatchEvent(new CustomEvent("nodeDeleted",{detail:{node:t}}))}updateConnectomeNodeByIndex(t,n){this.nodes[t]=n,this.updateLabels(),this.updateConnectome(this.gl),this.nodesChanged.dispatchEvent(new CustomEvent("nodeChanged",{detail:{node:n}}))}updateConnectomeNodeByPoint(t,n){const s=this.nodes;if(!s)throw new Error("Node to update does not exist");const r=s.find(l=>At.arraysAreEqual([l.x,l.y,l.z],t));if(!r)throw new Error(`Node with point ${t} to update does not exist`);const c=s.findIndex(l=>l===r);this.updateConnectomeNodeByIndex(c,n)}addConnectomeEdge(t,n,s){const r=this.edges;let c=r.find(l=>(l.first===t||l.second===t)&&l.first+l.second===t+n);return c||(c={first:t,second:n,colorValue:s},r.push(c),this.updateConnectome(this.gl),c)}deleteConnectomeEdge(t,n){const s=this.edges,r=s.find(c=>(c.first===t||c.first===n)&&c.first+c.second===t+n);if(r)this.edges=s.filter(c=>c!==r);else throw new Error(`edge between ${t} and ${n} not found`);return this.updateConnectome(this.gl),r}findClosestConnectomeNode(t,n){const s=this.nodes;if(!s||s.length===0)return null;const r=s.map((c,l)=>({node:c,distance:Math.sqrt(Math.pow(c.x-t[0],2)+Math.pow(c.y-t[1],2)+Math.pow(c.z-t[2],2)),index:l})).filter(c=>c.distance<n).sort((c,l)=>c.distance-l.distance);return r.length>0?r[0].node:null}updateConnectome(t){const n=[],s=[],r=[];let c=Pt.colormap(this.nodeColormap,this.colormapInvert),l=Pt.colormap(this.nodeColormapNegative,this.colormapInvert),d="nodeColormapNegative"in this;this.nodeMinColor===void 0&&(this.nodeMinColor=NaN),this.nodeMaxColor===void 0&&(this.nodeMaxColor=NaN),this.edgeMin===void 0&&(this.edgeMin=NaN),this.edgeMax===void 0&&(this.edgeMax=NaN);let h=this.nodeMinColor,u=this.nodeMaxColor;if(!isFinite(h)||!isFinite(h)){const C=this.nodes;h=C[0].colorValue,u=C[0].colorValue;for(let S=0;S<C.length;S++)h=Math.min(h,C[S].colorValue),u=Math.max(u,C[S].colorValue)}const m=this.nodes,g=m.length;for(let C=0;C<g;C++){const S=m[C].sizeValue*this.nodeScale;if(S<=0)continue;let E=m[C].colorValue,M=!1;if(d&&E<0&&(M=!0,E=-E),h<u){if(E<h)continue;E=(E-h)/(u-h)}else E=1;E=Math.round(Math.max(Math.min(255,E*255)))*4;let N=[c[E],c[E+1],c[E+2],255];M&&(N=[l[E],l[E+1],l[E+2],255]);const U=lt(m[C].x,m[C].y,m[C].z);Wn.makeColoredSphere(s,n,r,S,U,N)}c=Pt.colormap(this.edgeColormap,this.colormapInvert),l=Pt.colormap(this.edgeColormapNegative,this.colormapInvert),d="edgeColormapNegative"in this;const A=this.edges;if(A!==void 0&&A.length>0){if(h=this.edgeMin,u=this.edgeMax,!isFinite(h)||!isFinite(h)){h=A[0].colorValue,u=A[0].colorValue;for(let C=0;C<A.length;C++)h=Math.min(h,A[C].colorValue),u=Math.max(u,A[C].colorValue)}for(const C of A){let S=C.colorValue;const E=d&&S<0;E&&(S=-S);const M=S*this.edgeScale;if(M<=0)continue;if(h<u){if(S<h)continue;S=(S-h)/(u-h)}else S=1;S=Math.round(Math.max(Math.min(255,S*255)))*4;let N=[c[S],c[S+1],c[S+2],255];E&&(N=[l[S],l[S+1],l[S+2],255]);const U=lt(m[C.first].x,m[C.first].y,m[C.first].z),T=lt(m[C.second].x,m[C.second].y,m[C.second].z);Wn.makeColoredCylinder(s,n,r,U,T,M,N)}}const v=new Float32Array(s),y=new Uint32Array(n),w=Xn.getExtents(v);this.furthestVertexFromOrigin=w.mxDx,this.extentsMin=w.extentsMin,this.extentsMax=w.extentsMax;const b=this.generatePosNormClr(v,y,new Uint8Array(r));t.bindBuffer(t.ELEMENT_ARRAY_BUFFER,this.indexBuffer),t.bufferData(t.ELEMENT_ARRAY_BUFFER,Uint32Array.from(y),t.STATIC_DRAW),t.bindBuffer(t.ARRAY_BUFFER,this.vertexBuffer),t.bufferData(t.ARRAY_BUFFER,Float32Array.from(b),t.STATIC_DRAW),this.indexCount=n.length}updateMesh(t){this.updateConnectome(t),this.updateLabels()}json(){const t={};for(const n in this)(n in Ul||n==="nodes"||n==="edges")&&(t[n]=this[n]);return t}static async loadConnectomeFromUrl(t,n){const r=await(await fetch(n)).json();return new rm(t,r)}};function C4(i,t,n){if(!i.dimsRAS||!i.matRAS||!i.pixDimsRAS||!i.vox2mm)throw new Error("Cannot create NiivueObject3D: Missing required RAS properties or vox2mm access on NVImage.");const s=i.dimsRAS,r=i.matRAS,c=i.pixDimsRAS,l=-.5,d=-.5,h=-.5,u=s[1]-1+.5,m=s[2]-1+.5,g=s[3]-1+.5,A=i.vox2mm,v=A.call(i,[l,d,h],r),y=A.call(i,[l,m,h],r),w=A.call(i,[l,d,g],r),b=A.call(i,[l,m,g],r),C=A.call(i,[u,d,h],r),S=A.call(i,[u,m,h],r),E=A.call(i,[u,d,g],r),M=A.call(i,[u,m,g],r),N=[...w,0,0,1,...E,1,0,1,...M,1,1,1,...b,0,1,1,...v,0,0,0,...y,0,1,0,...S,1,1,0,...C,1,0,0],U=n.createBuffer();if(!U)throw new Error("Failed to create GL index buffer");n.bindBuffer(n.ELEMENT_ARRAY_BUFFER,U);const T=[0,3,2,2,1,0,4,7,6,6,5,4,5,6,2,2,3,5,4,0,1,1,7,4,7,1,2,2,6,7,4,5,3,3,0,4];n.bufferData(n.ELEMENT_ARRAY_BUFFER,new Uint16Array(T),n.STATIC_DRAW);const F=n.createBuffer();if(!F)throw new Error("Failed to create GL vertex buffer");n.bindBuffer(n.ARRAY_BUFFER,F),n.bufferData(n.ARRAY_BUFFER,new Float32Array(N),n.STATIC_DRAW);const I=n.createVertexArray();if(!I)throw new Error("Failed to create GL VAO");n.bindVertexArray(I),n.bindBuffer(n.ELEMENT_ARRAY_BUFFER,U),n.bindBuffer(n.ARRAY_BUFFER,F);const B=24;n.enableVertexAttribArray(0),n.vertexAttribPointer(0,3,n.FLOAT,!1,B,0),n.enableVertexAttribArray(1),n.vertexAttribPointer(1,3,n.FLOAT,!1,B,12),n.bindVertexArray(null);const V=new Wn(t,F,n.TRIANGLES,T.length,U,I),R=[...w,...E,...M,...b,...v,...y,...S,...C],Y=u4(R);return V.extentsMin=Y.min.slice(),V.extentsMax=Y.max.slice(),V.furthestVertexFromOrigin=Y.furthestVertexFromOrigin,V.originNegate=gi(Y.origin),lp(V.originNegate,V.originNegate),V.fieldOfViewDeObliqueMM=[s[1]*c[1],s[2]*c[2],s[3]*c[3]],V}function S4(i){const t=i.length;let n=0;const s=new Uint8Array(t+Math.ceil(.01*t)),r=new Int8Array(s.buffer);let c=0;for(;n<t;){let l=i[n];n++;let d=1;for(;d<129&&n<t&&i[n]===l;)n++,d++;if(d>1){r[c]=-d+1,c++,s[c]=l,c++;continue}for(;n<t&&!(d>127||n+2<t&&l!==i[n]&&i[n+2]===i[n]&&i[n+1]===i[n]);)l=i[n],n++,d++;s[c]=d-1,c++;for(let h=0;h<d;h++)s[c]=i[n-d+h],c++}return k.debug("PackBits "+t+" -> "+c+" bytes (x"+t/c+")"),s.slice(0,c)}function Wh(i,t){const n=new Uint8Array(i.buffer),s=new Int8Array(n.buffer);let r=0;const c=new Uint8Array(t);let l=0;for(;r<n.length;){const d=s[r];if(r++,d<0){const h=s[r];r++;for(let u=0;u<1-d;u++)c[l]=h,l++}else for(let h=0;h<d+1;h++)c[l]=s[r],r++,l++}return c}var M4=({drawUndoBitmaps:i,currentDrawUndoBitmap:t,drawBitmap:n})=>{const s=i.length;if(s<1){k.debug("undo bitmaps not loaded");return}if(t--,t<0&&(t=s-1),t>=s&&(t=0),i[t].length<2){k.debug("drawUndo is misbehaving");return}return n=Wh(i[t],n.length),{drawBitmap:n,currentDrawUndoBitmap:t}};function E4(i,t,n){const{dimX:s,dimY:r,dimZ:c}=n;let l;if(i===0)l=c;else if(i===1)l=r;else if(i===2)l=s;else return null;let d=-1,h=-1;for(let u=0;u<l;u++){let m=!1;if(i===0){const g=u*s*r;for(let A=0;A<s*r;A++)if(t[g+A]>0){m=!0;break}}else if(i===1)for(let g=0;g<c;g++){for(let A=0;A<s;A++){const v=A+u*s+g*s*r;if(t[v]>0){m=!0;break}}if(m)break}else if(i===2)for(let g=0;g<c;g++){for(let A=0;A<r;A++){const v=u+A*s+g*s*r;if(t[v]>0){m=!0;break}}if(m)break}m&&(d===-1&&(d=u),h=u)}return d===-1||h===-1?null:{first:d,last:h}}function Ih(i,t,n,s){const{dimX:r,dimY:c,dimZ:l}=s;let d;if(t===0){d=new Float32Array(r*c);const h=i*r*c;for(let u=0;u<r*c;u++)d[u]=n[h+u]}else if(t===1){d=new Float32Array(r*l);for(let h=0;h<l;h++)for(let u=0;u<r;u++){const m=u+i*r+h*r*c,g=u+h*r;d[g]=n[m]}}else if(t===2){d=new Float32Array(c*l);for(let h=0;h<l;h++)for(let u=0;u<c;u++){const m=i+u*r+h*r*c,g=u+h*c;d[g]=n[m]}}else throw new Error("Invalid slice type");return d}function Rh(i,t,n,s,r){const{dimX:c,dimY:l,dimZ:d}=s;let h;if(t===0){h=new Float32Array(c*l);const u=i*c*l;for(let m=0;m<c*l;m++)h[m]=n[u+m]/r}else if(t===1){h=new Float32Array(c*d);for(let u=0;u<d;u++)for(let m=0;m<c;m++){const g=m+i*c+u*c*l,A=m+u*c;h[A]=n[g]/r}}else if(t===2){h=new Float32Array(l*d);for(let u=0;u<d;u++)for(let m=0;m<l;m++){const g=i+m*c+u*c*l,A=m+u*l;h[A]=n[g]/r}}else throw new Error("Invalid slice type");return h}function D4(i,t,n,s,r,c,l){const{dimX:d,dimY:h,dimZ:u}=r;if(n===0){const m=t*d*h;for(let g=0;g<i.length;g++)i[g]>=c&&(s[m+g]=l)}else if(n===1)for(let m=0;m<u;m++)for(let g=0;g<d;g++){const A=g+m*d,v=g+t*d+m*d*h;i[A]>=c&&(s[v]=l)}else if(n===2)for(let m=0;m<u;m++)for(let g=0;g<h;g++){const A=g+m*h,v=t+g*d+m*d*h;i[A]>=c&&(s[v]=l)}else throw new Error("Invalid slice type")}function l2(i,t,n){if(t<3||n<3)return;const s=new Float32Array(i.length);for(let r=0;r<n;r++)for(let c=0;c<t;c++){const l=c+r*t;c===0||c===t-1?s[l]=i[l]:s[l]=(i[l-1]+2*i[l]+i[l+1])*.25}for(let r=0;r<n;r++)for(let c=0;c<t;c++){const l=c+r*t;r===0||r===n-1?i[l]=s[l]:i[l]=(s[l-t]+2*s[l]+s[l+t])*.25}}function T4(i,t,n,s){const r=Math.abs(n-i),c=Math.abs(n-t),l=Math.exp(-r*r/(2*s*s)),d=Math.exp(-c*c/(2*s*s)),h=l+d;return h<1e-6?.5:l/h}function U4(i,t,n,s,r,c){const l=(n-s)/(r-s),d=1-l;for(let h=0;h<i.length;h++)c[h]=i[h]*d+t[h]*l}function F4(i,t,n,s,r,c,l,d,h,u){const m=(n-s)/(r-s),g=1-m;for(let A=0;A<i.length;A++)if(i[A]>0||t[A]>0){const v=T4(d[A],h[A],u[A],l.intensitySigma),y=l.intensityWeight,w=y*v+(1-y)*g,b=1-w;c[A]=i[A]*w+t[A]*b}else c[A]=i[A]*g+t[A]*m}function B4(i,t,n,s,r,c,l,d){const{dimX:h,dimY:u,dimZ:m}=t,g=l.sliceType??0;let A,v,y;if(g===0)A=h,v=u,y=m-1;else if(g===1)A=h,v=m,y=u-1;else if(g===2)A=u,v=m,y=h-1;else throw new Error("Invalid slice type. Must be AXIAL, CORONAL, or SAGITTAL");const w={intensityWeight:l.intensityWeight??.7,binaryThreshold:l.binaryThreshold??.375,intensitySigma:l.intensitySigma??.1,applySmoothingToSlices:l.applySmoothingToSlices??!0,useIntensityGuided:l.useIntensityGuided??!0};if(r!==void 0&&c!==void 0){if(r>=c)throw new Error("Low slice index must be less than high slice index");if(r<0||c>y)throw new Error(`Slice indices out of bounds [0, ${y}]`)}const b=new Map;for(let C=0;C<=y;C++){const S=Ih(C,g,i,t);for(let E=0;E<S.length;E++){const M=S[E];if(M>0)if(!b.has(M))b.set(M,{min:C,max:C});else{const N=b.get(M);N.min=Math.min(N.min,C),N.max=Math.max(N.max,C)}}}for(const[C,S]of b){const E=r!==void 0?Math.max(r,S.min):S.min,M=c!==void 0?Math.min(c,S.max):S.max;if(E>=M||M-E<2)continue;const N=Ih(E,g,i,t),U=Ih(M,g,i,t),T=new Float32Array(N.length),F=new Float32Array(U.length);for(let I=0;I<N.length;I++)T[I]=N[I]===C?1:0,F[I]=U[I]===C?1:0;w.applySmoothingToSlices&&(l2(T,A,v),l2(F,A,v));for(let I=E+1;I<M;I++){const B=new Float32Array(A*v);if(w.useIntensityGuided&&n){const V=Rh(E,g,n,t,s),R=Rh(M,g,n,t,s),Y=Rh(I,g,n,t,s);F4(T,F,I,E,M,B,w,V,R,Y)}else U4(T,F,I,E,M,B);D4(B,I,g,i,t,w.binaryThreshold,C)}}d()}var Ga=`#version 300 es
+#line 4
+layout(location=0) in vec3 pos;
+layout(location=1) in vec3 texCoords;
+uniform mat4 mvpMtx;
+out vec3 vColor;
+void main(void) {
+	gl_Position = mvpMtx * vec4(pos, 1.0);
+	vColor = texCoords;
+}`,vu=`
+	vec4 drawColor(float scalar, float drawOpacity) {
+		float nlayer = float(textureSize(colormap, 0).y);
+		float layer = (nlayer - 0.5) / nlayer;
+		vec4 dcolor = texture(colormap, vec2((scalar * 255.0)/256.0 + 0.5/256.0, layer)).rgba;
+		dcolor.a *= drawOpacity;
+		return dcolor;
+}`,ar=`vec3 GetBackPosition(vec3 startPositionTex) {
+	vec3 startPosition = startPositionTex * volScale;
+	vec3 invR = 1.0 / rayDir;
+	vec3 tbot = invR * (vec3(0.0)-startPosition);
+	vec3 ttop = invR * (volScale-startPosition);
+	vec3 tmax = max(ttop, tbot);
+	vec2 t = min(tmax.xx, tmax.yz);
+	vec3 endPosition = startPosition + (rayDir * min(t.x, t.y));
+	//convert world position back to texture position:
+	endPosition = endPosition / volScale;
+	return endPosition;
+}
+
+float distance2Plane(in vec4 samplePos, in vec4 clipPlane) {
+	// treat clipPlane.a > 1 as "no clip" sentinel (keeps existing behavior)
+	if (clipPlane.a > 1.0) {
+			return 1000.0; // sentinel large distance
+	}
+	vec3 n = clipPlane.xyz;
+	const float EPS = 1e-6;
+	float nlen = length(n);
+	if (nlen < EPS) {
+			return 1000.0; // invalid plane normal
+	}
+	// signed plane value: dot(n, p-0.5) + a
+	float signedDist = dot(n, samplePos.xyz - 0.5) + clipPlane.a;
+	// perpendicular (Euclidean) distance is |signedDist| / |n|
+	return abs(signedDist) / nlen;
+}
+
+// see if clip plane trims ray sampling range sampleStartEnd.x..y
+void clipSampleRange(in vec3 dir, in vec4 rayStart, in vec4 clipPlane, inout vec2 sampleStartEnd, inout bool hasClip) {
+	const float CSR_EPS = 1e-6;
+	// quick exit: no clip plane
+	if (clipPlane.a > 1.0)
+			return;
+	hasClip = true;
+	// quick exit: empty range
+	if ((sampleStartEnd.y - sampleStartEnd.x) <= CSR_EPS)
+			return;
+	// Which side does the ray start on? (plane eqn: dot(n, p-0.5) + a = 0)
+	float sampleSide = dot(clipPlane.xyz, rayStart.xyz - 0.5) + clipPlane.a;
+	bool startsFront = (sampleSide < 0.0);
+	float dis = - 1.0;
+	// plane normal dot ray direction
+	float cdot = dot(dir, clipPlane.xyz);
+	// avoid division by 0 for near-parallel plne
+	if (abs(cdot) >= CSR_EPS)
+		dis = (-clipPlane.a - dot(clipPlane.xyz, rayStart.xyz - 0.5)) / cdot;
+	if (dis < 0.0 || dis > sampleStartEnd.y + CSR_EPS) {
+			if (startsFront)
+				sampleStartEnd = vec2(0.0, 0.0);
+			return;
+	}
+	bool frontface = (cdot > 0.0);
+	if (frontface)
+		sampleStartEnd.x = max(sampleStartEnd.x, dis);
+	else
+		sampleStartEnd.y = min(sampleStartEnd.y, dis);
+	// if nothing remains, mark empty
+	if (sampleStartEnd.y - sampleStartEnd.x <= CSR_EPS)
+		sampleStartEnd = vec2(0.0, 0.0);
+}
+
+bool skipSample (float pos, vec2 sampleRange) {
+	return (pos < sampleRange.x || pos > sampleRange.y);
+}
+
+float frac2ndc(vec3 frac) {
+//https://stackoverflow.com/questions/7777913/how-to-render-depth-linearly-in-modern-opengl-with-gl-fragcoord-z-in-fragment-sh
+	vec4 pos = vec4(frac.xyz, 1.0); //fraction
+	vec4 dim = vec4(vec3(textureSize(volume, 0)), 1.0);
+	pos = pos * dim;
+	vec4 shim = vec4(-0.5, -0.5, -0.5, 0.0);
+	pos += shim;
+	vec4 mm = transpose(matRAS) * pos;
+	float z_ndc = (mvpMtx * vec4(mm.xyz, 1.0)).z;
+	return (z_ndc + 1.0) / 2.0;
+}`+vu,xu=`void main() {
+	if (fColor.x > 2.0) {
+		fColor = vec4(1.0, 0.0, 0.0, 0.5);
+		return;
+	}
+	fColor = vec4(0.0,0.0,0.0,0.0);
+	vec4 clipPlaneColorX = clipPlaneColor;
+	//if (clipPlaneColor.a < 0.0)
+	//	clipPlaneColorX.a = - 1.0;
+	bool isColorPlaneInVolume = false;
+	if (clipPlaneColorX.a < 0.0) {
+		isColorPlaneInVolume = true;
+		clipPlaneColorX.a = 0.0;
+	}
+	//fColor = vec4(vColor.rgb, 1.0); return;
+	vec3 start = vColor;
+	gl_FragDepth = 1.0;
+	vec3 backPosition = GetBackPosition(start);
+	// fColor = vec4(backPosition, 1.0); return;
+	vec3 dir = normalize(backPosition - start);
+	//clipVolumeStart(start, backPosition);
+	dir = normalize(dir);
+	float len = length(backPosition - start);
+	float lenVox = length((texVox * start) - (texVox * backPosition));
+	if ((lenVox < 0.5) || (len > 3.0)) { //length limit for parallel rays
+		return;
+	}
+	float sliceSize = len / lenVox; //e.g. if ray length is 1.0 and traverses 50 voxels, each voxel is 0.02 in unit cube
+	float stepSize = sliceSize; //quality: larger step is faster traversal, but fewer samples
+	float opacityCorrection = stepSize/sliceSize;
+	vec4 deltaDir = vec4(dir.xyz * stepSize, stepSize);
+	vec4 samplePos = vec4(start.xyz, 0.0); //ray position
+
+	vec2 sampleRange = vec2(0.0, len);
+	bool hasClip = false;
+	for (int i = 0; i < MAX_CLIP_PLANES; i++)
+		clipSampleRange(dir, samplePos, clipPlanes[i], sampleRange, hasClip);
+	bool isClip = (sampleRange.x > 0.0) || ((sampleRange.y < len) && (sampleRange.y > 0.0));
+	float stepSizeFast = sliceSize * 1.9;
+	vec4 deltaDirFast = vec4(dir.xyz * stepSizeFast, stepSizeFast);
+	if ((isClipCutaway) && (sampleRange.x <= 0.0) && (sampleRange.y >= len)) {
+		//completely clipped, but ray does not intersect plane
+		if (hasClip)
+			samplePos.a = len + 1.0;
+		else
+			sampleRange = vec2(0.0, 0.0);
+	}
+	if ((!isClipCutaway) && (sampleRange.x >= sampleRange.y))
+		samplePos.a = len + 1.0;
+	while (samplePos.a <= len) {
+		if (skipSample(samplePos.a, sampleRange) ^^ isClipCutaway) {
+			samplePos += deltaDirFast;
+			continue;
+		}
+		float val = texture(volume, samplePos.xyz).a;
+		if (val > 0.01)
+			break;
+		samplePos += deltaDirFast; //advance ray position
+	}
+	float drawOpacityA = renderDrawAmbientOcclusionXY.y;
+	if ((samplePos.a >= len) && (((overlays < 1.0) && (drawOpacityA <= 0.0) ) || (backgroundMasksOverlays > 0)))  {
+		if (isClip)
+			fColor += clipPlaneColorX;
+		return;
+	}
+	fColor = vec4(1.0, 1.0, 1.0, 1.0);
+	//gl_FragDepth = frac2ndc(samplePos.xyz); //crude due to fast pass resolution
+	if (samplePos.a > deltaDirFast.a )
+		samplePos -= deltaDirFast;
+	//end: fast pass
+	vec4 colAcc = vec4(0.0,0.0,0.0,0.0);
+	vec4 firstHit = vec4(0.0,0.0,0.0,2.0 * len);
+	const float earlyTermination = 0.95;
+	float backNearest = len; //assume no hit
+	float ran = fract(sin(gl_FragCoord.x * 12.9898 + gl_FragCoord.y * 78.233) * 43758.5453);
+	// clip planes create steep gradients: reduce aliasing with more jitter
+	if (isClip)
+		samplePos += deltaDir * ran * 1.41; //jitter ray
+	else
+		samplePos += deltaDir * ran; //jitter ray
+`,Jl=`
+	if (firstHit.a < len) {
+		gl_FragDepth = frac2ndc(firstHit.xyz);
+		vec4 paqdSample = texture(paqd, samplePos.xyz);
+		if (paqdSample.a > 0.0) {
+			//colAcc.rgb = paqdSample.rgb;
+			float a = max(abs(paqdUniforms[2]), abs(paqdUniforms[3]));
+			colAcc.rgb = mix(colAcc.rgb, paqdSample.rgb, 0.5 * paqdSample.a * a);
+		}
+		if (isClip) {
+			//shade voxels with clip color
+			if (clipPlaneColor.a < 0.0) {
+					float thresh = 4.0 * sliceSize;
+					float firstHit1 = firstHit.a + deltaDir.a;
+				if (isClipCutaway) {
+					float min1 = abs(firstHit1 - sampleRange.y);
+					float dx = samplePos.a - firstHit1;
+					if (min1 < thresh)
+						colAcc.rgb = mix(colAcc.rgb, clipPlaneColorX.rgb, abs(clipPlaneColor.a));
+					else if (( colAcc.a > earlyTermination ) && (dx > thresh)) {
+						min1 = abs(firstHit1 - sampleRange.x);
+						if (min1 < (thresh * 0.5)) {
+							colAcc.rgb = mix(colAcc.rgb , clipPlaneColorX.rgb, abs(clipPlaneColor.a)*0.5);
+						}
+							
+					}
+				} else {
+					if (abs(firstHit1 - sampleRange.x) < thresh)
+						colAcc.rgb = mix(colAcc.rgb, clipPlaneColorX.rgb, abs(clipPlaneColor.a));
+				} // clipPlaneColor.a < 0.0
+			}
+			//ambient occlusion: make creases dark
+			float min1 = 1000.0;
+			float min2 = 1000.0;
+			// find smallest and second-smallest distances
+			vec4 firstHit1 = firstHit - deltaDir;
+			for (int i = 0; i < MAX_CLIP_PLANES; i++) {
+				float d = distance2Plane(firstHit1, clipPlanes[i]);
+				if (d < min1) {
+						min2 = min1;
+						min1 = d;
+				} else if (d < min2) {
+						min2 = d;
+				}
+			}
+			float thresh = 1.2 * sliceSize;
+			if ((isClipCutaway) && (min2 < thresh) && (sampleRange.x > 0.0)) {
+				if ((abs(sampleRange.x - firstHit.a) > ( 2.0 * thresh)) && ((abs(sampleRange.y - firstHit.a) > (2.0 * thresh))))
+					min2 = thresh; 
+			}
+			// if second is 0 -> factor 0 (black), if second >= sliceSize -> factor 1 (unchanged)
+			const float aoFrac = 0.5;
+			float factor = (1.0 - aoFrac) + aoFrac * clamp(min2 / thresh, 0.0, 1.0);
+			// linear darkening: multiply color by factor (or use mix(vec3(0), colAcc.rgb, factor))
+			colAcc.rgb *= factor;
+		}
+	}
+	colAcc.a = (colAcc.a / earlyTermination) * backOpacity;
+	fColor = colAcc;
+	float renderDrawAmbientOcclusionX = renderDrawAmbientOcclusionXY.x;
+	float drawOpacity = renderDrawAmbientOcclusionXY.y;
+	if ((overlays < 1.0) && (drawOpacity <= 0.0))
+		return;
+	//overlay pass
+	samplePos = vec4(start.xyz, 0.0); //ray position
+	//start: OPTIONAL fast pass: rapid traversal until first hit
+	stepSizeFast = sliceSize * 1.0;
+	deltaDirFast = vec4(dir.xyz * stepSizeFast, stepSizeFast);
+	while (samplePos.a <= len) {
+		float val = texture(overlay, samplePos.xyz).a;
+		if (drawOpacity > 0.0)
+			val = max(val, texture(drawing, samplePos.xyz).r);
+		if (val > 0.001)
+			break;
+		samplePos += deltaDirFast; //advance ray position
+	}
+	if (samplePos.a >= len) {
+		if (isClip && (fColor.a == 0.0))
+				fColor += clipPlaneColorX;
+			return;
+	}
+	samplePos -= deltaDirFast;
+	if (samplePos.a < 0.0)
+		vec4 samplePos = vec4(start.xyz, 0.0); //ray position
+	//end: fast pass
+	float overFarthest = len;
+	colAcc = vec4(0.0, 0.0, 0.0, 0.0);
+
+	samplePos += deltaDir * ran; //jitter ray
+	vec4 overFirstHit = vec4(0.0,0.0,0.0,2.0 * len);
+	if (backgroundMasksOverlays > 0)
+		samplePos = firstHit;
+	bool firstDraw = true;
+	while (samplePos.a <= len) {
+		vec4 colorSample = texture(overlay, samplePos.xyz);
+		if ((colorSample.a < 0.01) && (drawOpacity > 0.0)) {
+			float val = texture(drawing, samplePos.xyz).r;
+			vec4 draw = drawColor(val, drawOpacity);
+			if ((draw.a > 0.0) && (firstDraw)) {
+				firstDraw = false;
+				float sum = 0.0;
+				const float mn = 1.0 / 256.0;
+				const float sampleRadius = 1.1;
+				float dx = sliceSize * sampleRadius;
+				vec3 center = samplePos.xyz;
+				//six neighbors that share a face
+				sum += min(texture(drawing, center.xyz + cross(vec3(0.0,0.0,+dx), dir)).r, mn);
+				sum += min(texture(drawing, center.xyz + cross(vec3(0.0,0.0,-dx), dir)).r, mn);
+				sum += min(texture(drawing, center.xyz + cross(vec3(0.0,+dx,0.0), dir)).r, mn);
+				sum += min(texture(drawing, center.xyz + cross(vec3(0.0,-dx,0.0), dir)).r, mn);
+				sum += min(texture(drawing, center.xyz + cross(vec3(+dx,0.0,0.0), dir)).r, mn);
+				sum += min(texture(drawing, center.xyz + cross(vec3(-dx,0.0,0.0), dir)).r, mn);
+				//float proportion = (sum / mn) / 6.0;
+				
+				//12 neighbors that share an edge
+				dx = sliceSize * sampleRadius * sqrt(2.0) * 0.5;
+				sum += min(texture(drawing, center.xyz + cross(vec3(0.0,+dx,+dx), dir)).r, mn);
+				sum += min(texture(drawing, center.xyz + cross(vec3(+dx,0.0,+dx), dir)).r, mn);
+				sum += min(texture(drawing, center.xyz + cross(vec3(+dx,+dx,0.0), dir)).r, mn);
+				sum += min(texture(drawing, center.xyz + cross(vec3(0.0,-dx,-dx), dir)).r, mn);
+				sum += min(texture(drawing, center.xyz + cross(vec3(-dx,0.0,-dx), dir)).r, mn);
+				sum += min(texture(drawing, center.xyz + cross(vec3(-dx,-dx,0.0), dir)).r, mn);
+
+				sum += min(texture(drawing, center.xyz + cross(vec3(0.0,+dx,-dx), dir)).r, mn);
+				sum += min(texture(drawing, center.xyz + cross(vec3(+dx,0.0,-dx), dir)).r, mn);
+				sum += min(texture(drawing, center.xyz + cross(vec3(+dx,-dx,0.0), dir)).r, mn);
+				
+				sum += min(texture(drawing, center.xyz + cross(vec3(0.0,-dx,+dx), dir)).r, mn);
+				sum += min(texture(drawing, center.xyz + cross(vec3(-dx,0.0,+dx), dir)).r, mn);
+				sum += min(texture(drawing, center.xyz + cross(vec3(-dx,+dx,0.0), dir)).r, mn);
+				float proportion = (sum / mn) / 18.0; //proportion of six neighbors is non-zero
+				
+				//a high proportion of hits means crevice
+				//since the AO term adds shadows that darken most voxels, it will result in dark surfaces
+				//the term brighten adds a little illumination to balance this
+				// without brighten, only the most extreme ridges will not be darker
+				const float brighten = 1.2;
+				vec3 ao = draw.rgb * (1.0 - proportion) * brighten;
+				draw.rgb = mix (draw.rgb, ao , renderDrawAmbientOcclusionX);
+			}
+			colorSample = draw;
+		}
+		samplePos += deltaDir; //advance ray position
+		if (colorSample.a >= 0.01) {
+			if (overFirstHit.a > len)
+				overFirstHit = samplePos;
+			colorSample.a *= renderOverlayBlend;
+			colorSample.a = 1.0-pow((1.0 - colorSample.a), opacityCorrection);
+			colorSample.rgb *= colorSample.a;
+			colAcc= (1.0 - colAcc.a) * colorSample + colAcc;
+			overFarthest = samplePos.a;
+			if ( colAcc.a > earlyTermination )
+				break;
+		}
+	}
+	//if (samplePos.a >= len) {
+	if (colAcc.a <= 0.0) {
+		if (isClip && (fColor.a == 0.0))
+			fColor += clipPlaneColorX;
+		return;
+	}
+	if (overFirstHit.a < firstHit.a)
+		gl_FragDepth = frac2ndc(overFirstHit.xyz);
+	float overMix = colAcc.a;
+	float overlayDepth = 0.3;
+	if (fColor.a <= 0.0)
+		overMix = 1.0;
+	else if (((overFarthest) > backNearest)) {
+		float dx = (overFarthest - backNearest)/1.73;
+		dx = fColor.a * pow(dx, overlayDepth);
+		overMix *= 1.0 - dx;
+	}
+	fColor.rgb = mix(fColor.rgb, colAcc.rgb, overMix);
+	fColor.a = max(fColor.a, colAcc.a);
+}`,I4=`#version 300 es
+#line 215
+#define MAX_CLIP_PLANES 6
+precision highp int;
+precision highp float;
+uniform vec3 rayDir;
+uniform vec3 texVox;
+uniform int backgroundMasksOverlays;
+uniform vec3 volScale;
+uniform vec4 clipPlane;
+uniform vec4 clipPlanes[MAX_CLIP_PLANES];
+uniform highp sampler3D volume, overlay;
+uniform highp sampler3D paqd;
+uniform vec4 paqdUniforms;
+uniform float overlays;
+uniform float backOpacity;
+uniform mat4 mvpMtx;
+uniform mat4 matRAS;
+uniform vec4 clipPlaneColor;
+uniform float renderOverlayBlend;
+uniform highp sampler3D drawing;
+uniform highp sampler2D colormap;
+uniform vec2 renderDrawAmbientOcclusionXY;
+in vec3 vColor;
+out vec4 fColor;
+`+ar+`
+	void main() {
+	vec3 start = vColor;
+	gl_FragDepth = 1.0;
+	vec3 backPosition = GetBackPosition(start);
+	vec3 dir = normalize(backPosition - start);
+	//clipVolumeStart(start, backPosition);
+	float len = length(backPosition - start);
+	float lenVox = length((texVox * start) - (texVox * backPosition));
+	if ((lenVox < 0.5) || (len > 3.0)) { //length limit for parallel rays
+		fColor = vec4(0.0,0.0,0.0,0.0);
+		return;
+	}
+	float sliceSize = len / lenVox; //e.g. if ray length is 1.0 and traverses 50 voxels, each voxel is 0.02 in unit cube
+	float stepSize = sliceSize; //quality: larger step is faster traversal, but fewer samples
+	float opacityCorrection = stepSize/sliceSize;
+	vec4 deltaDir = vec4(dir.xyz * stepSize, stepSize);
+	vec4 samplePos = vec4(start.xyz, 0.0); //ray position
+	vec4 colAcc = vec4(0.0,0.0,0.0,0.0);
+	vec4 firstHit = vec4(0.0,0.0,0.0,2.0 * len);
+	const float earlyTermination = 0.95;
+	float backNearest = len; //assume no hit
+	float dis = len;
+	//check if axial plane is closest
+	vec4 aClip = vec4(0.0, 0.0, 1.0, (1.0- clipPlane.z) - 0.5);
+	float adis = (-aClip.a - dot(aClip.xyz, samplePos.xyz-0.5)) / dot(dir,aClip.xyz);
+	if (adis > 0.0)
+		dis = min(adis, dis);
+	//check of coronal plane is closest
+	vec4 cClip = vec4(0.0, 1.0, 0.0, (1.0- clipPlane.y) - 0.5);
+	float cdis = (-cClip.a - dot(cClip.xyz, samplePos.xyz-0.5)) / dot(dir,cClip.xyz);
+	if (cdis > 0.0)
+		dis = min(cdis, dis);
+	//check if coronal slice is closest
+	vec4 sClip = vec4(1.0, 0.0, 0.0, (1.0- clipPlane.x) - 0.5);
+	float sdis = (-sClip.a - dot(sClip.xyz, samplePos.xyz-0.5)) / dot(dir,sClip.xyz);
+	if (sdis > 0.0)
+		dis = min(sdis, dis);
+	if ((dis > 0.0) && (dis < len)) {
+		samplePos = vec4(samplePos.xyz+dir * dis, dis);
+		colAcc = texture(volume, samplePos.xyz);
+		colAcc.a = earlyTermination;
+		firstHit = samplePos;
+		backNearest = min(backNearest, samplePos.a);
+	}
+	//the following are only used by overlays
+	vec4 clipPlaneColorX = clipPlaneColor;
+	bool isColorPlaneInVolume = false;
+	bool isClip = false;
+	bool isClipCutaway = false;
+	vec2 sampleRange;
+	// vec4 clipPos = applyClip(dir, samplePos, len, isClip);
+	float stepSizeFast = sliceSize * 1.9;
+	vec4 deltaDirFast = vec4(dir.xyz * stepSizeFast, stepSizeFast);
+	if (samplePos.a < 0.0)
+		vec4 samplePos = vec4(start.xyz, 0.0); //ray position
+	float ran = fract(sin(gl_FragCoord.x * 12.9898 + gl_FragCoord.y * 78.233) * 43758.5453);
+	samplePos += deltaDir * ran; //jitter ray
+`+Jl,R4=`#version 300 es
+#line 215
+#define MAX_CLIP_PLANES 6
+precision highp int;
+precision highp float;
+uniform vec3 rayDir;
+uniform vec3 texVox;
+uniform int backgroundMasksOverlays;
+uniform vec3 volScale;
+uniform vec4 clipPlane;
+uniform vec4 clipPlanes[MAX_CLIP_PLANES];
+uniform bool isClipCutaway;
+uniform highp sampler3D volume, overlay;
+uniform highp sampler3D paqd;
+uniform vec4 paqdUniforms;
+uniform float overlays;
+uniform float backOpacity;
+uniform mat4 mvpMtx;
+uniform mat4 matRAS;
+uniform vec4 clipPlaneColor;
+uniform float renderOverlayBlend;
+uniform highp sampler3D drawing;
+uniform highp sampler2D colormap;
+uniform vec2 renderDrawAmbientOcclusionXY;
+in vec3 vColor;
+out vec4 fColor;
+`+ar+xu+`while (samplePos.a <= len) {
+		if (skipSample(samplePos.a, sampleRange) ^^ isClipCutaway) {
+			samplePos += deltaDirFast;
+			continue;
+		}
+		vec4 colorSample = texture(volume, samplePos.xyz);
+		samplePos += deltaDir; //advance ray position
+		if (colorSample.a >= 0.01) {
+			if (firstHit.a > len)
+				firstHit = samplePos;
+			// backNearest = min(backNearest, samplePos.a);
+			colorSample.a = 1.0-pow((1.0 - colorSample.a), opacityCorrection);
+			colorSample.rgb *= colorSample.a;
+			colAcc= (1.0 - colAcc.a) * colorSample + colAcc;
+			if ( colAcc.a > earlyTermination )
+				break;
+		}
+	}
+	if (firstHit.a < len)
+		backNearest = firstHit.a;
+`+Jl,$a=192,lm=`#version 300 es
+#line 215
+#define MAX_CLIP_PLANES 6
+precision highp int;
+precision highp float;
+uniform vec3 rayDir;
+uniform vec3 texVox;
+uniform int backgroundMasksOverlays;
+uniform vec3 volScale;
+uniform vec4 clipPlane;
+uniform vec4 clipPlanes[MAX_CLIP_PLANES];
+uniform bool isClipCutaway;
+uniform highp sampler3D volume, overlay;
+uniform highp sampler3D paqd;
+uniform vec4 paqdUniforms;
+uniform float overlays;
+uniform float backOpacity;
+uniform mat4 mvpMtx;
+uniform mat4 normMtx;
+uniform mat4 matRAS;
+uniform vec4 clipPlaneColor;
+uniform float renderOverlayBlend;
+uniform highp sampler3D drawing, gradient;
+uniform highp sampler2D colormap;
+uniform highp sampler2D matCap;
+uniform vec2 renderDrawAmbientOcclusionXY;
+uniform float gradientAmount;
+uniform float silhouettePower;
+uniform float gradientOpacity[${$a}];
+in vec3 vColor;
+out vec4 fColor;
+`,N4=lm+ar+xu+`
+	float startPos = samplePos.a;
+	float clipCloseThresh = 5.0 * deltaDir.a;
+	float clipClose = sampleRange.x;
+	if (isClipCutaway)
+		clipClose = sampleRange.y;
+	if (!isClip)
+		clipClose = -1.0;
+	float brighten = 2.0; //modulating makes average intensity darker 0.5 * 0.5 = 0.25
+	//vec4 prevGrad = vec4(0.0);
+	float silhouetteThreshold = 1.0 - silhouettePower;
+	while (samplePos.a <= len) {
+		if (skipSample(samplePos.a, sampleRange) ^^ isClipCutaway) {
+			samplePos += deltaDirFast;
+			continue;
+		}
+		vec4 colorSample = texture(volume, samplePos.xyz);
+		if (colorSample.a >= 0.0) {
+			vec4 grad = texture(gradient, samplePos.xyz);
+			grad.rgb = normalize(grad.rgb*2.0 - 1.0);
+			//if (grad.a < prevGrad.a)
+			//	grad.rgb = prevGrad.rgb;
+			//prevGrad = grad;
+			vec3 n = mat3(normMtx) * grad.rgb;
+			n.y = - n.y;
+			vec4 mc = vec4(texture(matCap, n.xy * 0.5 + 0.5).rgb, 1.0) * brighten;
+			mc = mix(vec4(1.0), mc, gradientAmount);
+			if (abs(samplePos.a - clipClose) > clipCloseThresh)
+				colorSample.rgb *= mc.rgb;
+			if (firstHit.a > len)
+				firstHit = samplePos;
+			backNearest = min(backNearest, samplePos.a);
+			colorSample.a = 1.0-pow((1.0 - colorSample.a), opacityCorrection);
+			int gradIdx = int(grad.a * ${$a}.0);
+			colorSample.a *= gradientOpacity[gradIdx];
+			float lightNormDot = dot(grad.rgb, rayDir);
+			// n.b. "lightNormDor" is cosTheta, "silhouettePower" is Fresnel effect exponent
+ 			colorSample.a *= pow(1.0 - abs(lightNormDot), silhouettePower);
+ 			float viewAlign = abs(lightNormDot); // 0 = perpendicular, 1 = aligned
+ 			// linearly map silhouettePower (0..1) to a threshold range, e.g., [1.0, 0.0]
+ 			// Cull voxels that are too aligned with the view direction
+ 			if (viewAlign > silhouetteThreshold)
+ 				colorSample.a = 0.0;
+			colorSample.rgb *= colorSample.a;
+			colAcc= (1.0 - colAcc.a) * colorSample + colAcc;
+			if ( colAcc.a > earlyTermination )
+				break;
+		}
+		samplePos += deltaDir; //advance ray position
+	}
+`+Jl,V4=lm+ar+xu+`
+	float startPos = samplePos.a;
+	//float clipClose = clipPos.a + 3.0 * deltaDir.a; //do not apply gradients near clip plane
+	float brighten = 2.0; //modulating makes average intensity darker 0.5 * 0.5 = 0.25
+	//vec4 prevGrad = vec4(0.0);
+	while (samplePos.a <= len) {
+		vec4 colorSample = texture(volume, samplePos.xyz);
+		if (colorSample.a >= 0.0) {
+			vec4 grad = texture(gradient, samplePos.xyz);
+			colorSample.rgb = abs(normalize(grad.rgb*2.0 - 1.0));
+			if (firstHit.a > len)
+				firstHit = samplePos;
+			backNearest = min(backNearest, samplePos.a);
+			colorSample.a = 1.0-pow((1.0 - colorSample.a), opacityCorrection);
+			colorSample.rgb *= colorSample.a;
+			colAcc= (1.0 - colAcc.a) * colorSample + colAcc;
+			if ( colAcc.a > earlyTermination )
+				break;
+		}
+		samplePos += deltaDir; //advance ray position
+	}
+`+Jl,Bl=`#version 300 es
+#line 392
+layout(location=0) in vec3 pos;
+uniform int axCorSag;
+uniform mat4 mvpMtx;
+uniform mat4 frac2mm;
+uniform float slice;
+out vec3 texPos;
+void main(void) {
+	texPos = vec3(pos.x, pos.y, slice);
+	if (axCorSag > 1)
+		texPos = vec3(slice, pos.x, pos.y);
+	else if (axCorSag > 0)
+		texPos = vec3(pos.x, slice, pos.y);
+	vec4 mm = frac2mm * vec4(texPos, 1.0);
+	gl_Position = mvpMtx * mm;
+}`,om=`#version 300 es
+#line 411
+precision highp int;
+precision highp float;
+uniform highp sampler3D volume, overlay;
+uniform highp sampler3D paqd;
+uniform vec4 paqdUniforms;
+uniform int backgroundMasksOverlays;
+uniform float overlayOutlineWidth;
+uniform float overlayAlphaShader;
+uniform int axCorSag;
+uniform float overlays;
+uniform float opacity;
+uniform float drawOpacity;
+uniform float drawRimOpacity;
+uniform bool isAlphaClipDark;
+uniform highp sampler3D drawing;
+uniform highp sampler2D colormap;
+in vec3 texPos;
+out vec4 color;
+`+vu+`
+vec4 blendRGBA(vec4 foreground, vec4 background) {
+  float alphaOut = foreground.a + background.a * (1.0 - foreground.a);
+  vec3 colorOut = (foreground.rgb * foreground.a + background.rgb * background.a * (1.0 - foreground.a)) / alphaOut;
+  return vec4(colorOut, alphaOut);
+}
+float paqdEaseAlpha(float alpha) {
+  // t are alpha transitions
+  // <t0 -> y0
+  // t0..t1  -> mix between y0..y1
+  // t1..t2 -> mix between y1..y2
+  // >t2 -> y2
+  float t0 = paqdUniforms[0]; // 0.3;
+  float t1 = 0.5 * (paqdUniforms[0] + paqdUniforms[1]); // 0.4;
+  float t2 = paqdUniforms[1]; // 0.9;
+  float y0 = 0.0;
+  float y1 = abs(paqdUniforms[2]); // 1.0;
+  float y2 = abs(paqdUniforms[3]); //0.25;
+  if (alpha <= t0) {
+    return y0;
+  } else if (alpha <= t1) {
+    return mix(y0, y1, (alpha - t0) / (t1 - t0)); // LERP 0.0 → 1.0
+  } else if (alpha <= t2) {
+    return mix(y1, y2, (alpha - t1) / (t2 - t1)); // LERP 1.0 → 0.2
+  } else {
+    return y2;
+  }
+}
+
+void main() {
+	//color = vec4(1.0, 0.0, 1.0, 1.0);return;
+	vec4 background = texture(volume, texPos);
+	color = vec4(background.rgb, opacity);
+	if ((isAlphaClipDark) && (background.a == 0.0)) color.a = 0.0; //FSLeyes clipping range
+	vec4 ocolor = vec4(0.0);
+	float overlayAlpha = overlayAlphaShader;
+	if (overlays > 0.0) {
+		ocolor = texture(overlay, texPos);
+		//dFdx for "boxing" issue 435 has aliasing on some implementations (coarse vs fine)
+		//however, this only identifies 50% of the edges due to aliasing effects
+		// http://www.aclockworkberry.com/shader-derivative-functions/
+		// https://bgolus.medium.com/distinctive-derivative-differences-cce38d36797b
+		//if ((ocolor.a >= 1.0) && ((dFdx(ocolor.a) != 0.0) || (dFdy(ocolor.a) != 0.0)  ))
+		//	ocolor.rbg = vec3(0.0, 0.0, 0.0);
+		bool isOutlineBelowNotAboveThreshold = true;
+		if (isOutlineBelowNotAboveThreshold) {
+			if ((overlayOutlineWidth > 0.0) && (ocolor.a < 1.0)) { //check voxel neighbors for edge
+				vec3 vx = (overlayOutlineWidth ) / vec3(textureSize(overlay, 0));
+				//6 voxel neighbors that share a face
+				vec3 vxR = vec3(texPos.x+vx.x, texPos.y, texPos.z);
+				vec3 vxL = vec3(texPos.x-vx.x, texPos.y, texPos.z);
+				vec3 vxA = vec3(texPos.x, texPos.y+vx.y, texPos.z);
+				vec3 vxP = vec3(texPos.x, texPos.y-vx.y, texPos.z);
+				vec3 vxS = vec3(texPos.x, texPos.y, texPos.z+vx.z);
+				vec3 vxI = vec3(texPos.x, texPos.y, texPos.z-vx.z);
+				float a = 0.0;
+				if (axCorSag != 2) {
+					a = max(a, texture(overlay, vxR).a);
+					a = max(a, texture(overlay, vxL).a);
+				}
+				if (axCorSag != 1) {
+					a = max(a, texture(overlay, vxA).a);
+					a = max(a, texture(overlay, vxP).a);
+				}
+				if (axCorSag != 0) {
+					a = max(a, texture(overlay, vxS).a);
+					a = max(a, texture(overlay, vxI).a);
+				}
+				bool isCheckCorners = true;
+				if (isCheckCorners) {
+					//12 voxel neighbors that share an edge
+					vec3 vxRA = vec3(texPos.x+vx.x, texPos.y+vx.y, texPos.z);
+					vec3 vxLA = vec3(texPos.x-vx.x, texPos.y+vx.y, texPos.z);
+					vec3 vxRP = vec3(texPos.x+vx.x, texPos.y-vx.y, texPos.z);
+					vec3 vxLP = vec3(texPos.x-vx.x, texPos.y-vx.y, texPos.z);
+					vec3 vxRS = vec3(texPos.x+vx.x, texPos.y, texPos.z+vx.z);
+					vec3 vxLS = vec3(texPos.x-vx.x, texPos.y, texPos.z+vx.z);
+					vec3 vxRI = vec3(texPos.x+vx.x, texPos.y, texPos.z-vx.z);
+					vec3 vxLI = vec3(texPos.x-vx.x, texPos.y, texPos.z-vx.z);
+					vec3 vxAS = vec3(texPos.x, texPos.y+vx.y, texPos.z+vx.z);
+					vec3 vxPS = vec3(texPos.x, texPos.y-vx.y, texPos.z+vx.z);
+					vec3 vxAI = vec3(texPos.x, texPos.y+vx.y, texPos.z-vx.z);
+					vec3 vxPI = vec3(texPos.x, texPos.y-vx.y, texPos.z-vx.z);
+
+					if (axCorSag == 0) { //axial corners
+						a = max(a, texture(overlay, vxRA).a);
+						a = max(a, texture(overlay, vxLA).a);
+						a = max(a, texture(overlay, vxRP).a);
+						a = max(a, texture(overlay, vxLP).a);
+					}
+					if (axCorSag == 1) { //coronal corners
+						a = max(a, texture(overlay, vxRS).a);
+						a = max(a, texture(overlay, vxLS).a);
+						a = max(a, texture(overlay, vxRI).a);
+						a = max(a, texture(overlay, vxLI).a);
+					}
+					if (axCorSag == 2) { //sagittal corners
+						a = max(a, texture(overlay, vxAS).a);
+						a = max(a, texture(overlay, vxPS).a);
+						a = max(a, texture(overlay, vxAI).a);
+						a = max(a, texture(overlay, vxPI).a);
+					}
+				}
+				if (a >= 1.0) {
+					ocolor = vec4(0.0, 0.0, 0.0, 1.0);
+					overlayAlpha = 1.0;
+				}
+			}
+
+		} else {
+			if ((overlayOutlineWidth > 0.0) && (ocolor.a >= 1.0)) { //check voxel neighbors for edge
+				vec3 vx = (overlayOutlineWidth ) / vec3(textureSize(overlay, 0));
+				vec3 vxR = vec3(texPos.x+vx.x, texPos.y, texPos.z);
+				vec3 vxL = vec3(texPos.x-vx.x, texPos.y, texPos.z);
+				vec3 vxA = vec3(texPos.x, texPos.y+vx.y, texPos.z);
+				vec3 vxP = vec3(texPos.x, texPos.y-vx.y, texPos.z);
+				vec3 vxS = vec3(texPos.x, texPos.y, texPos.z+vx.z);
+				vec3 vxI = vec3(texPos.x, texPos.y, texPos.z-vx.z);
+				float a = 1.0;
+				if (axCorSag != 2) {
+					a = min(a, texture(overlay, vxR).a);
+					a = min(a, texture(overlay, vxL).a);
+				}
+				if (axCorSag != 1) {
+					a = min(a, texture(overlay, vxA).a);
+					a = min(a, texture(overlay, vxP).a);
+				}
+				if (axCorSag != 0) {
+					a = min(a, texture(overlay, vxS).a);
+					a = min(a, texture(overlay, vxI).a);
+				}
+				if (a < 1.0) {
+					ocolor = vec4(0.0, 0.0, 0.0, 1.0);
+					overlayAlpha = 1.0;
+				}
+			}
+		} //outline above threshold
+	}
+
+`,L4=`#version 300 es
+#line 411
+precision highp int;
+precision highp float;
+uniform highp sampler2D volume, overlay;
+uniform int backgroundMasksOverlays;
+uniform float overlayOutlineWidth;
+uniform float overlayAlphaShader;
+uniform int axCorSag;
+uniform float overlays;
+uniform float opacity;
+uniform float drawOpacity;
+uniform bool isAlphaClipDark;
+uniform highp sampler2D drawing;
+uniform highp sampler2D colormap;
+in vec3 texPos;
+out vec4 color;`+vu+`void main() {
+	//color = vec4(1.0, 0.0, 1.0, 1.0);return;
+	vec4 background = texture(volume, texPos.xy);
+	color = vec4(background.rgb, opacity);
+	if ((isAlphaClipDark) && (background.a == 0.0)) color.a = 0.0; //FSLeyes clipping range
+	vec4 dcolor = drawColor(texture(drawing, texPos.xy).r, drawOpacity);
+	if (dcolor.a > 0.0) {
+		color.rgb = mix(color.rgb, dcolor.rgb, dcolor.a);
+		color.a = max(drawOpacity, color.a);
+	}
+}`,cm=`	ocolor.a *= overlayAlpha;
+	float drawV = texture(drawing, texPos).r;
+	vec4 dcolor = drawColor(drawV, drawOpacity);
+	if (dcolor.a > 0.0) {
+		if (drawRimOpacity >= 0.0) {
+			vec3 vx = 1.0 / vec3(textureSize(drawing, 0));
+			//6 voxel neighbors that share a face
+			vec3 offsetX = dFdx(texPos); // left-right spacing
+			vec3 offsetY = dFdy(texPos); // up-down spacing
+			float L = texture(drawing, texPos - offsetX).r;
+			float R = texture(drawing, texPos + offsetX).r;
+			float T = texture(drawing, texPos - offsetY).r;
+			float B = texture(drawing, texPos + offsetY).r;
+			if (L != drawV || R != drawV || T != drawV || B != drawV)
+				dcolor.a = drawRimOpacity;
+		}
+		color.rgb = mix(color.rgb, dcolor.rgb, dcolor.a);
+		color.a = max(drawOpacity, color.a);
+	}
+	vec4 pcolor = texture(paqd, texPos);
+	if (pcolor.a > 0.0) {
+		pcolor.a = paqdEaseAlpha(pcolor.a);
+		if (pcolor.a > 0.0) {
+			if (paqdUniforms[3] < 0.0)
+				ocolor = blendRGBA(pcolor, ocolor);
+			else
+				ocolor = blendRGBA(ocolor, pcolor);
+		}
+	}
+	if ((backgroundMasksOverlays > 0) && (background.a == 0.0))
+		return;
+	float a = color.a + ocolor.a * (1.0 - color.a); // premultiplied alpha
+	if (a == 0.0) return;
+	color.rgb = mix(color.rgb, ocolor.rgb, ocolor.a / a);
+	color.a = a;
+}`,O4=om+cm,z4=om+`	if (ocolor.a > 0.0) {
+		//https://gamedev.stackexchange.com/questions/102889/is-it-possible-to-convert-vec4-to-int-in-glsl-using-opengl-es
+		uint alpha = uint(ocolor.a * 255.0);
+		vec3 xyzFlip = vec3(float((uint(1) & alpha) > uint(0)), float((uint(2) & alpha) > uint(0)), float((uint(4) & alpha) > uint(0)));
+		//convert from 0 and 1 to -1 and 1
+		xyzFlip = (xyzFlip * 2.0) - 1.0;
+		//https://math.stackexchange.com/questions/1905533/find-perpendicular-distance-from-point-to-line-in-3d
+		//v1 principle direction of tensor for this voxel
+		vec3 v1 = ocolor.rgb;
+		//flips encode polarity to convert from 0..1 to -1..1 (27 bits vs 24 bit precision)
+		v1 = normalize( v1 * xyzFlip);
+		vec3 vxl = fract(texPos * vec3(textureSize(volume, 0))) - 0.5;
+		//vxl coordinates now -0.5..+0.5 so 0,0,0 is origin
+		vxl.x = -vxl.x;
+		float t = dot(vxl,v1);
+		vec3 P = t * v1;
+		float dx = length(P-vxl);
+		ocolor.a = 1.0 - smoothstep(0.2,0.25, dx);
+		//if modulation was applied, use that to scale alpha not color:
+		ocolor.a *= length(ocolor.rgb);
+		ocolor.rgb = normalize(ocolor.rgb);
+		//compute distance one half voxel closer to viewer:
+		float pan = 0.5;
+		if (axCorSag == 0)
+			vxl.z -= pan;
+		if (axCorSag == 1)
+			vxl.y -= pan;
+		if (axCorSag == 2)
+			vxl.x += pan;
+		t = dot(vxl,v1);
+		P = t * v1;
+		float dx2 = length(P-vxl);
+		ocolor.rgb += (dx2-dx-(0.5 * pan)) * 1.0;
+	}
+`+cm,Nh=`#version 300 es
+#line 480
+precision highp int;
+precision highp float;
+uniform vec4 lineColor;
+out vec4 color;
+void main() {
+	color = lineColor;
+}`,P4=`#version 300 es
+#line 723
+precision highp int;
+precision highp float;
+
+uniform vec4 lineColor;
+uniform vec4 leftTopWidthHeight;
+uniform float thickness; // line thickness in pixels
+uniform vec2 canvasWidthHeight;
+
+out vec4 color;
+
+void main() {
+    // fragment position in screen coordinates
+    vec2 fragCoord = gl_FragCoord.xy;
+
+    // canvas height
+    float canvasHeight = canvasWidthHeight.y;
+
+    // 'top' and 'bottom' to match gl_FragCoord.y coordinate system
+    float top = canvasHeight - leftTopWidthHeight.y;
+    float bottom = top - leftTopWidthHeight.w;
+
+    // left and right edges
+    float left = leftTopWidthHeight.x;
+    float right = left + leftTopWidthHeight.z;
+
+    bool withinLeft = fragCoord.x >= left && fragCoord.x <= left + thickness;
+    bool withinRight = fragCoord.x <= right && fragCoord.x >= right - thickness;
+    bool withinTop = fragCoord.y <= top && fragCoord.y >= top - thickness;
+    bool withinBottom = fragCoord.y >= bottom && fragCoord.y <= bottom + thickness;
+
+    bool isOutline = withinLeft || withinRight || withinTop || withinBottom;
+
+    if (isOutline) {
+        color = lineColor;
+    } else {
+        discard; 
+    }
+}`,k4=`#version 300 es
+#line 490
+layout(location=0) in vec3 pos;
+uniform vec2 canvasWidthHeight;
+uniform vec4 leftTopWidthHeight;
+out vec2 vColor;
+void main(void) {
+	//convert pixel x,y space 1..canvasWidth,1..canvasHeight to WebGL 1..-1,-1..1
+	vec2 frac;
+	frac.x = (leftTopWidthHeight.x + (pos.x * leftTopWidthHeight.z)) / canvasWidthHeight.x; //0..1
+	frac.y = 1.0 - ((leftTopWidthHeight.y + ((1.0 - pos.y) * leftTopWidthHeight.w)) / canvasWidthHeight.y); //1..0
+	frac = (frac * 2.0) - 1.0;
+	gl_Position = vec4(frac, 0.0, 1.0);
+	vColor = pos.xy;
+}`,Y4=`#version 300 es
+#line 506
+precision highp int;
+precision highp float;
+uniform highp sampler2D colormap;
+uniform float layer;
+in vec2 vColor;
+out vec4 color;
+void main() {
+	float nlayer = float(textureSize(colormap, 0).y);
+	float fmap = (0.5 + layer) / nlayer;
+	color = vec4(texture(colormap, vec2(vColor.x, fmap)).rgb, 1.0);
+}`,o2=`#version 300 es
+#line 520
+layout(location=0) in vec3 pos;
+uniform vec2 canvasWidthHeight;
+uniform vec4 leftTopWidthHeight;
+void main(void) {
+	//convert pixel x,y space 1..canvasWidth,1..canvasHeight to WebGL 1..-1,-1..1
+	vec2 frac;
+	frac.x = (leftTopWidthHeight.x + (pos.x * leftTopWidthHeight.z)) / canvasWidthHeight.x; //0..1
+	frac.y = 1.0 - ((leftTopWidthHeight.y + ((1.0 - pos.y) * leftTopWidthHeight.w)) / canvasWidthHeight.y); //1..0
+	frac = (frac * 2.0) - 1.0;
+	gl_Position = vec4(frac, 0.0, 1.0);
+}`,G4=`#version 300 es
+#line 534
+layout(location=0) in vec3 pos;
+uniform vec2 canvasWidthHeight;
+uniform float thickness;
+uniform vec4 startXYendXY;
+void main(void) {
+	vec2 posXY = mix(startXYendXY.xy, startXYendXY.zw, pos.x);
+	vec2 dir = normalize(startXYendXY.xy - startXYendXY.zw);
+	posXY += vec2(-dir.y, dir.x) * thickness * (pos.y - 0.5);
+	posXY.x = (posXY.x) / canvasWidthHeight.x; //0..1
+	posXY.y = 1.0 - (posXY.y / canvasWidthHeight.y); //1..0
+	gl_Position = vec4((posXY * 2.0) - 1.0, 0.0, 1.0);
+}`,H4=`#version 300 es
+#line 534
+layout(location=0) in vec3 pos;
+uniform vec2 canvasWidthHeight;
+uniform float thickness;
+uniform vec2 startXY;
+uniform vec3 endXYZ; // transformed XYZ point
+void main(void) {	
+	vec2 posXY = mix(startXY.xy, endXYZ.xy, pos.x);
+	vec2 startDiff = endXYZ.xy - startXY.xy;
+	float startDistance = length(startDiff);
+	vec2 diff = endXYZ.xy - posXY;
+	float currentDistance = length(diff);
+	vec2 dir = normalize(startXY.xy - endXYZ.xy);
+	posXY += vec2(-dir.y, dir.x) * thickness * (pos.y - 0.5);
+	posXY.x = (posXY.x) / canvasWidthHeight.x; //0..1
+	posXY.y = 1.0 - (posXY.y / canvasWidthHeight.y); //1..0	
+	float z = endXYZ.z * ( 1.0 - abs(currentDistance/startDistance)); 
+	gl_Position = vec4((posXY * 2.0) - 1.0, z, 1.0);
+}`,q4=`#version 300 es
+#line 549
+layout(location=0) in vec3 pos;
+uniform vec2 canvasWidthHeight;
+uniform vec4 leftTopWidthHeight;
+out vec2 vUV;
+void main(void) {
+	//convert pixel x,y space 1..canvasWidth,1..canvasHeight to WebGL 1..-1,-1..1
+	vec2 frac;
+	frac.x = (leftTopWidthHeight.x + (pos.x * leftTopWidthHeight.z)) / canvasWidthHeight.x; //0..1
+	frac.y = 1.0 - ((leftTopWidthHeight.y + ((1.0 - pos.y) * leftTopWidthHeight.w)) / canvasWidthHeight.y); //1..0
+	frac = (frac * 2.0) - 1.0;
+	gl_Position = vec4(frac, 0.0, 1.0);
+	vUV = vec2(pos.x, 1.0 - pos.y);
+}`,X4=`#version 300 es
+#line 565
+precision highp int;
+precision highp float;
+uniform highp sampler2D bmpTexture;
+in vec2 vUV;
+out vec4 color;
+void main() {
+	color = texture(bmpTexture, vUV);
+}`,K4=`#version 300 es
+#line 576
+layout(location=0) in vec3 pos;
+uniform vec2 canvasWidthHeight;
+uniform vec4 leftTopWidthHeight;
+uniform vec4 uvLeftTopWidthHeight;
+out vec2 vUV;
+void main(void) {
+	//convert pixel x,y space 1..canvasWidth,1..canvasHeight to WebGL 1..-1,-1..1
+	vec2 frac;
+	frac.x = (leftTopWidthHeight.x + (pos.x * leftTopWidthHeight.z)) / canvasWidthHeight.x; //0..1
+	frac.y = 1.0 - ((leftTopWidthHeight.y + ((1.0 - pos.y) * leftTopWidthHeight.w)) / canvasWidthHeight.y); //1..0
+	frac = (frac * 2.0) - 1.0;
+	gl_Position = vec4(frac, 0.0, 1.0);
+	vUV = vec2(uvLeftTopWidthHeight.x + (pos.x * uvLeftTopWidthHeight.z), uvLeftTopWidthHeight.y  + ((1.0 - pos.y) * uvLeftTopWidthHeight.w) );
+}`,j4=`#version 300 es
+#line 593
+precision highp int;
+precision highp float;
+uniform highp sampler2D fontTexture;
+uniform vec4 fontColor;
+uniform float screenPxRange;
+in vec2 vUV;
+out vec4 color;
+float median(float r, float g, float b) {
+	return max(min(r, g), min(max(r, g), b));
+}
+void main() {
+	vec3 msd = texture(fontTexture, vUV).rgb;
+	float sd = median(msd.r, msd.g, msd.b);
+	float screenPxDistance = screenPxRange*(sd - 0.5);
+	float opacity = clamp(screenPxDistance + 0.5, 0.0, 1.0);
+	color = vec4(fontColor.rgb , fontColor.a * opacity);
+}`,Q4=`#version 300 es
+layout(location=0) in vec3 pos;
+uniform vec2 canvasWidthHeight;
+uniform vec4 leftTopWidthHeight;
+uniform vec4 uvLeftTopWidthHeight;
+out vec2 vUV;
+void main(void) {
+	//convert pixel x,y space 1..canvasWidth,1..canvasHeight to WebGL 1..-1,-1..1
+	vec2 frac;
+	frac.x = (leftTopWidthHeight.x + (pos.x * leftTopWidthHeight.z)) / canvasWidthHeight.x; //0..1
+	frac.y = 1.0 - ((leftTopWidthHeight.y + ((1.0 - pos.y) * leftTopWidthHeight.w)) / canvasWidthHeight.y); //1..0
+	frac = (frac * 2.0) - 1.0;
+	gl_Position = vec4(frac, 0.0, 1.0);
+	vUV = pos.xy;
+}`,Z4=`#version 300 es
+precision highp int;
+precision highp float;
+uniform vec4 circleColor;
+uniform float fillPercent;
+in vec2 vUV;
+out vec4 color;
+void main() {
+	/* Check if the pixel is inside the circle
+		 and color it with a gradient. Otherwise, color it 
+		 transparent   */
+	float distance = length(vUV-vec2(0.5,0.5));
+	if ( distance < 0.5 && distance >= (1.0 - fillPercent) / 2.0){
+			color = vec4(circleColor.r,circleColor.g,circleColor.b,circleColor.a) ;			
+	}else{
+			color = vec4(0.0,0.0,0.0,0.0);
+	}
+}
+`,kn=`#version 300 es
+#line 613
+precision highp int;
+precision highp float;
+in vec3 vPos;
+out vec2 TexCoord;
+void main() {
+	TexCoord = vPos.xy;
+	gl_Position = vec4( (vPos.xy-vec2(0.5,0.5)) * 2.0, 0.0, 1.0);
+}`,Il=`#version 300 es
+uniform highp usampler3D intensityVol;
+`,c2=`#version 300 es
+uniform highp isampler3D intensityVol;
+`,W4=`#version 300 es
+uniform highp sampler3D intensityVol;
+`,h2=`#line 1042
+precision highp int;
+precision highp float;
+in vec2 TexCoord;
+out vec4 FragColor;
+uniform bool isAdditiveBlend;
+uniform float coordZ;
+uniform float layer;
+uniform highp sampler2D colormap;
+uniform lowp sampler3D blend3D;
+uniform float opacity;
+uniform uint activeIndex;
+uniform vec4 xyzaFrac;
+uniform mat4 mtx;
+float textureWidth;
+float nlayer;
+float layerY;
+
+vec4 scalar2color(uint idx) {
+	float fx = (float(idx) + 0.5) / textureWidth;
+	vec4 clr = texture(colormap, vec2(fx, layerY)).rgba;
+	if (clr.a > 0.0)
+		clr.a = 1.0;
+	clr.a *= opacity;
+	return clr;
+}
+void main(void) {
+	vec4 vx = vec4(TexCoord.x, TexCoord.y, coordZ, 1.0) * mtx;
+	uint idx = uint(texture(intensityVol, vx.xyz).r);
+	if (idx == uint(0)) {
+		if (layer < 1.0) {
+			FragColor = vec4(0.0, 0.0, 0.0, 0.0);
+			return;
+		}
+		FragColor = texture(blend3D, vec3(TexCoord.xy, coordZ));
+		return;
+	}
+	textureWidth = float(textureSize(colormap, 0).x);
+	nlayer = float(textureSize(colormap, 0).y);
+	layerY = ((2.0 * layer) + 1.5) / nlayer;
+	//idx = ((idx - uint(1)) % uint(100))+uint(1);
+	FragColor = scalar2color(idx);
+	bool isBorder = false;
+	vx = vec4(TexCoord.x+xyzaFrac.x, TexCoord.y, coordZ, 1.0) * mtx;
+	uint R = uint(texture(intensityVol, vx.xyz).r);
+	vx = vec4(TexCoord.x-xyzaFrac.x, TexCoord.y, coordZ, 1.0) * mtx;
+	uint L = uint(texture(intensityVol, vx.xyz).r);
+	vx = vec4(TexCoord.x, TexCoord.y+xyzaFrac.y, coordZ, 1.0) * mtx;
+	uint A = uint(texture(intensityVol, vx.xyz).r);
+	vx = vec4(TexCoord.x, TexCoord.y-xyzaFrac.y, coordZ, 1.0) * mtx;
+	uint P = uint(texture(intensityVol, vx.xyz).r);
+	vx = vec4(TexCoord.x, TexCoord.y, coordZ+xyzaFrac.z, 1.0) * mtx;
+	uint S = uint(texture(intensityVol, vx.xyz).r);
+	vx = vec4(TexCoord.x, TexCoord.y, coordZ-xyzaFrac.z, 1.0) * mtx;
+	uint I = uint(texture(intensityVol, vx.xyz).r);
+	vec4 centerColor = FragColor;
+	FragColor.a += scalar2color(R).a;
+	FragColor.a += scalar2color(L).a;
+	FragColor.a += scalar2color(A).a;
+	FragColor.a += scalar2color(P).a;
+	FragColor.a += scalar2color(S).a;
+	FragColor.a += scalar2color(I).a;
+	FragColor.a /= 7.0;
+	if ((!isBorder) &&(idx == activeIndex)) {
+		if (centerColor.a > 0.5)
+			FragColor.a *= 0.4;
+		else
+			FragColor.a =0.8;
+	}
+	if (xyzaFrac.a != 0.0) { //outline
+		if ((idx != R) || (idx != L) || (idx != A) || (idx != P) || (idx != S) || (idx != I)) {
+			isBorder = true;
+			if (xyzaFrac.a > 0.0)
+				FragColor.a = xyzaFrac.a;
+			else
+				FragColor = vec4(0.0, 0.0, 0.0, 1.0);
+		}
+	}
+	if (layer < 1.0) return;
+		vec4 prevColor = texture(blend3D, vec3(TexCoord.xy, coordZ));
+		// https://en.wikipedia.org/wiki/Alpha_compositing
+		float aout = FragColor.a + (1.0 - FragColor.a) * prevColor.a;
+		if (aout <= 0.0) return;
+		if (isAdditiveBlend)
+			FragColor.rgb = ((FragColor.rgb * FragColor.a) + (prevColor.rgb * prevColor.a)) / aout;
+		else
+			FragColor.rgb = ((FragColor.rgb * FragColor.a) + (prevColor.rgb * prevColor.a * (1.0 - FragColor.a))) / aout;
+		FragColor.a = aout;
+}`,Vh=`#line 691
+precision highp int;
+precision highp float;
+in vec2 TexCoord;
+out vec4 FragColor;
+uniform float coordZ;
+uniform float layer;
+uniform float scl_slope;
+uniform float scl_inter;
+uniform float cal_max;
+uniform float cal_min;
+uniform float cal_maxNeg;
+uniform float cal_minNeg;
+uniform bool isAlphaThreshold;
+uniform bool isColorbarFromZero;
+uniform bool isAdditiveBlend;
+uniform highp sampler2D colormap;
+uniform lowp sampler3D blend3D;
+uniform int modulation;
+uniform highp sampler3D modulationVol;
+uniform float opacity;
+uniform mat4 mtx;
+void main(void) {
+	vec4 vx = vec4(TexCoord.xy, coordZ, 1.0) * mtx;
+	if ((vx.x < 0.0) || (vx.x > 1.0) || (vx.y < 0.0) || (vx.y > 1.0) || (vx.z < 0.0) || (vx.z > 1.0)) {
+		//set transparent if out of range
+		//https://webglfundamentals.org/webgl/webgl-3d-textures-repeat-clamp.html
+		FragColor = texture(blend3D, vec3(TexCoord.xy, coordZ));
+		return;
+	}
+	float f = (scl_slope * float(texture(intensityVol, vx.xyz).r)) + scl_inter;
+	float mn = cal_min;
+	float mx = cal_max;
+	if ((isAlphaThreshold) || (isColorbarFromZero))
+		mn = 0.0;
+	float r = max(0.00001, abs(mx - mn));
+	mn = min(mn, mx);
+	float txl = mix(0.0, 1.0, (f - mn) / r);
+	if (f > mn) { //issue1139: survives threshold, so round up to opaque voxel
+		txl = max(txl, 2.0/256.0);
+	}
+	//https://stackoverflow.com/questions/5879403/opengl-texture-coordinates-in-pixel-space
+	float nlayer = float(textureSize(colormap, 0).y);
+	//each volume has two color maps:
+	// (layer*2) = negative and (layer * 2) + 1 = positive
+	float y = ((2.0 * layer) + 1.5)/nlayer;
+	FragColor = texture(colormap, vec2(txl, y)).rgba;
+	//negative colors
+	mn = cal_minNeg;
+	mx = cal_maxNeg;
+	if ((isAlphaThreshold) || (isColorbarFromZero))
+		mx = 0.0;
+	//if ((!isnan(cal_minNeg)) && ( f < mx)) {
+	if ((cal_minNeg < cal_maxNeg) && ( f < mx)) {
+		r = max(0.00001, abs(mx - mn));
+		mn = min(mn, mx);
+		txl = 1.0 - mix(0.0, 1.0, (f - mn) / r);
+		//issue1139: survives threshold, so round up to opaque voxel
+		txl = max(txl, 2.0/256.0);
+		y = ((2.0 * layer) + 0.5)/nlayer;
+		FragColor = texture(colormap, vec2(txl, y));
+	}
+	if (layer > 0.7)
+		FragColor.a = step(0.00001, FragColor.a);
+	//if (modulation > 10)
+	//	FragColor.a *= texture(modulationVol, vx.xyz).r;
+	//	FragColor.rgb *= texture(modulationVol, vx.xyz).r;
+	if (isAlphaThreshold) {
+		if ((cal_minNeg != cal_maxNeg) && ( f < 0.0) && (f > cal_maxNeg))
+			FragColor.a = pow(-f / -cal_maxNeg, 2.0);
+		else if ((f > 0.0) && (cal_min > 0.0))
+			FragColor.a *= pow(f / cal_min, 2.0); //issue435:  A = (V/X)**2
+		//FragColor.g = 0.0;
+	} else if (isColorbarFromZero) {
+		if ((cal_minNeg != cal_maxNeg) && ( f < 0.0) && (f > cal_maxNeg))
+			FragColor.a = 0.0;
+		else if ((f > 0.0) && (cal_min > 0.0) && (f < cal_min))
+			FragColor.a *= 0.0;
+
+	}
+	if (modulation == 1) {
+		FragColor.rgb *= texture(modulationVol, vx.xyz).r;
+	} else if (modulation == 2) {
+		FragColor.a = texture(modulationVol, vx.xyz).r;
+	}
+	FragColor.a *= opacity;
+	if (layer < 1.0) return;
+	vec4 prevColor = texture(blend3D, vec3(TexCoord.xy, coordZ));
+	// https://en.wikipedia.org/wiki/Alpha_compositing
+	float aout = FragColor.a + (1.0 - FragColor.a) * prevColor.a;
+	if (aout <= 0.0) return;
+	if (isAdditiveBlend)
+		FragColor.rgb = ((FragColor.rgb * FragColor.a) + (prevColor.rgb * prevColor.a)) / aout;
+	else
+		FragColor.rgb = ((FragColor.rgb * FragColor.a) + (prevColor.rgb * prevColor.a * (1.0 - FragColor.a))) / aout;
+	FragColor.a = aout;
+}`,_4=`#line 773
+precision highp int;
+precision highp float;
+in vec2 TexCoord;
+out vec4 FragColor;
+uniform float coordZ;
+uniform float layer;
+uniform float scl_slope;
+uniform float scl_inter;
+uniform float cal_max;
+uniform float cal_min;
+uniform highp sampler2D colormap;
+uniform lowp sampler3D blend3D;
+uniform float opacity;
+uniform mat4 mtx;
+uniform bool hasAlpha;
+uniform int modulation;
+uniform highp sampler3D modulationVol;
+float textureWidth;
+float nlayer;
+float layerY;
+
+vec4 scalar2color(uint idx) {
+	float fx = (float(idx) + 0.5) / textureWidth;
+	vec4 clr = texture(colormap, vec2(fx, layerY)).rgba;
+	if (clr.a > 0.0)
+		clr.a = 1.0;
+	clr.a *= opacity;
+	return clr;
+}
+
+vec4 paqd2color(uvec4 rgba) {
+  // paqd r: max prob index, g: 2nd index, b: max prob a: 2nd prob
+  float prob1 = float(rgba.b)/255.0;
+  float prob2 = float(rgba.a)/255.0;
+  vec4 clr1 = scalar2color(rgba.r);
+  vec4 clr2 = scalar2color(rgba.g);
+  float total = prob1 + prob2;
+  vec4 clr = vec4(clr1.rgb, total);
+  // vec4 clr = vec4(clr1.rgb, prob1);
+  if (total > 0.0) {
+    clr.rgb = mix(clr2.rgb, clr1.rgb, prob1 / total);
+  }
+  return clr;
+}
+void main(void) {
+	vec4 vx = vec4(TexCoord.xy, coordZ, 1.0) * mtx;
+	ivec3 voxelCoord = ivec3(vx.xyz * vec3(textureSize(intensityVol, 0)));
+	uvec4 rgba = texelFetch(intensityVol, voxelCoord, 0);
+	FragColor = vec4(0.0, 0.0, 0.0, 0.0);
+	if (rgba.r > uint(0)) {
+		textureWidth = float(textureSize(colormap, 0).x);
+		nlayer = float(textureSize(colormap, 0).y);
+		layerY = ((2.0 * layer) + 1.5) / nlayer;
+		FragColor = paqd2color(rgba);
+		return;
+	}
+	// if (layer > 2.0) return;
+	// FragColor = texture(blend3D, vec3(TexCoord.xy, coordZ));
+}`,J4=`#line 773
+precision highp int;
+precision highp float;
+in vec2 TexCoord;
+out vec4 FragColor;
+uniform float coordZ;
+uniform float layer;
+uniform float scl_slope;
+uniform float scl_inter;
+uniform float cal_max;
+uniform float cal_min;
+uniform highp sampler2D colormap;
+uniform lowp sampler3D blend3D;
+uniform float opacity;
+uniform mat4 mtx;
+uniform bool hasAlpha;
+uniform int modulation;
+uniform highp sampler3D modulationVol;
+void main(void) {
+	vec4 vx = vec4(TexCoord.xy, coordZ, 1.0) * mtx;
+	uvec4 aColor = texture(intensityVol, vx.xyz);
+	FragColor = vec4(float(aColor.r) / 255.0, float(aColor.g) / 255.0, float(aColor.b) / 255.0, float(aColor.a) / 255.0);
+	if (modulation == 1)
+		FragColor.rgb *= texture(modulationVol, vx.xyz).r;
+	if (!hasAlpha) {
+		FragColor.a = (FragColor.r * 0.21 + FragColor.g * 0.72 + FragColor.b * 0.07);
+		//next line: we could binarize alpha, but see rendering of visible human
+		//FragColor.a = step(0.01, FragColor.a);
+	}
+	if (modulation == 2)
+		FragColor.a = texture(modulationVol, vx.xyz).r;
+	FragColor.a *= opacity;
+	if (layer < 1.0) return;
+	vec4 prevColor = texture(blend3D, vec3(TexCoord.xy, coordZ));
+	// https://en.wikipedia.org/wiki/Alpha_compositing
+	float aout = FragColor.a + (1.0 - FragColor.a) * prevColor.a;
+	if (aout <= 0.0) return;
+	FragColor.rgb = ((FragColor.rgb * FragColor.a) + (prevColor.rgb * prevColor.a * (1.0 - FragColor.a))) / aout;
+	FragColor.a = aout;
+}`,$4=`#version 300 es
+#line 808
+precision highp int;
+precision highp float;
+in vec3 vPos;
+out vec2 TexCoord;
+void main() {
+	TexCoord = vPos.xy;
+	gl_Position = vec4((vPos.x - 0.5) * 2.0, (vPos.y - 0.5) * 2.0, 0.0, 1.0);
+}`,tv=`#version 300 es
+#line 829
+	precision highp float;
+	precision highp int;
+	precision highp isampler3D;
+	layout(location = 0) out int label;
+	layout(location = 1) out int strength;
+	in vec2 TexCoord;
+	uniform int finalPass;
+	uniform float coordZ;
+	uniform lowp sampler3D in3D;
+	uniform highp isampler3D backTex; // background
+	uniform highp isampler3D labelTex; // label
+	uniform highp isampler3D strengthTex; // strength
+void main(void) {
+	vec3 interpolatedTextureCoordinate = vec3(TexCoord.xy, coordZ);
+	ivec3 size = textureSize(backTex, 0);
+	ivec3 texelIndex = ivec3(floor(interpolatedTextureCoordinate * vec3(size)));
+	int background = texelFetch(backTex, texelIndex, 0).r;
+	label = texelFetch(labelTex, texelIndex, 0).r;
+	strength = texelFetch(strengthTex, texelIndex, 0).r;
+	for (int k = -1; k <= 1; k++) {
+		for (int j = -1; j <= 1; j++) {
+			for (int i = -1; i <= 1; i++) {
+				if (i != 0 && j != 0 && k != 0) {
+					ivec3 neighborIndex = texelIndex + ivec3(i,j,k);
+					int neighborBackground = texelFetch(backTex, neighborIndex, 0).r;
+					int neighborStrength = texelFetch(strengthTex, neighborIndex, 0).r;
+					int strengthCost = abs(neighborBackground - background);
+					int takeoverStrength = neighborStrength - strengthCost;
+					if (takeoverStrength > strength) {
+						strength = takeoverStrength;
+						label = texelFetch(labelTex, neighborIndex, 0).r;
+					}
+				}
+			}
+		}
+	}
+	if (finalPass < 1)
+		return;
+	int ok = 1;
+	ivec4 labelCount = ivec4(0,0,0,0);
+	for (int k = -1; k <= 1; k++)
+		for (int j = -1; j <= 1; j++)
+			for (int i = -1; i <= 1; i++) {
+				ivec3 neighborIndex = texelIndex + ivec3(i,j,k);
+				int ilabel = texelFetch(labelTex, neighborIndex, 0).r;
+				if ((ilabel < 0) || (ilabel > 3))
+					ok = 0;
+				else
+					labelCount[ilabel]++;
+			}
+	if (ok != 1) {
+		return;
+	}
+	int maxIdx = 0;
+	for (int i = 1; i < 4; i++) {
+		if (labelCount[i] > labelCount[maxIdx])
+			maxIdx = i;
+	}
+	label = maxIdx;
+}`,ev=`#version 300 es
+layout(location=0) in vec3 pos;
+uniform mat4 mvpMtx;
+void main(void) {
+	gl_Position = mvpMtx * vec4(pos, 1.0);
+}`,iv=`#version 300 es
+precision highp int;
+precision highp float;
+uniform vec4 surfaceColor;
+out vec4 color;
+void main() {
+	color = surfaceColor;
+}`,nv=`#version 300 es
+layout(location=0) in vec3 pos;
+layout(location=1) in vec4 clr;
+out vec4 vClr;
+uniform mat4 mvpMtx;
+void main(void) {
+	gl_Position = mvpMtx * vec4(pos, 1.0);
+	vClr = clr;
+}`,sv=`#version 300 es
+precision highp int;
+precision highp float;
+in vec4 vClr;
+out vec4 color;
+uniform float opacity;
+void main() {
+	color = vec4(vClr.rgb, opacity);
+}`,Lh=`#version 300 es
+layout(location=0) in vec3 pos;
+layout(location=1) in vec4 norm;
+layout(location=2) in vec4 clr;
+uniform mat4 mvpMtx;
+//uniform mat4 modelMtx;
+uniform mat4 normMtx;
+out vec4 vClr;
+out vec3 vN;
+out vec4 vP;
+out vec4 vPc;
+void main(void) {
+	vec3 lightPosition = vec3(0.0, 0.0, -10.0);
+	vP = vec4(pos, 1.0);
+	vPc = mvpMtx * vec4(pos, 1.0);
+	gl_Position = vPc;
+	vN = normalize((normMtx * vec4(norm.xyz,1.0)).xyz);
+	//vV = -vec3(modelMtx*vec4(pos,1.0));
+	vClr = clr;
+}`,av=`#version 300 es
+precision highp int;
+precision highp float;
+uniform float opacity;
+out vec4 color;
+vec4 packFloatToVec4i(const float value) {
+	const vec4 bitSh = vec4(256.0*256.0*256.0, 256.0*256.0, 256.0, 1.0);
+	const vec4 bitMsk = vec4(0.0, 1.0/256.0, 1.0/256.0, 1.0/256.0);
+	vec4 res = fract(value * bitSh);
+	res -= res.xxyz * bitMsk;
+	return res;
+}
+void main() {
+	color = packFloatToVec4i(gl_FragCoord.z);
+}`,rv=`#version 300 es
+precision highp int;
+precision highp float;
+uniform float opacity;
+in vec4 vClr;
+in vec3 vN;
+out vec4 color;
+float stepmix(float edge0, float edge1, float E, float x){
+	float T = clamp(0.5 * (x - edge0 + E) / E, 0.0, 1.0);
+	return mix(edge0, edge1, T);
+}
+void main() {
+	vec3 r = vec3(0.0, 0.0, 1.0);
+	float ambient = 0.3;
+	float diffuse = 0.6;
+	float specular = 0.5;
+	float shininess = 50.0;
+	vec3 n = normalize(vN);
+	vec3 lightPosition = vec3(0.0, 10.0, -5.0);
+	vec3 l = normalize(lightPosition);
+	float df = max(0.0, dot(n, l));
+	float sf = pow(max(dot(reflect(l, n), r), 0.0), shininess);
+	const float A = 0.1;
+	const float B = 0.3;
+	const float C = 0.6;
+	const float D = 1.0;
+	float E = fwidth(df);
+	if (df > A - E && df < A + E) df = stepmix(A, B, E, df);
+	else if (df > B - E && df < B + E) df = stepmix(B, C, E, df);
+	else if (df > C - E && df < C + E) df = stepmix(C, D, E, df);
+	else if (df < A) df = 0.0;
+	else if (df < B) df = B;
+	else if (df < C) df = C;
+	else df = D;
+	E = fwidth(sf);
+	if (sf > 0.5 - E && sf < 0.5 + E)
+		sf = smoothstep(0.5 - E, 0.5 + E, sf);
+	else
+		sf = step(0.5, sf);
+	vec3 a = vClr.rgb * ambient;
+	vec3 d = max(df, 0.0) * vClr.rgb * diffuse;
+	color.rgb = a + d + (specular * sf);
+	color.a = opacity;
+}`,lv=`#version 300 es
+precision highp int;
+precision highp float;
+uniform float opacity;
+in vec4 vClr;
+in vec3 vN;
+out vec4 color;
+void main() {
+	vec3 r = vec3(0.0, 0.0, 1.0); //rayDir: for orthographic projections moving in Z direction (no need for normal matrix)
+	float ambient = 0.3;
+	float diffuse = 0.6;
+	float specular = 0.25;
+	float shininess = 10.0;
+	float PenWidth = 0.6;
+	vec3 n = normalize(vN);
+	vec3 lightPosition = vec3(0.0, 10.0, -5.0);
+	vec3 l = normalize(lightPosition);
+	float lightNormDot = dot(n, l);
+	float view = abs(dot(n,r)); //with respect to viewer
+	if (PenWidth < view) discard;
+	vec3 a = vClr.rgb * ambient;
+	vec3 d = max(lightNormDot, 0.0) * vClr.rgb * diffuse;
+	float s = specular * pow(max(dot(reflect(l, n), r), 0.0), shininess);
+	color.rgb = a + d + s;
+	color.a = opacity;
+}`,ov=`#version 300 es
+precision highp int;
+precision highp float;
+uniform float opacity;
+in vec4 vClr;
+in vec3 vN;
+out vec4 color;
+void main() {
+	const float thresh = 0.4;
+	const vec3 viewDir = vec3(0.0, 0.0, -1.0);
+	vec3 n = normalize(vN);
+	// use abs() for two-sided lighting, max() for one sided
+	float cosTheta = abs(dot(n, viewDir));
+	// float cosTheta = max(dot(n, viewDir), 0.0);
+	// optional fresnel equation - adjust exponent
+	// cosTheta = 1.0 - pow(1.0 - cosTheta, 2.0);
+	// use step for binary edges, smoothstep for feathered edges
+	// vec3 d = step(thresh, cosTheta) * vClr.rgb;
+	vec3 d = smoothstep(thresh - 0.05, thresh + 0.05, cosTheta) * vClr.rgb;
+	color = vec4(d, opacity);
+}`,cv=`#version 300 es
+precision highp int;
+precision highp float;
+uniform float opacity;
+in vec4 vClr;
+in vec3 vN;
+out vec4 color;
+void main() {
+  const float edge0 = 0.1;
+  const float edge1 = 0.25;
+  const vec3 viewDir = vec3(0.0, 0.0, -1.0);
+  vec3 n = normalize(vN);
+  float cosTheta = abs(dot(n, viewDir));
+  float alpha = 1.0 - smoothstep(edge0, edge1, cosTheta);
+  if (alpha <= 0.0) {
+    discard;
+  }
+  color = vec4(0.0, 0.0, 0.0, opacity * alpha);
+}`,hv=`#version 300 es
+precision highp int;
+precision highp float;
+uniform float opacity;
+in vec4 vClr;
+in vec3 vN;
+out vec4 color;
+void main() {
+	vec3 r = vec3(0.0, 0.0, 1.0); //rayDir: for orthographic projections moving in Z direction (no need for normal matrix)
+	float diffuse = 1.0;
+	float specular = 0.2;
+	float shininess = 10.0;
+	vec3 n = normalize(vN);
+	vec3 lightPosition = vec3(0.0, 0.0, -5.0);
+	vec3 l = normalize(lightPosition);
+	float lightNormDot = max(dot(n, l), 0.0);
+	vec3 d = lightNormDot * vClr.rgb * diffuse;
+	float s = specular * pow(max(dot(reflect(l, n), r), 0.0), shininess);
+	color = vec4(d + s, opacity);
+}`,uv=`#version 300 es
+precision highp int;
+precision highp float;
+uniform float opacity;
+in vec4 vClr;
+in vec3 vN;
+out vec4 color;
+void main() {
+	float diffuse = 1.4;
+	vec3 l = vec3(0.0, 0.0, -1.0);
+	float lightNormDot = max(dot(normalize(vN), l), 0.0);
+	color = vec4(lightNormDot * vClr.rgb * diffuse, opacity);
+}`,fv=`#version 300 es
+precision highp int;
+precision highp float;
+uniform float opacity;
+in vec4 vClr;
+in vec3 vN;
+out vec4 color;
+void main() {
+	float specularRGB = 0.7;
+	float specularWhite = 0.3;
+	float shininess = 10.0;
+	float diffuse = 1.0;
+	vec3 r = vec3(0.0, 0.0, 1.0); //rayDir: for orthographic projections moving in Z direction (no need for normal matrix)
+	vec3 n = normalize(vN);
+	vec3 l = vec3(0.0, 0.0, -1.0);
+	float lightNormDot = max(dot(n, l), 0.0);
+	vec3 d3 = lightNormDot * vClr.rgb * diffuse;
+	float s = pow(max(dot(reflect(l, n), r), 0.0), shininess);
+	vec3 s3 = specularRGB * s * vClr.rgb;
+	s *= specularWhite;
+	color = vec4(d3 + s3 + s, opacity);
+}`,dv=`#version 300 es
+precision highp int;
+precision highp float;
+uniform float opacity;
+in vec4 vClr;
+in vec3 vN;
+in vec4 vPc;
+out vec4 color;
+void main() {
+	vec3 n = normalize(vN);
+	// Compute curvature
+	vec3 dx = dFdx(n);
+	vec3 dy = dFdy(n);
+	vec3 xneg = n - dx;
+	vec3 xpos = n + dx;
+	vec3 yneg = n - dy;
+	vec3 ypos = n + dy;
+	float depth = length(vPc.xyz);
+	float curv = (cross(xneg, xpos).y - cross(yneg, ypos).x) / depth;
+	//at this stage 0.5 for flat, with valleys dark and ridges bright
+	curv = 1.0 - (curv + 0.5);
+	//clamp
+	curv =  min(max(curv, 0.0), 1.0);
+	// easing function
+	curv = pow(curv, 0.5);
+	//modulate ambient and diffuse with curvature
+	vec3 r = vec3(0.0, 0.0, 1.0); //rayDir: for orthographic projections moving in Z direction (no need for normal matrix)
+	float ambient = 0.6;
+	float diffuse = 0.6;
+	float specular = 0.2;
+	float shininess = 10.0;
+	vec3 lightPosition = vec3(0.0, 10.0, -2.0);
+	vec3 l = normalize(lightPosition);
+	float lightNormDot = dot(n, l);
+	vec3 a = vClr.rgb * ambient * curv;
+	vec3 d = max(lightNormDot, 0.0) * vClr.rgb * diffuse;
+	float s = specular * pow(max(dot(reflect(l, n), r), 0.0), shininess);
+	color = vec4(a + d + s, opacity);
+}`,mv=`#version 300 es
+precision highp int;
+precision highp float;
+uniform vec4 sliceMM;
+uniform float thickMM ;
+in vec4 vClr;
+in vec4 vP;  // vertex position in mm
+out vec4 color;
+void main() {
+    const float LINE_WIDTH_PX = 4.0;   // target thickness in pixels
+    //const float LINE_THRESH_MM = 1.5;   // target thickness in pixels
+    const float TILT_STRENGTH = 1.0;   // >0 shrinks ribbon for oblique triangles
+    // --- signed distances to each orthogonal plane (object space) ---
+    vec3 d = vP.xyz - sliceMM.xyz;
+    vec3 ad = abs(d);
+    // --- derivatives to get pixel-consistent widths (per-axis) ---
+    vec3 fd = fwidth(vP.xyz);
+    //minDist is in mm not pixels
+    float minDist = min(ad.x, min(ad.y, ad.z));
+    if (minDist >  sliceMM.w) discard;
+    // --- per-plane obliqueness: use the two in-plane components' fwidth ---
+    float tiltX = length(fd.yz); // for plane with normal X
+    float tiltY = length(fd.xz); // for plane with normal Y
+    float tiltZ = length(fd.xy); // for plane with normal Z
+    float tfX = clamp(1.0 / (1.0 + TILT_STRENGTH * tiltX), 0.0, 1.0);
+    float tfY = clamp(1.0 / (1.0 + TILT_STRENGTH * tiltY), 0.0, 1.0);
+    float tfZ = clamp(1.0 / (1.0 + TILT_STRENGTH * tiltZ), 0.0, 1.0);
+    // --- half-widths for each plane (apply per-axis tilt factor) ---
+    vec3 halfWidth;
+    halfWidth.x = (LINE_WIDTH_PX * 0.5) * fd.x * tfX;
+    halfWidth.y = (LINE_WIDTH_PX * 0.5) * fd.y * tfY;
+    halfWidth.z = (LINE_WIDTH_PX * 0.5) * fd.z * tfZ;
+    // --- smooth alpha for each plane ---
+    vec3 edgeA = 1.0 - smoothstep(vec3(0.0), halfWidth, ad);
+    // combine planes (max of X,Y,Z ribbons)
+    float edgeAlpha = max(edgeA.x, max(edgeA.y, edgeA.z));
+    if (edgeAlpha <= 1e-4) discard; // outside ribbons
+    color = vec4(vClr.rgb, vClr.a * edgeAlpha);
+}`,gv=`#version 300 es
+precision highp int;
+precision highp float;
+uniform float opacity;
+in vec4 vClr;
+in vec3 vN;
+out vec4 color;
+void main() {
+	vec3 r = vec3(0.0, 0.0, 1.0); //rayDir: for orthographic projections moving in Z direction (no need for normal matrix)
+	float ambient = 0.35;
+	float diffuse = 0.5;
+	float specular = 0.2;
+	float shininess = 10.0;
+	vec3 n = normalize(vN);
+	vec3 lightPosition = vec3(0.0, 10.0, -5.0);
+	vec3 l = normalize(lightPosition);
+	float lightNormDot = dot(n, l);
+	vec3 a = vClr.rgb * ambient;
+	vec3 d = max(lightNormDot, 0.0) * vClr.rgb * diffuse;
+	float s = specular * pow(max(dot(reflect(l, n), r), 0.0), shininess);
+	color = vec4(a + d + s, opacity);
+}`,Av=`#version 300 es
+precision highp int;
+precision highp float;
+uniform float opacity;
+in vec4 vClr;
+in vec3 vN;
+uniform sampler2D matCap;
+out vec4 color;
+void main() {
+	vec3 n = normalize(vN);
+	vec2 uv = n.xy * 0.5 + 0.5;
+	uv.y = 1.0 - uv.y;
+	vec3 clr = texture(matCap,uv.xy).rgb * vClr.rgb;
+	color = vec4(clr, opacity);
+}`,pv=`#version 300 es
+precision highp int;
+precision highp float;
+uniform float opacity;
+in vec4 vClr;
+in vec3 vN;
+out vec4 color;
+void main() {
+	float ambient = 0.35;
+	float diffuse = 0.6;
+	vec3 n = normalize(vN);
+	vec3 lightPosition = vec3(0.0, 10.0, -5.0);
+	vec3 l = normalize(lightPosition);
+	float lightNormDot = dot(n, l);
+	vec3 a = vClr.rgb * ambient;
+	vec3 d = max(lightNormDot, 0.0) * vClr.rgb * diffuse;
+	color = vec4(a + d, opacity);
+}`,vv=`#version 300 es
+precision highp int;
+precision highp float;
+uniform float opacity;
+in vec4 vClr;
+in vec3 vN;
+out vec4 color;
+void main() {
+	vec3 r = vec3(0.0, 0.0, 1.0); //rayDir: for orthographic projections moving in Z direction (no need for normal matrix)
+	float ambient = 0.35;
+	float diffuse = 0.5;
+	float specular = 0.2;
+	float shininess = 10.0;
+	vec3 n = normalize(vN);
+	vec3 lightPosition = vec3(0.0, 10.0, -5.0);
+	vec3 l = normalize(lightPosition);
+	float lightNormDot = dot(n, l);
+	vec3 up = vec3(0.0, 1.0, 0.0);
+	float ax = dot(n, up) * 0.5 + 0.5;  //Shreiner et al. (2013) OpenGL Programming Guide, 8th Ed., p 388. ISBN-10: 0321773039
+	vec3 upClr = vec3(1.0, 1.0, 0.95);
+	vec3 downClr = vec3(0.4, 0.4, 0.6);
+	vec3 a = vClr.rgb * ambient;
+	a *= mix(downClr, upClr, ax);
+	vec3 d = max(lightNormDot, 0.0) * vClr.rgb * diffuse;
+	float s = specular * pow(max(dot(reflect(l, n), r), 0.0), shininess);
+	color = vec4(a + d + s, opacity);
+}`,xv=`#version 300 es
+precision highp int;
+precision highp float;
+uniform float opacity;
+in vec4 vClr;
+in vec3 vN;
+out vec4 color;
+//Spherical harmonics constants
+const float C1 = 0.429043;
+const float C2 = 0.511664;
+const float C3 = 0.743125;
+const float C4 = 0.886227;
+const float C5 = 0.247708;
+//Spherical harmonics coefficients
+// Ramamoorthi, R., and P. Hanrahan. 2001b. "An Efficient Representation for Irradiance Environment Maps." In Proceedings of SIGGRAPH 2001, pp. 497–500.
+// https://github.com/eskimoblood/processingSketches/blob/master/data/shader/shinyvert.glsl
+// https://github.com/eskimoblood/processingSketches/blob/master/data/shader/shinyvert.glsl
+// Constants for Eucalyptus Grove lighting
+const vec3 L00  = vec3( 0.3783264,  0.4260425,  0.4504587);
+const vec3 L1m1 = vec3( 0.2887813,  0.3586803,  0.4147053);
+const vec3 L10  = vec3( 0.0379030,  0.0295216,  0.0098567);
+const vec3 L11  = vec3(-0.1033028, -0.1031690, -0.0884924);
+const vec3 L2m2 = vec3(-0.0621750, -0.0554432, -0.0396779);
+const vec3 L2m1 = vec3( 0.0077820, -0.0148312, -0.0471301);
+const vec3 L20  = vec3(-0.0935561, -0.1254260, -0.1525629);
+const vec3 L21  = vec3(-0.0572703, -0.0502192, -0.0363410);
+const vec3 L22  = vec3( 0.0203348, -0.0044201, -0.0452180);
+vec3 SH(vec3 vNormal) {
+	vNormal = vec3(vNormal.x,vNormal.z,vNormal.y);
+	vec3 diffuseColor = C1 * L22 * (vNormal.x * vNormal.x - vNormal.y * vNormal.y) +
+	C3 * L20 * vNormal.z * vNormal.z +
+	C4 * L00 -
+	C5 * L20 +
+	2.0 * C1 * L2m2 * vNormal.x * vNormal.y +
+	2.0 * C1 * L21  * vNormal.x * vNormal.z +
+	2.0 * C1 * L2m1 * vNormal.y * vNormal.z +
+	2.0 * C2 * L11  * vNormal.x +
+	2.0 * C2 * L1m1 * vNormal.y +
+	2.0 * C2 * L10  * vNormal.z;
+	return diffuseColor;
+}
+void main() {
+	vec3 r = vec3(0.0, 0.0, 1.0); //rayDir: for orthographic projections moving in Z direction (no need for normal matrix)
+	float ambient = 0.3;
+	float diffuse = 0.6;
+	float specular = 0.1;
+	float shininess = 10.0;
+	vec3 n = normalize(vN);
+	vec3 lightPosition = vec3(0.0, 10.0, -5.0);
+	vec3 l = normalize(lightPosition);
+	float s = specular * pow(max(dot(reflect(l, n), r), 0.0), shininess);
+	vec3 a = vClr.rgb * ambient;
+	vec3 d = vClr.rgb * diffuse * SH(-reflect(n, vec3(l.x, l.y, -l.z)) );
+	color = vec4(a + d + s, opacity);
+}`,yv=`#version 300 es
+layout(location=0) in vec3 pos;
+layout(location=1) in vec4 norm;
+layout(location=2) in vec4 clr;
+uniform mat4 mvpMtx;
+//uniform mat4 modelMtx;
+uniform mat4 normMtx;
+out vec4 vClr;
+flat out vec3 vN;
+void main(void) {
+	gl_Position = mvpMtx * vec4(pos, 1.0);
+	vN = normalize((normMtx * vec4(norm.xyz,1.0)).xyz);
+	//vV = -vec3(modelMtx*vec4(pos,1.0));
+	vClr = clr;
+}`,u2=`#version 300 es
+precision highp int;
+precision highp float;
+uniform float opacity;
+in vec4 vClr;
+flat in vec3 vN;
+out vec4 color;
+void main() {
+	vec3 r = vec3(0.0, 0.0, 1.0); //rayDir: for orthographic projections moving in Z direction (no need for normal matrix)
+	float ambient = 0.35;
+	float diffuse = 0.5;
+	float specular = 0.2;
+	float shininess = 10.0;
+	vec3 n = normalize(vN);
+	vec3 lightPosition = vec3(0.0, 10.0, -5.0);
+	vec3 l = normalize(lightPosition);
+	float lightNormDot = dot(n, l);
+	vec3 a = vClr.rgb * ambient;
+	vec3 d = max(lightNormDot, 0.0) * vClr.rgb * diffuse;
+	float s = specular * pow(max(dot(reflect(l, n), r), 0.0), shininess);
+	color = vec4(a + d + s, opacity);
+}`,wv=`#version 300 es
+#line 1260
+#define MAX_CLIP_PLANES 6
+//precision highp int;
+precision highp float;
+uniform vec3 rayDir;
+uniform vec3 volScale;
+uniform vec3 texVox;
+uniform vec4 clipPlane;
+uniform vec4 clipPlanes[MAX_CLIP_PLANES];
+uniform bool isClipCutaway;
+uniform highp sampler3D volume, overlay;
+uniform highp sampler3D paqd;
+uniform vec4 paqdUniforms;
+uniform float overlays;
+uniform mat4 matRAS;
+uniform mat4 mvpMtx;
+uniform float drawOpacity, renderOverlayBlend;
+uniform highp sampler3D drawing;
+uniform highp sampler2D colormap;
+uniform int backgroundMasksOverlays;
+in vec3 vColor;
+out vec4 fColor;
+`+ar+`
+void main() {
+	int id = 254;
+	vec3 start = vColor;
+	gl_FragDepth = 1.0;
+	fColor = vec4(0.0, 0.0, 0.0, 0.0); //assume no hit: ID = 0
+	float fid = float(id & 255)/ 255.0;
+	vec3 backPosition = GetBackPosition(start);
+	vec3 dir = normalize(backPosition - start);
+	//clipVolumeStart(start, backPosition);
+	float len = length(backPosition - start);
+	float lenVox = length((texVox * start) - (texVox * backPosition));
+	if ((lenVox < 0.5) || (len > 3.0)) return;//discard; //length limit for parallel rays
+	float sliceSize = len / lenVox; //e.g. if ray length is 1.0 and traverses 50 voxels, each voxel is 0.02 in unit cube
+	float stepSize = sliceSize; //quality: larger step is faster traversal, but fewer samples
+	float opacityCorrection = stepSize/sliceSize;
+	dir = normalize(dir);
+	vec4 samplePos = vec4(start.xyz, 0.0); //ray position
+	bool hasClip = false;
+	vec2 sampleRange = vec2(0.0, len);
+	for (int i = 0; i < MAX_CLIP_PLANES; i++)
+		clipSampleRange(dir, samplePos, clipPlanes[i], sampleRange, hasClip);
+	bool isClip = (sampleRange.x > 0.0) || ((sampleRange.y < len) && (sampleRange.y > 0.0));
+	//vec4 clipPos = applyClip(dir, samplePos, len, isClip);
+	if (isClip) fColor = vec4(samplePos.xyz, 253.0 / 255.0); //assume no hit: ID = 0
+	if ((isClipCutaway) && (sampleRange.x <= 0.0) && (sampleRange.y >= len)) {
+		//completely clipped, but ray does not intersect plane
+		if (hasClip)
+			samplePos.a = len + 1.0;
+		else
+			sampleRange = vec2(0.0, 0.0);
+	}
+	//start: OPTIONAL fast pass: rapid traversal until first hit
+	float stepSizeFast = sliceSize * 1.9;
+	vec4 deltaDirFast = vec4(dir.xyz * stepSizeFast, stepSizeFast);
+	while (samplePos.a <= len) {
+		if (skipSample(samplePos.a, sampleRange) ^^ isClipCutaway) {
+			samplePos += deltaDirFast;
+			continue;
+		}
+		float val = texture(volume, samplePos.xyz).a;
+		if (val > 0.01) {
+			fColor = vec4(samplePos.rgb, fid);
+			gl_FragDepth = frac2ndc(samplePos.xyz);
+			break;
+		}
+		samplePos += deltaDirFast; //advance ray position
+	}
+	//end: fast pass
+	if ((overlays < 1.0) || (backgroundMasksOverlays > 0)) {
+		return; //background hit, no overlays
+	}
+	//overlay pass
+	len = min(len, samplePos.a); //only find overlay closer than background
+	samplePos = vec4(start.xyz, 0.0); //ray position
+	while (samplePos.a <= len) {
+		float val = texture(overlay, samplePos.xyz).a;
+		if (val > 0.01) {
+			fColor = vec4(samplePos.rgb, fid);
+			gl_FragDepth = frac2ndc(samplePos.xyz);
+			return;
+		}
+		samplePos += deltaDirFast; //advance ray position
+	}
+	//if (fColor.a == 0.0) discard; //no hit in either background or overlays
+	//you only get here if there is a hit with the background that is closer than any overlay
+}`,bv=`#version 300 es
+// an attribute is an input (in) to a vertex shader.
+// It will receive data from a buffer
+layout(location=0)  in vec3 a_position;
+layout(location=1)  in vec3 a_color;
+// A matrix to transform the positions by
+uniform mat4 u_matrix;
+out vec3 vColor;
+// all shaders have a main function
+void main() {
+	// Multiply the position by the matrix.
+	vec4 pos = vec4(a_position, 1.0);
+	gl_Position = u_matrix * vec4(pos);
+	vColor = a_color;
+}
+`,Cv=`#version 300 es
+precision highp float;
+uniform vec4 u_color;
+in vec3 vColor;
+out vec4 outColor;
+void main() {
+	outColor = vec4(vColor, 1.0);
+}`,Sv=`#version 300 es
+#line 1359
+precision highp int;
+precision highp float;
+in vec3 vPos;
+out vec2 TexCoord;
+void main() {
+	TexCoord = vPos.xy;
+	vec2 viewCoord = (vPos.xy - 0.5) * 2.0;
+	gl_Position = vec4((vPos.xy - 0.5) * 2.0, 0.0, 1.0);
+}`,Mv=`#version 300 es
+precision highp int;
+precision highp float;
+in vec2 TexCoord;
+out vec4 FragColor;
+uniform float coordZ;
+uniform lowp sampler3D in3D;
+void main(void) {
+ FragColor = texture(in3D, vec3(TexCoord.xy, coordZ));
+}`,Rl=`#version 300 es
+#line 286
+precision highp int;
+precision highp float;
+in vec3 vPos;
+out vec2 TexCoord;
+void main() {
+    TexCoord = vPos.xy;
+    gl_Position = vec4( (vPos.xy-vec2(0.5,0.5))* 2.0, 0.0, 1.0);
+}`,Ev=`#version 300 es
+#line 298
+precision highp int;
+precision highp float;
+in vec2 TexCoord;
+out vec4 FragColor;
+uniform float coordZ;
+uniform float dX;
+uniform float dY;
+uniform float dZ;
+uniform highp sampler3D intensityVol;
+void main(void) {
+ vec3 vx = vec3(TexCoord.xy, coordZ);
+ vec4 samp = texture(intensityVol,vx+vec3(+dX,+dY,+dZ));
+ samp += texture(intensityVol,vx+vec3(+dX,+dY,-dZ));
+ samp += texture(intensityVol,vx+vec3(+dX,-dY,+dZ));
+ samp += texture(intensityVol,vx+vec3(+dX,-dY,-dZ));
+ samp += texture(intensityVol,vx+vec3(-dX,+dY,+dZ));
+ samp += texture(intensityVol,vx+vec3(-dX,+dY,-dZ));
+ samp += texture(intensityVol,vx+vec3(-dX,-dY,+dZ));
+ samp += texture(intensityVol,vx+vec3(-dX,-dY,-dZ));
+ FragColor = samp*0.125;
+}`,Dv=`#version 300 es
+#line 298
+precision highp int;
+precision highp float;
+in vec2 TexCoord;
+out vec4 FragColor;
+uniform float coordZ;
+uniform float dX;
+uniform float dY;
+uniform float dZ;
+uniform highp sampler3D intensityVol;
+void main(void) {
+ vec3 vx = vec3(TexCoord.xy, coordZ);
+ vec4 XYZ = texture(intensityVol,vx+vec3(+dX,+dY,+dZ));
+ vec4 OYZ = texture(intensityVol,vx+vec3(0.0,+dY,+dZ));
+ vec4 xYZ = texture(intensityVol,vx+vec3(-dX,+dY,+dZ));
+ vec4 XOZ = texture(intensityVol,vx+vec3(+dX,0.0,+dZ));
+ vec4 OOZ = texture(intensityVol,vx+vec3(0.0,0.0,+dZ));
+ vec4 xOZ = texture(intensityVol,vx+vec3(-dX,0.0,+dZ));
+ vec4 XyZ = texture(intensityVol,vx+vec3(+dX,-dY,+dZ));
+ vec4 OyZ = texture(intensityVol,vx+vec3(0.0,-dY,+dZ));
+ vec4 xyZ = texture(intensityVol,vx+vec3(-dX,-dY,+dZ));
+
+ vec4 XYO = texture(intensityVol,vx+vec3(+dX,+dY,0.0));
+ vec4 OYO = texture(intensityVol,vx+vec3(0.0,+dY,0.0));
+ vec4 xYO = texture(intensityVol,vx+vec3(-dX,+dY,0.0));
+ vec4 XOO = texture(intensityVol,vx+vec3(+dX,0.0,0.0));
+ vec4 OOO = texture(intensityVol,vx+vec3(0.0,0.0,0.0));
+ vec4 xOO = texture(intensityVol,vx+vec3(-dX,0.0,0.0));
+ vec4 XyO = texture(intensityVol,vx+vec3(+dX,-dY,0.0));
+ vec4 OyO = texture(intensityVol,vx+vec3(0.0,-dY,0.0));
+ vec4 xyO = texture(intensityVol,vx+vec3(-dX,-dY,0.0));
+
+ vec4 XYz = texture(intensityVol,vx+vec3(+dX,+dY,-dZ));
+ vec4 OYz = texture(intensityVol,vx+vec3(0.0,+dY,-dZ));
+ vec4 xYz = texture(intensityVol,vx+vec3(-dX,+dY,-dZ));
+ vec4 XOz = texture(intensityVol,vx+vec3(+dX,0.0,-dZ));
+ vec4 OOz = texture(intensityVol,vx+vec3(0.0,0.0,-dZ));
+ vec4 xOz = texture(intensityVol,vx+vec3(-dX,0.0,-dZ));
+ vec4 Xyz = texture(intensityVol,vx+vec3(+dX,-dY,-dZ));
+ vec4 Oyz = texture(intensityVol,vx+vec3(0.0,-dY,-dZ));
+ vec4 xyz = texture(intensityVol,vx+vec3(-dX,-dY,-dZ));
+
+ vec4 blurred = vec4 (0.0, 0.0, 0.0, 0.0);
+ blurred.r = 2.0*(xOz.r +xOZ.r +xyO.r +xYO.r +xOO.r +XOz.r +XOZ.r +XyO.r +XYO.r +XOO.r) +xyz.r +xyZ.r +xYz.r +xYZ.r +Xyz.r +XyZ.r +XYz.r +XYZ.r;
+ blurred.g = 2.0*(Oyz.r +OyZ.r +xyO.r +XyO.r +OyO.r +OYz.r +OYZ.r +xYO.r +XYO.r +OYO.r) +xyz.r +Xyz.r +xyZ.r +XyZ.r +xYz.r +XYz.r +xYZ.r +XYZ.r;
+ blurred.b = 2.0*(Oyz.r +OYz.r +xOz.r +XOz.r +OOz.r +OyZ.r +OYZ.r +xOZ.r +XOZ.r +OOZ.r) +xyz.r +Xyz.r +xYz.r +XYz.r +xyZ.r +XyZ.r +XyZ.r +XYZ.r;
+ blurred.a = 0.32*(abs(blurred.r)+abs(blurred.g)+abs(blurred.b));
+ // 0.0357 = 1/28 to account for weights, rescale to 2**16,
+ FragColor = 0.0357*blurred;
+}`,hm=`
+  gradientSample.a = log2(gradientSample.r*gradientSample.r + gradientSample.g*gradientSample.g + gradientSample.b*gradientSample.b + 1.922337562475971e-06) + 18.988706873717717;
+`,Tv=`#version 300 es
+#line 323
+precision highp int;
+precision highp float;
+in vec2 TexCoord;
+out vec4 FragColor;
+uniform float coordZ;
+uniform float dX;
+uniform float dY;
+uniform float dZ;
+uniform highp sampler3D intensityVol;
+void main(void) {
+  vec3 vx = vec3(TexCoord.xy, coordZ);
+  //Neighboring voxels 'T'op/'B'ottom, 'A'nterior/'P'osterior, 'R'ight/'L'eft
+  float TAR = texture(intensityVol,vx+vec3(+dX,+dY,+dZ)).r;
+  float TAL = texture(intensityVol,vx+vec3(+dX,+dY,-dZ)).r;
+  float TPR = texture(intensityVol,vx+vec3(+dX,-dY,+dZ)).r;
+  float TPL = texture(intensityVol,vx+vec3(+dX,-dY,-dZ)).r;
+  float BAR = texture(intensityVol,vx+vec3(-dX,+dY,+dZ)).r;
+  float BAL = texture(intensityVol,vx+vec3(-dX,+dY,-dZ)).r;
+  float BPR = texture(intensityVol,vx+vec3(-dX,-dY,+dZ)).r;
+  float BPL = texture(intensityVol,vx+vec3(-dX,-dY,-dZ)).r;
+  vec4 gradientSample = vec4 (0.0, 0.0, 0.0, 0.0);
+  gradientSample.r = BAR+BAL+BPR+BPL -TAR-TAL-TPR-TPL;
+  gradientSample.g = TPR+TPL+BPR+BPL -TAR-TAL-BAR-BAL;
+  gradientSample.b = TAL+TPL+BAL+BPL -TAR-TPR-BAR-BPR;
+${hm}
+	// 0.04242020977371934 = 1/(log2(3*8) - log2(1/(255**2*8))) // 3*8 -> max for 1st order gradient
+	gradientSample.a *= 0.04242020977371934;
+  gradientSample.rgb = normalize(gradientSample.rgb);
+  gradientSample.rgb = (gradientSample.rgb * 0.5)+0.5;
+  FragColor = gradientSample;
+}`,Uv=`#version 300 es
+#line 323
+precision highp int;
+precision highp float;
+in vec2 TexCoord;
+out vec4 FragColor;
+uniform float coordZ;
+uniform float dX;
+uniform float dY;
+uniform float dZ;
+uniform float dX2;
+uniform float dY2;
+uniform float dZ2;
+uniform highp sampler3D intensityVol;
+void main(void) {
+  vec3 vx = vec3(TexCoord.xy, coordZ);
+  //Neighboring voxels 'T'op/'B'ottom, 'A'nterior/'P'osterior, 'R'ight/'L'eft
+  vec4 TAR = texture(intensityVol,vx+vec3(+dX,+dY,+dZ));
+  vec4 TAL = texture(intensityVol,vx+vec3(+dX,+dY,-dZ));
+  vec4 TPR = texture(intensityVol,vx+vec3(+dX,-dY,+dZ));
+  vec4 TPL = texture(intensityVol,vx+vec3(+dX,-dY,-dZ));
+  vec4 BAR = texture(intensityVol,vx+vec3(-dX,+dY,+dZ));
+  vec4 BAL = texture(intensityVol,vx+vec3(-dX,+dY,-dZ));
+  vec4 BPR = texture(intensityVol,vx+vec3(-dX,-dY,+dZ));
+  vec4 BPL = texture(intensityVol,vx+vec3(-dX,-dY,-dZ));
+  vec4 T = texture(intensityVol,vx+vec3(+dX2,0.0,0.0));
+  vec4 A = texture(intensityVol,vx+vec3(0.0,+dY2,0.0));
+  vec4 R = texture(intensityVol,vx+vec3(0.0,0.0,+dZ2));
+  vec4 B = texture(intensityVol,vx+vec3(-dX2,0.0,0.0));
+  vec4 P = texture(intensityVol,vx+vec3(0.0,-dY2,0.0));
+  vec4 L = texture(intensityVol,vx+vec3(0.0,0.0,-dZ2));
+  vec4 gradientSample = vec4 (0.0, 0.0, 0.0, 0.0);
+  gradientSample.r = -4.0*B.r +8.0*(BAR.r+BAL.r+BPR.r+BPL.r) -8.0*(TAR.r+TAL.r+TPR.r+TPL.r) +4.0*T.r;
+  gradientSample.g = -4.0*P.g +8.0*(TPR.g+TPL.g+BPR.g+BPL.g) -8.0*(TAR.g+TAL.g+BAR.g+BAL.g) +4.0*A.g;
+  gradientSample.b = -4.0*L.b +8.0*(TAL.b+TPL.b+BAL.b+BPL.b) -8.0*(TAR.b+TPR.b+BAR.b+BPR.b) +4.0*R.b;
+${hm}
+	gradientSample.a *= 0.0325;
+  gradientSample.rgb = normalize(gradientSample.rgb);
+  gradientSample.rgb =  (gradientSample.rgb * 0.5)+0.5;
+  FragColor = gradientSample;
+}`,Fv=function(i,t,n){const s=i.createShader(i.VERTEX_SHADER);i.shaderSource(s,t),i.compileShader(s);const r=i.createShader(i.FRAGMENT_SHADER);i.shaderSource(r,n),i.compileShader(r);const c=i.createProgram();if(i.attachShader(c,s),i.attachShader(c,r),i.linkProgram(c),!i.getProgramParameter(c,i.LINK_STATUS))throw console.log(i.getProgramInfoLog(c)),i.getShaderParameter(s,i.COMPILE_STATUS)||console.log("Vertex shader compilation error:",i.getShaderInfoLog(s)),i.getShaderParameter(r,i.COMPILE_STATUS)||console.log("Fragment shader compilation error:",i.getShaderInfoLog(r)),k.error(i.getProgramInfoLog(c)),new Error("Shader failed to link, see console for log");return c},Tt=class{constructor(i,t,n){z(this,"program"),z(this,"uniforms",{}),z(this,"isMatcap"),z(this,"isCrosscut"),this.program=Fv(i,t,n);const s=/uniform[^;]+[ ](\w+);/g,r=/uniform[^;]+[ ](\w+);/,c=t.match(s),l=n.match(s);c&&c.forEach(d=>{const h=d.match(r);this.uniforms[h[1]]=-1}),l&&l.forEach(d=>{const 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fontSizeScaling)"),this.opts.fontMinPx=this.opts.textHeight*217,this.opts.fontSizeScaling=.4,this.opts.textHeight=-1);const i=this.uiData.dpr||1,t=this.opts.fontMinPx,n=this.gl.canvas.width/i,s=this.gl.canvas.height/i,r=n*s,c=800*600,l=Math.max(r/c,1),d=Math.pow(l,this.opts.fontSizeScaling),h=t*d*i;this.fontPx=h,k.debug(`${n.toFixed(0)}x${s.toFixed(0)} pts (dpi=${i}) => areaScale=${l.toFixed(2)}, scale=${d.toFixed(2)}, minPx=${this.opts.fontMinPx} fontScale=${this.opts.fontSizeScaling} fontPx=${h.toFixed(2)}`)}resizeListener(){if(!(!this.canvas||!this.gl)){if(!this.opts.isResizeCanvas){this.opts.forceDevicePixelRatio>=0&&k.warn("this.opts.forceDevicePixelRatio requires isResizeCanvas"),this.drawScene();return}this.canvas.style.width="100%",this.canvas.style.height="100%",this.canvas.style.display="block",this.opts.forceDevicePixelRatio===0?this.uiData.dpr=window.devicePixelRatio||1:this.opts.forceDevicePixelRatio<0?this.uiData.dpr=1:this.uiData.dpr=this.opts.forceDevicePixelRatio,k.debug("devicePixelRatio: "+this.uiData.dpr),"width"in this.canvas.parentElement?(this.canvas.width=this.canvas.parentElement.width*this.uiData.dpr,this.canvas.height=this.canvas.parentElement.height*this.uiData.dpr):(this.canvas.width=this.canvas.offsetWidth*this.uiData.dpr,this.canvas.height=this.canvas.offsetHeight*this.uiData.dpr),this.gl.viewport(0,0,this.gl.canvas.width,this.gl.canvas.height),this.textSizePoints(),this.drawScene()}}getRelativeMousePosition(i,t){if(t=t||i.target,!t)return;const n=t.getBoundingClientRect();return{x:i.clientX-n.left,y:i.clientY-n.top}}getNoPaddingNoBorderCanvasRelativeMousePosition(i,t){return t=t||i.target,this.getRelativeMousePosition(i,t)}mouseContextMenuListener(i){i.preventDefault()}mouseDownListener(i){if(this.uiData.mousedown=!0,this.eventInBounds(i))this.opts.bounds&&(this.opts.showBoundsBorder=!0);else{this.opts.showBoundsBorder=!1,this.drawScene();return}i.preventDefault(),this.drawPenLocation=[NaN,NaN,NaN],this.drawPenAxCorSag=-1,this.drawShapeStartLocation=[NaN,NaN,NaN];const t=this.getNoPaddingNoBorderCanvasRelativeMousePosition(i,this.gl.canvas);if(this.opts.dragMode===7&&this.uiData.angleState==="drawing_second_line"||(this.setDragStart(t.x,t.y),this.setDragEnd(t.x,t.y)),k.debug("mouse down"),k.debug(i),!t)return;const[n,s]=[t.x*this.uiData.dpr,t.y*this.uiData.dpr];this.opts.clickToSegment&&(this.clickToSegmentXY=[n,s]);const r=this.getLabelAtPoint([n,s]);if(r){if(r.onClick){r.onClick(r,i);return}for(const c of this.meshes){if(c.type!=="connectome"){if(Array.isArray(r.points)&&r.points.length===3&&r.points.every(Number.isFinite)){const[l,d,h]=r.points;this.scene.crosshairPos=this.mm2frac([l,d,h]),this.updateGLVolume()}continue}for(const l of c.nodes)l.label===r&&(this.scene.crosshairPos=this.mm2frac([l.x,l.y,l.z]),this.updateGLVolume())}}this.uiData.clickedTile=this.tileIndex(n,s),i.button===qa&&i.shiftKey?(this.uiData.mouseButtonCenterDown=!0,this.setActiveDragMode(qa,!0,i.ctrlKey),this.handleMouseAction(this.uiData.activeDragMode,i,t)):i.button===qa?(this.uiData.mouseButtonLeftDown=!0,this.setActiveDragMode(qa,!1,i.ctrlKey),this.handleMouseAction(this.uiData.activeDragMode,i,t)):i.button===kh?(this.uiData.mouseButtonRightDown=!0,this.setActiveDragMode(kh,i.shiftKey,i.ctrlKey),this.handleMouseAction(this.uiData.activeDragMode,i,t)):i.button===Ph&&(this.uiData.mouseButtonCenterDown=!0,this.setActiveDragMode(Ph,i.shiftKey,i.ctrlKey),this.handleMouseAction(this.uiData.activeDragMode,i,t)),this.drawScene()}getMouseButtonDragMode(i,t,n){const s=this.opts.mouseEventConfig;return i===qa?s?.leftButton?t&&s.leftButton.withShift!==void 0?s.leftButton.withShift:n&&s.leftButton.withCtrl!==void 0?s.leftButton.withCtrl:s.leftButton.primary:n?8:this.opts.dragModePrimary:i===kh?s?.rightButton!==void 0?s.rightButton:this.opts.dragMode:i===Ph?s?.centerButton!==void 0?s.centerButton:this.opts.dragMode:this.opts.dragMode}getTouchDragMode(i){const t=this.opts.touchEventConfig;return i?t?.doubleTouch??this.opts.dragMode:t?.singleTouch??this.opts.dragModePrimary}setActiveDragMode(i,t,n){this.uiData.activeDragMode=this.getMouseButtonDragMode(i,t,n),this.uiData.activeDragButton=i}getCurrentDragMode(){return this.uiData.activeDragMode!==null?this.uiData.activeDragMode:this.opts.dragMode}clearActiveDragMode(){this.uiData.activeDragMode=null,this.uiData.activeDragButton=null}handleMouseAction(i,t,n){if(i===8)this.mouseDown(n.x,n.y),this.mouseClick(n.x,n.y);else if(i===9)this.uiData.windowX=t.x,this.uiData.windowY=t.y;else{if(this.mousePos=[n.x*this.uiData.dpr,n.y*this.uiData.dpr],i===0)return;if(i===7)if(this.uiData.angleState==="none")this.uiData.angleState="drawing_first_line";else if(this.uiData.angleState==="drawing_second_line"){const s=[n.x*this.uiData.dpr,n.y*this.uiData.dpr],r=this.tileIndex(s[0],s[1]);let c={sliceIndex:-1,sliceType:0,slicePosition:0};if(r>=0&&r<this.screenSlices.length){const g=this.screenSlices[r].axCorSag;let A=0;g===0?A=this.scene.crosshairPos[2]:g===1?A=this.scene.crosshairPos[1]:g===2&&(A=this.scene.crosshairPos[0]),c={sliceIndex:r,sliceType:g,slicePosition:A}}const l=[this.uiData.angleFirstLine[2],this.uiData.angleFirstLine[3],s[0],s[1]],d=this.canvasPos2frac([this.uiData.angleFirstLine[0],this.uiData.angleFirstLine[1]]),h=this.canvasPos2frac([this.uiData.angleFirstLine[2],this.uiData.angleFirstLine[3]]),u=this.canvasPos2frac([l[0],l[1]]),m=this.canvasPos2frac([l[2],l[3]]);if(d[0]>=0&&h[0]>=0&&u[0]>=0&&m[0]>=0){const g=this.frac2mm(d),A=this.frac2mm(h),v=this.frac2mm(u),y=this.frac2mm(m),w={firstLineMM:{start:lt(g[0],g[1],g[2]),end:lt(A[0],A[1],A[2])},secondLineMM:{start:lt(v[0],v[1],v[2]),end:lt(y[0],y[1],y[2])},sliceIndex:c.sliceIndex,sliceType:c.sliceType,slicePosition:c.slicePosition,angle:this.calculateAngleBetweenLines(this.uiData.angleFirstLine,l)};this.document.completedAngles.push(w)}this.resetAngleMeasurement(),this.uiData.angleState="complete",this.drawScene();return}else this.uiData.angleState==="complete"&&(this.resetAngleMeasurement(),this.uiData.angleState="drawing_first_line");this.setDragStart(n.x,n.y),this.uiData.isDragging||(this.uiData.pan2DxyzmmAtMouseDown=xn(this.scene.pan2Dxyzmm)),this.uiData.isDragging=!0,this.uiData.dragClipPlaneStartDepthAziElev=this.scene.clipPlaneDepthAziElevs[this.uiData.activeClipPlaneIndex]}}calculateMinMaxVoxIdx(i){if(i.length>2)throw new Error("array must not contain more than two values");return[Math.floor(Math.min(i[0],i[1])),Math.floor(Math.max(i[0],i[1]))]}calculateNewRange({volIdx:i=0}={}){if(this.opts.sliceType===4&&this.sliceMosaicString.length<1||this.uiData.dragStart[0]===this.uiData.dragEnd[0]&&this.uiData.dragStart[1]===this.uiData.dragEnd[1])return;let t=this.canvasPos2frac([this.uiData.dragStart[0],this.uiData.dragStart[1]]);if(t[0]<0)return;const n=this.frac2vox(t,i);if(t=this.canvasPos2frac([this.uiData.dragEnd[0],this.uiData.dragEnd[1]]),t[0]<0)return;const s=this.frac2vox(t,i);let r=-Number.MAX_VALUE,c=Number.MAX_VALUE;const l=this.calculateMinMaxVoxIdx([n[0],s[0]]),d=this.calculateMinMaxVoxIdx([n[1],s[1]]),h=this.calculateMinMaxVoxIdx([n[2],s[2]]);n[0]-s[0]===0?l[1]=n[0]+1:n[1]-s[1]===0?d[1]=n[1]+1:n[2]-s[2]===0&&(h[1]=n[2]+1);const u=this.volumes[i].hdr,m=this.volumes[i].img;if(!u||!m)return;const g=u.dims[1],A=u.dims[2];for(let w=h[0];w<h[1];w++){const b=w*g*A;for(let C=d[0];C<d[1];C++){const S=C*g;for(let E=l[0];E<l[1];E++){const M=b+S+E;c>m[M]&&(c=m[M]),r<m[M]&&(r=m[M])}}}if(c>=r)return;const v=d2(u,c),y=d2(u,r);this.volumes[i].cal_min=v,this.volumes[i].cal_max=y,this.onIntensityChange(this.volumes[i])}generateMouseUpCallback(i,t){const n=this.tileIndex(this.uiData.dragStart[0],this.uiData.dragStart[1]),s=this.tileIndex(this.uiData.dragEnd[0],this.uiData.dragEnd[1]);let r=-1;n===s&&(r=s);let c=-1;r>=0&&(c=this.screenSlices[r].axCorSag);const l=this.frac2mm(i),d=this.frac2mm(t),h=Gt();Nd(h,lt(l[0],l[1],l[2]),lt(d[0],d[1],d[2]));const u=tr(h),m=this.frac2vox(i),g=this.frac2vox(t);this.onDragRelease({fracStart:i,fracEnd:t,voxStart:m,voxEnd:g,mmStart:l,mmEnd:d,mmLength:u,tileIdx:r,axCorSag:c})}mouseUpListener(){this.uiData.mousedown=!1;function i(r){return Object.prototype.toString.call(r).indexOf("Function")>-1}const t={mouseButtonRightDown:this.uiData.mouseButtonRightDown,mouseButtonCenterDown:this.uiData.mouseButtonCenterDown,isDragging:this.uiData.isDragging,mousePos:this.mousePos,fracPos:this.canvasPos2frac(this.mousePos)};this.uiData.mouseButtonRightDown=!1;const n=this.uiData.mouseButtonCenterDown;this.uiData.mouseButtonCenterDown=!1,this.uiData.mouseButtonLeftDown=!1;const s=this.getCurrentDragMode();if(this.drawPenFillPts.length>0?this.drawPenFilled():this.opts.drawingEnabled&&!isNaN(this.drawPenLocation[0])?this.drawAddUndoBitmap():this.opts.drawingEnabled&&!isNaN(this.drawShapeStartLocation[0])&&(this.opts.penType===1||this.opts.penType===2)&&(this.opts.penValue===0?this.drawAddUndoBitmap():this.drawAddUndoBitmap(this.drawFillOverwrites),this.drawShapePreviewBitmap=null),this.drawPenLocation=[NaN,NaN,NaN],this.drawPenAxCorSag=-1,this.drawShapeStartLocation=[NaN,NaN,NaN],this.drawShapePreviewBitmap&&(this.drawBitmap=this.drawShapePreviewBitmap,this.drawShapePreviewBitmap=null,this.refreshDrawing(!0,!1)),i(this.onMouseUp)&&this.onMouseUp(t),this.uiData.isDragging){if(this.uiData.isDragging=!1,s===7){if(this.uiData.angleState==="drawing_first_line"){this.uiData.angleFirstLine=[this.uiData.dragStart[0],this.uiData.dragStart[1],this.uiData.dragEnd[0],this.uiData.dragEnd[1]],this.uiData.angleState="drawing_second_line",this.uiData.isDragging=!0,this.drawScene();return}if(this.uiData.angleState==="drawing_second_line"){this.uiData.angleState="complete",this.clearActiveDragMode(),this.drawScene();return}}s===5&&this.drawScene();const r=this.canvasPos2frac([this.uiData.dragStart[0],this.uiData.dragStart[1]]),c=this.canvasPos2frac([this.uiData.dragEnd[0],this.uiData.dragEnd[1]]);if(this.generateMouseUpCallback(r,c),s===6){this.clearActiveDragMode();return}if(s===1){if(n){this.clearActiveDragMode();return}if(this.uiData.dragStart[0]===this.uiData.dragEnd[0]&&this.uiData.dragStart[1]===this.uiData.dragEnd[1]){this.clearActiveDragMode();return}this.calculateNewRange({volIdx:0}),this.refreshLayers(this.volumes[0],0)}if(s===2){const l=this.getCurrentSliceInfo(),d=this.canvasPos2frac([this.uiData.dragStart[0],this.uiData.dragStart[1]]),h=this.canvasPos2frac([this.uiData.dragEnd[0],this.uiData.dragEnd[1]]);if(d[0]>=0&&h[0]>=0){const u=this.frac2mm(d),m=this.frac2mm(h);this.document.completedMeasurements.push({startMM:lt(u[0],u[1],u[2]),endMM:lt(m[0],m[1],m[2]),sliceIndex:l.sliceIndex,sliceType:l.sliceType,slicePosition:l.slicePosition,distance:rp(lt(u[0],u[1],u[2]),lt(m[0],m[1],m[2]))})}this.clearActiveDragMode(),this.drawScene();return}}this.clearActiveDragMode(),this.drawScene()}checkMultitouch(i){if(this.uiData.touchdown&&!this.uiData.multiTouchGesture){const t=this.canvas.getBoundingClientRect();this.mouseDown(i.touches[0].clientX-t.left,i.touches[0].clientY-t.top),this.mouseClick(i.touches[0].clientX-t.left,i.touches[0].clientY-t.top)}}touchStartListener(i){i.preventDefault(),this.uiData.touchTimer||(this.uiData.touchTimer=setTimeout(()=>{this.resetBriCon(i)},this.opts.longTouchTimeout)),this.uiData.touchdown=!0,this.uiData.currentTouchTime=new Date().getTime();const t=this.uiData.currentTouchTime-this.uiData.lastTouchTime;if(t<this.opts.doubleTouchTimeout&&t>0){this.uiData.doubleTouch=!0,this.setDragStart(i.targetTouches[0].clientX-i.target.getBoundingClientRect().left,i.targetTouches[0].clientY-i.target.getBoundingClientRect().top),this.resetBriCon(i),this.uiData.lastTouchTime=this.uiData.currentTouchTime;return}else this.uiData.doubleTouch=!1,this.setDragStart(0,0),this.setDragEnd(0,0),this.uiData.lastTouchTime=this.uiData.currentTouchTime;this.uiData.touchdown&&i.touches.length<2?this.uiData.multiTouchGesture=!1:this.uiData.multiTouchGesture=!0,setTimeout(this.checkMultitouch.bind(this),1,i)}touchEndListener(i){if(i.preventDefault(),this.uiData.touchdown=!1,this.uiData.lastTwoTouchDistance=0,this.uiData.multiTouchGesture=!1,this.uiData.touchTimer&&(clearTimeout(this.uiData.touchTimer),this.uiData.touchTimer=null),this.uiData.isDragging){this.uiData.isDragging=!1,this.getCurrentDragMode()===1&&(this.calculateNewRange(),this.refreshLayers(this.volumes[0],0));const t=this.canvasPos2frac([this.uiData.dragStart[0],this.uiData.dragStart[1]]),n=this.canvasPos2frac([this.uiData.dragEnd[0],this.uiData.dragEnd[1]]);this.generateMouseUpCallback(t,n)}this.mouseUpListener()}windowingHandler(i,t,n=0){const s=this.uiData.windowX,r=this.uiData.windowY;let c=this.volumes[0].cal_min,l=this.volumes[0].cal_max;const d=this.volumes[0].global_min,h=this.volumes[0].global_max;t<r?(c+=1,l+=1):t>r&&(c-=1,l-=1),i>s?(c-=1,l+=1):i<s&&(c+=1,l-=1),l-c<1&&(l=c+1),c<d&&(c=d),l>h&&(l=h),c>l&&(c=l-1),this.volumes[n].cal_min=c,this.volumes[n].cal_max=l,this.refreshLayers(this.volumes[n],0),this.uiData.windowX=i,this.uiData.windowY=t}mouseLeaveListener(){this.clickToSegmentIsGrowing&&(k.debug("Mouse left canvas, stopping clickToSegment preview."),this.clickToSegmentIsGrowing=!1,this.refreshDrawing(!0,!1)),this.opts.drawingEnabled&&!isNaN(this.drawPenLocation[0])&&(k.debug("Mouse left canvas during drawing, resetting pen state."),this.drawPenLocation=[NaN,NaN,NaN],this.drawPenAxCorSag=-1,this.drawPenFillPts=[]),this.opts.drawingEnabled&&!isNaN(this.drawShapeStartLocation[0])&&(k.debug("Mouse left canvas during shape drawing, resetting shape state."),this.drawShapeStartLocation=[NaN,NaN,NaN],this.drawShapePreviewBitmap&&(this.drawBitmap=this.drawShapePreviewBitmap,this.drawShapePreviewBitmap=null,this.refreshDrawing(!0,!1))),(this.uiData.isDragging||this.uiData.mousedown)&&(k.debug("Mouse left canvas during drag, resetting drag state."),this.uiData.isDragging=!1,this.uiData.mouseButtonLeftDown=!1,this.uiData.mouseButtonCenterDown=!1,this.uiData.mouseButtonRightDown=!1,this.uiData.mousedown=!1,this.drawScene()),this.mousePos=[-1,-1]}mouseMoveListener(i){this.uiData.mousedown&&this.drawScene();const t=this.getNoPaddingNoBorderCanvasRelativeMousePosition(i,this.gl.canvas);if(t){if(!this.eventInBounds(i)){this.updateMousePos(t.x,t.y);return}if(this.uiData.mousedown){const n=t.x*this.uiData.dpr,s=t.y*this.uiData.dpr;if(this.tileIndex(n,s)!==this.uiData.clickedTile)return;const c=this.getCurrentDragMode();if(c===8){this.mouseMove(t.x,t.y),this.mouseClick(t.x,t.y),this.drawScene(),this.uiData.prevX=this.uiData.currX,this.uiData.prevY=this.uiData.currY;return}if(c===9){this.windowingHandler(t.x,t.y),this.drawScene(),this.uiData.prevX=this.uiData.currX,this.uiData.prevY=this.uiData.currY;return}this.setDragEnd(t.x,t.y),this.drawScene(),this.uiData.prevX=this.uiData.currX,this.uiData.prevY=this.uiData.currY}else if(this.getCurrentDragMode()===7&&this.uiData.angleState==="drawing_second_line"){const n=this.getNoPaddingNoBorderCanvasRelativeMousePosition(i,this.gl.canvas);if(!n)return;this.setDragEnd(n.x,n.y),this.drawScene()}else if(!this.uiData.mousedown&&this.opts.clickToSegment){const n=this.getNoPaddingNoBorderCanvasRelativeMousePosition(i,this.gl.canvas);if(!n)return;const s=n.x*this.uiData.dpr,r=n.y*this.uiData.dpr;this.mousePos=[s,r];const c=this.tileIndex(s,r);c>=0&&this.opts.drawingEnabled&&this.screenSlices[c].axCorSag<=2&&(this.clickToSegmentXY=[s,r],this.clickToSegmentIsGrowing=!0,this.doClickToSegment({x:s,y:r,tileIndex:c}))}}}resetBriCon(i=null){if(this.uiData.isDragging)return;if(!this.eventInBounds(i)){this.opts.showBoundsBorder=!1;return}let t=!1;this.opts.sliceType===4&&(t=!0);let n=0,s=0;if(i!==null&&("targetTouches"in i?(n=i.targetTouches[0].clientX-i.target.getBoundingClientRect().left,s=i.targetTouches[0].clientY-i.target.getBoundingClientRect().top):(n=i.offsetX,s=i.offsetY),n*=this.uiData.dpr,s*=this.uiData.dpr,this.inRenderTile(n,s)>=0&&(t=!0)),t){this.uiData.mouseDepthPicker=!0,this.drawScene(),this.drawScene();return}this.getCurrentDragMode()!==4&&(this.volumes.length<1||this.uiData.doubleTouch||(this.volumes[0].cal_min=this.volumes[0].robust_min,this.volumes[0].cal_max=this.volumes[0].robust_max,this.onIntensityChange(this.volumes[0]),this.refreshLayers(this.volumes[0],0),this.drawScene()))}setDragStart(i,t){i*=this.uiData.dpr,t*=this.uiData.dpr,this.uiData.dragStart[0]=i,this.uiData.dragStart[1]=t}setDragEnd(i,t){i*=this.uiData.dpr,t*=this.uiData.dpr,this.uiData.dragEnd[0]=i,this.uiData.dragEnd[1]=t}touchMoveListener(i){if(this.uiData.touchdown&&i.touches.length<2){const t=this.canvas.getBoundingClientRect();if(this.uiData.isDragging||(this.uiData.pan2DxyzmmAtMouseDown=xn(this.scene.pan2Dxyzmm)),this.uiData.isDragging=!0,this.uiData.doubleTouch&&this.uiData.isDragging){this.setDragEnd(i.targetTouches[0].clientX-i.target.getBoundingClientRect().left,i.targetTouches[0].clientY-i.target.getBoundingClientRect().top),this.drawScene();return}const n=this.getTouchDragMode(!1);n===8?(this.mouseClick(i.touches[0].clientX-t.left,i.touches[0].clientY-t.top),this.mouseMove(i.touches[0].clientX-t.left,i.touches[0].clientY-t.top)):n===9&&(this.windowingHandler(i.touches[0].pageX,i.touches[0].pageY),this.drawScene())}else this.handlePinchZoom(i)}handlePinchZoom(i){if(i.targetTouches.length===2&&i.changedTouches.length===2){const t=Math.hypot(i.touches[0].pageX-i.touches[1].pageX,i.touches[0].pageY-i.touches[1].pageY),n=this.canvas.getBoundingClientRect();this.mousePos=[i.touches[0].clientX-n.left,i.touches[0].clientY-n.top],t<this.uiData.lastTwoTouchDistance?this.sliceScroll2D(-.01,i.touches[0].clientX-n.left,i.touches[0].clientY-n.top):this.sliceScroll2D(.01,i.touches[0].clientX-n.left,i.touches[0].clientY-n.top),this.uiData.lastTwoTouchDistance=t}}cycleActiveClipPlane(){const i=this.scene.clipPlanes.length||6;this.uiData.activeClipPlaneIndex==null?this.uiData.activeClipPlaneIndex=0:this.uiData.activeClipPlaneIndex=(this.uiData.activeClipPlaneIndex+1)%i;const t=this.uiData.activeClipPlaneIndex;return this.scene.clipPlanes[t]||(this.scene.clipPlanes[t]=[0,0,0,2]),this.scene.clipPlaneDepthAziElevs[t]||(this.scene.clipPlaneDepthAziElevs[t]=[2,0,0]),t}keyUpListener(i){if(!this.cursorInBounds()){this.opts.showBoundsBorder=!1,this.drawScene();return}const t=new Date().getTime(),n=t-this.lastCalled;if(i.code===this.opts.cycleClipPlaneHotKey&&n>this.opts.keyDebounceTime){const s=this.cycleActiveClipPlane();console.log("Active clip plane cycled to:",s),console.log("clip planes",this.scene.clipPlanes),this.lastCalled=t}if(i.code===this.opts.clipPlaneHotKey){if(n>this.opts.keyDebounceTime){switch(this.currentClipPlaneIndex=(this.currentClipPlaneIndex+1)%7,this.currentClipPlaneIndex){case 0:this.scene.clipPlaneDepthAziElevs[this.uiData.activeClipPlaneIndex]=[2,0,0];break;case 1:this.scene.clipPlaneDepthAziElevs[this.uiData.activeClipPlaneIndex]=[0,270,0];break;case 2:this.scene.clipPlaneDepthAziElevs[this.uiData.activeClipPlaneIndex]=[0,90,0];break;case 3:this.scene.clipPlaneDepthAziElevs[this.uiData.activeClipPlaneIndex]=[0,0,0];break;case 4:this.scene.clipPlaneDepthAziElevs[this.uiData.activeClipPlaneIndex]=[0,180,0];break;case 5:this.scene.clipPlaneDepthAziElevs[this.uiData.activeClipPlaneIndex]=[0,0,-90];break;case 6:this.scene.clipPlaneDepthAziElevs[this.uiData.activeClipPlaneIndex]=[0,0,90];break}this.setClipPlane(this.scene.clipPlaneDepthAziElevs[this.uiData.activeClipPlaneIndex])}this.lastCalled=t}else if(i.code===this.opts.viewModeHotKey){const s=new Date().getTime();s-this.lastCalled>this.opts.keyDebounceTime&&(this.setSliceType((this.opts.sliceType+1)%5),this.lastCalled=s)}this.drawScene()}keyDownListener(i){if(!this.cursorInBounds()){this.opts.showBoundsBorder=!1,this.drawScene();return}i.code==="KeyH"&&this.opts.sliceType===4?this.setRenderAzimuthElevation(this.scene.renderAzimuth-1,this.scene.renderElevation):i.code==="KeyL"&&this.opts.sliceType===4?this.setRenderAzimuthElevation(this.scene.renderAzimuth+1,this.scene.renderElevation):i.code==="KeyJ"&&this.opts.sliceType===4?this.setRenderAzimuthElevation(this.scene.renderAzimuth,this.scene.renderElevation+1):i.code==="KeyK"&&this.opts.sliceType===4?this.setRenderAzimuthElevation(this.scene.renderAzimuth,this.scene.renderElevation-1):i.code==="KeyH"&&this.opts.sliceType!==4?this.moveCrosshairInVox(-1,0,0):i.code==="KeyL"&&this.opts.sliceType!==4?this.moveCrosshairInVox(1,0,0):i.code==="KeyU"&&this.opts.sliceType!==4&&i.ctrlKey?this.moveCrosshairInVox(0,0,1):i.code==="KeyD"&&this.opts.sliceType!==4&&i.ctrlKey?this.moveCrosshairInVox(0,0,-1):i.code==="KeyJ"&&this.opts.sliceType!==4?this.moveCrosshairInVox(0,-1,0):i.code==="KeyK"&&this.opts.sliceType!==4?this.moveCrosshairInVox(0,1,0):i.code==="KeyM"&&this.opts.sliceType!==4?(this.opts.dragMode++,this.opts.dragMode>=4&&(this.opts.dragMode=0),k.info("drag mode changed to ",am[this.opts.dragMode])):i.code==="ArrowLeft"?this.setFrame4D(this.volumes[0].id,this.volumes[0].frame4D-1):i.code==="ArrowRight"?this.setFrame4D(this.volumes[0].id,this.volumes[0].frame4D+1):i.code==="Slash"&&i.shiftKey&&alert(`NIIVUE VERSION: ${g2}`),this.drawScene()}wheelListener(i){if(this.thumbnailVisible||this.opts.sliceMosaicString.length>0)return;if(this.eventInBounds(i))this.opts.bounds&&(this.opts.showBoundsBorder=!0);else{this.opts.showBoundsBorder=!1,this.drawScene();return}i.preventDefault(),i.stopPropagation();const t=this.uiData.dragStart.reduce((h,u)=>h+u,0),n=this.uiData.dragEnd.reduce((h,u)=>h+u,0),s=t>0&&n>0;if(this.getCurrentDragMode()===6&&s){const h=i.deltaY>0?1:-1;this.uiData.dragStart[0]<this.uiData.dragEnd[0]?(this.uiData.dragStart[0]-=h,this.uiData.dragEnd[0]+=h):(this.uiData.dragStart[0]+=h,this.uiData.dragEnd[0]-=h),this.uiData.dragStart[1]<this.uiData.dragEnd[1]?(this.uiData.dragStart[1]-=h,this.uiData.dragEnd[1]+=h):(this.uiData.dragStart[1]+=h,this.uiData.dragEnd[1]-=h),this.uiData.isDragging=!0,this.drawScene(),this.uiData.isDragging=!1;const u=this.tileIndex(this.uiData.dragStart[0],this.uiData.dragStart[1]);u>=0?this.generateMouseUpCallback(this.screenXY2TextureFrac(this.uiData.dragStart[0],this.uiData.dragStart[1],u),this.screenXY2TextureFrac(this.uiData.dragEnd[0],this.uiData.dragEnd[1],u)):k.warn("Could not generate drag release callback for ROI selection: Invalid tile index.");return}let r=i.deltaY<0?-.01:.01;if(this.opts.invertScrollDirection&&(r=-r),this.opts.clickToSegment){r<0?(this.opts.clickToSegmentPercent-=.01,this.opts.clickToSegmentPercent=Math.max(this.opts.clickToSegmentPercent,0)):(this.opts.clickToSegmentPercent+=.01,this.opts.clickToSegmentPercent=Math.min(this.opts.clickToSegmentPercent,1));const h=this.clickToSegmentXY[0],u=this.clickToSegmentXY[1],m=this.tileIndex(h,u);m>=0&&this.screenSlices[m].axCorSag<=2&&(k.debug(`Adjusting clickToSegment threshold: ${this.opts.clickToSegmentPercent.toFixed(3)}`),this.clickToSegmentIsGrowing=!0,this.doClickToSegment({x:h,y:u,tileIndex:m}));return}const c=this.canvas.getBoundingClientRect(),l=i.clientX-c.left,d=i.clientY-c.top;if(this.getCurrentDragMode()===3&&this.inRenderTile(this.uiData.dpr*l,this.uiData.dpr*d)===-1){const h=r<0?1:-1;let u=this.scene.pan2Dxyzmm[3]*(1+10*(.01*h));u=Math.round(u*10)/10;const m=this.scene.pan2Dxyzmm[3]-u;this.opts.yoke3Dto2DZoom&&(this.scene.volScaleMultiplier=u),this.scene.pan2Dxyzmm[3]=u;const g=this.frac2mm(this.scene.crosshairPos);this.scene.pan2Dxyzmm[0]+=m*g[0],this.scene.pan2Dxyzmm[1]+=m*g[1],this.scene.pan2Dxyzmm[2]+=m*g[2],this.drawScene(),this.canvas.focus(),this.sync();return}this.sliceScroll2D(r,l,d)}registerInteractions(){if(!this.canvas)throw new Error("canvas undefined");pn(this,Hn,new AbortController);const{signal:i}=dt(this,Hn);this.canvas.addEventListener("mousedown",this.mouseDownListener.bind(this),{signal:i}),this.canvas.addEventListener("mouseup",this.mouseUpListener.bind(this),{signal:i}),this.canvas.addEventListener("mousemove",this.mouseMoveListener.bind(this),{signal:i}),this.canvas.addEventListener("mouseleave",this.mouseLeaveListener.bind(this),{signal:i}),this.canvas.addEventListener("touchstart",this.touchStartListener.bind(this),{signal:i}),this.canvas.addEventListener("touchend",this.touchEndListener.bind(this),{signal:i}),this.canvas.addEventListener("touchmove",this.touchMoveListener.bind(this),{signal:i}),this.canvas.addEventListener("wheel",this.wheelListener.bind(this),{signal:i}),this.canvas.addEventListener("contextmenu",this.mouseContextMenuListener.bind(this),{signal:i}),this.canvas.addEventListener("dblclick",this.resetBriCon.bind(this),{signal:i}),this.canvas.addEventListener("dragenter",this.dragEnterListener.bind(this),{signal:i}),this.canvas.addEventListener("dragover",this.dragOverListener.bind(this),{signal:i}),this.canvas.addEventListener("drop",t=>{this.dropListener(t).catch(console.error)},{signal:i}),this.canvas.setAttribute("tabindex","0"),this.canvas.addEventListener("keyup",this.keyUpListener.bind(this),{signal:i}),this.canvas.addEventListener("keydown",this.keyDownListener.bind(this),{signal:i})}dragEnterListener(i){i.stopPropagation(),i.preventDefault()}dragOverListener(i){i.stopPropagation(),i.preventDefault()}getFileExt(i,t=!0){k.debug("fullname: ",i);const n=/(?:\.([^.]+))?$/;let s=n.exec(i)[1];if(s=s.toUpperCase(),s==="GZ")s=n.exec(i.slice(0,-3))[1],s=s.toUpperCase();else if(s==="CBOR"){const r=s;s=n.exec(i.slice(0,-5))[1],s=s.toUpperCase(),s=`${s}.${r}`}return t?s:s.toLowerCase()}async addVolumeFromUrl(i){const t=await Ue.loadFromUrl(i);return this.document.addImageOptions(t,i),t.onColormapChange=this.onColormapChange,this.mediaUrlMap.set(t,i.url),this.onVolumeAddedFromUrl&&this.onVolumeAddedFromUrl(i,t),this.addVolume(t),t}async addVolumesFromUrl(i){const t=i.map(async s=>{const r=this.getFileExt(s.name||s.url);if(r==="DCM")throw new Error("DICOM files must be loaded using useDicomLoader");if(this.loaders[r]){let d=s.url;const h=this.loaders[r].toExt;let u=s.name||s.url;if(u=u.split("/").pop(),typeof s.url=="string"){const g=s.url;try{const A=await fetch(g);if(!A.ok)throw new Error(`Failed to load file: ${A.statusText}`);d=await A.arrayBuffer()}catch(A){throw new Error(`Failed to load url ${g}: ${A}`)}}const m=await this.loaders[r].loader(d);s.url=m,s.name=`${u}.${h}`}const c={url:s.url,headers:s.headers,name:s.name,colormap:s.colormap?s.colormap:s.colorMap,colormapNegative:s.colormapNegative?s.colormapNegative:s.colorMapNegative,opacity:s.opacity,urlImgData:s.urlImgData,cal_min:s.cal_min,cal_max:s.cal_max,trustCalMinMax:this.opts.trustCalMinMax,isManifest:s.isManifest,frame4D:s.frame4D,limitFrames4D:s.limitFrames4D||this.opts.limitFrames4D,colorbarVisible:s.colorbarVisible},l=await Ue.loadFromUrl(c);return this.document.addImageOptions(l,c),l.onColormapChange=this.onColormapChange,this.mediaUrlMap.set(l,c.url),this.onVolumeAddedFromUrl&&this.onVolumeAddedFromUrl(c,l),l}),n=await Promise.all(t);for(let s=0;s<n.length;s++)this.addVolume(n[s]);return n}getMediaByUrl(i){return[...this.mediaUrlMap.entries()].filter(t=>t[1]===i).map(t=>t[0]).pop()}removeVolumeByUrl(i){const t=this.getMediaByUrl(i);if(t)this.removeVolume(t);else throw new Error("No volume with URL present")}async traverseFileTree(i,t="",n){return new Promise(s=>{if(i.isFile)i.file(r=>{r.fullPath=t+r.name,r._webkitRelativePath=t+r.name,n.push(r),s(n)});else if(i.isDirectory){const r=i.createReader(),c=()=>{r.readEntries(l=>{if(l.length>0){const d=[];for(const h of l)d.push(this.traverseFileTree(h,t+i.name+"/",n));Promise.all(d).then(c).catch(h=>{throw h})}else s(n)})};c()}})}readDirectory(i){const t=i.createReader();let n=[];const s=async c=>{const l=[],d=async h=>new Promise((u,m)=>h.file(u,m));for(let h=0;h<c.length;h++)l.push(await d(c[h]));return l},r=()=>{t.readEntries(c=>{c.length?(n=n.concat(c),r()):s(n).then(async()=>{}).catch(l=>{throw l})})};return r(),n}isMeshExt(i){const t=this.getFileExt(i);return k.debug("dropped ext"),k.debug(t),Yn.includes(t)}async loadFromArrayBuffer(i,t){const n=this.getFileExt(t);if(Yn.includes(n)){await this.addMeshFromUrl({url:t,buffer:i});return}const s=Gl(t);s.buffer=i,s.name=t,await this.addVolumeFromUrl(s)}async loadFromFile(i){const t=this.getFileExt(i.name);if(Yn.includes(t)){await Gs.loadFromFile({file:i,gl:this.gl,name:i.name}).then(n=>{this.addMesh(n)});return}await Ue.loadFromFile({file:i,name:i.name}).then(n=>{this.addVolume(n)})}useLoader(i,t,n){this.loaders={...this.loaders,[t.toUpperCase()]:{loader:i,toExt:n}}}useDicomLoader(i){this.dicomLoader=i}getDicomLoader(){return this.dicomLoader}async dropListener(i){if(this.eventInBounds(i))this.opts.bounds&&(this.opts.showBoundsBorder=!0);else{this.opts.showBoundsBorder=!1;return}if(i.stopPropagation(),i.preventDefault(),!this.opts.dragAndDropEnabled)return;const t=[],n=i.dataTransfer;if(!n)return;const s=n.getData("text/uri-list");if(s){const r=Gl(s),c=this.getFileExt(s);k.debug("dropped ext"),k.debug(c),Yn.includes(c)?this.addMeshFromUrl({url:s}).catch(l=>{throw l}):c==="NVD"?this.loadDocumentFromUrl(s).catch(l=>{throw l}):this.addVolumeFromUrl(r).catch(l=>{throw l})}else{const r=n.items;if(r.length>0){!i.shiftKey&&!i.altKey&&(this.volumes=[],this.overlays=[],this.meshes=[]),this.closeDrawing(),this.closePAQD();for(const c of Array.from(r)){const l=c.webkitGetAsEntry();if(k.debug(l),!l)throw new Error("could not get entry from file");if(l.isFile){const d=this.getFileExt(l.name);let h;if(l.name.lastIndexOf("HEAD")!==-1)for(const u of Array.from(r)){const m=u.webkitGetAsEntry();if(!m)throw new Error("could not get paired entry");const g=l.name.substring(0,l.name.lastIndexOf("HEAD")),A=m.name.substring(0,m.name.lastIndexOf("BRIK"));g===A&&(h=m)}if(l.name.toUpperCase().lastIndexOf("HDR")!==-1)for(const u of Array.from(r)){const m=u.webkitGetAsEntry();if(!m)throw new Error("could not get paired entry");const g=l.name.substring(0,l.name.toUpperCase().lastIndexOf("HDR")),A=m.name.substring(0,m.name.toUpperCase().lastIndexOf("IMG"));g===A&&(h=m)}if(l.name.lastIndexOf("BRIK")!==-1||l.name.toUpperCase().lastIndexOf("IMG")!==-1)continue;if(this.loaders[d]){const u=await Bv(l);await this.loadImages([{url:u,name:`${l.name}`}]);continue}if(Yn.includes(d)){l.file(u=>{(async()=>{try{const m=await Gs.loadFromFile({file:u,gl:this.gl,name:u.name});this.addMesh(m)}catch(m){console.error("Error loading mesh:",m)}})().catch(m=>console.error(m))});continue}else if(d==="NVD"){l.file(u=>{(async()=>{try{const m=await Bh.loadFromFile(u);await this.loadDocument(m),k.debug("loaded document")}catch(m){console.error(m)}})().catch(m=>console.error(m))});break}l.file(u=>{(async()=>{try{if(h)h.file(m=>{(async()=>{try{const g=await Ue.loadFromFile({file:u,urlImgData:m,limitFrames4D:this.opts.limitFrames4D});this.addVolume(g)}catch(g){console.error(g)}})().catch(console.error)});else{const m=await Ue.loadFromFile({file:u,urlImgData:h,limitFrames4D:this.opts.limitFrames4D});i.altKey?(k.debug("alt key detected: assuming this is a drawing overlay"),this.drawClearAllUndoBitmaps(),this.loadDrawing(m)):this.addVolume(m)}}catch(m){console.error(m)}})().catch(console.error)})}else l.isDirectory&&this.traverseFileTree(l,"",t).then(d=>{const h=this.getDicomLoader().loader;if(!h)throw new Error("No loader for DICOM files");h(d).then(async u=>{const m=u.map(g=>Ue.loadFromUrl({url:g.data,name:g.name,limitFrames4D:this.opts.limitFrames4D}));Promise.all(m).then(async g=>{await this.onDicomLoaderFinishedWithImages(g)}).catch(g=>{throw g})}).catch(u=>{console.error("Error loading DICOM files:",u)})}).catch(d=>{throw d})}}}this.drawScene()}setMultiplanarPadPixels(i){this.opts.multiplanarPadPixels=i,this.drawScene()}setMultiplanarLayout(i){typeof i=="string"&&(i=parseInt(i)),this.opts.multiplanarLayout=i,this.drawScene()}setCornerOrientationText(i){this.opts.isCornerOrientationText=i,this.updateGLVolume()}setIsOrientationTextVisible(i){this.opts.isOrientationTextVisible=i,this.drawScene()}setShowAllOrientationMarkers(i){this.opts.showAllOrientationMarkers=i,this.drawScene()}setHeroImage(i){this.opts.heroImageFraction=i,this.drawScene()}setCustomLayout(i){for(let t=0;t<i.length;t++){const[n,s,r,c]=i[t].position,l=n+r,d=s+c;for(let h=t+1;h<i.length;h++){const[u,m,g,A]=i[h].position,v=u+g,y=m+A,w=n<v&&l>u,b=s<y&&d>m;if(w&&b)throw new Error(`Custom layout is invalid. Tile ${t} overlaps with tile ${h}.`)}}this.customLayout=i,this.drawScene()}clearCustomLayout(){this.customLayout=null,this.drawScene()}getCustomLayout(){return this.customLayout}setRadiologicalConvention(i){this.opts.isRadiologicalConvention=i,this.updateGLVolume()}setDefaults(i={},t=!1){this.document.opts={...mi},this.scene.sceneData={...Za};for(const n in i)typeof i[n]=="function"?this[n]=i[n]:this.opts[n]=mi[n]===void 0?mi[n]:i[n];if(this.scene.pan2Dxyzmm=[0,0,0,1],t&&this.volumes&&this.volumes.length>0)for(let n=0;n<this.volumes.length;n++)this.volumes[n].cal_min=this.volumes[n].robust_min,this.volumes[n].cal_max=this.volumes[n].robust_max;this.updateGLVolume()}setMeshThicknessOn2D(i){this.opts.meshThicknessOn2D=i,this.updateGLVolume()}setSliceMosaicString(i){this.sliceMosaicString=i,this.updateGLVolume()}setSliceMM(i){this.opts.isSliceMM=i,this.updateGLVolume()}setAdditiveBlend(i){this.opts.isAdditiveBlend=i,this.updateGLVolume()}getRadiologicalConvention(){return this.opts.isRadiologicalConvention}setHighResolutionCapable(i){typeof i=="boolean"&&(i=i?0:-1),this.opts.forceDevicePixelRatio=i,this.resizeListener(),this.drawScene()}watchOptsChanges(i){this.onOptsChange=i}unwatchOptsChanges(){this.onOptsChange=()=>{}}addVolume(i){this.volumes.push(i);const t=this.volumes.length===1?0:this.volumes.length-1;this.setVolume(i,t),this.onImageLoaded(i),k.debug("loaded volume",i.name),k.debug(i)}addMesh(i){this.meshes.push(i);const t=this.meshes.length===1?0:this.meshes.length-1;this.setMesh(i,t),this.onMeshLoaded(i)}getVolumeIndexByID(i){const t=this.volumes.length;for(let n=0;n<t;n++)if(this.volumes[n].id===i)return n;return-1}drawAddUndoBitmap(i=!0){if(!this.drawBitmap||this.drawBitmap.length<1){k.debug("drawAddUndoBitmap error: No drawing open");return}if(!i&&this.drawUndoBitmaps.length>0){const t=this.drawBitmap.length,n=Wh(this.drawUndoBitmaps[this.currentDrawUndoBitmap],t);for(let s=0;s<t;s++)n[s]>0&&(this.drawBitmap[s]=n[s]);this.refreshDrawing(!1)}this.currentDrawUndoBitmap++,this.currentDrawUndoBitmap>=this.opts.maxDrawUndoBitmaps&&(this.currentDrawUndoBitmap=0),this.drawUndoBitmaps[this.currentDrawUndoBitmap]=S4(this.drawBitmap)}drawClearAllUndoBitmaps(){if(this.currentDrawUndoBitmap=this.opts.maxDrawUndoBitmaps,!(!this.drawUndoBitmaps||this.drawUndoBitmaps.length<1))for(let i=this.drawUndoBitmaps.length-1;i>=0;i--)this.drawUndoBitmaps[i]=new Uint8Array}drawUndo(){const{drawBitmap:i,currentDrawUndoBitmap:t}=M4({drawUndoBitmaps:this.drawUndoBitmaps,currentDrawUndoBitmap:this.currentDrawUndoBitmap,drawBitmap:this.drawBitmap});this.drawBitmap=i,this.currentDrawUndoBitmap=t,this.refreshDrawing(!0)}loadDrawing(i){if(this.drawBitmap&&k.debug("Overwriting open drawing!"),!this.back)throw new Error("back undefined");this.drawClearAllUndoBitmaps();const t=i.hdr.dims;if(t[1]!==this.back.hdr.dims[1]||t[2]!==this.back.hdr.dims[2]||t[3]!==this.back.hdr.dims[3])return k.debug("drawing dimensions do not match background image"),!1;i.img.constructor!==Uint8Array&&k.debug("Drawings should be UINT8");const n=i.permRAS,s=t[1]*t[2]*t[3];this.drawBitmap=new Uint8Array(s),this.opts.is2DSliceShader?this.drawTexture=this.r8Tex2D(this.drawTexture,gn,this.back.dims,!0):this.drawTexture=this.r8Tex(this.drawTexture,gn,this.back.dims,!0);const r=[0,0,0];for(let y=0;y<3;y++)for(let w=0;w<3;w++)Math.abs(n[y])-1===w&&(r[w]=y*Math.sign(n[y]));let c=1;const l=[1,1,1],d=[!1,!1,!1];for(let y=0;y<r.length;y++)for(let w=0;w<r.length;w++)Math.abs(r[w])===y&&(l[w]=c,(r[w]<0||Object.is(r[w],-0))&&(d[w]=!0),c*=t[w+1]);let h=At.range(0,t[1]-1,1);d[0]&&(h=At.range(t[1]-1,0,-1));for(let y=0;y<t[1];y++)h[y]*=l[0];let u=At.range(0,t[2]-1,1);d[1]&&(u=At.range(t[2]-1,0,-1));for(let y=0;y<t[2];y++)u[y]*=l[1];let m=At.range(0,t[3]-1,1);d[2]&&(m=At.range(t[3]-1,0,-1));for(let y=0;y<t[3];y++)m[y]*=l[2];const g=i.img,A=this.drawBitmap;let v=0;for(let y=0;y<t[3];y++)for(let w=0;w<t[2];w++)for(let b=0;b<t[1];b++)A[h[b]+u[w]+m[y]]=g[v],v++;return this.drawAddUndoBitmap(),this.refreshDrawing(!1),this.drawScene(),!0}binarize(i){const t=i.hdr.dims,n=t[1]*t[2]*t[3],s=new Uint8Array(n);for(let r=0;r<n;r++)i.img[r]!==0&&(s[r]=1);i.img=s,i.hdr.datatypeCode=2,i.hdr.cal_min=0,i.hdr.cal_max=1}async loadDrawingFromUrl(i,t=!1){this.drawBitmap&&k.debug("Overwriting open drawing!"),this.drawClearAllUndoBitmaps();let n=!1;try{const s=await Ue.loadFromUrl(Gl(i));t&&await this.binarize(s),n=this.loadDrawing(s)}catch{k.error("loadDrawingFromUrl() failed to load "+i),this.drawClearAllUndoBitmaps()}return n}findOtsu(i=2){if(this.volumes.length<1)return[];const t=this.volumes[0].img,n=t.length;if(n<1)return[];const s=256,r=s-1,c=new Array(s).fill(0),l=this.volumes[0].cal_min,d=this.volumes[0].cal_max;if(d<=l)return[];const h=(d-l)/s;function u(C){return C*h+l}const m=(s-1)/Math.abs(d-l),g=this.volumes[0].hdr.scl_inter,A=this.volumes[0].hdr.scl_slope;for(let C=0;C<n;C++){let S=t[C]*A+g;S=Math.min(Math.max(S,l),d),S=Math.round((S-l)*m),c[S]++}const v=Array(s).fill(0).map(()=>Array(s).fill(0)),y=Array(s).fill(0).map(()=>Array(s).fill(0));for(let C=1;C<s;++C)v[C][C]=c[C],y[C][C]=C*c[C];for(let C=1;C<s-1;++C)v[1][C+1]=v[1][C]+c[C+1],y[1][C+1]=y[1][C]+(C+1)*c[C+1];for(let C=2;C<s;C++)for(let S=C+1;S<s;S++)v[C][S]=v[1][S]-v[1][C-1],y[C][S]=y[1][S]-y[1][C-1];for(let C=1;C<s;++C)for(let S=C+1;S<s;S++)v[C][S]!==0&&(v[C][S]=y[C][S]*y[C][S]/v[C][S]);let w=0;const b=[1/0,1/0,1/0];if(i>3)for(let C=0;C<s-3;C++)for(let S=C+1;S<s-2;S++)for(let E=S+1;E<s-1;E++){const M=v[0][C]+v[C+1][S]+v[S+1][E]+v[E+1][r];M>w&&(b[0]=C,b[1]=S,b[2]=E,w=M)}else if(i===3)for(let C=0;C<s-2;C++)for(let S=C+1;S<s-1;S++){const E=v[0][C]+v[C+1][S]+v[S+1][r];E>w&&(b[0]=C,b[1]=S,w=E)}else for(let C=0;C<s-1;C++){const S=v[0][C]+v[C+1][r];S>w&&(b[0]=C,w=S)}return[u(b[0]),u(b[1]),u(b[2])]}drawOtsu(i=2){if(this.volumes.length===0)return;const t=this.volumes[0].img.length,n=this.findOtsu(i);if(n.length<3)return;this.drawBitmap||this.createEmptyDrawing();const s=this.drawBitmap,r=this.volumes[0].img;for(let c=0;c<t;c++){if(s[c]!==0)continue;const l=r[c];l>n[0]&&(s[c]=1),l>n[1]&&(s[c]=2),l>n[2]&&(s[c]=3)}this.drawAddUndoBitmap(),this.refreshDrawing(!0)}removeHaze(i=5,t=0){const n=this.volumes[t].img,s=this.volumes[t].hdr,r=n.length;let c=2;(i===5||i===1)&&(c=4),(i===4||i===2)&&(c=3);const l=this.findOtsu(c);if(l.length<3)return;let d=l[0];i===1&&(d=l[2]),i===2&&(d=l[1]);const h=s.scl_inter,u=s.scl_slope,m=this.volumes[t].global_min;for(let g=0;g<r;g++)n[g]*u+h<d&&(n[g]=m);this.refreshLayers(this.volumes[t],0),this.drawScene()}async saveImage(i=y2){const t={...y2,...i},{filename:n,isSaveDrawing:s,volumeByIndex:r}=t;return k.debug("saveImage",n,s,r),this.back?.dims===void 0?(k.debug("No voxelwise image open"),!1):s?this.drawBitmap?await this.volumes[0].saveToDisk(n,this.drawBitmap):(k.debug("No drawing open"),!1):(k.debug("saving image"),this.volumes[r].saveToDisk(n))}getMeshIndexByID(i){if(typeof i=="number")return i>=this.meshes.length?-1:i;const t=this.meshes.length;for(let n=0;n<t;n++)if(this.meshes[n].id===i)return n;return-1}setMeshProperty(i,t,n){const s=this.getMeshIndexByID(i);if(s<0){k.warn("setMeshProperty() id not loaded",i);return}this.meshes[s].setProperty(t,n,this.gl),this.updateGLVolume(),this.onMeshPropertyChanged(s,t,n)}indexNearestXYZmm(i,t,n,s){const r=this.getMeshIndexByID(i);return r<0?(k.warn("indexNearestXYZmm() id not loaded",i),[NaN,NaN]):this.meshes[r].indexNearestXYZmm(t,n,s)}decimateHierarchicalMesh(i,t=3){const n=this.getMeshIndexByID(i);if(n<0){k.warn("reverseFaces() id not loaded",i);return}const s=this.meshes[n].decimateHierarchicalMesh(this.gl,t);return this.updateGLVolume(),s}reverseFaces(i){const t=this.getMeshIndexByID(i);if(t<0){k.warn("reverseFaces() id not loaded",i);return}this.meshes[t].reverseFaces(this.gl),this.updateGLVolume()}async setMeshLayerProperty(i,t,n,s){const r=this.getMeshIndexByID(i);if(r<0){k.warn("setMeshLayerProperty() id not loaded",i);return}await this.meshes[r].setLayerProperty(t,n,s,this.gl),this.updateGLVolume()}setPan2Dxyzmm(i){this.scene.pan2Dxyzmm=i,this.opts.yoke3Dto2DZoom&&(this.scene.volScaleMultiplier=i[3]),this.drawScene()}setRenderAzimuthElevation(i,t){this.scene.renderAzimuth=i,this.scene.renderElevation=t,this.onAzimuthElevationChange(i,t),this.drawScene()}getOverlayIndexByID(i){const t=this.overlays.length;for(let n=0;n<t;n++)if(this.overlays[n].id===i)return n;return-1}setVolume(i,t=0){const n=this.volumes.length;if(t>n)return;const s=this.getVolumeIndexByID(i.id);t===0?(this.volumes.splice(s,1),this.volumes.unshift(i),this.back=this.volumes[0],this.overlays=this.volumes.slice(1)):t<0?(this.volumes.splice(this.getVolumeIndexByID(i.id),1),this.back=this.volumes[0],this.volumes.length>1?this.overlays=this.volumes.slice(1):this.overlays=[]):(this.volumes.splice(s,1),this.volumes.splice(t,0,i),this.overlays=this.volumes.slice(1),this.back=this.volumes[0]),this.updateGLVolume()}setMesh(i,t=0){this.meshes.forEach(r=>{k.debug("MESH: ",r.name)});const n=this.meshes.length;if(t>n)return;const s=this.getMeshIndexByID(i.id);t===0?(this.meshes.splice(s,1),this.meshes.unshift(i)):t<0?this.meshes.splice(this.getMeshIndexByID(i.id),1):(this.meshes.splice(s,1),this.meshes.splice(t,0,i)),this.updateGLVolume(),this.meshes.forEach(r=>{k.debug(r.name)})}removeVolume(i){if(this.setVolume(i,-1),this.mediaUrlMap.has(i)){const t=this.mediaUrlMap.get(i);this.onVolumeWithUrlRemoved(t),this.mediaUrlMap.delete(i)}this.drawScene()}removeVolumeByIndex(i){if(i>=this.volumes.length)throw new Error("Index of volume out of bounds");this.removeVolume(this.volumes[i])}removeMesh(i){if(i.unloadMesh(this.gl),this.setMesh(i,-1),this.mediaUrlMap.has(i)){const t=this.mediaUrlMap.get(i);this.onMeshWithUrlRemoved(t),this.mediaUrlMap.delete(i)}}removeMeshByUrl(i){const t=this.getMediaByUrl(i);t&&(this.removeMesh(t),this.mediaUrlMap.delete(t),this.onMeshWithUrlRemoved(i))}moveVolumeToBottom(i){this.setVolume(i,0)}moveVolumeUp(i){const t=this.getVolumeIndexByID(i.id);this.setVolume(i,t+1)}moveVolumeDown(i){const t=this.getVolumeIndexByID(i.id);this.setVolume(i,t-1)}moveVolumeToTop(i){this.setVolume(i,this.volumes.length-1)}mouseDown(i,t){i*=this.uiData.dpr,t*=this.uiData.dpr,this.mousePos=[i,t]}updateMousePos(i,t){return i*=this.uiData.dpr,t*=this.uiData.dpr,this.mousePos=[i,t],[i,t]}mouseMove(i,t){i*=this.uiData.dpr,t*=this.uiData.dpr;const n=(i-this.mousePos[0])/this.uiData.dpr,s=(t-this.mousePos[1])/this.uiData.dpr;this.mousePos=[i,t],!(this.inRenderTile(i,t)<0)&&(Math.abs(n)<1&&Math.abs(s)<1||(this.scene.renderAzimuth+=n,this.scene.renderElevation+=s,this.drawScene()))}sph2cartDeg(i,t){const n=-t*(Math.PI/180),s=(i-90)%360*(Math.PI/180),r=[Math.cos(n)*Math.cos(s),Math.cos(n)*Math.sin(s),Math.sin(n)],c=Math.sqrt(r[0]*r[0]+r[1]*r[1]+r[2]*r[2]);return c<=0||(r[0]/=c,r[1]/=c,r[2]/=c),r}setClipPlanes(i){this.scene.clipPlanes=[],this.scene.clipPlaneDepthAziElevs=[];for(let t=0;t<i.length;t++){const n=i[t],s=this.sph2cartDeg(n[1],n[2]),r=-n[0],c=[s[0],s[1],s[2],r];this.scene.clipPlanes.push(c),this.scene.clipPlaneDepthAziElevs.push(n)}this.drawScene()}setClipPlane(i){if(!i||i.length===0)return;const t=this.uiData.activeClipPlaneIndex??0;for(this.scene.clipPlanes||(this.scene.clipPlanes=[]),this.scene.clipPlaneDepthAziElevs||(this.scene.clipPlaneDepthAziElevs=[]);this.scene.clipPlanes.length<=t;)this.scene.clipPlanes.push([0,0,0,2]);for(;this.scene.clipPlaneDepthAziElevs.length<=t;)this.scene.clipPlaneDepthAziElevs.push([2,0,0]);const n=this.sph2cartDeg(i[1]+180,i[2]),s=[n[0],n[1],n[2],i[0]];this.scene.clipPlanes[t]=s,this.scene.clipPlaneDepthAziElevs[t]=i,this.onClipPlaneChange(s),this.drawScene()}setCrosshairColor(i){this.opts.crosshairColor=i,this.drawScene()}setCrosshairWidth(i){this.opts.crosshairWidth=i,this.crosshairs3D&&(this.crosshairs3D.mm[0]=NaN),this.drawScene()}setDrawColormap(i){this.drawLut=Pt.makeDrawLut(i),this.updateGLVolume()}setDrawingEnabled(i){this.opts.drawingEnabled=i,this.opts.drawingEnabled?this.drawBitmap||this.createEmptyDrawing():(this.clickToSegmentIsGrowing&&(this.clickToSegmentIsGrowing=!1,this.refreshDrawing(!0,!1)),this.drawPenLocation=[NaN,NaN,NaN],this.drawPenAxCorSag=-1,this.drawPenFillPts=[],this.drawShapeStartLocation=[NaN,NaN,NaN],this.drawShapePreviewBitmap&&(this.drawBitmap=this.drawShapePreviewBitmap,this.drawShapePreviewBitmap=null)),this.drawScene()}setPenValue(i,t=!1){this.opts.penValue=i,this.opts.isFilledPen=t,this.drawScene()}setDrawOpacity(i){this.drawOpacity=i,this.drawScene()}setSelectionBoxColor(i){this.opts.selectionBoxColor=i}setBounds(i){if(!Array.isArray(i)||i.length!==4)throw new Error("setBounds: expected [x1,y1,x2,y2] array");this.opts.bounds=[[i[0],i[1]],[i[2],i[3]]],this.gl&&this.drawScene()}sliceScroll2D(i,t,n,s=!0){if(this.opts.scrollRequiresFocus&&this.canvas!==document.activeElement){k.warn("Canvas element does not have focus. Scroll events will not be processed.");return}if(this.inGraphTile(t,n)){let r=this.volumes[0].frame4D;i>0&&r++,i<0&&r--,this.setFrame4D(this.volumes[0].id,r);return}if(i!==0&&this.opts.dragMode===3&&this.inRenderTile(this.uiData.dpr*t,this.uiData.dpr*n)===-1){let r=this.scene.pan2Dxyzmm[3]*(1+10*i);r=Math.round(r*10)/10;const c=this.scene.pan2Dxyzmm[3]-r;this.opts.yoke3Dto2DZoom&&(this.scene.volScaleMultiplier=r),this.scene.pan2Dxyzmm[3]=r;const l=this.frac2mm(this.scene.crosshairPos);this.scene.pan2Dxyzmm[0]+=c*l[0],this.scene.pan2Dxyzmm[1]+=c*l[1],this.scene.pan2Dxyzmm[2]+=c*l[2],this.drawScene(),this.canvas.focus(),this.sync();return}this.mouseClick(t,n,i,s)}setSliceType(i){return this.opts.sliceType=i,this.drawScene(),this}setOpacity(i,t){this.volumes[i].opacity=t,this.updateGLVolume()}setScale(i){this.scene.volScaleMultiplier=i,this.drawScene()}setClipPlaneColor(i){this.opts.clipPlaneColor=i,this.renderShader.use(this.gl),this.gl.uniform4fv(this.renderShader.uniforms.clipPlaneColor,this.opts.clipPlaneColor),this.drawScene()}setClipPlaneThick(i){k.warn("setClipPlaneThick() has been removed. use setClipPlanes() instead.")}setClipVolume(i,t){k.warn("setClipVolume() has been removed. use setClipPlanes() instead.")}async setVolumeRenderIllumination(i=0){this.renderGradientValues=Number.isNaN(i),this.renderShader=this.renderVolumeShader,this.renderGradientValues?this.renderShader=this.renderGradientValuesShader:(this.opts.gradientAmount=i,i>0||this.opts.gradientOpacity>0?this.renderShader=this.renderGradientShader:i<0&&(this.renderShader=this.renderSliceShader)),await this.refreshLayers(this.volumes[0],0),this.initRenderShader(this.renderShader,i),this.renderShader.use(this.gl),this.setClipPlaneColor(this.opts.clipPlaneColor),Number.isNaN(i)?this.gradientTextureAmount=1:this.gradientTextureAmount=i,!(this.volumes.length<1)&&this.drawScene()}async setGradientOpacity(i=0,t=0){this.opts.gradientOpacity=i,this.opts.renderSilhouette=t,this.renderGradientValues?this.renderShader=this.renderGradientValuesShader:this.gradientTextureAmount>0||i>0?this.renderShader=this.renderGradientShader:this.gradientTextureAmount<0&&(this.renderShader=this.renderSliceShader),this.initRenderShader(this.renderShader,this.gradientTextureAmount),this.renderShader.use(this.gl),this.gradientTextureAmount>0&&this.refreshLayers(this.volumes[0],0),this.drawScene()}overlayRGBA(i){const t=i.hdr,n=t.dims[1]*t.dims[2]*t.dims[3],s=new Uint8ClampedArray(n*4),r=.2*Math.min(Math.min(t.dims[1],t.dims[2]),t.dims[3]),c=.5*t.dims[1],l=.5*t.dims[2],d=.5*t.dims[3];let h=0;for(let u=0;u<t.dims[3];u++)for(let m=0;m<t.dims[2];m++)for(let g=0;g<t.dims[1];g++){const A=Math.abs(g-c),v=Math.abs(m-l),y=Math.abs(u-d),w=Math.sqrt(A*A+v*v+y*y);let b=0;w<r&&(b=255),s[h++]=0,s[h++]=b,s[h++]=0,s[h++]=b*.5}return s}vox2mm(i,t){return At.vox2mm(i,t)}cloneVolume(i){return this.volumes[i].clone()}async loadDocumentFromUrl(i){const t=await Bh.loadFromUrl(i);await this.loadDocument(t)}async loadDocument(i){this.volumes=[],this.meshes=[],this.document=i,this.document.labels=this.document.labels?this.document.labels:[];const t={...mi,...i.opts};this.scene.pan2Dxyzmm=i.scene.pan2Dxyzmm?i.scene.pan2Dxyzmm:[0,0,0,1],this.document.opts=t,this.scene.clipPlaneDepthAziElevs&&this.setClipPlane(this.scene.clipPlaneDepthAziElevs[this.uiData.activeClipPlaneIndex??0]),k.debug("load document",i),this.mediaUrlMap.clear(),this.createEmptyDrawing();const n=i.encodedImageBlobs;for(let r=0;r<i.imageOptionsArray.length;r++){const c=i.imageOptionsArray[r],l=n[r];if(l){"colorMap"in c&&(c.colormap=c.colorMap);const d=await Ue.loadFromBase64({base64:l,...c});if(d){if(d.colormapLabel){const h=Object.keys(d.colormapLabel.lut).length,u=new Uint8ClampedArray(h);for(const m in d.colormapLabel.lut)u[m]=d.colormapLabel.lut[m];d.colormapLabel.lut=u}this.addVolume(d)}}}this.volumes.length>0&&(this.back=this.volumes[0]);for(const r of i.meshDataObjects??[]){const c={gl:this.gl,...r};r.offsetPt0&&(c.rgba255[3]=0,c.tris=new Uint32Array(r.offsetPt0)),k.debug(c);const l=new Gs(c.pts,c.tris,c.name,c.rgba255,c.opacity,c.visible,this.gl,c.connectome,c.dpg,c.dps,c.dpv);r.offsetPt0&&(l.fiberGroupColormap=r.fiberGroupColormap,l.fiberColor=r.fiberColor,l.fiberDither=r.fiberDither,l.fiberRadius=r.fiberRadius,l.colormap=r.colormap),l.meshShaderIndex=c.meshShaderIndex,l.layers=c.layers,l.updateMesh(this.gl),k.debug(l),this.addMesh(l)}if(i.data.connectomes)for(const r of i.data.connectomes){const c=JSON.parse(r),l=this.loadConnectomeAsMesh(c);l.updateMesh(this.gl),this.addMesh(l)}this.createEmptyDrawing();const s=i.encodedDrawingBlob;if(s){const r=await At.b64toUint8(s);if(r){const c=this.back.dims;let l=c[1]*c[2]*c[3];if(r.length-352===l&&(l+=352),r.length!==l)throw new Error(`drawBitmap size does not match the texture dimensions (${c[1]}×${c[2]}×${c[3]}) ${l} != ${c[1]*c[2]*c[3]}.`);this.drawBitmap=r,this.refreshDrawing()}}return await this.setGradientOpacity(this.opts.gradientOpacity),await this.setVolumeRenderIllumination(this.opts.gradientAmount),this.updateGLVolume(),this.drawScene(),this.onDocumentLoaded(i),this}async generateLoadDocumentJavaScript(i,t){const n=this.json(),s=await At.compressToBase64String(JSON.stringify(n));return`
+        ${t}
+
+        async function saveNiivueAsHtml(pageName) {
+          //get new docstring
+          const docString = nv1.json();
+          const html =
+          document.getElementsByTagName("html")[0]
+              .innerHTML.replace(base64, await NVUtilities.compressToBase64String(JSON.stringify(docString)));
+          NVUtilities.download(html, pageName, "application/html");
+        }
+
+        var nv1 = new Niivue();
+        await nv1.attachTo("${i}");
+        var base64 = "${s}";
+        NVUtilities.decompressBase64String(base64).then((jsonText) => {
+          var json = JSON.parse(jsonText); // string -> JSON
+          var doc = NVDocument.loadFromJSON(json);
+          nv1.loadDocument(doc);
+          nv1.updateGLVolume();
+        });
+
+      `}async generateHTML(i="gl1",t){return`<!DOCTYPE html>
+        <html lang="en">
+          <head>
+            <meta charset="utf-8" />
+            <meta http-equiv="X-UA-Compatible" content="IE=edge" />
+            <meta name="viewport" content="width=device-width,initial-scale=1.0" />
+            <title>Save as HTML</title>
+            <style>
+            html {
+              height: auto;
+              min-height: 100%;
+              margin: 0;
+            }
+            body {
+              display: flex;
+              flex-direction: column;
+              margin: 0;
+              min-height: 100%;
+              width: 100%;
+              position: absolute;
+              font-family: system-ui, Arial, Helvetica, sans-serif;
+              background: #ffffff;
+              color: black;
+              user-select: none; /* Standard syntax */
+            }
+            header {
+              margin: 10px;
+            }
+            main {
+              flex: 1;
+              background: #000000;
+              position: relative;
+            }
+            footer {
+              margin: 10px;
+            }
+            canvas {
+              position: absolute;
+              cursor: crosshair;
+            }
+            canvas:focus {
+              outline: 0px;
+            }
+            div {
+              display: table-row;
+              background-color: blue;
+            }
+            </style>
+          </head>
+          <body>
+            <noscript>niivue requires JavaScript.</noscript>
+            <header>
+            Save the current scene as HTML
+            <button id="save">Save as HTML</button>
+            </header>
+            <main>
+              <canvas id="gl1"></canvas>
+            </main>
+            <script type="module" async>
+              ${await this.generateLoadDocumentJavaScript(i,t)}
+              function saveAsHtml() {
+                saveNiivueAsHtml("page.html");
+              }
+              // assign our event handler
+              var button = document.getElementById("save");
+              button.onclick = saveAsHtml;
+            <\/script>
+          </body>
+        </html>`}async saveHTML(i="untitled.html",t="gl1",n){const s=await this.generateHTML(t,n);return At.download(s,i,"application/html")}json(){return this.document.opts=this.opts,this.document.scene=this.scene,this.document.volumes=this.volumes,this.document.meshes=this.meshes,this.drawScene(),this.document.previewImageDataURL=this.canvas.toDataURL(),this.document.json()}async saveDocument(i="untitled.nvd",t=!0,n={}){const{embedImages:s=!0,embedPreview:r=!0}=n;this.document.title=i,this.document.volumes=this.volumes,this.document.meshes=this.meshes,r?(this.drawScene(),this.document.previewImageDataURL=this.canvas.toDataURL()):this.document.previewImageDataURL="",await this.document.download(i,t,{embedImages:s})}async loadImages(i){const t=[],n=[];for(const s of i)if("url"in s){const r=this.getFileExt(s.name?s.name:s.url);if(this.loaders[r]){const c=this.loaders[r].toExt.toUpperCase();Yn.includes(c)?n.push(s):t.push(s);continue}Yn.includes(r.toUpperCase())?n.push(s):t.push(s)}return t.length>0&&await this.loadVolumes(t),n.length>0&&await this.loadMeshes(n),this}async loadDicoms(i){if(!this.getDicomLoader())throw new Error("No dicom loader set. Please set a dicom loader before loading dicoms");this.drawScene(),this.volumes=[];const t=i.map(async s=>{let r=null;if(s.isManifest)r=await Ue.fetchDicomData(s.url);else{const m=await fetch(s.url);if(!m.ok)throw new Error(`Failed to load file: ${m.statusText}`);const g=await m.arrayBuffer();r=[{name:s.url.split("/").pop(),data:g}]}const c=this.getDicomLoader().loader,l=await c(r),d=l[0].name,h=l[0].data;return await Ue.loadFromUrl({url:h,name:d})}),n=await Promise.all(t);return n.length===1?this.addVolume(n[0]):this.onDicomLoaderFinishedWithImages(n),this}async loadVolumes(i){return this.drawScene(),this.thumbnailVisible?(this.deferredVolumes=i,this):(this.volumes=[],this.closePAQD(),await this.addVolumesFromUrl(i),this)}async addMeshFromUrl(i){const t=this.getFileExt(i.url);if(t==="JCON"||t==="JSON"){const r=await(await fetch(i.url,{})).json(),c=this.loadConnectomeAsMesh(r);return this.mediaUrlMap.set(c,i.url),this.onMeshAddedFromUrl(i,c),this.addMesh(c),c}const n=await Gs.loadFromUrl({...i,gl:this.gl});return this.mediaUrlMap.set(n,i.url),this.onMeshAddedFromUrl(i,n),this.addMesh(n),n}async addMeshesFromUrl(i){const t=i.map(async s=>{const r=this.getFileExt(s.name||s.url);if(this.loaders[r]){let l=s.url;const d=this.loaders[r].toExt;let h=s.name||s.url;if(h=h.split("/").pop(),typeof s.url=="string"){const v=s.url;try{const y=await fetch(v);if(!y.ok)throw new Error(`Failed to load file: ${y.statusText}`);l=await y.arrayBuffer()}catch(y){throw new Error(`Failed to load url ${v}: ${y}`)}}const{positions:u,indices:m,colors:g=null}=await this.loaders[r].loader(l);s.name=`${h}.${d}`;const A=await Xn.createMZ3Async(u,m,!1,g);s.buffer=A}if(r==="JCON"||r==="JSON"){const d=await(await fetch(s.url,{})).json(),h=this.loadConnectomeAsMesh(d);return this.mediaUrlMap.set(h,s.url),this.onMeshAddedFromUrl(s,h),h}const c=await Gs.loadFromUrl({...s,gl:this.gl});return this.mediaUrlMap.set(c,s.url),this.onMeshAddedFromUrl(s,c),c}),n=await Promise.all(t);for(let s=0;s<n.length;s++)this.addMesh(n[s]);return n}async loadMeshes(i){return this.drawScene(),this.thumbnailVisible?(this.deferredMeshes=i,this):(this.initialized,this.meshes=[],await this.addMeshesFromUrl(i),this.updateGLVolume(),this.drawScene(),this)}async loadConnectomeFromUrl(i,t={}){const s=await(await fetch(i,{headers:t})).json();return this.loadConnectome(s)}async loadFreeSurferConnectomeFromUrl(i,t={}){const s=await(await fetch(i,{headers:t})).json();return this.loadFreeSurferConnectome(s)}async loadFreeSurferConnectome(i){const t=Fl.convertFreeSurferConnectome(i);return this.loadConnectome(t)}handleNodeAdded(i){const t=i.detail.node,n=[1,1,1,1];this.addLabel(t.name,{textColor:n,bulletScale:1,bulletColor:n,lineWidth:0,lineColor:n,lineTerminator:"none",textScale:1},[t.x,t.y,t.z]),this.drawScene()}loadConnectomeAsMesh(i){let t=i;if("data_type"in i&&i.data_type==="fs_pointset")t=Fl.convertFreeSurferConnectome(i),k.warn("converted FreeSurfer connectome",t);else if("nodes"in i){const n=i.nodes;"names"in n&&"X"in n&&"Y"in n&&"Z"in n&&"Color"in n&&"Size"in n&&(t=Fl.convertLegacyConnectome(i))}else throw new Error("not a known connectome format");return new Fl(this.gl,t)}loadConnectome(i){this.drawScene(),this.meshes=[];const t=this.loadConnectomeAsMesh(i);return this.addMesh(t),this.drawScene(),this}createEmptyDrawing(){if(this.back===null||!this.back.dims||Math.min(Math.min(this.back.dims[1],this.back.dims[2]),this.back.dims[3])<1)return;const t=this.back.dims[1]*this.back.dims[2]*this.back.dims[3];this.drawBitmap=new Uint8Array(t),this.clickToSegmentGrowingBitmap=new Uint8Array(t),this.drawClearAllUndoBitmaps(),this.drawAddUndoBitmap(),this.opts.is2DSliceShader?this.drawTexture=this.r8Tex2D(this.drawTexture,gn,this.back.dims):this.drawTexture=this.r8Tex(this.drawTexture,gn,this.back.dims,!0),this.refreshDrawing(!1)}r16Tex(i,t,n,s){i&&this.gl.deleteTexture(i),i=this.gl.createTexture(),this.gl.activeTexture(t),this.gl.bindTexture(this.gl.TEXTURE_3D,i),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_MIN_FILTER,this.gl.NEAREST),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_MAG_FILTER,this.gl.NEAREST),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_R,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_S,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_T,this.gl.CLAMP_TO_EDGE),this.gl.pixelStorei(this.gl.UNPACK_ALIGNMENT,1),this.gl.texStorage3D(this.gl.TEXTURE_3D,1,this.gl.R16I,n[1],n[2],n[3]);const r=n[1]*n[2]*n[3];return s.length!==r&&(s=new Int16Array(r)),this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,n[1],n[2],n[3],this.gl.RED_INTEGER,this.gl.SHORT,s),i}drawGrowCut(){if(!this.back||!this.back.dims)throw new Error("back not defined");const i=this.back.hdr,t=this.gl,n=i.dims[1]*i.dims[2]*i.dims[3];if(!this.drawBitmap||this.drawBitmap.length!==n){k.debug("bitmap dims are wrong");return}const s=t.createFramebuffer();t.bindFramebuffer(t.FRAMEBUFFER,s),t.disable(t.CULL_FACE),t.viewport(0,0,this.back.dims[1],this.back.dims[2]),t.disable(t.BLEND);let r=Iv(this.back);const c=this.r16Tex(null,Ov,this.back.dims,r);for(let M=1;M<n;M++)r[M]=this.drawBitmap[M];const l=this.r16Tex(null,kv,this.back.dims,r),d=this.r16Tex(null,Yv,this.back.dims,r),h=1e4;for(let M=1;M<n;M++)r[M]>0&&(r[M]=h);const u=this.r16Tex(null,zv,this.back.dims,r),m=this.r16Tex(null,Pv,this.back.dims,r);t.bindVertexArray(this.genericVAO);const g=this.growCutShader;g.use(t);const A=128;t.uniform1i(g.uniforms.finalPass,0),t.uniform1i(g.uniforms.backTex,11);for(let M=0;M<A;M++){t.uniform1i(g.uniforms.labelTex,14),t.uniform1i(g.uniforms.strengthTex,12);for(let N=0;N<this.back.dims[3];N++){const U=1/this.back.dims[3]*(N+.5);t.uniform1f(g.uniforms.coordZ,U),t.framebufferTextureLayer(t.FRAMEBUFFER,t.COLOR_ATTACHMENT0,d,0,N),t.framebufferTextureLayer(t.FRAMEBUFFER,t.COLOR_ATTACHMENT1,m,0,N),t.drawBuffers([t.COLOR_ATTACHMENT0,t.COLOR_ATTACHMENT1]),t.checkFramebufferStatus(t.FRAMEBUFFER)!==t.FRAMEBUFFER_COMPLETE&&k.error("Incomplete framebuffer"),t.drawArrays(t.TRIANGLE_STRIP,0,4)}M===A-1&&t.uniform1i(g.uniforms.finalPass,1),t.uniform1i(g.uniforms.labelTex,15),t.uniform1i(g.uniforms.strengthTex,13);for(let N=0;N<this.back.dims[3];N++){const U=1/this.back.dims[3]*(N+.5);t.uniform1f(g.uniforms.coordZ,U),t.framebufferTextureLayer(t.FRAMEBUFFER,t.COLOR_ATTACHMENT0,l,0,N),t.framebufferTextureLayer(t.FRAMEBUFFER,t.COLOR_ATTACHMENT1,u,0,N),t.drawBuffers([t.COLOR_ATTACHMENT0,t.COLOR_ATTACHMENT1]),t.checkFramebufferStatus(t.FRAMEBUFFER)!==t.FRAMEBUFFER_COMPLETE&&k.error("Incomplete framebuffer"),t.drawArrays(t.TRIANGLE_STRIP,0,4)}}t.drawBuffers([t.COLOR_ATTACHMENT0]);const v=t.COLOR_ATTACHMENT1,y=l;t.readBuffer(v);const w=t.getParameter(t.IMPLEMENTATION_COLOR_READ_FORMAT),b=t.getParameter(t.IMPLEMENTATION_COLOR_READ_TYPE);(w!==t.RED_INTEGER||b!==t.SHORT)&&k.debug("readPixels will fail."),r=new Int16Array;const C=this.back.dims[1]*this.back.dims[2],S=new Int16Array(C);for(let M=0;M<this.back.dims[3];M++)t.framebufferTextureLayer(t.FRAMEBUFFER,v,y,0,M),t.readPixels(0,0,this.back.dims[1],this.back.dims[2],w,b,S),r=Int16Array.from([...r,...S]);let E=r[0];for(let M=0;M<r.length;M++)E=Math.max(E,r[M]);for(let M=1;M<n;M++)this.drawBitmap[M]=r[M];t.deleteTexture(c),t.deleteTexture(u),t.deleteTexture(m),t.deleteTexture(l),t.deleteTexture(d),t.bindVertexArray(this.unusedVAO),t.viewport(0,0,t.canvas.width,t.canvas.height),t.bindFramebuffer(t.FRAMEBUFFER,null),t.deleteFramebuffer(s),this.drawAddUndoBitmap(),this.refreshDrawing(!0)}drawPt(i,t,n,s,r=null){if(r===null&&(r=this.drawBitmap),!this.back?.dims)throw new Error("back.dims not set");const c=this.back.dims[1],l=this.back.dims[2],d=this.back.dims[3];i=Math.min(Math.max(i,0),c-1),t=Math.min(Math.max(t,0),l-1),n=Math.min(Math.max(n,0),d-1),r[i+t*c+n*c*l]=s;const h=this.drawPenAxCorSag===0,u=this.drawPenAxCorSag===1,m=this.drawPenAxCorSag===2;if(this.opts.penSize>1){const g=Math.floor(this.opts.penSize/2);for(let A=-g;A<=g;A++)for(let v=-g;v<=g;v++)h?r[i+A+(t+v)*c+n*c*l]=s:u?r[i+A+t*c+(n+v)*c*l]=s:m&&(r[i+(t+v)*c+(n+A)*c*l]=s)}}drawPenLine(i,t,n){const s=Math.abs(i[0]-t[0]),r=Math.abs(i[1]-t[1]),c=Math.abs(i[2]-t[2]);let l=-1,d=-1,h=-1;t[0]>i[0]&&(l=1),t[1]>i[1]&&(d=1),t[2]>i[2]&&(h=1);let u=i[0],m=i[1],g=i[2];const A=t[0],v=t[1],y=t[2];if(s>=r&&s>=c){let w=2*r-s,b=2*c-s;for(;u!==A;)u+=l,w>=0&&(m+=d,w-=2*s),b>=0&&(g+=h,b-=2*s),w+=2*r,b+=2*c,this.drawPt(u,m,g,n)}else if(r>=s&&r>=c){let w=2*s-r,b=2*c-r;for(;m!==v;)m+=d,w>=0&&(u+=l,w-=2*r),b>=0&&(g+=h,b-=2*r),w+=2*s,b+=2*c,this.drawPt(u,m,g,n)}else{let w=2*r-c,b=2*s-c;for(;g!==y;)g+=h,w>=0&&(m+=d,w-=2*c),b>=0&&(u+=l,b-=2*c),w+=2*r,b+=2*s,this.drawPt(u,m,g,n)}}drawRectangleMask(i,t,n){if(!this.back?.dims)throw new Error("back.dims not set");const s=this.back.dims[1],r=this.back.dims[2],c=this.back.dims[3],l=Math.min(Math.max(Math.min(i[0],t[0]),0),s-1),d=Math.min(Math.max(Math.min(i[1],t[1]),0),r-1),h=Math.min(Math.max(Math.min(i[2],t[2]),0),c-1),u=Math.min(Math.max(Math.max(i[0],t[0]),0),s-1),m=Math.min(Math.max(Math.max(i[1],t[1]),0),r-1),g=Math.min(Math.max(Math.max(i[2],t[2]),0),c-1);for(let A=h;A<=g;A++)for(let v=d;v<=m;v++)for(let y=l;y<=u;y++)this.drawPt(y,v,A,n)}drawEllipseMask(i,t,n){if(!this.back?.dims)throw new Error("back.dims not set");const s=this.back.dims[1],r=this.back.dims[2],c=this.back.dims[3],l=Math.min(Math.max(Math.min(i[0],t[0]),0),s-1),d=Math.min(Math.max(Math.min(i[1],t[1]),0),r-1),h=Math.min(Math.max(Math.min(i[2],t[2]),0),c-1),u=Math.min(Math.max(Math.max(i[0],t[0]),0),s-1),m=Math.min(Math.max(Math.max(i[1],t[1]),0),r-1),g=Math.min(Math.max(Math.max(i[2],t[2]),0),c-1),A=(l+u)/2,v=(d+m)/2,y=(h+g)/2,w=Math.abs(u-l)/2,b=Math.abs(m-d)/2,C=Math.abs(g-h)/2;for(let S=h;S<=g;S++)for(let E=d;E<=m;E++)for(let M=l;M<=u;M++){const N=(M-A)/(w+.5),U=(E-v)/(b+.5),T=(S-y)/(C+.5);N*N+U*U+T*T<=1&&this.drawPt(M,E,S,n)}}drawingBinaryDilationWithSeed(i,t=6){try{let n=function(b){return b[0]+b[1]*d+b[2]*h};const s=this.drawBitmap,r=this.back.dims[1],c=this.back.dims[2],l=this.back.dims[3],d=r,h=r*c,u=h*l,m=n(i);if(m<0||m>=u)throw new Error("Seed index is out of bounds.");const g=s[m];if(g===0)throw new Error("Seed voxel is not part of a filled cluster.");const A=s.slice();for(let b=0;b<u;b++)A[b]=A[b]===g?1:0;this.drawFloodFillCore(A,m,t);const v=s.slice(),y=[],w=[-h,h,-r,r,-1,1];y.push(...w),t>6&&y.push(-r-1,-r+1,r-1,r+1,-h-r,-h+r,-h-1,-h+1,h-r,h+r,h-1,h+1),t>18&&y.push(-h-r-1,-h-r+1,-h+r-1,-h+r+1,h-r-1,h-r+1,h+r-1,h+r+1);for(let b=0;b<u;b++)if(A[b]===2){const C=b%r,S=Math.floor(b%h/r),E=Math.floor(b/h);for(const M of y){const N=b+M;if(N<0||N>=u)continue;const U=N%r,T=Math.floor(N%h/r),F=Math.floor(N/h);Math.abs(U-C)>1||Math.abs(T-S)>1||Math.abs(F-E)>1||s[N]===0&&(v[N]=g)}}this.drawBitmap=v,this.drawAddUndoBitmap(),this.refreshDrawing(!0)}catch(n){k.error("Error in drawingBinaryDilationWithSeed:",n)}}drawFloodFillCore(i,t,n=6){if(!this.back?.dims)throw new Error("back.dims undefined");const s=[this.back.dims[1],this.back.dims[2],this.back.dims[3]],r=s[0],c=r*s[1];function l(u){return u[0]+u[1]*r+u[2]*c}function d(u){const m=Math.floor(u/c),g=Math.floor((u-m*c)/r);return[Math.floor(u%r),g,m]}const h=[];for(h.push(t),i[t]=2;h.length>0;){let u=function(A){const v=g.slice();if(v[0]+=A[0],v[1]+=A[1],v[2]+=A[2],v[0]<0||v[1]<0||v[2]<0||v[0]>=s[0]||v[1]>=s[1]||v[2]>=s[2])return;const y=l(v);i[y]===1&&(i[y]=2,h.push(y))};const m=h[0];h.shift();const g=d(m);u([0,0,-1]),u([0,0,1]),u([0,-1,0]),u([0,1,0]),u([-1,0,0]),u([1,0,0]),!(n<=6)&&(u([-1,-1,0]),u([1,1,0]),u([-1,1,0]),u([1,1,0]),u([0,-1,-1]),u([0,1,-1]),u([-1,0,-1]),u([1,0,-1]),u([0,-1,1]),u([0,1,1]),u([-1,0,1]),u([1,0,1]),!(n<=18)&&(u([-1,-1,-1]),u([1,-1,-1]),u([-1,1,-1]),u([1,1,-1]),u([-1,-1,1]),u([1,-1,1]),u([-1,1,1]),u([1,1,1])))}}drawFloodFill(i,t=0,n=0,s=NaN,r=NaN,c=6,l=Number.POSITIVE_INFINITY,d=!1,h=null,u=!1){if(!this.drawBitmap&&(k.warn("drawFloodFill called without an initialized drawBitmap."),this.createEmptyDrawing(),!this.drawBitmap)){k.error("Failed to create drawing bitmap.");return}if(this.clickToSegmentIsGrowing&&!this.clickToSegmentGrowingBitmap){if(k.warn("drawFloodFill called in preview mode without initialized clickToSegmentGrowingBitmap."),this.drawBitmap)this.clickToSegmentGrowingBitmap=this.drawBitmap.slice();else{k.error("Cannot initialize growing bitmap as drawBitmap is null.");return}if(!this.clickToSegmentGrowingBitmap){k.error("Failed to create growing bitmap.");return}}if(h===null&&(h=this.drawBitmap),!h){k.error("drawFloodFill targetBitmap is null.");return}if(!this.back?.dims)throw new Error("back.dims undefined");t=Math.abs(t);const m=[this.back.dims[1],this.back.dims[2],this.back.dims[3]];if(i[0]<0||i[1]<0||i[2]<0||i[0]>=m[0]||i[1]>=m[1]||i[2]>=m[2])return;const g=m[0],A=g*m[1],v=A*m[2],y=this.clickToSegmentIsGrowing?this.drawBitmap:h;if(!y){k.error("Could not determine original bitmap state.");return}const w=new Uint8Array(v).fill(0);let b=-1;d&&this.drawPenAxCorSag===0?b=2:d&&this.drawPenAxCorSag===1?b=1:d&&this.drawPenAxCorSag===2&&(b=0);function C(B){const V=Math.floor(B/A),R=Math.floor((B-V*A)/g);return[Math.floor(B%g),R,V]}function S(B){return B[0]+B[1]*g+B[2]*A}const E=B=>this.vox2mm(B,this.back.matRAS),M=E(i),N=l**2;function U(B){const V=C(B);if(b>=0&&V[b]!==i[b])return!1;const R=E(V);return(R[0]-M[0])**2+(R[1]-M[1])**2+(R[2]-M[2])**2<=N}const T=S(i),F=y[T];if(u&&F===0){k.debug("Grow/Erase Cluster tool requires starting on a masked voxel."),this.clickToSegmentIsGrowing&&this.clickToSegmentGrowingBitmap&&this.drawBitmap&&(this.clickToSegmentGrowingBitmap.set(this.drawBitmap),this.refreshDrawing(!0,!0));return}if(n===0&&F===t&&!u&&t!==0&&(k.debug("drawFloodFill selected voxel is already desired color"),!this.clickToSegmentIsGrowing))return;let I=NaN;if(u&&(n===Number.POSITIVE_INFINITY||n===Number.NEGATIVE_INFINITY)){const B=y.slice();for(let L=0;L<v;L++)B[L]=B[L]===F&&U(L)?1:0;if(B[T]!==1){k.error("Seed voxel could not be marked for cluster ID.");return}this.drawFloodFillCore(B,T,c);const V=this.volumes[0].img2RAS();let R=0,Y=0;for(let L=0;L<v;L++)B[L]===2&&(R+=V[L],Y++);I=Y>0?R/Y:V[T],k.debug(`Grow Cluster using mean intensity: ${I.toFixed(2)} from ${Y} voxels.`);let P=-1/0,X=1/0;n===Number.POSITIVE_INFINITY&&(P=I),n===Number.NEGATIVE_INFINITY&&(X=I);for(let L=0;L<v;L++)if(B[L]===2)w[L]=1;else if(y[L]===0){const H=V[L];H>=P&&H<=X&&U(L)&&(w[L]=1)}t=F}else if(n===0)if(u&&t===0){k.debug(`Erase Cluster: Identifying cluster with color ${F}`);for(let B=0;B<v;B++)w[B]=y[B]===F&&U(B)?1:0}else for(let B=0;B<v;B++)y[B]===F&&U(B)&&F!==0&&(w[B]=1);else{const B=this.volumes[0].img2RAS();I=B[T];let V=-1/0,R=1/0;isFinite(s)&&isFinite(r)?(V=s,R=r):n===Number.POSITIVE_INFINITY?V=I:n===Number.NEGATIVE_INFINITY&&(R=I);for(let Y=0;Y<v;Y++){const P=B[Y];P>=V&&P<=R&&U(Y)&&(w[Y]=1)}t=y[T],t===0&&(t=this.opts.penValue,(t<1||!isFinite(t))&&(t=1))}if(w[T]!==1){let B=!1;if(u&&n!==0?F!==0&&(B=!0):(F!==0||t===0)&&(B=!0),B&&U(T))w[T]=1,k.debug("Forcing seed voxel to 1 in working buffer.");else{k.debug("Seed voxel not marked as candidate '1' and not valid originally."),this.clickToSegmentIsGrowing&&this.clickToSegmentGrowingBitmap&&this.drawBitmap&&this.clickToSegmentGrowingBitmap.set(this.drawBitmap);return}}this.drawFloodFillCore(w,T,c);for(let B=0;B<v;B++)w[B]===2?h[B]=t:this.clickToSegmentIsGrowing&&h===this.clickToSegmentGrowingBitmap&&(h[B]=y[B]);this.clickToSegmentIsGrowing?this.refreshDrawing(!0,!0):(this.drawAddUndoBitmap(),this.refreshDrawing(!0,!1))}floodFillSectionFIFO(i,t,n,s){const r=t[0],[c,l]=n,[d,h]=s,u=4*(d-c+h-l+2),m=new Int32Array(u*2);let g=0,A=0;function v(b,C){if(b<c||b>d||C<l||C>h)return;const S=b+C*r;i[S]===0&&(i[S]=2,m[A]=b,m[A+1]=C,A=(A+2)%m.length)}function y(){if(g===A)return null;const b=m[g],C=m[g+1];return g=(g+2)%m.length,[b,C]}for(let b=c;b<=d;b++)v(b,l),v(b,h);for(let b=l+1;b<=h-1;b++)v(c,b),v(d,b);let w;for(;(w=y())!==null;){const[b,C]=w;v(b-1,C),v(b+1,C),v(b,C-1),v(b,C+1)}}drawPenFilled(){const i=this.drawPenFillPts.length;if(i<2){this.drawPenFillPts=[];return}const t=this.drawPenAxCorSag;let n=0,s=1;if(t===1&&(s=2),t===2&&(n=1,s=2),!this.back?.dims)throw new Error("back.dims undefined");const r=[this.back.dims[n+1],this.back.dims[s+1]],c=new Uint8Array(r[0]*r[1]);let l=1;function d(b,C){const S=Math.abs(b[0]-C[0]),E=Math.abs(b[1]-C[1]);c[b[0]+b[1]*r[0]]=l,c[C[0]+C[1]*r[0]]=l;let M=-1,N=-1;C[0]>b[0]&&(M=1),C[1]>b[1]&&(N=1);let U=b[0],T=b[1];const F=C[0],I=C[1];if(S>=E){let B=2*E-S;for(;U!==F;)U+=M,B>=0&&(T+=N,B-=2*S),B+=2*E,c[U+T*r[0]]=l}else{let B=2*S-E;for(;T!==I;)T+=N,B>=0&&(U+=M,B-=2*E),B+=2*S,c[U+T*r[0]]=l}}function h(b){const C=Math.min(Math.max(b[0],0),r[0]-1),S=Math.min(Math.max(b[1],0),r[1]-1);return[C,S]}const u=h([this.drawPenFillPts[0][n],this.drawPenFillPts[0][s]]);let m=[...u],g=[...u],A=u;for(let b=1;b<i;b++){let C=[this.drawPenFillPts[b][n],this.drawPenFillPts[b][s]];C=h(C),m=[Math.min(C[0],m[0]),Math.min(C[1],m[1])],g=[Math.max(C[0],g[0]),Math.max(C[1],g[1])],d(A,C),A=C}d(u,A);const v=1;m[0]=Math.max(0,m[0]-v),m[1]=Math.max(0,m[1]-v),g[0]=Math.min(r[0]-1,g[0]+v),g[1]=Math.min(r[1]-1,g[1]+v);for(let b=0;b<r[1];b++)for(let C=0;C<r[0];C++){if(C>=m[0]&&C<g[0]&&b>=m[1]&&b<=g[1])continue;const S=C+b*r[0];c[S]===0&&(c[S]=2)}const y=Date.now();this.floodFillSectionFIFO(c,r,m,g),k.debug(`FloodFill ${Date.now()-y}`),l=this.opts.penValue;const w=this.drawPenFillPts[0][3-(n+s)];if(!this.drawBitmap)throw new Error("drawBitmap undefined");if(t===0){const b=w*r[0]*r[1];for(let C=0;C<r[0]*r[1];C++)c[C]!==2&&(this.drawBitmap[C+b]=l)}else{let b=1;const C=this.back.dims[1]*this.back.dims[2];let S=w*this.back.dims[1];t===2&&(b=this.back.dims[1],S=w);let E=0;for(let M=0;M<r[1];M++)for(let N=0;N<r[0];N++)c[E]!==2&&(this.drawBitmap[N*b+M*C+S]=l),E++}if(!this.drawFillOverwrites&&this.drawUndoBitmaps[this.currentDrawUndoBitmap].length>0){const b=this.drawBitmap.length,C=Wh(this.drawUndoBitmaps[this.currentDrawUndoBitmap],b);for(let S=0;S<b;S++)C[S]!==0&&(this.drawBitmap[S]=C[S])}this.drawPenFillPts=[],this.drawAddUndoBitmap(),this.refreshDrawing(!1)}closeDrawing(){this.drawClearAllUndoBitmaps(),this.drawTexture=this.rgbaTex(this.drawTexture,gn,[2,2,2,2],!0),this.drawBitmap=null,this.clickToSegmentGrowingBitmap=null,this.drawScene()}refreshDrawing(i=!0,t=!1){t&&(!this.opts.drawingEnabled||!this.opts.clickToSegment)&&(k.debug("refreshDrawing: Conditions not met for clickToSegment bitmap, using drawBitmap."),t=!1);const n=t?this.clickToSegmentGrowingBitmap:this.drawBitmap;!n&&!t&&this.clickToSegmentGrowingBitmap?k.warn("refreshDrawing: drawBitmap is null, but clickToSegmentGrowingBitmap exists. Check state."):!n&&t&&this.drawBitmap?(k.warn("refreshDrawing: clickToSegmentGrowingBitmap is null, falling back to drawBitmap."),t=!1):n||k.warn("refreshDrawing: Both bitmaps are null. Uploading empty data.");const s=t?this.clickToSegmentGrowingBitmap:this.drawBitmap;if(!this.back?.dims){k.warn("refreshDrawing: back.dims undefined, cannot refresh drawing texture yet.");return}const r=this.back.dims.slice(),c=this.back.dims[1]*this.back.dims[2]*this.back.dims[3];if(!s){k.warn(`refreshDrawing: Bitmap data source (${t?"growing":"main"}) is null. Cannot update texture.`),i&&this.drawScene();return}if(s.length===8?(r[1]=2,r[2]=2,r[3]=2):c!==s.length&&k.warn(`Drawing bitmap length (${s.length}) must match the background image (${c})`),this.gl.activeTexture(gn),this.opts.is2DSliceShader){const l=this.frac2vox(this.scene.crosshairPos),d=Math.min(Math.max(l[2],0),r[3]-1),h=r[1]*r[2],u=d*h;k.debug(`refresh huge 2D drawing x×y×z ${r[1]}×${r[2]}×${r[3]} slice ${u}`);const m=s.subarray(u,u+h);this.gl.bindTexture(this.gl.TEXTURE_2D,this.drawTexture),this.gl.texSubImage2D(this.gl.TEXTURE_2D,0,0,0,r[1],r[2],this.gl.RED,this.gl.UNSIGNED_BYTE,m)}else this.gl.bindTexture(this.gl.TEXTURE_3D,this.drawTexture),this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,r[1],r[2],r[3],this.gl.RED,this.gl.UNSIGNED_BYTE,s);if(!this.drawTexture){k.error("refreshDrawing: drawTexture (GPU texture) is null.");return}i&&this.drawScene()}closePAQD(){!this._gl||!this.paqdTexture||(this.paqdTexture=this.rgbaTex(this.paqdTexture,zs,[2,2,2,2],!0))}r8Tex2D(i,t,n,s=!1){if(i&&this.gl.deleteTexture(i),i=this.gl.createTexture(),this.gl.activeTexture(t),this.gl.bindTexture(this.gl.TEXTURE_2D,i),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MIN_FILTER,this.gl.NEAREST),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MAG_FILTER,this.gl.NEAREST),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_WRAP_R,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_WRAP_S,this.gl.CLAMP_TO_EDGE),this.gl.pixelStorei(this.gl.UNPACK_ALIGNMENT,1),this.gl.texStorage2D(this.gl.TEXTURE_2D,1,this.gl.R8,n[1],n[2]),s){const r=new Uint8Array(n[1]*n[2]);this.gl.texSubImage2D(this.gl.TEXTURE_2D,0,0,0,n[1],n[2],this.gl.RED,this.gl.UNSIGNED_BYTE,r)}return i}r8Tex(i,t,n,s=!1){if(i&&this.gl.deleteTexture(i),i=this.gl.createTexture(),this.gl.activeTexture(t),this.gl.bindTexture(this.gl.TEXTURE_3D,i),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_MIN_FILTER,this.gl.NEAREST),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_MAG_FILTER,this.gl.NEAREST),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_R,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_S,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_T,this.gl.CLAMP_TO_EDGE),this.gl.pixelStorei(this.gl.UNPACK_ALIGNMENT,1),this.gl.texStorage3D(this.gl.TEXTURE_3D,1,this.gl.R8,n[1],n[2],n[3]),s){const r=new Uint8Array(n[1]*n[2]*n[3]);this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,n[1],n[2],n[3],this.gl.RED,this.gl.UNSIGNED_BYTE,r)}return i}rgbaTex2D(i,t,n,s=null,r=!0){if(i&&this.gl.deleteTexture(i),i=this.gl.createTexture(),this.gl.activeTexture(t),this.gl.bindTexture(this.gl.TEXTURE_2D,i),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MIN_FILTER,this.gl.LINEAR),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MAG_FILTER,this.gl.LINEAR),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_WRAP_S,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_WRAP_T,this.gl.CLAMP_TO_EDGE),this.gl.pixelStorei(this.gl.UNPACK_ALIGNMENT,1),this.gl.texStorage2D(this.gl.TEXTURE_2D,1,this.gl.RGBA8,n[1],n[2]),s){let c=s;const l=n[1],d=n[2];if(r){c=new Uint8Array(s.length);const h=l*4;for(let u=0;u<d;u++){const m=u*h,g=(d-1-u)*h;c.set(s.subarray(m,m+h),g)}}this.gl.texSubImage2D(this.gl.TEXTURE_2D,0,0,0,l,d,this.gl.RGBA,this.gl.UNSIGNED_BYTE,c)}return i}rgbaTex(i,t,n,s=!1){if(i&&this.gl.deleteTexture(i),i=this.gl.createTexture(),this.gl.activeTexture(t),this.gl.bindTexture(this.gl.TEXTURE_3D,i),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_MIN_FILTER,this.gl.LINEAR),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_MAG_FILTER,this.gl.LINEAR),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_R,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_S,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_T,this.gl.CLAMP_TO_EDGE),this.gl.pixelStorei(this.gl.UNPACK_ALIGNMENT,1),this.gl.texStorage3D(this.gl.TEXTURE_3D,1,this.gl.RGBA8,n[1],n[2],n[3]),s){const r=new Uint8Array(n[1]*n[2]*n[3]*4);this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,n[1],n[2],n[3],this.gl.RGBA,this.gl.UNSIGNED_BYTE,r)}return i}rgba16Tex(i,t,n,s=!1){if(i&&this.gl.deleteTexture(i),i=this.gl.createTexture(),this.gl.activeTexture(t),this.gl.bindTexture(this.gl.TEXTURE_3D,i),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_MIN_FILTER,this.gl.NEAREST),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_MAG_FILTER,this.gl.NEAREST),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_R,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_S,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_T,this.gl.CLAMP_TO_EDGE),this.gl.pixelStorei(this.gl.UNPACK_ALIGNMENT,2),this.gl.pixelStorei(this.gl.PACK_ALIGNMENT,2),this.gl.texStorage3D(this.gl.TEXTURE_3D,1,this.gl.RGBA16UI,n[1],n[2],n[3]),s){const r=new Uint16Array(n[1]*n[2]*n[3]*4);this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,n[1],n[2],n[3],this.gl.RGBA_INTEGER,this.gl.UNSIGNED_SHORT,r)}return i}requestCORSIfNotSameOrigin(i,t){new URL(t,window.location.href).origin!==window.location.origin&&(i.crossOrigin="")}async loadPngAsTexture(i,t){return new Promise((n,s)=>{const r=new Image;r.onload=()=>{if(!this.bmpShader)return;let c;t===4?(this.bmpTexture!==null&&this.gl.deleteTexture(this.bmpTexture),this.bmpTexture=this.gl.createTexture(),c=this.bmpTexture,this.bmpTextureWH=r.width/r.height,this.gl.activeTexture(Lv),this.bmpShader.use(this.gl),this.gl.uniform1i(this.bmpShader.uniforms.bmpTexture,4)):t===5?(this.gl.activeTexture(Yh),this.matCapTexture!==null&&this.gl.deleteTexture(this.matCapTexture),this.matCapTexture=this.gl.createTexture(),c=this.matCapTexture):(this.fontShader.use(this.gl),this.gl.activeTexture(A2),this.gl.uniform1i(this.fontShader.uniforms.fontTexture,3),this.fontTexture!==null&&this.gl.deleteTexture(this.fontTexture),this.fontTexture=this.gl.createTexture(),c=this.fontTexture),this.gl.bindTexture(this.gl.TEXTURE_2D,c),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_WRAP_S,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_WRAP_T,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MIN_FILTER,this.gl.LINEAR),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MAG_FILTER,this.gl.LINEAR),this.gl.texImage2D(this.gl.TEXTURE_2D,0,this.gl.RGBA,this.gl.RGBA,this.gl.UNSIGNED_BYTE,r),n(c),t!==4&&this.drawScene()},r.onerror=s,this.requestCORSIfNotSameOrigin(r,i),r.src=i})}async loadFontTexture(i){return this.loadPngAsTexture(i,3)}async loadBmpTexture(i){return this.loadPngAsTexture(i,4)}async loadMatCapTexture(i){return this.loadPngAsTexture(i,5)}initFontMets(){if(!this.fontMetrics)throw new Error("fontMetrics undefined");this.fontMets={distanceRange:this.fontMetrics.atlas.distanceRange,size:this.fontMetrics.atlas.size,mets:{}};for(let n=0;n<256;n++)this.fontMets.mets[n]={xadv:0,uv_lbwh:[0,0,0,0],lbwh:[0,0,0,0]};const i=this.fontMetrics.atlas.width,t=this.fontMetrics.atlas.height;for(let n=0;n<this.fontMetrics.glyphs.length;n++){const s=this.fontMetrics.glyphs[n],r=s.unicode;if(this.fontMets.mets[r].xadv=s.advance,s.planeBounds===void 0)continue;let c=s.atlasBounds.left/i,l=(t-s.atlasBounds.top)/t,d=(s.atlasBounds.right-s.atlasBounds.left)/i,h=(s.atlasBounds.top-s.atlasBounds.bottom)/t;this.fontMets.mets[r].uv_lbwh=[c,l,d,h],c=s.planeBounds.left,l=s.planeBounds.bottom,d=s.planeBounds.right-s.planeBounds.left,h=s.planeBounds.top-s.planeBounds.bottom,this.fontMets.mets[r].lbwh=[c,l,d,h]}}async loadFont(i=a2,t=r2){await this.loadFontTexture(i);const n=await fetch(t);if(!n.ok)throw Error(n.statusText);const s=await n.text();this.fontMetrics=JSON.parse(s),this.initFontMets(),this.fontShader.use(this.gl),this.drawScene()}async loadDefaultMatCap(){return this.loadMatCapTexture(b4)}async loadDefaultFont(){await this.loadFontTexture(this.DEFAULT_FONT_GLYPH_SHEET),this.fontMetrics=this.DEFAULT_FONT_METRICS,this.initFontMets()}async initText(){this.fontShader=new Tt(this.gl,K4,j4),this.fontShader.use(this.gl),await this.loadDefaultFont(),await this.loadDefaultMatCap(),this.drawLoadingText(this.opts.loadingText)}meshShaderNameToNumber(i="Phong"){const t=i.toLowerCase();for(let n=0;n<this.meshShaders.length;n++)if(this.meshShaders[n].Name.toLowerCase()===t)return n}setMeshShader(i,t=2){let n=0;if(typeof t=="number"?n=t:n=this.meshShaderNameToNumber(t),n===void 0)throw new Error("shaderIndex undefined");n=Math.min(n,this.meshShaders.length-1),n=Math.max(n,0);const s=this.getMeshIndexByID(i);if(s>=this.meshes.length){k.debug("Unable to change shader until mesh is loaded (maybe you need async)");return}this.meshes[s].meshShaderIndex=n,this.updateGLVolume(),this.onMeshShaderChanged(s,n)}createCustomMeshShader(i,t="Custom"){if(!i)throw new Error("Need fragment shader");const n=this.meshShaderNameToNumber(t);n>=0&&(this.gl.deleteProgram(this.meshShaders[n].shader.program),this.meshShaders.splice(n,1));const s=new Tt(this.gl,Lh,i);return s.use(this.gl),{Name:t,Frag:i,shader:s}}setCustomSliceShader(i=""){const t=this.gl;if(this.customSliceShader&&(t.deleteProgram(this.customSliceShader.program),this.customSliceShader=null),!i){this.updateGLVolume();return}const n=new Tt(t,Bl,i);n.use(t),t.uniform1i(n.uniforms.volume,0),t.uniform1i(n.uniforms.colormap,1),t.uniform1i(n.uniforms.overlay,2),t.uniform1i(n.uniforms.drawing,7),t.uniform1i(n.uniforms.paqd,8),t.uniform1f(n.uniforms.drawOpacity,this.drawOpacity),this.customSliceShader=n,this.updateGLVolume()}setCustomMeshShader(i="",t="Custom"){const n=this.createCustomMeshShader(i,t);return this.meshShaders.push(n),this.onCustomMeshShaderAdded(i,t),this.meshShaders.length-1}meshShaderNames(i=!0){const t=[];for(let n=0;n<this.meshShaders.length;n++)t.push(this.meshShaders[n].Name);return i===!0?t.sort():t}initRenderShader(i,t=0){i.use(this.gl),this.gl.uniform1i(i.uniforms.volume,0),this.gl.uniform1i(i.uniforms.colormap,1),this.gl.uniform1i(i.uniforms.overlay,2),this.gl.uniform1i(i.uniforms.drawing,7),this.gl.uniform1i(i.uniforms.paqd,8),this.gl.uniform1fv(i.uniforms.renderDrawAmbientOcclusion,[this.renderDrawAmbientOcclusion,1]),this.gl.uniform1f(i.uniforms.gradientAmount,t),this.gl.uniform1f(i.uniforms.silhouettePower,this.opts.renderSilhouette);const n=new Float32Array($a);for(let s=0;s<$a;s++)this.opts.gradientOpacity===0?n[s]=1:n[s]=Math.pow(s/($a-1),this.opts.gradientOpacity*8);this.gl.uniform1fv(this.gl.getUniformLocation(i.program,"gradientOpacity"),n),i.uniforms.clipPlanes=this.gl.getUniformLocation(i.program,"clipPlanes[0]")}async init(){const i=this.gl.getExtension("WEBGL_debug_renderer_info");if(i){const c=this.gl.getParameter(i.UNMASKED_VENDOR_WEBGL),l=this.gl.getParameter(i.UNMASKED_RENDERER_WEBGL);k.info("renderer vendor: ",c),k.info("renderer: ",l)}else k.info("debug_renderer_info unavailable");const t=this.gl.getParameter(this.gl.RENDERER);k.info("firefox renderer: ",t),this.gl.enable(this.gl.CULL_FACE),this.gl.cullFace(this.gl.FRONT),this.gl.enable(this.gl.BLEND),this.gl.blendFunc(this.gl.SRC_ALPHA,this.gl.ONE_MINUS_SRC_ALPHA),this.volumeTexture=this.rgbaTex(this.volumeTexture,Gn,[2,2,2,2],!0),this.overlayTexture=this.rgbaTex(this.overlayTexture,Nl,[2,2,2,2],!0),this.drawTexture=this.r8Tex(this.drawTexture,gn,[2,2,2,2],!0),this.paqdTexture=this.rgbaTex(this.paqdTexture,zs,[2,2,2,2],!0);const n=[1,1,0,1,0,0,0,1,0,0,0,0],s=this.gl;this.cuboidVertexBuffer=s.createBuffer(),s.bindBuffer(s.ARRAY_BUFFER,this.cuboidVertexBuffer),s.bufferData(s.ARRAY_BUFFER,new Float32Array(n),s.STATIC_DRAW),this.genericVAO=s.createVertexArray(),s.bindVertexArray(this.genericVAO),s.bindBuffer(s.ARRAY_BUFFER,this.cuboidVertexBuffer),s.enableVertexAttribArray(0),s.vertexAttribPointer(0,3,s.FLOAT,!1,0,0),s.bindVertexArray(this.unusedVAO),this.pickingMeshShader=new Tt(s,Lh,av),this.pickingMeshShader.use(s),this.pickingImageShader=new Tt(s,Ga,wv),this.pickingImageShader.use(s),this.pickingImageShader.uniforms.clipPlanes=this.gl.getUniformLocation(this.pickingImageShader.program,"clipPlanes[0]"),s.uniform1i(this.pickingImageShader.uniforms.volume,0),s.uniform1i(this.pickingImageShader.uniforms.colormap,1),s.uniform1i(this.pickingImageShader.uniforms.overlay,2),s.uniform1i(this.pickingImageShader.uniforms.drawing,7),this.slice2DShader=new Tt(s,Bl,L4),this.slice2DShader.use(s),s.uniform1i(this.slice2DShader.uniforms.volume,0),s.uniform1i(this.slice2DShader.uniforms.colormap,1),s.uniform1i(this.slice2DShader.uniforms.overlay,2),s.uniform1i(this.slice2DShader.uniforms.drawing,7),s.uniform1f(this.slice2DShader.uniforms.drawOpacity,this.drawOpacity),this.sliceMMShader=new Tt(s,Bl,O4),this.sliceMMShader.use(s),s.uniform1i(this.sliceMMShader.uniforms.volume,0),s.uniform1i(this.sliceMMShader.uniforms.colormap,1),s.uniform1i(this.sliceMMShader.uniforms.overlay,2),s.uniform1i(this.sliceMMShader.uniforms.drawing,7),s.uniform1f(this.sliceMMShader.uniforms.drawOpacity,this.drawOpacity),this.sliceV1Shader=new Tt(s,Bl,z4),this.sliceV1Shader.use(s),s.uniform1i(this.sliceV1Shader.uniforms.volume,0),s.uniform1i(this.sliceV1Shader.uniforms.colormap,1),s.uniform1i(this.sliceV1Shader.uniforms.overlay,2),s.uniform1i(this.sliceV1Shader.uniforms.drawing,7),s.uniform1f(this.sliceV1Shader.uniforms.drawOpacity,this.drawOpacity),this.orientCubeShader=new Tt(s,bv,Cv),this.orientCubeShaderVAO=s.createVertexArray(),s.bindVertexArray(this.orientCubeShaderVAO);const r=s.createBuffer();s.enableVertexAttribArray(0),s.enableVertexAttribArray(1),s.bindBuffer(s.ARRAY_BUFFER,r),s.bufferData(s.ARRAY_BUFFER,q5,s.STATIC_DRAW),s.vertexAttribPointer(0,3,s.FLOAT,!1,24,0),s.enableVertexAttribArray(1),s.vertexAttribPointer(1,3,s.FLOAT,!1,24,12),s.bindVertexArray(this.unusedVAO),this.rectShader=new Tt(s,o2,Nh),this.rectShader.use(s),this.rectOutlineShader=new Tt(s,o2,P4),this.rectOutlineShader.use(s),this.lineShader=new Tt(s,G4,Nh),this.lineShader.use(s),this.line3DShader=new Tt(s,H4,Nh),this.line3DShader.use(s),this.circleShader=new Tt(s,Q4,Z4),this.circleShader.use(s),this.renderVolumeShader=new Tt(s,Ga,R4),this.initRenderShader(this.renderVolumeShader),this.renderSliceShader=new Tt(s,Ga,I4),this.initRenderShader(this.renderSliceShader),this.renderGradientShader=new Tt(s,Ga,N4),this.initRenderShader(this.renderGradientShader,.3),s.uniform1i(this.renderGradientShader.uniforms.matCap,5),s.uniform1i(this.renderGradientShader.uniforms.gradient,6),this.renderGradientValuesShader=new Tt(s,Ga,V4),this.initRenderShader(this.renderGradientValuesShader),s.uniform1i(this.renderGradientValuesShader.uniforms.matCap,5),s.uniform1i(this.renderGradientValuesShader.uniforms.gradient,6),this.renderShader=this.renderVolumeShader,this.colorbarShader=new Tt(s,k4,Y4),this.colorbarShader.use(s),s.uniform1i(this.colorbarShader.uniforms.colormap,1),this.blurShader=new Tt(s,Rl,Ev),this.sobelBlurShader=new Tt(s,Rl,Dv),this.sobelFirstOrderShader=new Tt(s,Rl,Tv),this.sobelSecondOrderShader=new Tt(s,Rl,Uv),this.growCutShader=new Tt(s,$4,tv),this.passThroughShader=new Tt(s,Sv,Mv),this.orientShaderAtlasU=new Tt(s,kn,Il.concat(h2)),this.orientShaderAtlasI=new Tt(s,kn,c2.concat(h2)),this.orientShaderU=new Tt(s,kn,Il.concat(Vh)),this.orientShaderI=new Tt(s,kn,c2.concat(Vh)),this.orientShaderF=new Tt(s,kn,W4.concat(Vh)),this.orientShaderRGBU=new Tt(s,kn,Il.concat(J4)),this.orientShaderPAQD=new Tt(s,kn,Il.concat(_4)),this.surfaceShader=new Tt(s,ev,iv),this.surfaceShader.use(s),this.fiberShader=new Tt(s,nv,sv),this.pickingImageShader.use(s);for(let c=0;c<this.meshShaders.length;c++){const l=this.meshShaders[c];l.Name==="Flat"?l.shader=new Tt(s,yv,u2):l.shader=new Tt(s,Lh,l.Frag),l.shader.use(s),l.shader.isCrosscut=l.Name==="Crosscut",l.shader.isMatcap=l.Name==="Matcap",l.shader.isMatcap&&s.uniform1i(l.shader.uniforms.matCap,5)}return this.bmpShader=new Tt(s,q4,X4),await this.initText(),this.opts.thumbnail.length>0&&(await this.loadBmpTexture(this.opts.thumbnail),this.thumbnailVisible=!0),this.updateGLVolume(),this.initialized=!0,this.resizeListener(),this.drawScene(),this}gradientGL(i){const t=this.gl;t.bindVertexArray(this.genericVAO);const n=t.createFramebuffer();t.bindFramebuffer(t.FRAMEBUFFER,n),t.viewport(0,0,i.dims[1],i.dims[2]),t.disable(t.BLEND);const s=this.rgbaTex(null,p2,i.dims,!0),r=this.opts.gradientOrder===2?this.sobelBlurShader:this.blurShader;r.use(t),t.activeTexture(Gn),t.bindTexture(t.TEXTURE_3D,this.volumeTexture),t.texParameteri(t.TEXTURE_3D,t.TEXTURE_MIN_FILTER,t.LINEAR),t.texParameteri(t.TEXTURE_3D,t.TEXTURE_MAG_FILTER,t.LINEAR);const c=.7;t.uniform1i(r.uniforms.intensityVol,0),t.uniform1f(r.uniforms.dX,c/i.dims[1]),t.uniform1f(r.uniforms.dY,c/i.dims[2]),t.uniform1f(r.uniforms.dZ,c/i.dims[3]);for(let h=0;h<i.dims[3]-1;h++){const u=1/i.dims[3]*(h+.5);t.uniform1f(r.uniforms.coordZ,u),t.framebufferTextureLayer(t.FRAMEBUFFER,t.COLOR_ATTACHMENT0,s,0,h);const m=t.checkFramebufferStatus(t.FRAMEBUFFER);m!==t.FRAMEBUFFER_COMPLETE&&k.error("blur shader: ",m),t.drawArrays(t.TRIANGLE_STRIP,0,4)}const l=this.opts.gradientOrder===2?this.sobelSecondOrderShader:this.sobelFirstOrderShader;l.use(t),t.activeTexture(p2),t.bindTexture(t.TEXTURE_3D,s),t.texParameteri(t.TEXTURE_3D,t.TEXTURE_MIN_FILTER,t.LINEAR),t.texParameteri(t.TEXTURE_3D,t.TEXTURE_MAG_FILTER,t.LINEAR),t.uniform1i(l.uniforms.intensityVol,8);const d=.7;t.uniform1f(l.uniforms.dX,d/i.dims[1]),t.uniform1f(l.uniforms.dY,d/i.dims[2]),t.uniform1f(l.uniforms.dZ,d/i.dims[3]),this.opts.gradientOrder===2&&(t.uniform1f(l.uniforms.dX2,2*d/i.dims[1]),t.uniform1f(l.uniforms.dY2,2*d/i.dims[2]),t.uniform1f(l.uniforms.dZ2,2*d/i.dims[3])),t.uniform1f(l.uniforms.coordZ,.5),this.gradientTexture!==null&&t.deleteTexture(this.gradientTexture),this.gradientTexture=this.rgbaTex(this.gradientTexture,Vl,i.dims);for(let h=0;h<i.dims[3]-1;h++){const u=1/i.dims[3]*(h+.5);t.uniform1f(l.uniforms.coordZ,u),t.framebufferTextureLayer(t.FRAMEBUFFER,t.COLOR_ATTACHMENT0,this.gradientTexture,0,h);const m=t.checkFramebufferStatus(t.FRAMEBUFFER);m!==t.FRAMEBUFFER_COMPLETE&&k.error("sobel shader: ",m),t.drawArrays(t.TRIANGLE_STRIP,0,4)}t.deleteFramebuffer(n),t.deleteTexture(s),t.bindFramebuffer(t.FRAMEBUFFER,null),t.activeTexture(zs),t.bindTexture(t.TEXTURE_3D,this.paqdTexture),this.gl.bindVertexArray(this.unusedVAO)}getGradientTextureData(){if(!this.gradientTexture||!this.back)return null;const i=this.gl,t=this.back.dims,n=t[1],s=t[2],r=t[3],c=n*s*r,l=i.createFramebuffer();i.bindFramebuffer(i.FRAMEBUFFER,l);const d=new Float32Array(c*4);try{for(let h=0;h<r;h++){i.framebufferTextureLayer(i.FRAMEBUFFER,i.COLOR_ATTACHMENT0,this.gradientTexture,0,h);const u=i.checkFramebufferStatus(i.FRAMEBUFFER);if(u!==i.FRAMEBUFFER_COMPLETE){console.warn("Framebuffer not complete for gradient texture reading, slice",h,"status:",u.toString(16));continue}try{const m=new Uint8Array(n*s*4);i.readPixels(0,0,n,s,i.RGBA,i.UNSIGNED_BYTE,m);const g=new Float32Array(n*s*4);for(let v=0;v<m.length;v++)g[v]=m[v]/127.5-1;const A=h*n*s*4;d.set(g,A)}catch(m){console.warn("Failed to read pixels for slice",h,":",m);const g=h*n*s*4,A=new Float32Array(n*s*4);d.set(A,g)}}}catch(h){return console.error("Error reading gradient texture:",h),null}finally{i.deleteFramebuffer(l),i.bindFramebuffer(i.FRAMEBUFFER,null)}return d}setCustomGradientTexture(i,t){const n=this.gl;if(i===null){this.useCustomGradientTexture=!1,this.back&&this.gradientTextureAmount>0&&this.gradientGL(this.back.hdr);return}if(!t&&!this.back){console.warn("No dimensions provided and no background volume loaded");return}const s=t||this.back.dims,r=s[1],c=s[2],l=s[3],d=r*c*l*4;if(i.length!==d){console.warn(`Custom gradient data size mismatch. Expected ${d}, got ${i.length}`);return}this.useCustomGradientTexture=!0,this.gradientTexture!==null&&n.deleteTexture(this.gradientTexture),this.gradientTexture=n.createTexture(),n.activeTexture(Vl),n.bindTexture(n.TEXTURE_3D,this.gradientTexture),n.texParameteri(n.TEXTURE_3D,n.TEXTURE_MIN_FILTER,n.LINEAR),n.texParameteri(n.TEXTURE_3D,n.TEXTURE_MAG_FILTER,n.LINEAR),n.texParameteri(n.TEXTURE_3D,n.TEXTURE_WRAP_R,n.CLAMP_TO_EDGE),n.texParameteri(n.TEXTURE_3D,n.TEXTURE_WRAP_S,n.CLAMP_TO_EDGE),n.texParameteri(n.TEXTURE_3D,n.TEXTURE_WRAP_T,n.CLAMP_TO_EDGE),n.pixelStorei(n.UNPACK_ALIGNMENT,1);let h;if(i instanceof Float32Array){h=new Uint8Array(i.length);for(let u=0;u<i.length;u++){const m=Math.max(-1,Math.min(1,i[u]));h[u]=Math.round((m+1)*127.5)}}else h=i;n.texStorage3D(n.TEXTURE_3D,1,n.RGBA8,r,c,l),n.texSubImage3D(n.TEXTURE_3D,0,0,0,0,r,c,l,n.RGBA,n.UNSIGNED_BYTE,h),this.drawScene()}updateGLVolume(){let i=0;const t=this.volumes.length;this.refreshColormaps(),this.closePAQD();for(let n=0;n<t;n++)this.volumes[n].toRAS&&(this.refreshLayers(this.volumes[n],i),i++);if(this.furthestVertexFromOrigin=0,t>0&&(this.furthestVertexFromOrigin=this.volumeObject3D?.furthestVertexFromOrigin??0),this.meshes)for(let n=0;n<this.meshes.length;n++)this.furthestVertexFromOrigin=Math.max(this.furthestVertexFromOrigin,this.meshes[n].furthestVertexFromOrigin);this.onVolumeUpdated&&this.onVolumeUpdated(),this.drawScene()}getDescriptives(i){const{layer:t=0,masks:n=[],drawingIsMask:s=!1,roiIsMask:r=!1,startVox:c=[0,0,0],endVox:l=[0,0,0]}=i;let d=null;const h=this.volumes[t].hdr,u=this.volumes[t].pixDimsRAS;let m=h.scl_slope;isNaN(m)&&(m=1);let g=h.scl_inter;isNaN(g)&&(g=1);const A=this.volumes[t].img,v=A.length,y=new Float32Array(v);for(let R=0;R<v;R++)y[R]=A[R]*m+g;const w=new Uint8Array(v);for(let R=0;R<v;R++)w[R]=1;if(n.length>0)for(let R=0;R<n.length;R++){const Y=this.volumes[n[R]].img;if(Y.length!==v){k.debug("Mask resolution does not match image. Skipping masking layer "+n[R]);continue}for(let P=0;P<v;P++)(Y[P]===0||isNaN(Y[P]))&&(w[P]=0)}else if(n.length<1&&s)for(let R=0;R<v;R++)(this.drawBitmap[R]===0||isNaN(this.drawBitmap[R]))&&(w[R]=0);else if(n.length<1&&r){w.fill(0);let R=-1;if(c[0]===l[0])R=0;else if(c[1]===l[1])R=1;else if(c[2]===l[2])R=2;else{console.error("Error: No constant dimension found.");return}const P=[0,1,2].filter(Rt=>Rt!==R),X=[];X[R]=c[R],X[P[0]]=(c[P[0]]+l[P[0]])/2,X[P[1]]=(c[P[1]]+l[P[1]])/2;const L=Math.abs(l[P[0]]-c[P[0]])/2,H=Math.abs(l[P[1]]-c[P[1]])/2,W=h.dims[1],at=h.dims[2],ct=Math.max(0,Math.floor(X[P[0]]-L)),G=Math.min(h.dims[P[0]+1]-1,Math.ceil(X[P[0]]+L)),j=Math.max(0,Math.floor(X[P[1]]-H)),$=Math.min(h.dims[P[1]+1]-1,Math.ceil(X[P[1]]+H)),et=X[R];if(et<0||et>=h.dims[R+1]){console.error("Error: Constant dimension value is out of bounds.");return}for(let Rt=ct;Rt<=G;Rt++)for(let Mt=j;Mt<=$;Mt++){const _t=[];_t[R]=et,_t[P[0]]=Rt,_t[P[1]]=Mt;const ue=(_t[P[0]]-X[P[0]])/L,fe=(_t[P[1]]-X[P[1]])/H;if(ue*ue+fe*fe<=1){const wi=_t[0],Xs=_t[1],$l=_t[2]*W*at+Xs*W+wi;w[$l]=1}}const ot=L*u[P[0]+1],mt=H*u[P[1]+1];d=Math.PI*ot*mt}let b=0,C=0,S=0,E=Number.NEGATIVE_INFINITY,M=Number.POSITIVE_INFINITY,N=0,U=0,T=0;for(let R=0;R<v;R++){if(w[R]<1)continue;const Y=y[R];b++;let P=C+(Y-C)/b;S=S+(Y-C)*(Y-P),C=P,Y!==0&&(N++,P=U+(Y-U)/N,T=T+(Y-U)*(Y-P),U=P,M=Math.min(Y,M),E=Math.max(Y,E))}const F=Math.sqrt(S/(b-1)),I=Math.sqrt(T/(N-1)),B=M,V=E;return b!==N&&(M=Math.min(0,M),E=Math.max(0,E)),{mean:C,stdev:F,nvox:b,volumeMM3:b*h.pixDims[1]*h.pixDims[2]*h.pixDims[3],volumeML:b*h.pixDims[1]*h.pixDims[2]*h.pixDims[3]*.001,min:M,max:E,meanNot0:U,stdevNot0:I,nvoxNot0:N,minNot0:B,maxNot0:V,cal_min:this.volumes[t].cal_min,cal_max:this.volumes[t].cal_max,robust_min:this.volumes[t].robust_min,robust_max:this.volumes[t].robust_max,area:d}}refreshLayers(i,t){if(this.volumes.length<1)return;this.refreshColormaps();const n=i.hdr;let s=i.img;i.frame4D>0&&i.frame4D<i.nFrame4D&&(s=i.img.slice(i.frame4D*i.nVox3D,(i.frame4D+1)*i.nVox3D));const r=i.opacity;if(t>1&&r===0)return;let c=null;if(!this.back)throw new Error("back undefined");this.gl.bindVertexArray(this.unusedVAO),this.crosshairs3D&&(this.crosshairs3D.mm[0]=NaN);let l=re(i.toRAS);if(t===0){this.volumeObject3D=C4(i,this.VOLUME_ID,this.gl),Pe(l,l),this.back.matRAS=i.matRAS,this.back.dims=i.dimsRAS,this.back.pixDims=i.pixDimsRAS;const{volScale:U,vox:T}=this.sliceScale(!0);this.volScale=U,this.vox=T,this.volumeObject3D.scale=U,(n.dims[1]>this.uiData.max2D||n.dims[2]>this.uiData.max2D)&&k.error("Image dimensions exceed maximum texture size of hardware.");const I=n.dims[1]>this.uiData.max3D||n.dims[2]>this.uiData.max3D||n.dims[3]>this.uiData.max3D;if(I&&n.datatypeCode===2304&&n.dims[3]<2){k.info(`Large RGBA image (>${this.uiData.max3D}) requires Texture2D`),this.opts.is2DSliceShader=!0,c=this.rgbaTex2D(this.volumeTexture,Gn,i.dimsRAS,s);return}if(I){k.info(`Large scalar image (>${this.uiData.max3D}) requires Texture2D (${n.dims[1]}×${n.dims[2]}×${n.dims[3]})`);const V=n.dims[1]*n.dims[2],R=this.frac2vox(this.scene.crosshairPos),P=Math.min(Math.max(R[2],0),n.dims[3]-1)*V,X=new Uint8Array(V*4),L=new Uint32Array(X.buffer),H=Math.floor(i.opacity*255),W=255*n.scl_slope/(i.cal_max-i.cal_min),at=255*(n.scl_inter-i.cal_min)/(i.cal_max-i.cal_min),ct=new Uint8Array(this.colormap(i.colormap)),G=new Uint32Array(ct.buffer);let j=-1;for(let $=0;$<V;$++){const et=s[$+P]*W+at,ot=Math.round(Math.min(255,Math.max(0,et)));L[$]=G[ot],X[j+=4]=H}this.opts.is2DSliceShader=!0,c=this.rgbaTex2D(this.volumeTexture,Gn,i.dimsRAS,X,!1);return}if(I&&k.warn(`dimensions exceed 3D limits ${n.dims}`),this.opts.is2DSliceShader=!1,c=this.rgbaTex(this.volumeTexture,Gn,i.dimsRAS),!this.renderShader)throw new Error("renderShader undefined");this.renderShader.use(this.gl),this.gl.uniform3fv(this.renderShader.uniforms.texVox,T),this.gl.uniform3fv(this.renderShader.uniforms.volScale,U);const B=this.pickingImageShader;B.use(this.gl),this.gl.uniform1i(B.uniforms.volume,0),this.gl.uniform1i(B.uniforms.colormap,1),this.gl.uniform1i(B.uniforms.overlay,2),this.gl.uniform3fv(B.uniforms.volScale,U),k.debug(this.volumeObject3D)}else{this.back?.dims===void 0&&k.error("Fatal error: Unable to render overlay: background dimensions not defined!");const U=this.mm2frac(i.mm000,0,!0);let T=this.mm2frac(i.mm100,0,!0),F=this.mm2frac(i.mm010,0,!0),I=this.mm2frac(i.mm001,0,!0);T=jt(T,T,U),F=jt(F,F,U),I=jt(I,I,U),l=oi(T[0],F[0],I[0],U[0],T[1],F[1],I[1],U[1],T[2],F[2],I[2],U[2],0,0,0,1),Pe(l,l),t===1?(c=this.rgbaTex(this.overlayTexture,Nl,this.back.dims),this.overlayTexture=c,this.overlayTextureID=c):c=this.overlayTextureID}const d=this.gl.createFramebuffer();this.gl.bindFramebuffer(this.gl.FRAMEBUFFER,d),this.gl.disable(this.gl.CULL_FACE),this.gl.viewport(0,0,this.back.dims[1],this.back.dims[2]),this.gl.disable(this.gl.BLEND);const h=this.gl.createTexture();this.gl.activeTexture(v2),this.gl.bindTexture(this.gl.TEXTURE_3D,h),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_MIN_FILTER,this.gl.NEAREST),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_MAG_FILTER,this.gl.NEAREST),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_R,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_S,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_WRAP_T,this.gl.CLAMP_TO_EDGE),this.gl.pixelStorei(this.gl.UNPACK_ALIGNMENT,1);let u=this.orientShaderU;if(!n)throw new Error("hdr undefined");if(!s)throw new Error("img undefined");if(n.datatypeCode===2)n.intent_code===1002&&(u=this.orientShaderAtlasU),this.gl.texStorage3D(this.gl.TEXTURE_3D,1,this.gl.R8UI,n.dims[1],n.dims[2],n.dims[3]),this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,n.dims[1],n.dims[2],n.dims[3],this.gl.RED_INTEGER,this.gl.UNSIGNED_BYTE,s);else if(n.datatypeCode===4)u=this.orientShaderI,n.intent_code===1002&&(u=this.orientShaderAtlasI),this.gl.texStorage3D(this.gl.TEXTURE_3D,1,this.gl.R16I,n.dims[1],n.dims[2],n.dims[3]),this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,n.dims[1],n.dims[2],n.dims[3],this.gl.RED_INTEGER,this.gl.SHORT,s);else if(n.datatypeCode===16)this.gl.texStorage3D(this.gl.TEXTURE_3D,1,this.gl.R32F,n.dims[1],n.dims[2],n.dims[3]),this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,n.dims[1],n.dims[2],n.dims[3],this.gl.RED,this.gl.FLOAT,s),u=this.orientShaderF;else if(n.datatypeCode===64){let U=new Float32Array;U=Float32Array.from(s),this.gl.texStorage3D(this.gl.TEXTURE_3D,1,this.gl.R32F,n.dims[1],n.dims[2],n.dims[3]),this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,n.dims[1],n.dims[2],n.dims[3],this.gl.RED,this.gl.FLOAT,U),u=this.orientShaderF}else if(n.datatypeCode===128)u=this.orientShaderRGBU,u.use(this.gl),this.gl.uniform1i(u.uniforms.hasAlpha,0),this.gl.texStorage3D(this.gl.TEXTURE_3D,1,this.gl.RGB8UI,n.dims[1],n.dims[2],n.dims[3]),this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,n.dims[1],n.dims[2],n.dims[3],this.gl.RGB_INTEGER,this.gl.UNSIGNED_BYTE,s);else if(n.datatypeCode===512)n.intent_code===1002&&(u=this.orientShaderAtlasU),this.gl.texStorage3D(this.gl.TEXTURE_3D,1,this.gl.R16UI,n.dims[1],n.dims[2],n.dims[3]),this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,n.dims[1],n.dims[2],n.dims[3],this.gl.RED_INTEGER,this.gl.UNSIGNED_SHORT,s);else if(n.datatypeCode===2304){if(u=this.orientShaderRGBU,i.colormapLabel){u=this.orientShaderPAQD;let U=!0;for(let T=0;T<t;T++){const F=this.volumes[T].hdr.datatypeCode===2304,I=!!this.volumes[T].colormapLabel;F&&I&&(U=!1)}U?this.paqdTexture=this.rgbaTex(this.paqdTexture,zs,this.back.dims):k.warn("Current version only one probabilistic atlas (PAQD) at a time"),c=this.paqdTexture,this.gl.activeTexture(v2)}u.use(this.gl),this.gl.uniform1i(u.uniforms.hasAlpha,1),this.gl.texStorage3D(this.gl.TEXTURE_3D,1,this.gl.RGBA8UI,n.dims[1],n.dims[2],n.dims[3]),this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,n.dims[1],n.dims[2],n.dims[3],this.gl.RGBA_INTEGER,this.gl.UNSIGNED_BYTE,s)}i.global_min===void 0&&i.calMinMax();let m=null;if(this.gl.bindVertexArray(this.genericVAO),t>1){if(!this.back.dims)throw new Error("back.dims undefined");m=this.rgbaTex(m,x2,this.back.dims),this.gl.bindTexture(this.gl.TEXTURE_3D,m);const U=this.passThroughShader;U.use(this.gl),this.gl.uniform1i(U.uniforms.in3D,2);for(let T=0;T<this.back.dims[3];T++){const F=1/this.back.dims[3]*(T+.5);this.gl.uniform1f(U.uniforms.coordZ,F),this.gl.framebufferTextureLayer(this.gl.FRAMEBUFFER,this.gl.COLOR_ATTACHMENT0,m,0,T),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4)}}else m=this.rgbaTex(m,x2,[2,2,2,2]);u.use(this.gl),this.gl.activeTexture(Xa);let g=null;if(i.colormapLabel!==null&&i.colormapLabel.lut.length>7){const U=i.colormapLabel.max-i.colormapLabel.min+1;g=this.createColormapTexture(g,1,U),this.gl.texSubImage2D(this.gl.TEXTURE_2D,0,0,0,U,1,this.gl.RGBA,this.gl.UNSIGNED_BYTE,i.colormapLabel.lut),this.gl.uniform1f(u.uniforms.cal_min,i.colormapLabel.min-.5),this.gl.uniform1f(u.uniforms.cal_max,i.colormapLabel.max+.5),this.gl.bindTexture(this.gl.TEXTURE_2D,g)}else this.gl.bindTexture(this.gl.TEXTURE_2D,this.colormapTexture),this.gl.uniform1f(u.uniforms.cal_min,i.cal_min),this.gl.uniform1f(u.uniforms.cal_max,i.cal_max);"alphaThreshold"in i&&(k.warn("alphaThreshold is deprecated: use colormapType"),i.alphaThreshold===!0&&(i.colormapType=2),i.alphaThreshold===!1&&(i.colormapType=1),delete i.alphaThreshold);const A=i.colormapType!==0?1:0,v=i.colormapType===2?1:0;this.gl.uniform1i(u.uniforms.isAlphaThreshold,v),this.gl.uniform1i(u.uniforms.isColorbarFromZero,A),this.gl.uniform1i(u.uniforms.isAdditiveBlend,this.opts.isAdditiveBlend?1:0);let y=Number.POSITIVE_INFINITY,w=Number.NEGATIVE_INFINITY;if(i.colormapNegative.length>0&&(y=Math.min(-i.cal_min,-i.cal_max),w=Math.max(-i.cal_min,-i.cal_max),isFinite(i.cal_minNeg)&&isFinite(i.cal_maxNeg)&&(y=Math.min(i.cal_minNeg,i.cal_maxNeg),w=Math.max(i.cal_minNeg,i.cal_maxNeg))),t>0&&this.overlayOutlineWidth>0){const U=i.cal_min,T=i.cal_max;let F=Math.min(U,T)<=0&&Math.max(U,T)>=0;!F&&y<w&&(F=y<=0&&w>=0),F&&k.error("issue1139: do not use overlayOutlineWidth when thresholds cross or touch zero")}if(!u)throw new Error("orientShader undefined");this.gl.uniform1f(u.uniforms.layer??null,t),this.gl.uniform1f(u.uniforms.cal_minNeg??null,y),this.gl.uniform1f(u.uniforms.cal_maxNeg??null,w),this.gl.bindTexture(this.gl.TEXTURE_3D,h),this.gl.uniform1i(u.uniforms.intensityVol??null,9),this.gl.uniform1i(u.uniforms.blend3D??null,10),this.gl.uniform1i(u.uniforms.colormap??null,1),this.gl.uniform1f(u.uniforms.scl_inter??null,n.scl_inter),this.gl.uniform1f(u.uniforms.scl_slope??null,n.scl_slope),this.gl.uniform1f(u.uniforms.opacity??null,r),this.gl.uniform1i(u.uniforms.modulationVol??null,7);let b=null;if(i.modulationImage!==null&&i.modulationImage>=0&&i.modulationImage<this.volumes.length){k.debug("modulating",this.volumes);const U=this.volumes[i.modulationImage].hdr;if(U.dims[1]===n.dims[1]&&U.dims[2]===n.dims[2]&&U.dims[3]===n.dims[3]){i.modulateAlpha?(this.gl.uniform1i(u.uniforms.modulation,2),this.gl.uniform1f(u.uniforms.opacity,1)):this.gl.uniform1i(u.uniforms.modulation,1),b=this.r8Tex(b,this.gl.TEXTURE7,n.dims,!0),this.gl.activeTexture(this.gl.TEXTURE7),this.gl.bindTexture(this.gl.TEXTURE_3D,b);const T=n.dims[1]*n.dims[2]*n.dims[3],F=new Uint8Array(T),I=this.volumes[i.modulationImage].cal_min,B=1/(this.volumes[i.modulationImage].cal_max-I),V=this.volumes[i.modulationImage].img.buffer;let R=new Uint8Array(V);switch(U.datatypeCode){case 4:R=new Int16Array(V);break;case 16:R=new Float32Array(V);break;case 64:R=new Float64Array(V);break;case 128:R=new Uint8Array(V);break;case 512:R=new Uint16Array(V);break}k.debug(this.volumes[i.modulationImage]);const Y=this.volumes[i.modulationImage].colormapNegative.length>0;let P=this.volumes[i.modulationImage].cal_min,X=this.volumes[i.modulationImage].cal_max;isFinite(this.volumes[i.modulationImage].cal_minNeg)&&isFinite(this.volumes[i.modulationImage].cal_maxNeg)&&(P=this.volumes[i.modulationImage].cal_minNeg,X=this.volumes[i.modulationImage].cal_minNeg),P=Math.abs(P),X=Math.abs(X),P>X&&([P,X]=[X,P]);const L=1/(X-P);let H=Math.abs(i.modulateAlpha);H=Math.max(H,1);const W=this.volumes[i.modulationImage].frame4D*T;for(let at=0;at<T;at++){const ct=R[at+W]*U.scl_slope+U.scl_inter;let G=(ct-I)*B;Y&&ct<0&&(G=(Math.abs(ct)-P)*L),G=Math.min(Math.max(G,0),1),G=Math.pow(G,H)*255,F[at]=G}this.gl.texSubImage3D(this.gl.TEXTURE_3D,0,0,0,0,n.dims[1],n.dims[2],n.dims[3],this.gl.RED,this.gl.UNSIGNED_BYTE,F)}else k.debug("Modulation image dimensions do not match target")}else this.gl.uniform1i(u.uniforms.modulation,0);if(this.gl.uniformMatrix4fv(u.uniforms.mtx,!1,l),!this.back.dims)throw new Error("back.dims undefined");let C=0;n.intent_code===1002&&(C=this.opts.atlasOutline,this.gl.uniform1ui(u.uniforms.activeIndex,this.opts.atlasActiveIndex|0)),this.gl.uniform4fv(u.uniforms.xyzaFrac,[1/this.back.dims[1],1/this.back.dims[2],1/this.back.dims[3],C]),k.debug("back dims: ",this.back.dims);for(let U=0;U<this.back.dims[3];U++){const T=1/this.back.dims[3]*(U+.5);this.gl.uniform1f(u.uniforms.coordZ,T),this.gl.framebufferTextureLayer(this.gl.FRAMEBUFFER,this.gl.COLOR_ATTACHMENT0,c,0,U),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4)}if(this.gl.bindVertexArray(this.unusedVAO),this.gl.deleteTexture(h),this.gl.deleteTexture(b),this.gl.deleteTexture(m),this.gl.viewport(0,0,this.gl.canvas.width,this.gl.canvas.height),this.gl.bindFramebuffer(this.gl.FRAMEBUFFER,null),this.gl.deleteFramebuffer(d),t===0&&(this.volumeTexture=c,this.gradientTextureAmount>0&&!this.useCustomGradientTexture?(this.gradientGL(n),this.gl.bindVertexArray(this.genericVAO)):this.gradientTextureAmount<=0&&(this.gradientTexture!==null&&this.gl.deleteTexture(this.gradientTexture),this.gradientTexture=null)),!this.renderShader)throw new Error("renderShader undefined");this.renderShader.use(this.gl);const S=this.sliceScale(!0),E=S.vox,M=S.volScale;if(this.gl.uniform1f(this.renderShader.uniforms.overlays,this.overlays.length),this.gl.uniform4fv(this.renderShader.uniforms.clipPlaneColor,this.opts.clipPlaneColor),this.gl.uniform1f(this.renderShader.uniforms.backOpacity,this.volumes[0].opacity),this.gl.uniform1f(this.renderShader.uniforms.renderOverlayBlend,this.opts.renderOverlayBlend),this.gl.uniform4fv(this.renderShader.uniforms.clipPlane,this.scene.clipPlane),this.gl.uniform3fv(this.renderShader.uniforms.texVox,E),this.gl.uniform3fv(this.renderShader.uniforms.volScale,M),!this.pickingImageShader)throw new Error("pickingImageShader undefined");this.pickingImageShader.use(this.gl),this.gl.uniform1f(this.pickingImageShader.uniforms.overlays,this.overlays.length),this.gl.uniform3fv(this.pickingImageShader.uniforms.texVox,E);let N=this.sliceMMShader;if(this.opts.is2DSliceShader&&(N=this.slice2DShader),this.opts.isV1SliceShader&&(N=this.sliceV1Shader),this.customSliceShader&&(N=this.customSliceShader),!N)throw new Error("slice shader undefined");N.use(this.gl),this.gl.uniform1f(N.uniforms.overlays,this.overlays.length),this.gl.uniform1f(N.uniforms.drawOpacity,this.drawOpacity),g!==null&&(this.gl.deleteTexture(g),this.gl.activeTexture(Xa),this.gl.bindTexture(this.gl.TEXTURE_2D,this.colormapTexture)),this.gl.uniform1i(N.uniforms.drawing,7),this.gl.activeTexture(gn),this.opts.is2DSliceShader?this.gl.bindTexture(this.gl.TEXTURE_2D,this.drawTexture):this.gl.bindTexture(this.gl.TEXTURE_3D,this.drawTexture),this.gl.uniform4fv(N.uniforms.paqdUniforms,this.opts.paqdUniforms),this.gl.uniform1i(N.uniforms.paqd,8),this.gl.activeTexture(zs),this.gl.bindTexture(this.gl.TEXTURE_3D,this.paqdTexture),this.updateInterpolation(t)}colormaps(){return Pt.colormaps()}addColormap(i,t){Pt.addColormap(i,t)}setColormap(i,t){const n=this.getVolumeIndexByID(i);this.volumes[n].colormap=t,this.updateGLVolume()}idx(i,t,n,s){return n*s[0]*s[1]+t*s[0]+i}check_previous_slice(i,t,n,s,r,c,l,d){const h=new Uint32Array(27);let u=0;if(!r)return 0;const m=i[this.idx(n,s,r,c)];if(l>=6){const g=this.idx(n,s,r-1,c);m===i[g]&&(h[u++]=t[g])}if(l>=18){if(n){const g=this.idx(n-1,s,r-1,c);m===i[g]&&(h[u++]=t[g])}if(s){const g=this.idx(n,s-1,r-1,c);m===i[g]&&(h[u++]=t[g])}if(n<c[0]-1){const g=this.idx(n+1,s,r-1,c);m===i[g]&&(h[u++]=t[g])}if(s<c[1]-1){const g=this.idx(n,s+1,r-1,c);m===i[g]&&(h[u++]=t[g])}}if(l===26){if(n&&s){const g=this.idx(n-1,s-1,r-1,c);m===i[g]&&(h[u++]=t[g])}if(n<c[0]-1&&s){const g=this.idx(n+1,s-1,r-1,c);m===i[g]&&(h[u++]=t[g])}if(n&&s<c[1]-1){const g=this.idx(n-1,s+1,r-1,c);m===i[g]&&(h[u++]=t[g])}if(n<c[0]-1&&s<c[1]-1){const g=this.idx(n+1,s+1,r-1,c);m===i[g]&&(h[u++]=t[g])}}return u?(this.fill_tratab(d,h,u),h[0]):0}do_initial_labelling(i,t,n){let s=1;const r=8192;let c=r,l=new Uint32Array(c).fill(0);const d=new Uint32Array(t[0]*t[1]*t[2]).fill(0),h=new Uint32Array(27);for(let u=0;u<t[2];u++)for(let m=0;m<t[1];m++)for(let g=0;g<t[0];g++){let A=0;const v=i[this.idx(g,m,u,t)];if(v!==0){if(h[0]=this.check_previous_slice(i,d,g,m,u,t,n,l),h[0]&&(A+=1),n>=6){if(g){const y=this.idx(g-1,m,u,t);v===i[y]&&(h[A++]=d[y])}if(m){const y=this.idx(g,m-1,u,t);v===i[y]&&(h[A++]=d[y])}}if(n>=18){if(m&&g){const y=this.idx(g-1,m-1,u,t);v===i[y]&&(h[A++]=d[y])}if(m&&g<t[0]-1){const y=this.idx(g+1,m-1,u,t);v===i[y]&&(h[A++]=d[y])}}if(A)d[this.idx(g,m,u,t)]=h[0],this.fill_tratab(l,h,A);else{if(d[this.idx(g,m,u,t)]=s,s>=c){c+=r;const y=new Uint32Array(c);y.set(l),l=y}l[s-1]=s,s++}}}for(let u=0;u<s-1;u++){let m=u;for(;l[m]!==m+1;)m=l[m]-1;l[u]=m+1}return[s-1,l,d]}fill_tratab(i,t,n){let s=0;const r=new Uint32Array(n+5).fill(0);let l=2147483647;for(let d=0;d<n;d++){let h=t[d];for(s=0;i[h-1]!==h;)if(h=i[h-1],s++,s>100){k.info(`
+Ooh no!!`);break}r[d]=h,l=Math.min(l,h)}for(let d=0;d<n;d++)i[r[d]-1]=l}translate_labels(i,t,n,s){const r=t[0]*t[1]*t[2];let c=0;const l=new Uint32Array(r).fill(0);for(let u=0;u<s;u++)c=Math.max(c,n[u]);const d=new Uint32Array(c).fill(0);let h=0;for(let u=0;u<r;u++)i[u]&&(d[n[i[u]-1]-1]||(h+=1,d[n[i[u]-1]-1]=h),l[u]=d[n[i[u]-1]-1]);return[h,l]}largest_original_cluster_labels(i,t,n){const s=i.length,r=new Uint32Array(t+1).fill(0),c=new Uint32Array(t+1).fill(0);for(let h=0;h<s;h++){const u=i[h],m=n[h];r[m]=u,c[m]++}let l=0;for(let h=0;h<t+1;h++){const u=r[h];l=Math.max(l,u);for(let m=0;m<t+1;m++)m!==h&&u===r[m]&&(c[h]<c[m]||c[h]===c[m]&&h<m)&&(r[h]=0)}const d=new Uint32Array(s).fill(0);for(let h=0;h<s;h++)d[h]=r[n[h]];return[l,d]}bwlabel(i,t,n=26,s=!1,r=!1){const c=Date.now(),l=t[0]*t[1]*t[2],d=new Uint32Array(l).fill(0);if(![6,18,26].includes(n))return k.info("bwlabel: conn must be 6, 18 or 26."),[0,d];if(t[0]<2||t[1]<2||t[2]<1)return k.info("bwlabel: img must be 2 or 3-dimensional"),[0,d];if(s)for(let v=0;v<l;v++)i[v]!==0&&(d[v]=1);else d.set(i);let[h,u,m]=this.do_initial_labelling(d,t,n);u===void 0&&(u=new Uint32Array);const[g,A]=this.translate_labels(m,t,u,h);if(k.info(n+" neighbor clustering into "+g+" regions in "+(Date.now()-c)+"ms"),r){const[v,y]=this.largest_original_cluster_labels(d,g,A);return[v,y]}return[g,A]}async createConnectedLabelImage(i,t=26,n=!1,s=!1){const r=this.getVolumeIndexByID(i),c=Uint32Array.from(this.volumes[r].dims?.slice(1,4)??[]),l=Uint32Array.from(this.volumes[r].img?.slice()??[]),[d,h]=this.bwlabel(l,c,t,n,s),u=this.volumes[r].clone();u.opacity=.5,u.colormap="random";for(let m=0;m<u.img.length;m++)u.img[m]=h[m];return u.cal_min=0,u.cal_max=d,u}async scalecropUint8(i,t=0,n=255,s,r){const c=i.length,l=new Uint8Array(c);for(let d=0;d<c;d++){let h=i[d];h=t+r*(h-s),h=Math.max(h,t),h=Math.min(h,n),l[d]=h}return l}async scalecropFloat32(i,t=0,n=1,s,r){const c=i.length,l=new Float32Array(c);for(let d=0;d<c;d++){let h=i[d];h=t+r*(h-s),h=Math.max(h,t),h=Math.min(h,n),l[d]=h}return l}getScale(i,t=0,n=255,s=0,r=.999){let c=i.global_min,l=i.global_max;if(i.hdr.datatypeCode===2)return[c,1];if((!isFinite(s)||!isFinite(r))&&isFinite(i.cal_min)&&isFinite(i.cal_max)&&i.cal_max>i.cal_min){c=i.cal_min,l=i.cal_max;const S=(n-t)/(l-c);return k.info(" Robust Rescale:  min: "+c+"  max: "+l+" scale: "+S),[c,S]}let d=i.img;const h=i.hdr.dims[1]*i.hdr.dims[2]*i.hdr.dims[3];if(i.hdr.scl_slope!==1||i.hdr.scl_inter!==0){const S=i.img;d=new Float32Array(i.img.length);for(let E=0;E<h;E++)d[E]=S[E]*i.hdr.scl_slope+i.hdr.scl_inter}if(c<0&&k.warn("WARNING: Input image has value(s) below 0.0 !"),k.info(" Input:    min: "+c+"  max: "+l),s===0&&r===1)return[c,1];let u=0;for(let S=0;S<h;S++)Math.abs(d[S])>=1e-15&&u++;const m=1e3,g=(l-c)/m,A=new Array(m).fill(0);for(let S=0;S<h;S++){const E=d[S];let M=Math.floor((E-c)/g);M=Math.min(M,m-1),A[M]++}const v=new Array(m).fill(0);v[0]=A[0];for(let S=1;S<m;S++)v[S]=v[S-1]+A[S];let y=Math.floor(s*h),w=0;for(;w<m&&!(v[w]>=y);)w++;const b=c;for(c=w*g+b,y=h-Math.floor((1-r)*u),w=0;w<m-1&&!(v[w+1]>=y);)w++;l=w*g+b;let C=1;return c!==l&&(C=(n-t)/(l-c)),k.info(" Rescale:  min: "+c+"  max: "+l+" scale: "+C),[c,C]}conformVox2Vox(i,t,n=256,s=1,r=!1){const c=t.flat(),l=oi(c[0],c[1],c[2],c[3],c[4],c[5],c[6],c[7],c[8],c[9],c[10],c[11],c[12],c[13],c[14],c[15]),d=te(i[1]/2,i[2]/2,i[3]/2,1),h=ki(),u=Ut();We(u,l),De(h,d,u);const m=lt(h[0],h[1],h[2]),g=lt(s,s,s);let A=oi(-1,0,0,0,0,0,1,0,0,-1,0,0,0,0,0,1);r&&(A=oi(1,0,0,0,0,1,0,0,0,0,1,0,0,0,0,1)),We(A,A);const v=te(n,n,n,1),y=Ut();Bd(y,A,g);const w=te(v[0],v[1],v[2],1);De(w,w,y),up(w,w,.5);const b=Gt();jt(b,m,lt(w[0],w[1],w[2]));const C=Ut();We(C,y),C[3]=b[0],C[7]=b[1],C[11]=b[2];const S=Ut();Pe(S,C);const E=Ut();S2(E,l,S);const M=Ut();return Pe(M,E),[C,E,M]}async createNiftiArray(i=[256,256,256],t=[1,1,1],n=[1,0,0,-128,0,1,0,-128,0,0,1,-128,0,0,0,1],s=2,r=new Uint8Array){return await Ue.createNiftiArray(i,t,n,s,r)}async niftiArray2NVImage(i=new Uint8Array){return await Ue.loadFromUrl({url:i})}async loadFromUrl(i){return await Ue.loadFromUrl({url:i})}async conform(i,t=!1,n=!0,s=!1,r=!1){const d=this.conformVox2Vox(i.hdr.dims,i.hdr.affine.flat(),256,1,t),h=d[0],u=d[2],m=256*256*256,g=new Float32Array(m),A=new Float32Array(i.img),v=i.hdr.dims[1]*i.hdr.dims[2]*i.hdr.dims[3];if(i.hdr.scl_slope!==1||i.hdr.scl_inter!==0)for(let B=0;B<v;B++)A[B]=A[B]*i.hdr.scl_slope+i.hdr.scl_inter;const y=i.hdr.dims[1],w=i.hdr.dims[2],b=i.hdr.dims[3],C=y*w;let S=-1;function E(B,V,R){return B+V*y+R*C}const M=u[0],N=u[4],U=u[8];if(n)for(let B=0;B<256;B++)for(let V=0;V<256;V++){const R=V*u[1]+B*u[2]+u[3],Y=V*u[5]+B*u[6]+u[7],P=V*u[9]+B*u[10]+u[11];for(let X=0;X<256;X++){const L=X*M+R,H=X*N+Y,W=X*U+P,at=Math.floor(L),ct=Math.floor(H),G=Math.floor(W);if(S++,at<0||ct<0||G<0)continue;const j=Math.ceil(L),$=Math.ceil(H),et=Math.ceil(W);if(j>=y||$>=w||et>=b)continue;const ot=L-at,mt=H-ct,vt=W-G,Rt=1-ot,Mt=1-mt,_t=1-vt,ue=E(at,ct,G);let fe=0;fe+=A[ue]*Rt*Mt*_t,fe+=A[ue+C]*Rt*Mt*vt,fe+=A[ue+y]*Rt*mt*_t,fe+=A[ue+y+C]*Rt*mt*vt,fe+=A[ue+1]*ot*Mt*_t,fe+=A[ue+1+C]*ot*Mt*vt,fe+=A[ue+1+y]*ot*mt*_t,fe+=A[ue+1+y+C]*ot*mt*vt,g[S]=fe}}else for(let B=0;B<256;B++)for(let V=0;V<256;V++){const R=V*u[1]+B*u[2]+u[3],Y=V*u[5]+B*u[6]+u[7],P=V*u[9]+B*u[10]+u[11];for(let X=0;X<256;X++){const L=Math.round(X*M+R),H=Math.round(X*N+Y),W=Math.round(X*U+P);S++,!(L<0||H<0||W<0)&&(L>=y||H>=w||W>=b||(g[S]=A[E(L,H,W)]))}}let T=0;r&&(T=NaN);let F=new Uint8Array;if(s){const B=await this.getScale(i,0,1,T),V=await this.scalecropFloat32(g,0,1,B[0],B[1]);F=await this.createNiftiArray([256,256,256],[1,1,1],Array.from(h),16,new Uint8Array(V.buffer))}else{const B=await this.getScale(i,0,255,T),V=await this.scalecropUint8(g,0,255,B[0],B[1]);F=await this.createNiftiArray([256,256,256],[1,1,1],Array.from(h),2,V)}return await this.niftiArray2NVImage(F)}setRenderDrawAmbientOcclusion(i){if(!this.renderShader)throw new Error("renderShader undefined");this.renderDrawAmbientOcclusion=i,this.renderShader.use(this.gl),this.gl.uniform1fv(this.renderShader.uniforms.renderDrawAmbientOcclusion,[this.renderDrawAmbientOcclusion,1]),this.drawScene()}setColorMap(i,t){this.setColormap(i,t)}setColormapNegative(i,t){const n=this.getVolumeIndexByID(i);this.volumes[n].colormapNegative=t,this.updateGLVolume()}setModulationImage(i,t,n=0){const s=this.getVolumeIndexByID(i);let r=null;t.length>0&&(r=this.getVolumeIndexByID(t)),this.volumes[s].modulationImage=r,this.volumes[s].modulateAlpha=n,this.updateGLVolume()}setGamma(i=1){this.scene.gamma=i,Pt.gamma=i,this.updateGLVolume()}async loadDeferred4DVolumes(i){const t=this.getVolumeIndexByID(i),n=this.volumes[t];if(n.nTotalFrame4D<=n.nFrame4D)return;n.nTotalFrame4D=n.nFrame4D;let s;n.fileObject?s=await Ue.loadFromFile({file:n.fileObject}):s=await Ue.loadFromUrl({url:n.url}),s&&(n.img=s.img.slice(),n.nTotalFrame4D=s.nTotalFrame4D,n.nFrame4D=s.nFrame4D,this.updateGLVolume())}setFrame4D(i,t){const n=this.getVolumeIndexByID(i),s=this.volumes[n];t>s.nFrame4D-1&&(t=s.nFrame4D-1),t<0&&(t=0),t!==s.frame4D&&(s.frame4D=t,this.updateGLVolume(),this.onFrameChange(s,t),this.createOnLocationChange())}getFrame4D(i){const t=this.getVolumeIndexByID(i);return this.volumes[t].frame4D}colormapFromKey(i){return Pt.colormapFromKey(i)}colormap(i="",t=!1){return Pt.colormap(i,t)}createColormapTexture(i=null,t=0,n=256){return i!==null&&this.gl.deleteTexture(i),t<1||n<1?null:(i=this.gl.createTexture(),this.gl.activeTexture(Xa),this.gl.bindTexture(this.gl.TEXTURE_2D,i),this.gl.texStorage2D(this.gl.TEXTURE_2D,1,this.gl.RGBA8,n,t),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MIN_FILTER,this.gl.LINEAR),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MAG_FILTER,this.gl.LINEAR),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_WRAP_R,this.gl.CLAMP_TO_EDGE),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_WRAP_S,this.gl.CLAMP_TO_EDGE),this.gl.pixelStorei(this.gl.UNPACK_ALIGNMENT,1),i)}addColormapList(i="",t=NaN,n=NaN,s=!1,r=!1,c=!0,l=!1){i.length<1&&(c=!1),this.colormapLists.push({name:i,min:t,max:n,isColorbarFromZero:s,negative:r,visible:c,invert:l})}refreshColormaps(){if(this.colormapLists=[],this.volumes.length<1&&this.meshes.length<1)return;const i=this.volumes.length;if(i>0)for(let c=0;c<i;c++){const l=this.volumes[c],d=Oh(l.cal_min,l.cal_max,l.cal_minNeg,l.cal_maxNeg),h=l.colormapType!==0;this.addColormapList(l.colormapNegative,d[0],d[1],h,!0,l.colorbarVisible,l.colormapInvert),this.addColormapList(l.colormap,l.cal_min,l.cal_max,h,!1,l.colorbarVisible,l.colormapInvert)}const t=this.meshes.length;if(t>0)for(let c=0;c<t;c++){const l=this.meshes[c];if(!l.colorbarVisible)continue;const d=l.layers.length,h=l.fiberColor.toLowerCase();if(l.offsetPt0&&h.startsWith("dp")){let u=null;const m=parseInt(h.substring(3));h.startsWith("dpg")&&!l.fiberGroupColormap&&(u=m<l.dpg.length?l.dpg[m]:l.dpg[0]),h.startsWith("dps")&&(u=m<l.dps.length?l.dps[m]:l.dps[0]),h.startsWith("dpv")&&(u=m<l.dpv.length?l.dpv[m]:l.dpv[0]),u&&typeof l.colormap=="string"&&this.addColormapList(l.colormap,u.cal_min,u.cal_max,!1,!1,!0,l.colormapInvert)}if("edgeColormap"in l&&"edges"in l&&l.edges!==void 0){const u=Oh(l.edgeMin,l.edgeMax,NaN,NaN);this.addColormapList(l.edgeColormapNegative,u[0],u[1],!1,!0,!0,l.colormapInvert),this.addColormapList(l.edgeColormap,l.edgeMin,l.edgeMax,!1,!1,!0,l.colormapInvert)}if(!(d<1))for(let u=0;u<d;u++){const m=this.meshes[c].layers[u];if(!m.colorbarVisible||m.colormap.length<1)continue;const g=m.colormapType!==0;if(m.useNegativeCmap){const A=Oh(m.cal_min,m.cal_max,m.cal_minNeg,m.cal_maxNeg);this.addColormapList(m.colormapNegative,A[0],A[1],g,!0,!0,m.colormapInvert)}this.addColormapList(m.colormap,m.cal_min,m.cal_max,g,!1,!0,m.colormapInvert)}}const n=this.colormapLists.length;if(n<1)return;this.colormapTexture=this.createColormapTexture(this.colormapTexture,n+1);let s=new Uint8ClampedArray;function r(c){const l=new Uint8ClampedArray(s.length+c.length);l.set(s),l.set(c,s.length),s=l}for(let c=0;c<n;c++)r(Array.from(this.colormap(this.colormapLists[c].name,this.colormapLists[c].invert)));return r(Array.from(this.drawLut.lut)),this.gl.texSubImage2D(this.gl.TEXTURE_2D,0,0,0,256,n+1,this.gl.RGBA,this.gl.UNSIGNED_BYTE,s),this}sliceScale(i=!1){let t=this.screenFieldOfViewMM(0);i&&(t=this.screenFieldOfViewVox(0));const n=Math.max(t[0],Math.max(t[1],t[2])),s=[t[0]/n,t[1]/n,t[2]/n];if(!this.back?.dims)throw new Error("back.dims undefined");const r=[this.back.dims[1],this.back.dims[2],this.back.dims[3]];return{volScale:s,vox:r,longestAxis:n,dimsMM:t}}tileIndex(i,t){for(let n=0;n<this.screenSlices.length;n++){const s=this.screenSlices[n].leftTopWidthHeight;if(i>s[0]&&t>s[1]&&i<s[0]+s[2]&&t<s[1]+s[3])return n}return-1}inRenderTile(i,t){const n=this.tileIndex(i,t);return n>=0&&this.screenSlices[n].axCorSag===4?n:-1}sliceScroll3D(i=0){if(i!==0){if(this.volumes.length>0&&this.scene.clipPlaneDepthAziElevs[this.uiData.activeClipPlaneIndex][0]<1.8){const t=this.scene.clipPlaneDepthAziElevs[this.uiData.activeClipPlaneIndex].slice();return i>0&&(t[0]=Math.min(1.5,t[0]+.025)),i<0&&(t[0]=Math.max(-1.5,t[0]-.025)),t[0]!==this.scene.clipPlaneDepthAziElevs[this.uiData.activeClipPlaneIndex][0]?(this.scene.clipPlaneDepthAziElevs[this.uiData.activeClipPlaneIndex]=t,this.setClipPlane(this.scene.clipPlaneDepthAziElevs[this.uiData.activeClipPlaneIndex])):void 0}i>0&&(this.scene.volScaleMultiplier=Math.min(2,this.scene.volScaleMultiplier*1.1)),i<0&&(this.scene.volScaleMultiplier=Math.max(.5,this.scene.volScaleMultiplier*.9)),this.drawScene()}}inGraphTile(i,t){if(this.graph.opacity<=0||this.volumes.length<1||this.volumes[0].nFrame4D<1||!this.graph.plotLTWH||this.graph.plotLTWH[2]<1||this.graph.plotLTWH[3]<1)return!1;const n=[(i-this.graph.LTWH[0])/this.graph.LTWH[2],(t-this.graph.LTWH[1])/this.graph.LTWH[3]];return n[0]>0&&n[1]>0&&n[0]<=1&&n[1]<=1}updateBitmapFromClickToSegment(){if(this.clickToSegmentGrowingBitmap===null||this.drawBitmap===null||this.clickToSegmentGrowingBitmap.length!==this.drawBitmap.length)return;const i=this.drawBitmap.length;for(let t=0;t<i;t++)this.drawBitmap[t]=this.clickToSegmentGrowingBitmap[t]}sumBitmap(i){let t=0;for(let n=0;n<i.length;n++)t+=i[n];return t}doClickToSegment(i){const{tileIndex:t}=i;if(t<0||t>=this.screenSlices.length){k.warn(`Invalid tileIndex ${t} received in doClickToSegment.`);return}const n=this.screenSlices[t].axCorSag;if(n>2){k.warn("ClickToSegment attempted on non-2D slice tile.");return}const s=this.screenXY2TextureFrac(this.clickToSegmentXY[0],this.clickToSegmentXY[1],t,!1);if(s[0]<0){k.debug("Click location outside valid texture fraction for the tile.");return}const r=this.frac2vox(s),c=this.opts.clickToSegmentPercent;let l=this.back.getValue(r[0],r[1],r[2]);this.opts.clickToSegmentAutoIntensity&&(c!==0&&(l===0&&(l=.01),this.opts.clickToSegmentIntensityMax=l*(1+c),this.opts.clickToSegmentIntensityMin=l*(1-c)),l>(this.back.cal_min+this.back.cal_max)*.5?this.opts.clickToSegmentBright=!0:this.opts.clickToSegmentBright=!1);const d=this.opts.clickToSegmentBright?Number.POSITIVE_INFINITY:Number.NEGATIVE_INFINITY;this.drawPenAxCorSag=n;const h=this.clickToSegmentIsGrowing?this.clickToSegmentGrowingBitmap:this.drawBitmap;if(!h){if(k.error("Target bitmap for flood fill is null."),this.clickToSegmentIsGrowing){if(this.drawBitmap||this.createEmptyDrawing(),!this.drawBitmap)return;this.clickToSegmentGrowingBitmap=this.drawBitmap.slice()}else if(this.createEmptyDrawing(),!this.drawBitmap)return;k.warn("Initialized missing bitmap in doClickToSegment.")}if(this.drawFloodFill([r[0],r[1],r[2]],this.opts.penValue,d,this.opts.clickToSegmentIntensityMin,this.opts.clickToSegmentIntensityMax,this.opts.floodFillNeighbors,this.opts.clickToSegmentMaxDistanceMM,this.opts.clickToSegmentIs2D,h),!this.clickToSegmentIsGrowing&&(k.debug("Applying clickToSegment mask to drawBitmap."),this.drawBitmap?(this.refreshDrawing(!1,!1),this.drawScene()):k.error("Cannot refresh drawing after click-to-segment apply, drawBitmap is null."),this.drawBitmap)){const u=this.getDescriptives({layer:0,masks:[],drawingIsMask:!0});this.onClickToSegment({mL:u.volumeML,mm3:u.volumeMM3})}this.createOnLocationChange(n)}mouseClick(i,t,n=0,s=!0){if(i*=this.uiData.dpr,t*=this.uiData.dpr,this.canvas.focus(),this.thumbnailVisible){this.thumbnailVisible=!1,Promise.all([this.loadVolumes(this.deferredVolumes),this.loadMeshes(this.deferredMeshes)]).catch(r=>{throw r});return}if(this.inGraphTile(i,t)){if(!this.graph.plotLTWH)throw new Error("plotLTWH undefined");const r=[(i-this.graph.plotLTWH[0])/this.graph.plotLTWH[2],(t-this.graph.plotLTWH[1])/this.graph.plotLTWH[3]];if(r[0]>0&&r[1]>0&&r[0]<=1&&r[1]<=1){const c=Math.round(r[0]*(this.volumes[0].nFrame4D-1));this.setFrame4D(this.volumes[0].id,c);return}r[0]>.5&&r[1]>1&&this.loadDeferred4DVolumes(this.volumes[0].id).catch(c=>{throw c});return}if(this.inRenderTile(i,t)>=0){this.sliceScroll3D(n),this.drawScene();return}if(!(this.screenSlices.length<1||this.gl.canvas.height<1||this.gl.canvas.width<1))for(let r=0;r<this.screenSlices.length;r++){const c=this.screenSlices[r].axCorSag;if(this.drawPenAxCorSag>=0&&this.drawPenAxCorSag!==c||c>2&&!this.opts.clickToSegment&&n===0)continue;const l=this.screenXY2TextureFrac(i,t,r,!0);if(!(l[0]<0)){if(n!==0||!s){if(!s){c<=2&&(this.scene.crosshairPos[2-c]=n,this.drawScene(),this.createOnLocationChange(c));return}const d=n<0?-1:1,h=[0,0,0];c<=2&&(h[2-c]=d,this.moveCrosshairInVox(h[0],h[1],h[2]));return}if(this.opts.isForceMouseClickToVoxelCenters?this.scene.crosshairPos=gi(this.vox2frac(this.frac2vox(l))):this.scene.crosshairPos=gi(l),this.opts.drawingEnabled){const d=this.frac2vox(this.scene.crosshairPos);if(!isFinite(this.opts.penValue)||this.opts.penValue<0||Object.is(this.opts.penValue,-0)){let h=0,u=Math.abs(this.opts.penValue);const m=!0;Object.is(this.opts.penValue,-0)?(h=0,u=0,k.debug("Erase Cluster selected")):(h=this.opts.penValue,k.debug("Intensity Grow selected",h)),this.drawFloodFill(d,u,h,NaN,NaN,this.opts.floodFillNeighbors,Number.POSITIVE_INFINITY,!1,this.drawBitmap,m),this.drawScene(),this.createOnLocationChange(c);return}else if(this.opts.clickToSegment){c<=2&&(this.clickToSegmentIsGrowing=!1,this.doClickToSegment({x:this.clickToSegmentXY[0],y:this.clickToSegmentXY[1],tileIndex:r})),this.createOnLocationChange(c);return}else if(this.opts.penType===0){if(isNaN(this.drawPenLocation[0]))this.drawPenAxCorSag=c,this.drawPenFillPts=[],this.drawPt(...d,this.opts.penValue);else{if(d[0]===this.drawPenLocation[0]&&d[1]===this.drawPenLocation[1]&&d[2]===this.drawPenLocation[2]){this.drawScene(),this.createOnLocationChange(c);return}this.drawPenLine(d,this.drawPenLocation,this.opts.penValue)}this.drawPenLocation=d,this.opts.isFilledPen&&this.drawPenFillPts.push(d),this.refreshDrawing(!1,!1)}else(this.opts.penType===1||this.opts.penType===2)&&(isNaN(this.drawShapeStartLocation[0])?(this.drawPenAxCorSag=c,this.drawShapeStartLocation=[...d],this.drawBitmap&&(this.drawShapePreviewBitmap=this.drawBitmap.slice())):this.drawShapePreviewBitmap&&this.drawBitmap&&(this.drawBitmap.set(this.drawShapePreviewBitmap),this.opts.penType===1?this.drawRectangleMask(this.drawShapeStartLocation,d,this.opts.penValue):this.opts.penType===2&&this.drawEllipseMask(this.drawShapeStartLocation,d,this.opts.penValue),this.refreshDrawing(!1,!1)))}this.drawScene(),this.createOnLocationChange(c);return}}}drawRuler(){let i=[],t=[];for(let C=0;C<this.screenSlices.length;C++)if(this.screenSlices[C].axCorSag!==4&&this.screenSlices[C].fovMM.length>1){t=this.screenSlices[C].leftTopWidthHeight,i=this.screenSlices[C].fovMM;break}if(t.length<4)return;const[n,s,r,c]=this.getBoundsRegion(),d=100/i[0]*t[2],h=Math.max(Math.round(d*.1),2),u=Number(this.opts.rulerWidth),m=Math.floor(t[0]+.5*t[2]-.5*d),g=Math.floor(t[1]+t[3]-h)+.5*u,A=Math.max(n,m),v=Math.min(n+r,m+d),y=Math.min(s+c,g);if(v<=A)return;const w=[A,y,v,y];let b=[0,0,0,1];this.opts.rulerColor[0]+this.opts.rulerColor[1]+this.opts.rulerColor[2]<.8&&(b=[1,1,1,1]),this.drawRuler10cm(w,b,u+1),this.drawRuler10cm(w,this.opts.rulerColor,u)}drawRuler10cm(i,t,n=1){if(!this.lineShader)throw new Error("lineShader undefined");this.gl.bindVertexArray(this.genericVAO),this.lineShader.use(this.gl),this.gl.uniform4fv(this.lineShader.uniforms.lineColor,t),this.gl.uniform2fv(this.lineShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform1f(this.lineShader.uniforms.thickness,n),this.gl.uniform4fv(this.lineShader.uniforms.startXYendXY,i),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4);const s=-.1*(i[0]-i[2]),r=i[1]-Math.floor(.5*this.opts.rulerWidth),c=Math.floor(r-.35*s),l=Math.floor(r-.7*s);for(let d=0;d<11;d++){let h=i[0]+d*s;h=Math.max(h,i[0]+.5*n),h=Math.min(h,i[2]-.5*n);const u=[h,r,h,c];d%5===0&&(u[3]=l),this.gl.uniform4fv(this.lineShader.uniforms.startXYendXY,u),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4)}this.gl.bindVertexArray(this.unusedVAO)}screenXY2mm(i,t,n=-1){let s;for(let r=0;r<this.screenSlices.length;r++){let c=r;if(n>=0&&(c=n),this.screenSlices[c].axCorSag>2)continue;const d=this.screenSlices[c].leftTopWidthHeight;if(i<d[0]||t<d[1]||i>d[0]+d[2]||t>d[1]+d[3]||(s=this.screenXY2TextureFrac(i,t,c,!1),s[0]<0))continue;const h=this.frac2mm(s);return te(h[0],h[1],h[2],c)}return te(NaN,NaN,NaN,NaN)}dragForPanZoom(i){const t=this.screenXY2mm(i[2],i[3]);if(isNaN(t[0]))return;const n=this.screenXY2mm(i[0],i[1],t[3]);if(isNaN(n[0])||isNaN(t[0])||isNaN(t[3]))return;const s=ki(),r=this.uiData.pan2DxyzmmAtMouseDown[3];fp(s,t,n),this.scene.pan2Dxyzmm[0]=this.uiData.pan2DxyzmmAtMouseDown[0]+r*s[0],this.scene.pan2Dxyzmm[1]=this.uiData.pan2DxyzmmAtMouseDown[1]+r*s[1],this.scene.pan2Dxyzmm[2]=this.uiData.pan2DxyzmmAtMouseDown[2]+r*s[2],this.canvas.focus()}dragForCenterButton(i){this.dragForPanZoom(i)}dragForSlicer3D(i){let t=this.uiData.pan2DxyzmmAtMouseDown[3];const n=i[3]-i[1];t+=n*.01,t=Math.max(t,.1),t=Math.min(t,10);const r=this.scene.pan2Dxyzmm[3]-t;this.opts.yoke3Dto2DZoom&&(this.scene.volScaleMultiplier=t),this.scene.pan2Dxyzmm[3]=t;const c=this.frac2mm(this.scene.crosshairPos);this.scene.pan2Dxyzmm[0]+=r*c[0],this.scene.pan2Dxyzmm[1]+=r*c[1],this.scene.pan2Dxyzmm[2]+=r*c[2]}drawMeasurementTool(i,t=!0){function n(u,m,g,A,v){const y=u-g,w=m-A;if(y===0&&w===0)return{origin:[g+v,A],terminus:[g+v,A]};const b=Math.sqrt(y*y+w*w),C=v*y/b,S=v*w/b;return{origin:[u+C,m+S],terminus:[g-C,A-S]}}const s=this.gl;if(s.viewport(0,0,s.canvas.width,s.canvas.height),s.bindVertexArray(this.genericVAO),s.depthFunc(s.ALWAYS),s.enable(s.BLEND),s.blendFunc(s.SRC_ALPHA,s.ONE_MINUS_SRC_ALPHA),!this.lineShader)throw new Error("lineShader undefined");this.lineShader.use(this.gl),s.uniform4fv(this.lineShader.uniforms.lineColor,this.opts.rulerColor),s.uniform2fv(this.lineShader.uniforms.canvasWidthHeight,[s.canvas.width,s.canvas.height]),s.uniform1f(this.lineShader.uniforms.thickness,this.opts.rulerWidth),s.uniform4fv(this.lineShader.uniforms.startXYendXY,i),s.drawArrays(s.TRIANGLE_STRIP,0,4);const r=this.opts.measureLineColor;r[3]=1,s.uniform4fv(this.lineShader.uniforms.lineColor,r);const c=this.opts.rulerWidth;s.uniform1f(this.lineShader.uniforms.thickness,c*2);let l=[i[0],i[1]-c,i[0],i[1]+c];s.uniform4fv(this.lineShader.uniforms.startXYendXY,l),s.drawArrays(s.TRIANGLE_STRIP,0,4),l=[i[2],i[3]-c,i[2],i[3]+c],s.uniform4fv(this.lineShader.uniforms.startXYendXY,l),s.drawArrays(s.TRIANGLE_STRIP,0,4);let d=this.canvasPos2frac([i[0],i[1]]),h=this.canvasPos2frac([i[2],i[3]]);if(d[0]>=0&&h[0]>=0){const u=this.frac2mm(d);d=lt(u[0],u[1],u[2]);const m=this.frac2mm(h);h=lt(m[0],m[1],m[2]);const g=Gt();Nd(g,d,h);const A=tr(g);let v=2;A>9&&(v=1),A>99&&(v=0);let y=A.toFixed(v);this.opts.showMeasureUnits&&(y=`${y} mm`);let w=i;const[b,C,S,E]=i,{origin:M,terminus:N}=n(b,C,S,E,30);switch(this.opts.measureTextJustify){case"start":w=[...M,...M.map(U=>U+1)];break;case"end":w=w=[...N,...N.map(U=>U+1)];break;default:w=i;break}t&&this.drawTextBetween(w,y,this.opts.measureTextHeight/.06,this.opts.measureTextColor)}s.bindVertexArray(this.unusedVAO)}drawAngleMeasurementTool(){this.uiData.angleState==="drawing_first_line"?this.drawMeasurementTool([this.uiData.dragStart[0],this.uiData.dragStart[1],this.uiData.dragEnd[0],this.uiData.dragEnd[1]],!1):this.uiData.angleState==="drawing_second_line"&&(this.drawMeasurementTool(this.uiData.angleFirstLine,!1),this.drawMeasurementTool([this.uiData.angleFirstLine[2],this.uiData.angleFirstLine[3],this.uiData.dragEnd[0],this.uiData.dragEnd[1]],!1),this.drawAngleText())}drawAngleText(){const i=this.uiData.angleFirstLine,t=[this.uiData.angleFirstLine[2],this.uiData.angleFirstLine[3],this.uiData.dragEnd[0],this.uiData.dragEnd[1]],n=this.calculateAngleBetweenLines(i,t),s=this.uiData.angleFirstLine[2],r=this.uiData.angleFirstLine[3],c=`${n.toFixed(1)}°`;this.drawTextBetween([s,r,s+1,r+1],c,this.opts.measureTextHeight/.06,this.opts.measureTextColor)}drawAngleTextForAngle(i){const t=this.calculateAngleBetweenLines(i.firstLine,i.secondLine),n=i.firstLine[2],s=i.firstLine[3],r=`${t.toFixed(1)}°`;this.drawTextBetween([n,s,n+1,s+1],r,this.opts.measureTextHeight/.06,this.opts.measureTextColor)}calculateAngleBetweenLines(i,t){const n=i[2],s=i[3],r=i[0]-n,c=i[1]-s,l=t[2]-n,d=t[3]-s,h=r*l+c*d,u=Math.sqrt(r*r+c*c),m=Math.sqrt(l*l+d*d);if(u===0||m===0)return 0;const g=Math.max(-1,Math.min(1,h/(u*m)));return Math.acos(g)*(180/Math.PI)}resetAngleMeasurement(){this.uiData.angleState="none",this.uiData.angleFirstLine=[0,0,0,0]}getCurrentSliceInfo(){const i=this.tileIndex(this.uiData.dragStart[0],this.uiData.dragStart[1]);if(i>=0&&i<this.screenSlices.length){const s=this.screenSlices[i].axCorSag;let r=0;return s===0?r=this.scene.crosshairPos[2]:s===1?r=this.scene.crosshairPos[1]:s===2&&(r=this.scene.crosshairPos[0]),{sliceIndex:i,sliceType:s,slicePosition:r}}const t=this.opts.sliceType;let n=0;return t===0?n=this.scene.crosshairPos[2]:t===1?n=this.scene.crosshairPos[1]:t===2?n=this.scene.crosshairPos[0]:t===3&&this.canvasPos2frac([this.uiData.dragStart[0],this.uiData.dragStart[1]])[0]>=0&&(n=this.scene.crosshairPos[2]),{sliceIndex:-1,sliceType:t,slicePosition:n}}getCurrentSlicePosition(i){return i===0?this.scene.crosshairPos[2]:i===1?this.scene.crosshairPos[1]:i===2?this.scene.crosshairPos[0]:0}shouldDrawOnCurrentSlice(i,t,n){if(this.opts.sliceType===3){if(t>2)return!1;for(let d=0;d<this.screenSlices.length;d++)if(this.screenSlices[d].axCorSag===t){const h=this.getCurrentSlicePosition(t);if(Math.abs(h-n)<.001)return!0}return!1}else if(this.opts.sliceType!==t)return!1;const s=this.getCurrentSlicePosition(t);return Math.abs(s-n)<.001}clearMeasurements(){this.document.completedMeasurements=[],this.drawScene()}clearAngles(){this.document.completedAngles=[],this.drawScene()}clearAllMeasurements(){this.document.completedMeasurements=[],this.document.completedAngles=[],this.drawScene()}setDragMode(i){if(typeof i=="string")switch(i){case"none":this.opts.dragMode=0;break;case"contrast":this.opts.dragMode=1;break;case"measurement":this.opts.dragMode=2;break;case"angle":this.opts.dragMode=7;break;case"pan":this.opts.dragMode=3;break;case"slicer3D":this.opts.dragMode=4;break;case"callbackOnly":this.opts.dragMode=5;break;case"roiSelection":this.opts.dragMode=6;break;default:console.warn(`Unknown drag mode: ${i}`);return}else this.opts.dragMode=i;this.opts.dragMode!==7&&this.resetAngleMeasurement(),this.clearActiveDragMode()}setMouseEventConfig(i){this.opts.mouseEventConfig=i,this.clearActiveDragMode()}setTouchEventConfig(i){this.opts.touchEventConfig=i,this.clearActiveDragMode()}getMouseEventConfig(){return this.opts.mouseEventConfig}getTouchEventConfig(){return this.opts.touchEventConfig}drawRect(i,t=[1,0,0,-1]){if(t[3]<0&&(t=this.opts.crosshairColor),!this.rectShader)throw new Error("rectShader undefined");this.gl.disable(this.gl.CULL_FACE),this.opts.selectionBoxIsOutline?(this.drawCircle(i,t,.1),this.rectOutlineShader.use(this.gl),this.gl.enable(this.gl.BLEND),this.gl.uniform1f(this.rectOutlineShader.uniforms.thickness,this.opts.selectionBoxLineThickness),this.gl.uniform4fv(this.rectOutlineShader.uniforms.lineColor,t),this.gl.uniform2fv(this.rectOutlineShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform4f(this.rectOutlineShader.uniforms.leftTopWidthHeight,i[0],i[1],i[2],i[3]),this.gl.bindVertexArray(this.genericVAO),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO)):(this.rectShader.use(this.gl),this.gl.enable(this.gl.BLEND),this.gl.uniform4fv(this.rectShader.uniforms.lineColor,t),this.gl.uniform2fv(this.rectShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform4f(this.rectShader.uniforms.leftTopWidthHeight,i[0],i[1],i[2],i[3]),this.gl.bindVertexArray(this.genericVAO),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO))}drawBoundsBox(i,t,n=2){if(!this.rectOutlineShader)throw new Error("rectOutlineShader undefined");const s=this.gl,[r,c,l,d]=i;s.viewport(0,0,s.canvas.width,s.canvas.height),this.rectOutlineShader.use(s),s.enable(s.BLEND),s.uniform1f(this.rectOutlineShader.uniforms.thickness,n),s.uniform4fv(this.rectOutlineShader.uniforms.lineColor,t),s.uniform2fv(this.rectOutlineShader.uniforms.canvasWidthHeight,[s.canvas.width,s.canvas.height]),s.uniform4f(this.rectOutlineShader.uniforms.leftTopWidthHeight,r,c,l,d),s.bindVertexArray(this.genericVAO),s.drawArrays(s.TRIANGLE_STRIP,0,4),s.bindVertexArray(this.unusedVAO)}drawCircle(i,t=this.opts.fontColor,n=1){if(!this.circleShader)throw new Error("circleShader undefined");this.circleShader.use(this.gl),this.gl.enable(this.gl.BLEND),this.gl.uniform4fv(this.circleShader.uniforms.circleColor,t),this.gl.uniform2fv(this.circleShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform4f(this.circleShader.uniforms.leftTopWidthHeight,i[0],i[1],i[2],i[3]),this.gl.uniform1f(this.circleShader.uniforms.fillPercent,n),this.gl.uniform4fv(this.circleShader.uniforms.circleColor,t),this.gl.bindVertexArray(this.genericVAO),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO)}drawSelectionBox(i){if(this.gl.viewport(0,0,this.gl.canvas.width,this.gl.canvas.height),this.getCurrentDragMode()===6){this.drawCircle(i,this.opts.selectionBoxColor,.1);return}this.drawRect(i,this.opts.selectionBoxColor)}effectiveCanvasHeight(){let i=this.gl.canvas.height;if(this.opts.bounds){const[[,t],[,n]]=this.opts.bounds,s=Math.round(t*this.gl.canvas.height);i=Math.round(n*this.gl.canvas.height)-s}return i-this.colorbarHeight}effectiveCanvasWidth(){let i=this.gl.canvas.width;if(this.opts.bounds){const[[t],[n]]=this.opts.bounds;i=Math.round((n-t)*this.gl.canvas.width)}return i-this.getLegendPanelWidth()}getAllLabels(){const s=this.meshes.filter(c=>c.type==="connectome").flatMap(c=>c.nodes).map(c=>c.label).filter(c=>c!==void 0);return[...this.document.labels,...s]}getConnectomeLabels(){const s=this.meshes.filter(d=>d.type==="connectome"&&d.showLegend!==!1).flatMap(d=>d.nodes).map(d=>d.label).filter(d=>d!==void 0&&d.text!==""),r=this.document.labels.filter(d=>d.anchor==null||d.anchor===0),c=new Set(s);for(const d of r)c.add(d);const l=this.meshes.filter(d=>d.type==="mesh");for(let d=0;d<l.length;d++)for(let h=0;h<l[d].layers.length;h++)if(l[d].layers[h].labels)for(let u=0;u<l[d].layers[h].labels.length;u++)c.add(l[d].layers[h].labels[u]);return Array.from(c)}getBulletMarginWidth(){let i=0;const t=this.getConnectomeLabels();if(t.length===0)return 0;const n=t.length===1?t[0].style.bulletScale:t.reduce((c,l)=>c.style.bulletScale>l.style.bulletScale?c:l).style.bulletScale,s=t.length===1?t[0]:t.reduce((c,l)=>{const d=this.fontPx*c.style.textScale,h=this.fontPx*l.style.textScale;return this.textHeight(d,c.text)>this.textHeight(h,l.text)?c:l}),r=this.fontPx*s.style.textScale;return i=this.textHeight(r,s.text)*n,i+=r,i}getLegendPanelWidth(){const i=this.getConnectomeLabels();if(!this.opts.showLegend||i.length===0)return 0;const n=this.fontPx*1;let s=0;const r=i.reduce((h,u)=>{const m=this.fontPx*h.style.textScale,g=this.fontPx*u.style.textScale;return this.textWidth(m,h.text)>this.textWidth(g,u.text)?h:u}),c=this.fontPx*r.style.textScale,l=this.textWidth(c,r.text),d=this.getBulletMarginWidth();return l&&(s=d+l,s+=n*2),s>=this.gl.canvas.width?0:s}getLegendPanelHeight(i=1){const t=this.getConnectomeLabels();let n=0;const s=this.fontPx;for(const r of t){const c=this.fontPx*r.style.textScale*i,l=this.textHeight(c,r.text);n+=l}return n&&(n+=s/2*(t.length+1)*i),n}reserveColorbarPanel(){const i=3*this.fontPx;if(i<0)return[0,0,0,0];const[t,n,s,r]=this.getBoundsRegion(),l=(this.opts.colorbarWidth>0&&this.opts.colorbarWidth<=1?this.opts.colorbarWidth:1)*s,d=[t+(s-l)/2,n+r-i,l,i];return this.colorbarHeight=d[3]+1,d}drawColorbarCore(i=0,t=[0,0,0,0],n=!1,s=0,r=1,c){if(t[2]<=0||t[3]<=0)return;const l=this.fontPx;if(l<=0)return;this.gl.viewport(0,0,this.gl.canvas.width,this.gl.canvas.height);let d=l;const h=3*l;let u=l;if(t[3]<h){if(t[3]<3)return;d=1,u=t[3]-2}this.gl.disable(this.gl.DEPTH_TEST),this.colorbarHeight=t[3]+1;const m=[t[0]+d,t[1],t[2]-2*d,u],g=[m[0]-1,m[1]-1,m[2]+2,m[3]+2];if(this.opts.showColorbarBorder&&this.drawRect(g,this.opts.crosshairColor),!this.colorbarShader)throw new Error("colorbarShader undefined");this.colorbarShader.use(this.gl),this.gl.activeTexture(Xa),this.gl.bindTexture(this.gl.TEXTURE_2D,this.colormapTexture),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MIN_FILTER,this.gl.NEAREST),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MAG_FILTER,this.gl.NEAREST);const A=i;if(this.gl.uniform1f(this.colorbarShader.uniforms.layer,A),this.gl.uniform2fv(this.colorbarShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.disable(this.gl.CULL_FACE),n){const U=[m[0]+m[2],m[1],-m[2],m[3]];this.gl.uniform4fv(this.colorbarShader.uniforms.leftTopWidthHeight,U)}else this.gl.uniform4fv(this.colorbarShader.uniforms.leftTopWidthHeight,m);this.gl.bindVertexArray(this.genericVAO),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MIN_FILTER,this.gl.LINEAR),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MAG_FILTER,this.gl.LINEAR);let v=0;if(c&&r<0&&n?(v=r,r=0):c&&s>0&&(v=s,s=0),s===r||l<1)return;const y=Math.abs(r-s);let[w,b]=m2(s,r);b<s&&(b+=w);function C(U){return U.toFixed(6).replace(/\.?0*$/,"")}let S=b;const E=[0,m[1]+m[3]-l*.5,2,l*.75],M=E[1]+E[3],N=1;for(;S<=r;){E[0]=m[0]+(S-s)/y*m[2],this.drawRect(E);const U=C(N*S);this.drawTextBelow([E[0],M],U),S+=w}if(v!==0){const U=[m[0]+(v-s)/y*m[2],m[1]-m[3]*.25,2,m[3]*1.5];this.drawRect(U)}}drawColorbar(){const i=this.colormapLists,t=i.length;if(t<1)return;let n=0;for(let l=0;l<t;l++)i[l].visible&&n++;if(n<1)return;let s=this.reserveColorbarPanel();const r=3*this.fontPx;if(r<0)return;let c=s[2]/n;(s[2]<=0||s[3]<=0)&&(c=this.gl.canvas.width/n,s=[0,this.gl.canvas.height-r,c,r]),s[2]=c;for(let l=0;l<t;l++)i[l].visible&&(this.drawColorbarCore(l,s,i[l].negative,i[l].min,i[l].max,i[l].isColorbarFromZero),s[0]+=c)}textWidth(i,t){if(!t)return 0;let n=0;const s=new TextEncoder().encode(t);for(let r=0;r<t.length;r++)n+=i*this.fontMets.mets[s[r]].xadv;return n}textHeight(i,t){if(!t)return 0;const n=new Set(Array.from(t)),s=new TextEncoder().encode(Array.from(n).join("")),c=Object.values(this.fontMets.mets).filter((l,d)=>s.includes(d)).reduce((l,d)=>l.lbwh[3]>d.lbwh[3]?l:d).lbwh[3];return i*c}drawChar(i,t,n){if(!this.fontShader)throw new Error("fontShader undefined");const s=this.fontMets.mets[n],r=i[0]+t*s.lbwh[0],c=-(t*s.lbwh[1]),l=t*s.lbwh[2],d=t*s.lbwh[3],h=i[1]+(c-d)+t;return this.gl.uniform4f(this.fontShader.uniforms.leftTopWidthHeight,r,h,l,d),this.gl.uniform4fv(this.fontShader.uniforms.uvLeftTopWidthHeight,s.uv_lbwh),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),t*s.xadv}drawLoadingText(i){if(!i)return;if(!this.canvas)throw new Error("canvas undefined");const[t,n,s,r]=this.getBoundsRegion();this.gl.viewport(t,n,s,r),this.gl.enable(this.gl.CULL_FACE),this.gl.enable(this.gl.BLEND);const c=t+s/2,l=n+r/2;this.drawTextBelow([c,l],i,3)}drawText(i,t,n=1,s=null){if(this.fontPx<=0)return;if(!this.fontShader)throw new Error("fontShader undefined");this.fontShader.use(this.gl);const r=this.fontPx*n;this.gl.enable(this.gl.BLEND),this.gl.uniform2f(this.fontShader.uniforms.canvasWidthHeight,this.gl.canvas.width,this.gl.canvas.height),s===null&&(s=this.opts.fontColor),this.gl.uniform4fv(this.fontShader.uniforms.fontColor,s);let c=r/this.fontMets.size*this.fontMets.distanceRange;c=Math.max(c,1),this.gl.uniform1f(this.fontShader.uniforms.screenPxRange,c);const l=new TextEncoder().encode(t);this.gl.bindVertexArray(this.genericVAO);for(let d=0;d<t.length;d++)i[0]+=this.drawChar(i,r,l[d]);this.gl.bindVertexArray(this.unusedVAO)}drawTextRight(i,t,n=1,s=null){this.fontPx<=0||(i[1]-=.5*this.fontPx,this.drawText(i,t,n,s))}drawTextLeft(i,t,n=1,s=null){if(this.fontPx<=0)return;const r=this.fontPx*n;i[0]-=this.textWidth(r,t),i[1]-=.5*r,this.drawText(i,t,n,s)}drawTextRightBelow(i,t,n=1,s=null){this.fontPx<=0||this.drawText(i,t,n,s)}drawTextBetween(i,t,n=1,s=null){if(this.fontPx<=0)return;const r=[(i[0]+i[2])*.5,(i[1]+i[3])*.5],c=this.fontPx*n,l=this.textWidth(c,t);r[0]-=.5*l,r[1]-=.5*c;const d=[r[0]-1,r[1]-1,l+2,c+2];let h=s;h===null&&(h=this.opts.crosshairColor),h&&h[0]+h[1]+h[2]>.8?h=[0,0,0,.5]:h=[1,1,1,.5],this.drawRect(d,h),this.drawText(r,t,n,s)}drawTextBelow(i,t,n=1,s=null){if(this.fontPx<=0)return;if(!this.canvas)throw new Error("canvas undefined");let r=this.fontPx*n,c=this.textWidth(r,t);c>this.canvas.width&&(n*=(this.canvas.width-2)/c,r=this.fontPx*n,c=this.textWidth(r,t)),i[0]-=.5*this.textWidth(r,t),i[0]=Math.max(i[0],1),i[0]=Math.min(i[0],this.canvas.width-c-1),this.drawText(i,t,n,s)}drawTextAbove(i,t,n=1,s=null){if(this.fontPx<=0)return;if(!this.canvas)throw new Error("canvas undefined");let r=this.fontPx*n,c=this.textWidth(r,t);c>this.canvas.width&&(n*=(this.canvas.width-2)/c,r=this.fontPx*n,c=this.textWidth(r,t)),i[0]-=.5*this.textWidth(r,t),i[0]=Math.max(i[0],1),i[0]=Math.min(i[0],this.canvas.width-c-1),i[1]-=r,this.drawText(i,t,n,s)}updateInterpolation(i,t=!1){let n=this.gl.LINEAR;!t&&this.opts.isNearestInterpolation&&(n=this.gl.NEAREST),i===0?this.gl.activeTexture(Gn):this.gl.activeTexture(Nl),this.opts.is2DSliceShader?(this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MIN_FILTER,n),this.gl.texParameteri(this.gl.TEXTURE_2D,this.gl.TEXTURE_MAG_FILTER,n)):(this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_MIN_FILTER,n),this.gl.texParameteri(this.gl.TEXTURE_3D,this.gl.TEXTURE_MAG_FILTER,n))}setAtlasOutline(i){this.opts.atlasOutline=i,this.updateGLVolume(),this.drawScene()}setInterpolation(i){this.opts.isNearestInterpolation=i;const t=this.volumes.length;if(!(t<1)){for(let n=0;n<t;n++)this.updateInterpolation(n);this.drawScene()}}calculateMvpMatrix2D(i,t,n,s=1/0,r=0,c=0,l=0,d=!1){this.gl.viewport(i[0],this.gl.canvas.height-(i[1]+i[3]),i[2],i[3]);let u=t[0],m=n[0],g=[u,t[1]],A=[m-u,n[1]-t[1]];d&&(g=[n[0],t[1]],A=[t[0]-n[0],n[1]-t[1]],u=-n[0],m=-t[0]);const v=2*Math.max(Math.abs(t[2]),Math.abs(n[2])),y=Ut();let w=.01,b=v*8;if(s!==1/0){let U=d;l===0&&(c===0||c===180)&&(U=!U);let T=v*1.8-r;U||(T=v*1.8+r),b=T-s,w=T+s}El(y,u,m,t[1],n[1],b,w);const C=Ut();C[0]=-1;const S=lt(0,0,-v*1.8);Ps(C,C,S),Sl(C,C,mn(270-l)),Ml(C,C,mn(c-180));const E=Ut();Pe(E,C);const M=Ut();We(M,E);const N=Ut();return qn(N,y,C),{modelViewProjectionMatrix:N,modelMatrix:C,normalMatrix:M,leftTopMM:g,fovMM:A}}swizzleVec3MM(i,t){return t===1?i=ne(i,[0,2,1]):t===2&&(i=ne(i,[1,2,0])),i}screenFieldOfViewVox(i=0){const t=gi(this.volumeObject3D.fieldOfViewDeObliqueMM);return this.swizzleVec3MM(t,i)}screenFieldOfViewMM(i=0,t=!1){if(this.volumes.length<1){let d=lt(this.extentsMin[0],this.extentsMin[1],this.extentsMin[2]),h=lt(this.extentsMax[0],this.extentsMax[1],this.extentsMax[2]);d=this.swizzleVec3MM(d,i),h=this.swizzleVec3MM(h,i);const u=Gt();return jt(u,h,d),u}if(!t&&!this.opts.isSliceMM)return this.screenFieldOfViewVox(i);const n=this.volumeObject3D.extentsMin,s=this.volumeObject3D.extentsMax;let r=lt(n[0],n[1],n[2]),c=lt(s[0],s[1],s[2]);r=this.swizzleVec3MM(r,i),c=this.swizzleVec3MM(c,i);const l=Gt();return jt(l,c,r),l}screenFieldOfViewExtendedVox(i=0){const t=this.volumes[0].extentsMinOrtho,n=this.volumes[0].extentsMaxOrtho;let s=lt(t[0],t[1],t[2]),r=lt(n[0],n[1],n[2]);const c=Ut();s=this.swizzleVec3MM(s,i),r=this.swizzleVec3MM(r,i);const l=Gt();return jt(l,r,s),{mnMM:s,mxMM:r,rotation:c,fovMM:l}}screenFieldOfViewExtendedMM(i=0){if(this.volumes.length<1){let d=lt(this.extentsMin[0],this.extentsMin[1],this.extentsMin[2]),h=lt(this.extentsMax[0],this.extentsMax[1],this.extentsMax[2]);const u=Ut();d=this.swizzleVec3MM(d,i),h=this.swizzleVec3MM(h,i);const m=Gt();return jt(m,h,d),{mnMM:d,mxMM:h,rotation:u,fovMM:m}}if(!this.volumeObject3D)throw new Error("volumeObject3D undefined");const t=this.volumeObject3D.extentsMin,n=this.volumeObject3D.extentsMax;let s=lt(t[0],t[1],t[2]),r=lt(n[0],n[1],n[2]);const c=Ut();s=this.swizzleVec3MM(s,i),r=this.swizzleVec3MM(r,i);const l=Gt();return jt(l,r,s),{mnMM:s,mxMM:r,rotation:c,fovMM:l}}drawSliceOrientationText(i,t,n=[NaN,NaN]){this.gl.viewport(0,0,this.gl.canvas.width,this.gl.canvas.height);let s="S";t===0&&(s="A");let r=this.opts.isRadiologicalConvention?"R":"L";t===2&&(r=this.opts.sagittalNoseLeft?"A":"P");let c="I";t===0&&(c="P");let l=this.opts.isRadiologicalConvention?"L":"R";if(t===2&&(l=this.opts.sagittalNoseLeft?"P":"A"),this.opts.isCornerOrientationText){this.drawTextRightBelow([i[0],i[1]],r+s);return}let d=!0,h=!0;const u=this.opts.showAllOrientationMarkers,m=this.opts.showAllOrientationMarkers;if(!isNaN(n[0])){const g=this.fontPx+2;n[1]>g&&(this.drawTextBelow([i[0]+i[2]*.5,i[1]+n[1]-g],s),d=!1);const A=this.textWidth(g,r)+2;n[0]>A&&(this.drawTextRight([i[0]+n[0]-A,i[1]+i[3]*.5],r),h=!1)}d&&this.drawTextBelow([i[0]+i[2]*.5,i[1]],s),h&&this.drawTextRight([i[0],i[1]+i[3]*.5],r),u&&this.drawTextAbove([i[0]+i[2]*.5,i[1]+i[3]],c),m&&this.drawTextLeft([i[0]+i[2],i[1]+i[3]*.5],l)}xyMM2xyzMM(i,t){let n=2;i===1&&(n=1),i===2&&(n=0);let s=[0,0,0],r=[1,1,0],c=[1,0,1];s[n]=t,r[n]=t,c[n]=t,s=this.frac2mm(s),r=this.frac2mm(r),c=this.frac2mm(c),s=this.swizzleVec3MM(lt(s[0],s[1],s[2]),i),r=this.swizzleVec3MM(lt(r[0],r[1],r[2]),i),c=this.swizzleVec3MM(lt(c[0],c[1],c[2]),i);const l=(r[0]-s[0])*(c[1]-s[1])-(c[0]-s[0])*(r[1]-s[1]);let d=(r[0]-s[0])*(c[2]-s[2])-(c[0]-s[0])*(r[2]-s[2]);d/=l;let h=(r[1]-s[1])*(c[2]-s[2])-(c[1]-s[1])*(r[2]-s[2]);h/=l;const u=[0,0,0,0,0];return u[0]=s[0],u[1]=s[1],u[2]=s[2],u[3]=h,u[4]=d,u}draw2DMain(i,t,n=NaN){let s=new Float32Array([0,0,0]);this.volumes.length>0&&(s=new Float32Array(this.volumes[0].frac2mm.slice()));let r=this.screenFieldOfViewExtendedMM(t),c=Ut();!this.opts.isSliceMM&&this.volumes.length>0&&(s=new Float32Array(this.volumes[0].frac2mmOrtho.slice()),c=re(this.volumes[0].mm2ortho),r=this.screenFieldOfViewExtendedVox(t));let l=this.opts.isRadiologicalConvention&&t<2;n===1/0||n===-1/0?(l=n!==1/0,t===1&&(l=!l)):this.opts.sagittalNoseLeft&&t===2&&(l=!l);let d=0,h=0;t===2?h=l?90:-90:t===1?h=l?180:0:(h=l?180:0,d=l?-90:90);const u=this.gl;let m=!1;if(i[2]===0||i[3]===0){m=!0;const S=u.canvas.width/r.fovMM[0],E=u.canvas.height/r.fovMM[1],M=Math.min(S,E),N=S/M,U=E/M;r.fovMM[0]*=N,r.fovMM[1]*=U;let T=(r.mnMM[0]+r.mxMM[0])*.5;r.mnMM[0]=T-r.fovMM[0]*.5,r.mxMM[0]=T+r.fovMM[0]*.5,T=(r.mnMM[1]+r.mxMM[1])*.5,r.mnMM[1]=T-r.fovMM[1]*.5,r.mxMM[1]=T+r.fovMM[1]*.5,i=[0,0,u.canvas.width,u.canvas.height]}if(isNaN(n)){const S=this.scene.pan2Dxyzmm,E=this.swizzleVec3MM(lt(S[0],S[1],S[2]),t),M=this.scene.pan2Dxyzmm[3];r.mnMM[0]-=E[0],r.mxMM[0]-=E[0],r.mnMM[1]-=E[1],r.mxMM[1]-=E[1],r.mnMM[0]/=M,r.mxMM[0]/=M,r.mnMM[1]/=M,r.mxMM[1]/=M}let g=2;t===1&&(g=1),t===2&&(g=0);let A=this.scene.crosshairPos[g],v=this.frac2mm(this.scene.crosshairPos);!isNaN(n)&&n!==1/0&&n!==-1/0&&(v=this.frac2mm([.5,.5,.5]),v[g]=n,A=this.mm2frac(v)[g]);const y=v[g],w=u.canvas.height-i[1]-i[3],b=[i[0],w,i[2],i[3]];this.clearBounds(u.DEPTH_BUFFER_BIT,b),u.viewport(b[0],b[1],b[2],b[3]);let C=this.calculateMvpMatrix2D(i,r.mnMM,r.mxMM,1/0,0,h,d,l);if(n===1/0||n===-1/0){const S=i.slice();this.draw3D(i,C.modelViewProjectionMatrix,C.modelMatrix,C.normalMatrix,h,d);const E=this.screenSlices[this.screenSlices.length-1];E.leftTopWidthHeight=S,E.axCorSag=t,E.sliceFrac=1/0,E.AxyzMxy=this.xyMM2xyzMM(t,A),E.leftTopMM=C.leftTopMM,E.fovMM=C.fovMM;return}if(u.enable(u.DEPTH_TEST),u.blendFunc(u.SRC_ALPHA,u.ONE_MINUS_SRC_ALPHA),u.disable(u.BLEND),u.depthFunc(u.ALWAYS),u.disable(u.CULL_FACE),this.volumes.length>0){let S=this.sliceMMShader;if(this.opts.is2DSliceShader&&(S=this.slice2DShader),this.opts.isV1SliceShader&&(S=this.sliceV1Shader),this.customSliceShader&&(S=this.customSliceShader),!S)throw new Error("slice Shader undefined");S.use(this.gl),u.uniform1f(S.uniforms.overlayOutlineWidth,this.overlayOutlineWidth),u.uniform1f(S.uniforms.overlayAlphaShader,this.overlayAlphaShader),u.uniform1i(S.uniforms.isAlphaClipDark,this.isAlphaClipDark?1:0),u.uniform1i(S.uniforms.backgroundMasksOverlays,this.backgroundMasksOverlays),u.uniform1f(S.uniforms.drawOpacity,this.drawOpacity),u.uniform1f(S.uniforms.drawRimOpacity,this.drawRimOpacity),u.enable(u.BLEND),u.blendFunc(u.SRC_ALPHA,u.ONE_MINUS_SRC_ALPHA),u.uniform1f(S.uniforms.opacity,this.volumes[0].opacity),u.uniform1i(S.uniforms.axCorSag,t),u.uniform1f(S.uniforms.slice,A),u.uniformMatrix4fv(S.uniforms.frac2mm,!1,s),u.uniformMatrix4fv(S.uniforms.mvpMtx,!1,C.modelViewProjectionMatrix.slice()),u.bindVertexArray(this.genericVAO),u.drawArrays(u.TRIANGLE_STRIP,0,4),u.bindVertexArray(this.unusedVAO),this.screenSlices.push({leftTopWidthHeight:i,axCorSag:t,sliceFrac:A,AxyzMxy:this.xyMM2xyzMM(t,A),leftTopMM:C.leftTopMM,screen2frac:[],fovMM:C.fovMM})}if(u.depthMask(!0),u.depthFunc(u.LEQUAL),isNaN(n)&&this.drawCrosshairs3D(!0,1,C.modelViewProjectionMatrix,!0,this.opts.isSliceMM),this.opts.meshThicknessOn2D>0){this.opts.meshThicknessOn2D!==1/0&&(C=this.calculateMvpMatrix2D(i,r.mnMM,r.mxMM,this.opts.meshThicknessOn2D,y,h,d,l));const S=re(C.modelViewProjectionMatrix);qn(S,S,c),this.drawMesh3D(!0,1,S,C.modelMatrix,C.normalMatrix,!0)}isNaN(n)&&this.drawCrosshairs3D(!1,.15,C.modelViewProjectionMatrix,!0,this.opts.isSliceMM),m&&this.opts.isOrientationTextVisible&&this.drawSliceOrientationText(i,t),this.readyForSync=!0}draw2D(i,t,n=NaN,s=[NaN,NaN]){const[r,c,l,d]=this.getBoundsRegion();let h;i[2]===0&&i[3]===0?this.opts.bounds?h=[r,c,l,d]:h=[0,0,this.gl.canvas.width,this.gl.canvas.height]:h=i.slice();const u=[NaN,NaN];if(s[0]===1/0){const m=this.sliceScale().volScale;let g=this.scaleSlice(m[0],m[1],[0,0],[h[2],h[3]]);t===1&&(g=this.scaleSlice(m[0],m[2],[0,0],[h[2],h[3]])),t===2&&(g=this.scaleSlice(m[1],m[2],[0,0],[h[2],h[3]])),s[0]=g[2],s[1]=g[3]}isNaN(s[0])?this.draw2DMain(h,t,n):(u[0]=Math.floor(.5*(h[2]-s[0])),u[1]=Math.floor(.5*(h[3]-s[1])),h[0]+=u[0],h[1]+=u[1],h[2]=s[0],h[3]=s[1],this.draw2DMain(h,t,n)),!(n===1/0||n===-1/0||t===4)&&h[2]!==0&&h[3]!==0&&this.opts.isOrientationTextVisible&&this.drawSliceOrientationText(h,t,u)}calculateMvpMatrix(i,t=[0,0,0,0],n,s){const r=this.gl;(t[2]===0||t[3]===0)&&(t=[0,0,r.canvas.width,r.canvas.height]);const c=t[2]/t[3];let l=this.furthestFromPivot;const d=this.pivot3D,h=Ut();l=.8*l/this.scene.volScaleMultiplier,c<1?El(h,-l,l,-l/c,l/c,l*8,l*.01):El(h,-l*c,l*c,-l,l,l*8,l*.01);const u=Ut();u[0]=-1;const m=lt(0,0,-l*1.8);Ps(u,u,m),this.position&&Ps(u,u,this.position),Sl(u,u,mn(270-s)),Ml(u,u,mn(n-180)),Ps(u,u,[-d[0],-d[1],-d[2]]);const g=Ut();Pe(g,u);const A=Ut();We(A,g);const v=Ut();return qn(v,h,u),[v,u,A]}calculateModelMatrix(i,t){if(!this.back)throw new Error("back undefined");const n=Ut();if(n[0]=-1,Sl(n,n,mn(270-t)),Ml(n,n,mn(i-180)),this.back.obliqueRAS){const s=re(this.back.obliqueRAS);qn(n,n,s)}return n}calculateRayDirection(i,t){const n=lt(0,0,-1),s=this.calculateModelMatrix(i,t),r=vn(1,0,0,0,-1,0,0,0,-1),c=Gt();Rd(c,n,r);const l=Hh();$A(l,s);const d=Hh();if(!tp(d,l))return lt(0,0,1);const h=Gt();Rd(h,c,d),li(h,h);const u=5e-5;for(let m=0;m<3;m++)Math.abs(h[m])<u&&(h[m]=Math.sign(h[m])*u||u);return h}sceneExtentsMinMax(i=!0){let t=lt(0,0,0),n=lt(0,0,0);if(this.volumes.length>0){if(!this.volumeObject3D)throw new Error("volumeObject3D undefined");t=lt(this.volumeObject3D.extentsMin[0],this.volumeObject3D.extentsMin[1],this.volumeObject3D.extentsMin[2]),n=lt(this.volumeObject3D.extentsMax[0],this.volumeObject3D.extentsMax[1],this.volumeObject3D.extentsMax[2]),i||(t=lt(this.volumes[0].extentsMinOrtho[0],this.volumes[0].extentsMinOrtho[1],this.volumes[0].extentsMinOrtho[2]),n=lt(this.volumes[0].extentsMaxOrtho[0],this.volumes[0].extentsMaxOrtho[1],this.volumes[0].extentsMaxOrtho[2]))}if(this.meshes.length>0){if(this.volumes.length<1){const r=this.meshes[0].extentsMin,c=this.meshes[0].extentsMax;t=lt(r[0],r[1],r[2]),n=lt(c[0],c[1],c[2])}for(let r=0;r<this.meshes.length;r++){const c=this.meshes[r].extentsMin,l=this.meshes[r].extentsMax,d=lt(c[0],c[1],c[2]);Jh(t,t,d);const h=lt(l[0],l[1],l[2]);$h(n,n,h)}}const s=Gt();return jt(s,n,t),[t,n,s]}setPivot3D(){const[i,t]=this.sceneExtentsMinMax(),n=Gt();Qn(n,i,t),ap(n,n,.5),this.pivot3D=[n[0],n[1],n[2]],jt(n,t,i),this.extentsMin=i,this.extentsMax=t,this.furthestFromPivot=wn(n)*.5}getMaxVols(){if(this.volumes.length<1)return 0;let i=0;for(let t=0;t<this.volumes.length;t++)i=Math.max(i,this.volumes[t].nFrame4D);return i}detectPartialllyLoaded4D(){if(this.volumes.length<1)return!1;for(let i=0;i<this.volumes.length;i++)if(this.volumes[i].nFrame4D<this.volumes[i].hdr.dims[4])return!0;return!1}drawGraph(){if(this.getMaxVols()<2)return;const i=this.graph,[t,n,s,r]=this.getBoundsRegion();let c=0;if(i.autoSizeMultiplanar&&this.opts.sliceType===3)for(let j=0;j<this.screenSlices.length;j++){const $=this.screenSlices[j].axCorSag;if($===0&&(c=this.screenSlices[j].leftTopWidthHeight[1]),$!==2)continue;const et=this.screenSlices[j].leftTopWidthHeight.slice();et[1]===c?(i.LTWH[0]=et[0]+et[2],i.LTWH[1]=et[1]):(i.LTWH[0]=et[0],i.LTWH[1]=et[1]+et[3]),i.LTWH[2]=et[2],i.LTWH[3]=et[2]}if(i.LTWH[0]=Math.max(t,i.LTWH[0]),i.LTWH[1]=Math.max(n,i.LTWH[1]),i.LTWH[2]=Math.min(s,i.LTWH[2]),i.LTWH[3]=Math.min(r,i.LTWH[3]),i.opacity<=0||i.LTWH[2]<=5||i.LTWH[3]<=5||Math.floor(i.LTWH[0]+i.LTWH[2])>t+s||Math.floor(i.LTWH[1]+i.LTWH[3])>n+r)return;i.backColor=[.15,.15,.15,i.opacity],i.lineColor=[1,1,1,1],this.opts.backColor[0]+this.opts.backColor[1]+this.opts.backColor[2]>1.5&&(i.backColor=[.95,.95,.95,i.opacity],i.lineColor=[0,0,0,1]);const l=.2,d=.3;i.lineColor[3]=l,i.textColor=i.lineColor.slice(),i.textColor[3]=1,i.lineThickness=3,i.gridLineThickness=1,i.lineAlpha=1,i.lines=[];const h=[];if(i.vols.length<1)this.volumes[0]!=null&&h.push(0);else for(let j=0;j<i.vols.length;j++){const $=i.vols[j];this.volumes[$]==null||this.volumes[$].nFrame4D<2||h.push($)}if(h.length<1)return;const u=this.volumes[h[0]].nFrame4D;if(this.graph.selectedColumn=this.volumes[h[0]].frame4D,u<2){k.debug("Unable to generate a graph: Selected volume is 3D not 4D");return}for(let j=0;j<h.length;j++){i.lines[j]=[];const $=this.frac2vox(this.scene.crosshairPos),et=this.volumes[h[j]];let ot=et.nFrame4D;ot=Math.min(ot,u);for(let mt=0;mt<ot;mt++){const vt=et.getValue($[0],$[1],$[2],mt);i.lines[j].push(vt)}}i.lineRGB=[[.8,0,0],[0,.7,0],[0,0,.9],[.7,.7,0],[.8,0,.8],[0,.7,.7],[.6,.6,.6],[0,0,0]];let m=i.lines[0][0],g=i.lines[0][0];for(let j=0;j<i.lines.length;j++)for(let $=0;$<i.lines[j].length;$++){const et=i.lines[j][$];m=Math.min(et,m),g=Math.max(et,g)}const A=this.volumes[h[0]].cal_min,v=this.volumes[h[0]].cal_max;if(i.isRangeCalMinMax&&A<v&&isFinite(A)&&isFinite(v)&&(m=A,g=v),i.normalizeValues&&g>m){const j=g-m;for(let $=0;$<i.lines.length;$++)for(let et=0;et<i.lines[$].length;et++){const ot=i.lines[$][et];i.lines[$][et]=(ot-m)/j}m=0,g=1}m>=g&&(g=m+1),this.drawRect(i.LTWH,i.backColor);const[y,w,b]=m2(m,g),C=Math.max(0,-1*Math.floor(Math.log(y)/Math.log(10)));m=Math.min(w,m),g=Math.max(b,g);function S(j){return j.toFixed(6).replace(/\.?0*$/,"")}let E=this.fontPx*.7;const M=s/this.uiData.dpr,N=r/this.uiData.dpr,U=M*N,T=800*600;U<T?E=0:E=Math.max(E,this.opts.fontMinPx);const F=E/this.fontPx;let I=0,B=w;if(E>0)for(;B<=g;){const j=B.toFixed(C),$=this.textWidth(E,j);I=Math.max($,I),B+=y}const V=.05,R=Math.abs(i.LTWH[2]),Y=Math.abs(i.LTWH[3]),P=[i.LTWH[0]+V*R+I,i.LTWH[1]+V*Y,i.LTWH[2]-I-2*V*R,i.LTWH[3]-E-2.5*V*Y];this.graph.LTWH=i.LTWH,this.graph.plotLTWH=P,this.drawRect(P,this.opts.backColor);const X=g-m,L=P[3]/X,H=P[2]/(i.lines[0].length-1),W=P[1]+P[3];B=w+.5*y;const at=i.lineColor.slice();for(at[3]=.5*i.lineColor[3];B<=g;){const j=W-(B-m)*L;this.drawLine([P[0],j,P[0]+P[2],j],i.gridLineThickness,at),B+=y}B=w;const ct=.5*i.gridLineThickness;for(;B<=g;){const j=W-(B-m)*L;this.drawLine([P[0]-ct,j,P[0]+P[2]+i.gridLineThickness,j],i.gridLineThickness,i.lineColor);const $=B.toFixed(C);E>0&&this.drawTextLeft([P[0]-6,j],$,F,i.textColor),B+=y}let G=1;for(;i.lines[0].length/G>20;)G*=5;for(let j=0;j<i.lines[0].length;j+=G){const $=j*H+P[0];let et=i.gridLineThickness;if(j%2===1)et*=.5,this.drawLine([$,P[1],$,P[1]+P[3]],et,at);else{const ot=S(j);E>0&&this.drawTextBelow([$,2+P[1]+P[3]],ot,F,i.textColor),this.drawLine([$,P[1],$,P[1]+P[3]],et,i.lineColor)}}for(let j=0;j<i.lines.length;j++){let $=[1,0,0,i.lineAlpha];j<i.lineRGB.length&&($=[i.lineRGB[j][0],i.lineRGB[j][1],i.lineRGB[j][2],i.lineAlpha]);for(let et=1;et<i.lines[j].length;et++){const ot=(et-1)*H,mt=et*H,vt=(i.lines[j][et-1]-m)*L,Rt=(i.lines[j][et]-m)*L,Mt=[P[0]+ot,P[1]+P[3]-vt,P[0]+mt,P[1]+P[3]-Rt];this.drawLine(Mt,i.lineThickness,$)}}if(i.selectedColumn>=0&&i.selectedColumn<i.lines[0].length){const j=i.selectedColumn*H+P[0];this.drawLine([j,P[1],j,P[1]+P[3]],i.lineThickness,[i.lineRGB[0][0],i.lineRGB[0][1],i.lineRGB[0][2],d])}E>0&&i.LTWH[1]+i.LTWH[3]>P[1]+P[3]+E*2.4&&this.drawTextBelow([P[0]+.5*P[2],P[1]+P[3]+E*1.2],"Volume",F,i.textColor),this.detectPartialllyLoaded4D()&&this.drawTextBelow([P[0]+P[2],P[1]+P[3]+E*.5],"...",F,i.textColor)}depthPicker(i,t){if(!this.uiData.mouseDepthPicker)return;this.uiData.mouseDepthPicker=!1;const n=this.gl,s=this.mousePos[0]*i[2]/i[2],r=n.canvas.height-this.mousePos[1]*i[3]/i[3]-1,c=new Uint8Array(4);if(n.readPixels(s,r,1,1,n.RGBA,n.UNSIGNED_BYTE,c),this.selectedObjectId=c[3],this.selectedObjectId===this.VOLUME_ID){this.scene.crosshairPos=new Float32Array(c.slice(0,3)).map(g=>g/255);return}const l=Rv(c);if(l>1)return;const d=(this.mousePos[0]-i[0])/i[2],h=(n.canvas.height-this.mousePos[1]-i[1])/i[3],u=Vv(d,h,l,t),m=this.mm2frac(u,0,!0);m[0]<0||m[0]>1||m[1]<0||m[1]>1||m[2]<0||m[2]>1||(this.scene.crosshairPos=this.mm2frac(u,0,!0))}drawImage3D(i,t,n){if(this.volumes.length===0)return;const s=this.gl,r=this.calculateRayDirection(t,n),c=this.volumeObject3D;if(c){s.enable(s.BLEND),s.blendFunc(s.SRC_ALPHA,s.ONE_MINUS_SRC_ALPHA),s.enable(s.CULL_FACE),s.cullFace(s.FRONT);let l=this.renderShader;if(this.uiData.mouseDepthPicker&&(l=this.pickingImageShader),l.use(this.gl),s.uniform1i(l.uniforms.backgroundMasksOverlays,this.backgroundMasksOverlays),this.gradientTextureAmount>0&&l.uniforms.normMtx&&this.gradientTexture){s.activeTexture(Vl),s.bindTexture(s.TEXTURE_3D,this.gradientTexture);const d=this.calculateModelMatrix(t,n),h=Ut();Pe(h,d);const u=Ut();We(u,h),s.uniformMatrix4fv(l.uniforms.normMtx,!1,u)}if(this.drawBitmap&&this.drawBitmap.length>8?s.uniform2f(l.uniforms.renderDrawAmbientOcclusionXY,this.renderDrawAmbientOcclusion,this.drawOpacity):s.uniform2f(l.uniforms.renderDrawAmbientOcclusionXY,this.renderDrawAmbientOcclusion,0),this.gl.uniform4fv(l.uniforms.paqdUniforms,this.opts.paqdUniforms),s.uniformMatrix4fv(l.uniforms.mvpMtx,!1,i),s.uniformMatrix4fv(l.uniforms.matRAS,!1,this.back.matRAS),s.uniform3fv(l.uniforms.rayDir,r),this.gradientTextureAmount<0)s.uniform4fv(l.uniforms.clipPlane,[this.scene.crosshairPos[0],this.scene.crosshairPos[1],this.scene.crosshairPos[2],30]);else{const h=new Float32Array(24).fill(2);for(let u=0;u<this.scene.clipPlaneDepthAziElevs.length;u++){const m=this.scene.clipPlaneDepthAziElevs[u],g=this.sph2cartDeg(m[1]+180,m[2]),A=[g[0],g[1],g[2],m[0]];h.set(A,u*4)}this.gl.uniform4fv(l.uniforms.clipPlanes,h)}s.uniform1f(l.uniforms.drawOpacity,1),s.uniform1i(l.uniforms.isClipCutaway,this.opts.isClipPlanesCutaway?1:0),s.bindVertexArray(c.vao),s.drawElements(c.mode,c.indexCount,s.UNSIGNED_SHORT,0),s.bindVertexArray(this.unusedVAO)}}drawOrientationCube(i,t=0,n=0){if(!this.opts.isOrientCube)return;const s=.05*Math.min(i[2],i[3]);if(s<5)return;const r=this.gl;r.enable(r.CULL_FACE),r.cullFace(r.BACK),r.disable(r.DEPTH_TEST),this.orientCubeShader.use(this.gl),r.bindVertexArray(this.orientCubeShaderVAO);const c=Ut(),l=Ut();El(l,0,r.canvas.width,0,r.canvas.height,-10*s,10*s);let d=0;i[1]===0&&(d=r.canvas.height-this.effectiveCanvasHeight()),Ps(c,c,[1.8*s+i[0],d+1.8*s+i[1],0]),Bd(c,c,[s,s,s]),Sl(c,c,mn(270-n)),Ml(c,c,mn(-t));const h=Ut();qn(h,l,c),r.uniformMatrix4fv(this.orientCubeShader.uniforms.u_matrix,!1,h),r.drawArrays(r.TRIANGLE_STRIP,0,168),r.bindVertexArray(this.unusedVAO),this.gl.disable(this.gl.CULL_FACE)}createOnLocationChange(i=NaN){const[t,n,s]=this.sceneExtentsMinMax(!0),r=Math.max(Math.max(s[0],s[1]),s[2]);function c(g){return Math.max(0,-Math.ceil(Math.log10(Math.abs(g))))}let l=c(r*.001);const d=this.frac2mm(this.scene.crosshairPos,0,!0);function h(g,A=0){return parseFloat(g.toFixed(A))}let u=h(d[0],l)+"×"+h(d[1],l)+"×"+h(d[2],l);if(this.volumes.length>0&&this.volumes[0].nFrame4D>0&&(u+="×"+h(this.volumes[0].frame4D)),this.volumes.length>0){let g=" = ";for(let y=0;y<this.volumes.length;y++){const w=this.volumes[y].mm2vox(d);let b=this.volumes[y].getValue(w[0],w[1],w[2],this.volumes[y].frame4D);if(l=3,this.volumes[y].colormapLabel!==null){const C=Math.round(b);if(this.volumes[y].hdr.intent_code===1002&&this.volumes[y].hdr.datatypeCode===2304){const S=this.volumes[y].getValues(w[0],w[1],w[2],this.volumes[y].frame4D);if(S[2]>2){const E=Math.round(100*S[2]/255);if(g+=this.volumes[y].colormapLabel.labels[S[0]]+` (${E}%)`,S[3]>2){const M=Math.round(100*S[3]/255);g+=" "+this.volumes[y].colormapLabel.labels[S[1]]+` (${M}%)`}}}else C>=0&&this.volumes[y].colormapLabel.labels&&C<this.volumes[y].colormapLabel.labels.length?g+=this.volumes[y].colormapLabel.labels[C]:g+="undefined("+h(b,l)+")"}else g+=h(b,l);this.volumes[y].imaginary&&(b=this.volumes[y].getValue(w[0],w[1],w[2],this.volumes[y].frame4D,!0),b>=0&&(g+="+"),g+=h(b,l)),g+="   "}u+=g;const A=this.back.dimsRAS,v=A[1]*A[2]*A[3];if(this.drawBitmap&&this.drawBitmap.length===v){const y=this.frac2vox(this.scene.crosshairPos),w=y[0]+y[1]*A[1]+y[2]*A[1]*A[2];u+=" "+this.drawLut.labels[this.drawBitmap[w]]}}const m={mm:this.frac2mm(this.scene.crosshairPos,0,!0),axCorSag:i,vox:this.frac2vox(this.scene.crosshairPos),frac:this.scene.crosshairPos,xy:[this.mousePos[0],this.mousePos[1]],values:this.volumes.map(g=>{const A=this.frac2mm(this.scene.crosshairPos,0,!0),v=g.mm2vox(A),y=g.getValue(v[0],v[1],v[2],g.frame4D);return{name:g.name,value:y,id:g.id,mm:A,vox:v}}),string:u};this.onLocationChange(m)}addLabel(i,t,n,s,r){const c={textColor:this.opts.legendTextColor,textScale:1,textAlignment:"left",lineWidth:0,lineColor:this.opts.legendTextColor,lineTerminator:"none",bulletScale:0,bulletColor:this.opts.legendTextColor},l=t?{...c,...t}:{...c},d=new pu(i,{...l},n,s,r);return this.document.labels.push(d),d}calculateScreenPoint(i,t,n){const s=ki();return De(s,[...i,1],t),s[3]!==0&&(s[0]=(s[0]/s[3]+1)*.5*n[2],s[1]=(1-s[1]/s[3])*.5*n[3],s[2]/=s[3],s[0]+=n[0],s[1]+=n[1]),s}getLabelAtPoint(i){const t=this.legendFontScaling,n=this.fontPx*t,s=this.fontPx*t;for(const u of this.document.labels){if(u.anchor==null||u.anchor===0)continue;const m=this.fontPx*u.style.textScale*t,g=this.textHeight(m,u.text),A=this.textWidth(m,u.text);if(!(u.anchor&1&&i[0]>A)&&!(u.anchor&2&&(i[0]<(this.gl.canvas.width-A)/2||i[0]>(this.gl.canvas.width+A)/2))&&!(u.anchor&4&&i[0]<this.gl.canvas.width-A)&&!(u.anchor&8&&(i[1]<s/2||i[1]>g+s/2))&&!(u.anchor&16&&(i[1]<(this.gl.canvas.height-g-s)/2||i[1]>(this.gl.canvas.height+g-s/2)/2))&&!(u.anchor&32&&(i[1]<this.gl.canvas.height-g-s||i[1]>this.gl.canvas.height-s/2)))return u}k.debug("screenPoint",i);const r=this.getLegendPanelHeight(t),c=this.getLegendPanelWidth(),l=this.gl.canvas.width-c;let d=(this.canvas.height-r)/2;if(k.debug("panelrect",l,d,l+c,d+r),i[0]<l||i[1]<d||i[0]>l+c||i[1]>d+r)return null;const h=this.getConnectomeLabels();for(const u of h){const m=this.fontPx*u.style.textScale*t,g=this.textHeight(m,u.text);if(i[1]>=d&&i[1]<=d+g+n/2)return k.debug(`label clicked ${u.text}`),u;d+=g,d+=n/2}return null}drawLabelLine(i,t,n,s,r=!1){const c=Array.isArray(i.points)&&Array.isArray(i.points[0])?i.points:[i.points];for(const l of c){const d=this.calculateScreenPoint(l,n,s);r?this.drawDottedLine([...t,d[0],d[1]],i.style.lineWidth,i.style.lineColor):this.draw3DLine(t,[d[0],d[1],d[2]],i.style.lineWidth,i.style.lineColor)}}draw3DLabel(i,t,n,s,r,c,l,d=1){const h=i.text,u=t[0],m=t[1],g=this.fontPx*d,A=this.textHeight(i.style.textScale,h)*g;if(i.style.lineWidth>0&&Array.isArray(i.points)&&this.drawLabelLine(i,[u,m+A],n,s,l),i.style.bulletScale){const w=i.style.bulletScale*A,b=A-w,C=m+b/2+w/2,S=u+(r-w)/2;this.drawCircle([S,C,w,w],i.style.bulletColor)}let v=u;if(c)if(i.style.textAlignment!=="left"){const w=this.textWidth(i.style.textScale,i.text)*g;if(i.style.textAlignment==="right")v=u+c-g*1.5-w;else{const b=c-(r||g);v+=(b-w)/2}}else v+=r;const y=i.style.textScale;this.drawText([v,m],h,y,i.style.textColor)}draw3DLabels(i,t,n=!1){const s=this.getConnectomeLabels();if(!this.opts.showLegend||s.length===0)return;let r=this.getLegendPanelHeight(1);if(!this.canvas||r<1)return;const c=this.gl;if(c.disable(c.CULL_FACE),c.viewport(0,0,this.canvas.width,this.canvas.height),this.legendFontScaling=1,r>this.canvas.height){const v=10*this.uiData.dpr;this.legendFontScaling=Math.max(this.canvas.height-v,1)/r,k.debug(`Legend too large for screen, font reduction factor x${this.legendFontScaling}`),r=this.getLegendPanelHeight(this.legendFontScaling)}const l=this.fontPx*this.legendFontScaling,d=this.getBulletMarginWidth(),h=this.getLegendPanelWidth(),u=c.canvas.width-h;let m=(this.canvas.height-r)/2;this.drawRect([c.canvas.width-h,m,h-l,r],this.opts.legendBackgroundColor);const g=c.getParameter(c.BLEND),A=c.getParameter(c.DEPTH_FUNC);n||(c.disable(c.BLEND),c.depthFunc(c.LEQUAL));for(const v of s){this.draw3DLabel(v,[u,m],i,t,d,h,n,this.legendFontScaling);const y=this.fontPx*v.style.textScale,w=this.textHeight(y,v.text)*this.legendFontScaling;m+=w,m+=l/2}n||(c.depthFunc(A),g&&c.enable(c.BLEND))}drawAnchoredLabels(){const i=this.fontPx,t=this.document.labels.filter(n=>n.anchor!=null&&n.anchor!==0);for(const n of t){const s=n.text,r=this.textHeight(n.style.textScale,s)*i,c=this.textWidth(n.style.textScale,s)*i;let l,d;const u=this.fontPx*1,m=u;let g=u/4,A=0,v=0;n.anchor&1&&(l=0),n.anchor&4&&(l=this.canvas.width-c,A-=u/4),n.anchor&2&&(l=(this.canvas.width-c)/2,A-=u/4,g+=u/4),n.anchor&8&&(d=0),n.anchor&16&&(d=(this.canvas.height-r-u)/2,v-=u/4),n.anchor&32&&(d=this.canvas.height-r-u,v-=u/4),this.drawRect([l+A,d+v,c+g,r+m],n.style.backgroundColor),this.draw3DLabel(n,[l,d])}}draw3D(i=[0,0,0,0],t=null,n=null,s=null,r=null,c=0){const l=this.gl,[d,h,u,m]=this.getBoundsRegion();let g=[...i];(g[2]===0||g[3]===0)&&(g=this.opts.bounds?[d,h,u,m]:[0,0,l.canvas.width,l.canvas.height]);const A=r!==null;this.setPivot3D(),A||(r=this.scene.renderAzimuth,c=this.scene.renderElevation),t===null&&([t,n,s]=this.calculateMvpMatrix(null,g,r,c));const v=[...g];this.screenSlices.push({leftTopWidthHeight:g.slice(),axCorSag:4,sliceFrac:0,AxyzMxy:[],leftTopMM:[],fovMM:[Nv(n),0]});const y=[g[0],l.canvas.height-g[3]-g[1],g[2],g[3]];if(g[1]=l.canvas.height-g[3]-g[1],l.clear(l.DEPTH_BUFFER_BIT),l.enable(l.DEPTH_TEST),l.depthFunc(l.ALWAYS),l.depthMask(!0),this.draw3DLabels(t,v,!1),this.gl.viewport(y[0],y[1],y[2],y[3]),this.volumes.length>0&&(this.updateInterpolation(0,!0),this.updateInterpolation(1,!0),this.drawImage3D(t,r,c)),this.updateInterpolation(0),this.updateInterpolation(1),A||this.drawCrosshairs3D(!0,1,t),this.drawMesh3D(!0,1,t,n,s),this.uiData.mouseDepthPicker){this.depthPicker(g,t),this.createOnLocationChange(),this.draw3D(v,t,n,s,r,c);return}this.opts.meshXRay>0&&this.drawMesh3D(!1,this.opts.meshXRay,t,n,s),this.gl.disable(this.gl.CULL_FACE),this.draw3DLabels(t,v,!1),l.viewport(g[0],g[1],g[2],g[3]),A||this.drawCrosshairs3D(!1,.15,t),l.viewport(d,h,u,m),this.drawOrientationCube(g,r,c);const w="azimuth: "+this.scene.renderAzimuth.toFixed(0)+" elevation: "+this.scene.renderElevation.toFixed(0);return this.readyForSync=!0,this.sync(),this.draw3DLabels(t,v,!0),w}drawMesh3D(i=!0,t=1,n,s,r,c=!1){if(this.meshes.length<1)return;const l=this.gl;n||([n,s,r]=this.calculateMvpMatrix(this.volumeObject3D,void 0,this.scene.renderAzimuth,this.scene.renderElevation)),l.enable(l.DEPTH_TEST),i?l.depthFunc(l.LEQUAL):l.depthFunc(l.ALWAYS),l.cullFace(l.BACK),l.blendFunc(l.SRC_ALPHA,l.ONE_MINUS_SRC_ALPHA);let d=!1;for(const h of this.meshes){if(!h.visible||h.opacity<=0||h.indexCount<3)continue;const u=h.opacity*t;let m=this.meshShaders[h.meshShaderIndex].shader;if(this.uiData.mouseDepthPicker&&(m=this.pickingMeshShader),m.use(l),m.isCrosscut){l.disable(l.DEPTH_TEST),l.disable(l.CULL_FACE);const g=this.frac2mm(this.scene.crosshairPos,0,this.opts.isSliceMM);l.uniformMatrix4fv(m.uniforms.modelMtx,!1,s),c&&(Math.abs(s[2])+Math.abs(s[4])+Math.abs(s[9])>=2.95&&(g[1]=1e9,g[2]=1e9),Math.abs(s[0])+Math.abs(s[6])+Math.abs(s[9])>=2.95&&(g[0]=1e9,g[2]=1e9),Math.abs(s[0])+Math.abs(s[5])+Math.abs(s[10])>=2.95&&(g[0]=1e9,g[1]=1e9));let A=Number(this.opts.meshThicknessOn2D);Number.isFinite(A)||(A=1),l.uniform4fv(m.uniforms.sliceMM,[g[0],g[1],g[2],A])}else l.enable(l.CULL_FACE),l.enable(l.DEPTH_TEST);if(l.uniformMatrix4fv(m.uniforms.mvpMtx,!1,n),l.uniformMatrix4fv(m.uniforms.normMtx,!1,r),l.uniform1f(m.uniforms.opacity,u),u>=1?(l.disable(l.BLEND),l.depthMask(!0)):(l.enable(l.BLEND),l.depthMask(!1)),h.offsetPt0&&(h.fiberSides<3||h.fiberRadius<=0)){d=!0;continue}m.isMatcap&&(l.activeTexture(Yh),l.bindTexture(l.TEXTURE_2D,this.matCapTexture)),l.bindVertexArray(h.vao),l.drawElements(l.TRIANGLES,h.indexCount,l.UNSIGNED_INT,0),l.bindVertexArray(this.unusedVAO)}if(l.enable(l.CULL_FACE),this.opts.meshXRay>0&&!d){l.enable(l.BLEND),l.depthMask(!1),l.depthFunc(l.ALWAYS);for(const h of this.meshes){if(!h.visible||h.indexCount<3)continue;const u=this.meshShaders[h.meshShaderIndex].shader;u.use(l),l.uniformMatrix4fv(u.uniforms.mvpMtx,!1,n),l.uniformMatrix4fv(u.uniforms.normMtx,!1,r),l.uniform1f(u.uniforms.opacity,h.opacity*t*this.opts.meshXRay),l.bindVertexArray(h.vao),l.drawElements(l.TRIANGLES,h.indexCount,l.UNSIGNED_INT,0),l.bindVertexArray(this.unusedVAO)}l.depthMask(!0),l.depthFunc(l.GREATER),l.disable(l.BLEND)}if(d){const h=this.fiberShader;h.use(l),l.uniformMatrix4fv(h.uniforms.mvpMtx,!1,n),l.uniform1f(h.uniforms.opacity,t);for(const u of this.meshes)u.offsetPt0&&(u.fiberSides>=3&&u.fiberRadius>0||(l.bindVertexArray(u.vaoFiber),l.drawElements(l.LINE_STRIP,u.indexCount,l.UNSIGNED_INT,0),l.bindVertexArray(this.unusedVAO)))}l.depthMask(!0),l.disable(l.BLEND),this.readyForSync=!0}drawCrosshairs3D(i=!0,t=1,n=null,s=!1,r=!0){if(!this.opts.show3Dcrosshair&&!s||this.opts.crosshairWidth<=0&&s)return;const c=this.gl,l=this.frac2mm(this.scene.crosshairPos,0,r);let d=1;const[h,u,m]=this.sceneExtentsMinMax(r);if(this.volumes.length>0){if(!this.back)throw new Error("back undefined");d=.5*Math.min(Math.min(this.back.pixDims[1],this.back.pixDims[2]),this.back.pixDims[3])}else(m[0]<50||m[0]>1e3)&&(d=m[0]*.02);if(d*=this.opts.crosshairWidth,this.opts?.crosshairWidthUnit==="percent"&&(d=m[0]*this.opts.crosshairWidth*.5*.01),this.opts?.crosshairWidthUnit==="mm"&&(d=this.opts.crosshairWidth*.5),(this.crosshairs3D===null||this.crosshairs3D.mm[0]!==l[0]||this.crosshairs3D.mm[1]!==l[1]||this.crosshairs3D.mm[2]!==l[2])&&(this.crosshairs3D!==null&&(c.deleteBuffer(this.crosshairs3D.indexBuffer),c.deleteBuffer(this.crosshairs3D.vertexBuffer)),this.crosshairs3D=Wn.generateCrosshairs(this.gl,1,l,h,u,d,20,this.opts.crosshairGap),this.crosshairs3D.mm=l),!this.surfaceShader)throw new Error("surfaceShader undefined");const g=this.surfaceShader;g.use(this.gl),n==null&&([n]=this.calculateMvpMatrix(this.crosshairs3D,void 0,this.scene.renderAzimuth,this.scene.renderElevation)),c.uniformMatrix4fv(g.uniforms.mvpMtx,!1,n),c.disable(c.CULL_FACE),c.bindBuffer(c.ELEMENT_ARRAY_BUFFER,this.crosshairs3D.indexBuffer),c.enable(c.DEPTH_TEST);const A=[...this.opts.crosshairColor];i?(c.disable(c.BLEND),c.depthFunc(c.LEQUAL)):(c.enable(c.BLEND),c.blendFunc(c.SRC_ALPHA,c.ONE_MINUS_SRC_ALPHA),c.depthFunc(c.ALWAYS)),A[3]=t,c.uniform4fv(g.uniforms.surfaceColor,A),c.bindVertexArray(this.crosshairs3D.vao),c.drawElements(c.TRIANGLES,this.crosshairs3D.indexCount,c.UNSIGNED_INT,0),c.bindVertexArray(this.unusedVAO)}mm2frac(i,t=0,n=!1){if(this.volumes.length<1){const s=lt(.1,.5,.5),[r,c,l]=this.sceneExtentsMinMax();return s[0]=(i[0]-r[0])/l[0],s[1]=(i[1]-r[1])/l[1],s[2]=(i[2]-r[2])/l[2],isFinite(s)||(isFinite(s[0])||(s[0]=.5),isFinite(s[1])||(s[1]=.5),isFinite(s[2])||(s[2]=.5),this.meshes.length<1&&k.error("mm2frac() not finite: objects not (yet) loaded.")),s}return this.volumes[t].convertMM2Frac(i,n||this.opts.isSliceMM)}vox2frac(i,t=0){return this.volumes[t].convertVox2Frac(i)}frac2vox(i,t=0){return this.volumes.length<=t?[0,0,0]:this.volumes[t].convertFrac2Vox(i)}moveCrosshairInVox(i,t,n){const s=this.frac2vox(this.scene.crosshairPos),r=s[2];s[0]+=i,s[1]+=t,s[2]+=n,s[0]=zh(s[0],0,this.volumes[0].dimsRAS[1]-1),s[1]=zh(s[1],0,this.volumes[0].dimsRAS[2]-1),s[2]=zh(s[2],0,this.volumes[0].dimsRAS[3]-1),this.scene.crosshairPos=this.vox2frac(s),this.createOnLocationChange(),this.opts.is2DSliceShader&&r!==s[2]&&(this.updateGLVolume(),this.refreshDrawing(!1)),this.drawScene()}frac2mm(i,t=0,n=!1){const s=te(i[0],i[1],i[2],1);if(this.volumes.length>0)return this.volumes[t].convertFrac2MM(i,n||this.opts.isSliceMM);{const[r,c]=this.sceneExtentsMinMax(),l=(d,h,u)=>d*(1-u)+h*u;s[0]=l(r[0],c[0],i[0]),s[1]=l(r[1],c[1],i[1]),s[2]=l(r[2],c[2],i[2])}return s}screenXY2TextureFrac(i,t,n,s=!0){const r=lt(-1,-1,-1),c=this.screenSlices[n].axCorSag;if(c>2)return r;const l=this.screenSlices[n].leftTopWidthHeight.slice();let d=!1;l[2]<0&&(d=!0,l[0]+=l[2],l[2]=-l[2]);let h=(i-l[0])/l[2];d&&(h=1-h);const u=1-(t-l[1])/l[3];if(h<0||h>1||u<0||u>1||this.screenSlices[n].AxyzMxy.length<4)return r;let m=lt(0,0,0);m[0]=this.screenSlices[n].leftTopMM[0]+h*this.screenSlices[n].fovMM[0],m[1]=this.screenSlices[n].leftTopMM[1]+u*this.screenSlices[n].fovMM[1];const g=this.screenSlices[n].AxyzMxy;m[2]=g[2]+g[4]*(m[1]-g[1])-g[3]*(m[0]-g[0]),c===1&&(m=ne(m,[0,2,1])),c===2&&(m=ne(m,[2,0,1]));const A=this.mm2frac(m);return s&&(A[0]<0||A[0]>1||A[1]<0||A[1]>1||A[2]<0||A[2]>1)?r:A}canvasPos2frac(i){for(let t=0;t<this.screenSlices.length;t++){const n=this.screenXY2TextureFrac(i[0],i[1],t);if(n[0]>=0)return n}return[-1,-1,-1]}frac2canvasPosWithTile(i,t){const n=this.frac2mm(i);let s={distance:1/0};for(let r=0;r<this.screenSlices.length;r++){const c=this.screenSlices[r].axCorSag;if(c>2||this.screenSlices[r].AxyzMxy.length<4||t!==void 0&&c!==t)continue;let l=lt(n[0],n[1],n[2]);c===1&&(l=ne(l,[0,2,1])),c===2&&(l=ne(l,[1,2,0]));const d=this.screenSlices[r].AxyzMxy,h=d[2]+d[4]*(l[1]-d[1])-d[3]*(l[0]-d[0]),u=Math.abs(l[2]-h),m=this.opts.sliceType===3?1:.1;if(u<s.distance&&(s={index:r,distance:u}),u<=m){const g=(l[0]-this.screenSlices[r].leftTopMM[0])/this.screenSlices[r].fovMM[0],A=(l[1]-this.screenSlices[r].leftTopMM[1])/this.screenSlices[r].fovMM[1];if(g>=0&&g<=1&&A>=0&&A<=1){const v=this.screenSlices[r].leftTopWidthHeight.slice();let y=!1;v[2]<0&&(y=!0,v[0]+=v[2],v[2]=-v[2]);let w=g;y&&(w=1-g);const b=1-A,C=v[0]+w*v[2],S=v[1]+b*v[3];return{pos:[C,S],tileIndex:r}}}}return null}frac2canvasPos(i){const t=this.frac2mm(i);let n={index:-1,distance:1/0};for(let s=0;s<this.screenSlices.length;s++){const r=this.screenSlices[s].axCorSag;if(r>2||this.screenSlices[s].AxyzMxy.length<4)continue;let c=lt(t[0],t[1],t[2]);r===1&&(c=ne(c,[0,2,1])),r===2&&(c=ne(c,[1,2,0]));const l=this.screenSlices[s].AxyzMxy,d=l[2]+l[4]*(c[1]-l[1])-l[3]*(c[0]-l[0]),h=Math.abs(c[2]-d),u=this.opts.sliceType===3?1:.1;if(h<n.distance&&(n={index:s,distance:h}),h<=u){const m=(c[0]-this.screenSlices[s].leftTopMM[0])/this.screenSlices[s].fovMM[0],g=(c[1]-this.screenSlices[s].leftTopMM[1])/this.screenSlices[s].fovMM[1];if(m>=0&&m<=1&&g>=0&&g<=1){const A=this.screenSlices[s].leftTopWidthHeight.slice();let v=!1;A[2]<0&&(v=!0,A[0]+=A[2],A[2]=-A[2]);let y=m;v&&(y=1-m);const w=1-g,b=A[0]+y*A[2],C=A[1]+w*A[3];return[b,C]}}}if(n.index>=0&&n.distance<2){const s=n.index,r=this.screenSlices[s].axCorSag;let c=lt(t[0],t[1],t[2]);r===1&&(c=ne(c,[0,2,1])),r===2&&(c=ne(c,[1,2,0]));const l=this.screenSlices[s].AxyzMxy;c[2]=l[2]+l[4]*(c[1]-l[1])-l[3]*(c[0]-l[0]);const d=(c[0]-this.screenSlices[s].leftTopMM[0])/this.screenSlices[s].fovMM[0],h=(c[1]-this.screenSlices[s].leftTopMM[1])/this.screenSlices[s].fovMM[1];if(d>=-.1&&d<=1.1&&h>=-.1&&h<=1.1){const u=Math.max(0,Math.min(1,d)),m=Math.max(0,Math.min(1,h)),g=this.screenSlices[s].leftTopWidthHeight.slice();let A=!1;g[2]<0&&(A=!0,g[0]+=g[2],g[2]=-g[2]);let v=u;A&&(v=1-u);const y=1-m,w=g[0]+v*g[2],b=g[1]+y*g[3];return[w,b]}}return null}scaleSlice(i,t,n=[0,0],s=[0,0]){const r=s[0]===0?this.effectiveCanvasWidth()-n[0]:s[0]-n[0],c=s[1]===0?this.effectiveCanvasHeight()-n[1]:s[1]-n[1];let l=r/i;t*l>c&&(l=c/t);const d=i*l,h=t*l;return[(r-d)*.5,(c-h)*.5,d,h,l]}drawThumbnail(){if(!this.bmpShader)throw new Error("bmpShader undefined");this.bmpShader.use(this.gl);const[i,t,n,s]=this.getBoundsRegion();this.gl.uniform2f(this.bmpShader.uniforms.canvasWidthHeight,n,s);let r=s,c=s*this.bmpTextureWH;c>n&&(r=n/this.bmpTextureWH,c=n);const l=i+(n-c)/2,d=t+(s-r)/2;this.gl.uniform4f(this.bmpShader.uniforms.leftTopWidthHeight,l,d,c,r),this.gl.bindVertexArray(this.genericVAO),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO)}drawLine(i,t=1,n=[1,0,0,-1]){if(this.gl.bindVertexArray(this.genericVAO),!this.lineShader)throw new Error("lineShader undefined");this.lineShader.use(this.gl),n[3]<0&&(n=this.opts.crosshairColor),this.gl.uniform4fv(this.lineShader.uniforms.lineColor,n),this.gl.uniform2fv(this.lineShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform1f(this.lineShader.uniforms.thickness,t),this.gl.uniform4fv(this.lineShader.uniforms.startXYendXY,i),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO)}draw3DLine(i,t,n=1,s=[1,0,0,-1]){if(this.gl.bindVertexArray(this.genericVAO),!this.line3DShader)throw new Error("line3DShader undefined");this.line3DShader.use(this.gl),s[3]<0&&(s=this.opts.crosshairColor),this.gl.uniform4fv(this.line3DShader.uniforms.lineColor,s),this.gl.uniform2fv(this.line3DShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform1f(this.line3DShader.uniforms.thickness,n),this.gl.uniform2fv(this.line3DShader.uniforms.startXY,i),this.gl.uniform3fv(this.line3DShader.uniforms.endXYZ,t),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),this.gl.bindVertexArray(this.unusedVAO)}drawDottedLine(i,t=1,n=[1,0,0,-1]){if(this.gl.bindVertexArray(this.genericVAO),!this.lineShader)throw new Error("lineShader undefined");this.lineShader.use(this.gl);const s=n[3]<0?[...this.opts.crosshairColor]:[...n];s[3]=.3;const r=Ld(i[2]-i[0],i[3]-i[1]),c=Od(r);gp(r,r);const d=this.fontPx*1;mp(r,r,d/2);const h=Od(r);let u=Math.floor(c/h);c%h&&u++;const m=[i[0],i[1]];this.gl.uniform4fv(this.lineShader.uniforms.lineColor,s),this.gl.uniform2fv(this.lineShader.uniforms.canvasWidthHeight,[this.gl.canvas.width,this.gl.canvas.height]),this.gl.uniform1f(this.lineShader.uniforms.thickness,t);for(let g=0;g<u-1;g++){if(g%2){m[0]+=r[0],m[1]+=r[1];continue}const A=[m[0],m[1],m[0]+r[0],m[1]+r[1]];this.gl.uniform4fv(this.lineShader.uniforms.startXYendXY,A),this.gl.drawArrays(this.gl.TRIANGLE_STRIP,0,4),m[0]+=r[0],m[1]+=r[1]}this.gl.bindVertexArray(this.unusedVAO)}drawGraphLine(i,t=[1,0,0,.5],n=2){this.drawLine(i,n,t)}drawCrossLinesMM(i,t,n,s,r){if(i<0||this.screenSlices.length<=i)return;const c=this.screenSlices[i];let l=c.sliceFrac;l===1/0&&k.debug("Rendering approximate cross lines in world view mode"),l===1/0&&(l=.5);let h=s.slice(),u=r.slice();const m=Math.max(1,this.opts.crosshairWidth);t===1&&(h=n.slice()),t===2&&(h=n.slice(),u=s.slice());function g(A){const v=Ld(0,0);return v[0]=c.leftTopWidthHeight[0]+(A[0]-c.leftTopMM[0])/c.fovMM[0]*c.leftTopWidthHeight[2],v[1]=c.leftTopWidthHeight[1]+c.leftTopWidthHeight[3]-(A[1]-c.leftTopMM[1])/c.fovMM[1]*c.leftTopWidthHeight[3],v}if(h.length>0&&t===0){const A=l,v=1;for(let y=0;y<h.length;y++){const w=this.frac2mm([.5,.5,.5]);w[v]=h[y];let b=this.mm2frac(w);b=b[v];let C=this.frac2mm([0,b,A]);C=ne(C,[0,1,2]);let S=this.frac2mm([1,b,A]);S=ne(S,[0,1,2]),C=g(C),S=g(S),this.drawLine([C[0],C[1],S[0],S[1]],m)}}if(h.length>0&&t===1){const A=l,v=2;for(let y=0;y<h.length;y++){const w=this.frac2mm([.5,.5,.5]);w[v]=h[y];let b=this.mm2frac(w);b=b[v];let C=this.frac2mm([0,A,b]);C=ne(C,[0,2,1]);let S=this.frac2mm([1,A,b]);S=ne(S,[0,2,1]),C=g(C),S=g(S),this.drawLine([C[0],C[1],S[0],S[1]],m)}}if(h.length>0&&t===2){const A=l,v=2;for(let y=0;y<h.length;y++){const w=this.frac2mm([.5,.5,.5]);w[v]=h[y];let b=this.mm2frac(w);b=b[v];let C=this.frac2mm([A,0,b]);C=ne(C,[1,2,0]);let S=this.frac2mm([A,1,b]);S=ne(S,[1,2,0]),C=g(C),S=g(S),this.drawLine([C[0],C[1],S[0],S[1]],m)}}if(u.length>0&&t===0){const A=l,v=0;for(let y=0;y<u.length;y++){const w=this.frac2mm([.5,.5,.5]);w[v]=u[y];let b=this.mm2frac(w);b=b[v];let C=this.frac2mm([b,0,A]);C=ne(C,[0,1,2]);let S=this.frac2mm([b,1,A]);S=ne(S,[0,1,2]),C=g(C),S=g(S),this.drawLine([C[0],C[1],S[0],S[1]],m)}}if(u.length>0&&t===1){const A=l,v=0;for(let y=0;y<u.length;y++){const w=this.frac2mm([.5,.5,.5]);w[v]=u[y];let b=this.mm2frac(w);b=b[v];let C=this.frac2mm([b,A,0]);C=ne(C,[0,2,1]);let S=this.frac2mm([b,A,1]);S=ne(S,[0,2,1]),C=g(C),S=g(S),this.drawLine([C[0],C[1],S[0],S[1]],m)}}if(u.length>0&&t===2){const A=l,v=1;for(let y=0;y<u.length;y++){const w=this.frac2mm([.5,.5,.5]);w[v]=u[y];let b=this.mm2frac(w);b=b[v];let C=this.frac2mm([A,b,0]);C=ne(C,[1,2,0]);let S=this.frac2mm([A,b,1]);S=ne(S,[1,2,0]),C=g(C),S=g(S),this.drawLine([C[0],C[1],S[0],S[1]],m)}}}drawCrossLines(i,t,n,s,r){if(i<0||this.screenSlices.length<=i)return;if(this.opts.isSliceMM)return this.drawCrossLinesMM(i,t,n,s,r);if(this.screenSlices[i].sliceFrac===1/0)return this.drawCrossLinesMM(i,t,n,s,r);const c=this.screenSlices[i];let l=s.slice(),d=r.slice();if(t===1&&(l=n.slice()),t===2&&(l=n.slice(),d=s.slice()),l.length>0){const h=c.leftTopWidthHeight.slice();let u=2;t===0&&(u=1);const m=this.frac2mm([.5,.5,.5]);for(let g=0;g<l.length;g++){m[u]=l[g];const A=this.mm2frac(m);this.drawRect([h[0],h[1]+h[3]-A[u]*h[3],h[2],1])}}if(d.length>0){const h=c.leftTopWidthHeight.slice(),u=c.fovMM[0]<0;let m=0;t===2&&(m=1);const g=this.frac2mm([.5,.5,.5]);for(let A=0;A<d.length;A++){g[m]=d[A];const v=this.mm2frac(g);u?this.drawRect([h[0]+(h[2]-v[m]*h[2]),h[1],1,h[3]]):this.drawRect([h[0]+v[m]*h[2],h[1],1,h[3]])}}}drawMosaic(i){this.screenSlices=[];const[t,n,s,r]=this.getBoundsRegion(),c=this.screenFieldOfViewMM(0,!0),l=this.screenFieldOfViewMM(0);i=i.replaceAll(";"," ;").trim();const d=[],h=[],u=[],m=i.split(/\s+/);let g=1;const A=this.fontPx;let v=0,y=0,w=0;this.volumes[0]?.dims||(w=Math.ceil(this.opts.tileMargin*.3));for(let b=0;b<2;b++){let C=!1,S=!1,E=0,M=0,N=0,U=0,T=!1,F=0,I=0,B=0,V=0;for(let P=0;P<m.length;P++){const X=m[P];if(X.includes("X")){S=!0;continue}if(X.includes("L")){T=!X.includes("-");continue}if(X.includes("H")){P++,I=Math.abs(Math.max(0,Math.min(1,parseFloat(m[P]))));continue}if(X.includes("V")){P++;continue}if(X.includes("A")){F=0;continue}if(X.includes("C")){F=1;continue}if(X.includes("S")){F=2;continue}if(X.includes("R")){C=!0;continue}if(X.includes(";")){N+=E,U=Math.max(U,M+B),E=0,M=0,B=0;continue}V=B,I>0&&!C&&(V=Math.round(V*(1-I))),M+=V,V=0;const L=parseFloat(X);if(isNaN(L))continue;let H=0,W=l;if(C&&(W=c),F===2?V=W[1]:V=W[0],F===0?H=W[1]:H=W[2],b===0)C||(F===0&&d.push(L),F===1&&h.push(L),F===2&&u.push(L));else{const at=[t+v+g*M,n+y+g*N,g*V,g*H];if(this.fontPx=T?A:0,C){let ct=L<0?-1/0:1/0;Object.is(L,-0)&&(ct=-1/0),this.draw2D(at,F,ct)}else this.draw2D(at,F,L);S&&this.drawCrossLines(this.screenSlices.length-1,F,d,h,u),C=!1,S=!1}B=V,M+=w,E=Math.max(E,H)}if(N+=E,U=Math.max(U,M+B),U<=0||N<=0)break;const R=(s-2*this.opts.tileMargin-w)/U,Y=(r-2*this.opts.tileMargin)/N;g=Math.min(R,Y),this.opts.centerMosaic?(v=Math.floor(.5*(s-U*g)),y=Math.floor(.5*(r-N*g))):(v=this.opts.tileMargin,y=this.opts.tileMargin)}this.fontPx=A}calculateWidthHeight(i,t,n,s){let r,c;switch(i){case 0:r=t[0],c=t[1];break;case 1:r=t[0],c=t[2];break;case 2:r=t[1],c=t[2];break;default:return[n,s]}const l=r/c,d=n/s;let h,u;return l>d?(h=n,u=n/l):(u=s,h=s*l),[h,u]}getBoundsRegionCSS(){const i=this.gl.canvas.getBoundingClientRect();if(!this.opts.bounds)return[0,0,i.width,i.height];const[[t,n],[s,r]]=this.opts.bounds,c=Math.round(t*i.width),l=Math.round((s-t)*i.width),d=Math.round(n*i.height),h=Math.round(r*i.height),u=h-d,m=i.height-h;return[c,m,l,u]}eventInBounds(i){const t=this.gl.canvas.getBoundingClientRect();let n,s;if(i instanceof MouseEvent)n=i.clientX,s=i.clientY;else if(i instanceof TouchEvent){const m=i.touches[0]??i.changedTouches[0];if(!m)return!1;n=m.clientX,s=m.clientY}else n=i.clientX,s=i.clientY;const r=n-t.left,c=s-t.top,[l,d,h,u]=this.getBoundsRegionCSS();return r>=l&&r<=l+h&&c>=d&&c<=d+u}cursorInBounds(){if(this.mousePos[0]<0||this.mousePos[1]<0)return!1;const[i,t,n,s]=this.getBoundsRegion(),[r,c]=this.mousePos;return r>=i&&r<=i+n&&c>=t&&c<=t+s}getBoundsRegion(){const i=this.gl,t=this.uiData?.dpr||window.devicePixelRatio||1,n=i.canvas,s=n.clientWidth,r=n.clientHeight;if(!this.opts.bounds)return[0,0,i.canvas.width,i.canvas.height];const[[c,l],[d,h]]=this.opts.bounds,u=Math.floor(c*s*t),m=Math.ceil((d-c)*s*t);let g=Math.floor((1-h)*r*t),A=Math.ceil((h-l)*r*t);return g<0&&(A+=g,g=0),g+A>i.canvas.height&&(A=i.canvas.height-g),[u,g,m,A]}inBounds(i,t){const[n,s,r,c]=this.getBoundsRegion(),l=i*this.uiData.dpr,d=this.gl.canvas.height-t*this.uiData.dpr;return l>=n&&l<=n+r&&d>=s&&d<=s+c}bindTextures(){this.gl.activeTexture(Gn),this.gl.bindTexture(this.gl.TEXTURE_3D,this.volumeTexture),this.gl.activeTexture(Nl),this.gl.bindTexture(this.gl.TEXTURE_3D,this.overlayTexture),this.gl.activeTexture(zs),this.gl.bindTexture(this.gl.TEXTURE_3D,this.paqdTexture),this.gl.activeTexture(A2),this.gl.bindTexture(this.gl.TEXTURE_2D,this.fontTexture),this.gl.activeTexture(Xa),this.gl.bindTexture(this.gl.TEXTURE_2D,this.colormapTexture),this.gl.activeTexture(Yh),this.gl.bindTexture(this.gl.TEXTURE_2D,this.matCapTexture),this.gl.activeTexture(Vl),this.gl.bindTexture(this.gl.TEXTURE_3D,this.gradientTexture)}clearBounds(i=this.gl.COLOR_BUFFER_BIT|this.gl.DEPTH_BUFFER_BIT,t){const n=this.gl,[s,r,c,l]=t??this.getBoundsRegion(),d=n.canvas.height-r-l;i&n.DEPTH_BUFFER_BIT&&n.clearDepth(1),n.enable(n.SCISSOR_TEST),n.scissor(s,d,c,l),i&n.COLOR_BUFFER_BIT&&n.clearColor(this.opts.backColor[0],this.opts.backColor[1],this.opts.backColor[2],this.opts.backColor[3]),n.clear(i),n.disable(n.SCISSOR_TEST)}drawBoundsBorder(){if(!this.opts.showBoundsBorder)return;const[i,t,n,s]=this.getBoundsRegion();this.drawBoundsBox([i,t,n,s],this.opts.boundsBorderColor,this.opts.selectionBoxLineThickness)}drawSceneCore(){if(!this.initialized)return;this.colorbarHeight=0;const[i,t,n,s]=this.getBoundsRegion();if(this.gl.viewport(i,t,n,s),this.clearBounds(this.gl.COLOR_BUFFER_BIT|this.gl.DEPTH_BUFFER_BIT),this.bindTextures(),this.bmpTexture&&this.thumbnailVisible){this.drawThumbnail();return}let r="";if(this.volumes.length===0||typeof this.volumes[0].dims>"u"){if(this.meshes.length>0){if(this.sliceMosaicString.length>0){this.opts.isColorbar&&this.reserveColorbarPanel(),this.drawMosaic(this.sliceMosaicString),this.opts.isColorbar&&this.drawColorbar();return}this.screenSlices=[],this.draw3D([i,t,n,s]),this.opts.isColorbar&&this.drawColorbar();return}this.drawLoadingText(this.opts.loadingText);return}if(this.uiData.isDragging&&this.scene.clipPlaneDepthAziElevs[this.uiData.activeClipPlaneIndex][0]<1.8&&this.inRenderTile(this.uiData.dragStart[0],this.uiData.dragStart[1])>=0){const h=this.uiData.dragStart[0]-this.uiData.dragEnd[0],u=this.uiData.dragStart[1]-this.uiData.dragEnd[1],m=this.uiData.dragClipPlaneStartDepthAziElev.slice();if(m[1]-=h,m[1]=m[1]%360,m[2]+=u,m[1]!==this.scene.clipPlaneDepthAziElevs[this.uiData.activeClipPlaneIndex][1]||m[2]!==this.scene.clipPlaneDepthAziElevs[this.uiData.activeClipPlaneIndex][2])return this.scene.clipPlaneDepthAziElevs[this.uiData.activeClipPlaneIndex]=m,this.setClipPlane(this.scene.clipPlaneDepthAziElevs[this.uiData.activeClipPlaneIndex])}if(this.sliceMosaicString.length<1&&this.opts.sliceType===4){this.opts.isColorbar&&this.reserveColorbarPanel(),this.screenSlices=[],this.draw3D(),this.opts.isColorbar&&this.drawColorbar();return}this.opts.isColorbar&&this.reserveColorbarPanel();const c=this.getMaxVols(),l=this.opts.sliceType===3&&c>1&&this.graph.autoSizeMultiplanar&&this.graph.opacity>0;if(this.sliceMosaicString.length>0)this.drawMosaic(this.sliceMosaicString);else{const h=[0,0];let u=!1;if(this.screenSlices=[],this.customLayout&&this.customLayout.length>0){this.screenSlices=[];const{volScale:m}=this.sliceScale();for(const g of this.customLayout){const{sliceType:A,position:v,sliceMM:y}=g,w=[i+v[0]*n,t+v[1]*s,v[2]*n,v[3]*s];if(w[0]+w[2]>i+n&&(k.warn("adjusting slice width because it would have been clipped"),w[2]=i+n-w[0]),w[1]+w[3]>t+s&&(k.warn("adjusting slice height because it would have been clipped"),w[3]=t+s-w[1]),A===4)this.draw3D(w);else{const b=this.calculateWidthHeight(A,m,w[2],w[3]);this.draw2D(w,A,y??NaN,b)}}}else if(this.opts.sliceType===0||this.opts.sliceType===1||this.opts.sliceType===2){const{volScale:m}=this.sliceScale(),g=[i,t,n,s],A=this.calculateWidthHeight(this.opts.sliceType,m,g[2],g[3]);this.draw2D([0,0,0,0],this.opts.sliceType,NaN,A)}else{let m=function($,et){return[($-1)*w+$*b,(et-1)*w+et*b]},g=!1;this.opts.multiplanarForceRender?(g=!0,this.opts.multiplanarForceRender?this.opts.multiplanarShowRender=1:this.opts.multiplanarShowRender=2,delete this.opts.multiplanarForceRender):this.opts.multiplanarShowRender===1&&(g=!0);const A=isFinite(this.drawPenLocation[0])&&this.opts.drawingEnabled,{volScale:v}=this.sliceScale(),y=v.slice();this.opts.multiplanarEqualSize&&(v[0]=1,v[1]=1,v[2]=1),typeof this.opts.multiplanarPadPixels!="number"&&k.debug("multiplanarPadPixels must be numeric");const w=parseFloat(`${this.opts.multiplanarPadPixels}`)*this.uiData.dpr;let b=this.opts.tileMargin*this.uiData.dpr;b<0&&(b=2*(2+Math.ceil(this.fontPx)));const[C,S,E,M]=this.getBoundsRegion();let N=[this.effectiveCanvasWidth(),this.effectiveCanvasHeight()];this.opts.heroImageFraction>0&&this.opts.heroImageFraction<1&&(g=!1,u=!0,N[0]>N[1]&&this.opts.multiplanarLayout!==3?h[0]=N[0]*this.opts.heroImageFraction:h[1]=N[1]*this.opts.heroImageFraction,N=[N[0]-h[0],N[1]-h[1]]);const U=this.scaleSlice(v[0]+v[1],v[1]+v[2],m(2,2),N),T=Math.max(Math.max(v[1],v[2]),v[0]),F=this.scaleSlice(v[0]+v[0]+v[1],Math.max(v[1],v[2]),m(3,1),N),I=this.scaleSlice(v[0]+v[0]+v[1]+T,Math.max(v[1],v[2]),m(4,1),N),B=this.scaleSlice(T,v[1]+v[2]+v[2],m(1,3),N),V=this.scaleSlice(T,v[1]+v[2]+v[2]+T,m(1,4),N);let R=!A&&(c<2||!l),Y=!1,P=!1,X=!1;this.opts.multiplanarLayout===1?Y=!0:this.opts.multiplanarLayout===2?P=!0:this.opts.multiplanarLayout===3?X=!0:B[4]>F[4]&&B[4]>U[4]?Y=!0:F[4]>U[4]?X=!0:P=!0;let L=U;if(Y?(L=B,!u&&(g||this.opts.multiplanarShowRender===2&&V[4]>=B[4])?L=V:R=!1):X&&(L=F,!u&&(g||this.opts.multiplanarShowRender===2&&I[4]>=F[4])?L=I:R=!1),u){const $=h[0]===0?E:h[0],et=h[1]===0?M:h[1];if(this.opts?.heroSliceType===0||this.opts?.heroSliceType===1||this.opts?.heroSliceType===2)this.draw2D([C,S,$,et],this.opts.heroSliceType,NaN,[1/0,1/0]);else{const ot=L.slice();$===E&&(ot[0]=0),this.draw3D([C+ot[0],S,$,et])}L[0]+=h[0],L[1]+=h[1],R=!1}const H=v[0]*L[4]+b,W=v[1]*L[4]+b,at=v[2]*L[4]+b,ct=y[0]*L[4],G=y[1]*L[4],j=y[2]*L[4];if(Y){if(this.draw2D([C+L[0],S+L[1],H,W],0,NaN,[ct,G]),this.draw2D([C+L[0],S+L[1]+W+w,H,at],1,NaN,[ct,j]),this.draw2D([C+L[0],S+L[1]+W+w+at+w,W,at],2,NaN,[G,j]),R){const $=T*L[4];this.draw3D([C+L[0],S+L[1]+W+at+at+w*3,$,$])}}else if(X){if(this.draw2D([C+L[0],S+L[1],H,W],0,NaN,[ct,G]),this.draw2D([C+L[0]+H+w,S+L[1],H,at],1,NaN,[ct,j]),this.draw2D([C+L[0]+H+H+w*2,S+L[1],W,at],2,NaN,[G,j]),R){const $=T*L[4];this.draw3D([C+L[0]+H+H+W+w*3,S+L[1],$,$])}}else P&&(g||(R=!1),this.opts.multiplanarShowRender===2&&(R=!0),u&&(R=!1),this.draw2D([C+L[0],S+L[1]+at+w,H,W],0,NaN,[ct,G]),this.draw2D([C+L[0],S+L[1],H,at],1,NaN,[ct,j]),this.draw2D([C+L[0]+H+w,S+L[1],W,at],2,NaN,[G,j]),R&&this.draw3D([C+L[0]+H+w,S+L[1]+at+w,W,W]))}}if(this.opts.isRuler&&this.drawRuler(),this.opts.isColorbar&&this.drawColorbar(),l&&this.drawGraph(),this.uiData.isDragging){if(this.uiData.mouseButtonCenterDown){this.dragForCenterButton([this.uiData.dragStart[0],this.uiData.dragStart[1],this.uiData.dragEnd[0],this.uiData.dragEnd[1]]);return}if(this.getCurrentDragMode()===4){this.dragForSlicer3D([this.uiData.dragStart[0],this.uiData.dragStart[1],this.uiData.dragEnd[0],this.uiData.dragEnd[1]]);return}if(this.getCurrentDragMode()===3){this.dragForPanZoom([this.uiData.dragStart[0],this.uiData.dragStart[1],this.uiData.dragEnd[0],this.uiData.dragEnd[1]]);return}if(this.inRenderTile(this.uiData.dragStart[0],this.uiData.dragStart[1])>=0)return;this.getCurrentDragMode()===2&&this.drawMeasurementTool([this.uiData.dragStart[0],this.uiData.dragStart[1],this.uiData.dragEnd[0],this.uiData.dragEnd[1]]),this.getCurrentDragMode()===7&&this.drawAngleMeasurementTool();const h=this.getCurrentDragMode();if(h===1||h===6){const u=Math.abs(this.uiData.dragStart[0]-this.uiData.dragEnd[0]),m=Math.abs(this.uiData.dragStart[1]-this.uiData.dragEnd[1]);this.drawSelectionBox([Math.min(this.uiData.dragStart[0],this.uiData.dragEnd[0]),Math.min(this.uiData.dragStart[1],this.uiData.dragEnd[1]),u,m])}}for(const h of this.document.completedMeasurements)if(this.shouldDrawOnCurrentSlice(h.sliceIndex,h.sliceType,h.slicePosition)){const u=this.mm2frac(h.startMM),m=this.mm2frac(h.endMM),g=this.frac2canvasPosWithTile(u,h.sliceType),A=this.frac2canvasPosWithTile(m,h.sliceType);g&&A&&g.tileIndex===A.tileIndex&&this.drawMeasurementTool([g.pos[0],g.pos[1],A.pos[0],A.pos[1]])}for(let h=0;h<this.document.completedAngles.length;h++){const u=this.document.completedAngles[h];if(this.shouldDrawOnCurrentSlice(u.sliceIndex,u.sliceType,u.slicePosition)){const g=this.mm2frac(u.firstLineMM.start),A=this.mm2frac(u.firstLineMM.end),v=this.mm2frac(u.secondLineMM.start),y=this.mm2frac(u.secondLineMM.end),w=this.frac2canvasPosWithTile(g,u.sliceType),b=this.frac2canvasPosWithTile(A,u.sliceType),C=this.frac2canvasPosWithTile(v,u.sliceType),S=this.frac2canvasPosWithTile(y,u.sliceType);if(w&&b&&C&&S&&w.tileIndex===b.tileIndex&&w.tileIndex===C.tileIndex&&w.tileIndex===S.tileIndex){this.drawMeasurementTool([w.pos[0],w.pos[1],b.pos[0],b.pos[1]],!1),this.drawMeasurementTool([C.pos[0],C.pos[1],S.pos[0],S.pos[1]],!1);const E={firstLine:[w.pos[0],w.pos[1],b.pos[0],b.pos[1]],secondLine:[C.pos[0],C.pos[1],S.pos[0],S.pos[1]],sliceIndex:u.sliceIndex,sliceType:u.sliceType,slicePosition:u.slicePosition};this.drawAngleTextForAngle(E)}}}const d=this.frac2mm([this.scene.crosshairPos[0],this.scene.crosshairPos[1],this.scene.crosshairPos[2]]);return r=d[0].toFixed(2)+"×"+d[1].toFixed(2)+"×"+d[2].toFixed(2),this.readyForSync=!0,this.sync(),this.drawAnchoredLabels(),this.drawBoundsBorder(),r}drawScene(){if(this.isBusy){this.needsRefresh=!0;return}this.isBusy=!1,this.needsRefresh=!1;let i=this.drawSceneCore();return this._gl!==null&&this.gl.finish(),this.needsRefresh&&(i=this.drawScene()),i}get gl(){if(!this._gl)throw new Error("unable to get WebGL context. Maybe the browser doesn't support WebGL2.");return this._gl}set gl(i){this._gl=i}findDrawingBoundarySlices(i){if(!this.back||!this.back.dims||!this.drawBitmap)return null;const t={dimX:this.back.dims[1],dimY:this.back.dims[2],dimZ:this.back.dims[3]};return E4(i,this.drawBitmap,t)}interpolateMaskSlices(i,t,n={}){if(!this.back||!this.back.dims||!this.drawBitmap)throw new Error("Background image and drawing bitmap must be loaded");const s={dimX:this.back.dims[1],dimY:this.back.dims[2],dimZ:this.back.dims[3]},r=this.back.img,c=this.back.global_max;B4(this.drawBitmap,s,r,c,i,t,n,()=>this.refreshDrawing(!0))}};Hn=new WeakMap;function Hv({backgroundUrl:i,overlayUrl:t,onError:n}){const s=Lt.useRef(null),r=Lt.useRef(null),c=Lt.useRef(n),[l,d]=Lt.useState(null);return Lt.useEffect(()=>{c.current=n}),Lt.useEffect(()=>{if(!s.current)return;const h=new Gv({backColor:[.05,.05,.05,1],show3Dcrosshair:!0,crosshairColor:[1,0,0,.5]});return h.attachToCanvas(s.current),r.current=h,()=>{const u=h.gl;try{h.cleanup(),u&&u.getExtension("WEBGL_lose_context")?.loseContext()}catch{}r.current=null}},[]),Lt.useEffect(()=>{const h=r.current;if(!h)return;let u=!0;d(null);const m=[{url:i,colormap:"gray",opacity:1}];return t&&m.push({url:t,colormap:"red",opacity:.5}),h.loadVolumes(m).catch(g=>{if(!u)return;const A=g instanceof Error?g.message:"Failed to load volume";d(A),c.current?.(A)}),()=>{u=!1}},[i,t]),ht.jsxs("div",{className:"bg-gray-900 rounded-lg p-2",children:[ht.jsx("canvas",{ref:s,className:"w-full h-[500px] rounded"}),l&&ht.jsxs("div",{className:"mt-2 p-2 bg-red-900/50 rounded text-red-300 text-sm",children:["Failed to load volume: ",l]}),ht.jsxs("div",{className:"flex gap-4 mt-2 text-xs text-gray-400",children:[ht.jsx("span",{children:"Scroll: Navigate slices"}),ht.jsx("span",{children:"Drag: Adjust contrast"}),ht.jsx("span",{children:"Right-click: Pan"})]})]})}function qv({metrics:i}){return ht.jsxs("div",{className:"bg-gray-800 rounded-lg p-4 space-y-3",children:[ht.jsx("h3",{className:"font-medium text-lg",children:"Results"}),ht.jsxs("div",{className:"grid grid-cols-2 gap-3 text-sm",children:[ht.jsxs("div",{children:[ht.jsx("span",{className:"text-gray-400",children:"Case:"}),ht.jsx("span",{className:"ml-2 font-mono",children:i.caseId})]}),i.diceScore!==null&&ht.jsxs("div",{children:[ht.jsx("span",{className:"text-gray-400",children:"Dice Score:"}),ht.jsx("span",{className:"ml-2 font-mono text-green-400",children:i.diceScore.toFixed(3)})]}),i.volumeMl!==null&&ht.jsxs("div",{children:[ht.jsx("span",{className:"text-gray-400",children:"Volume:"}),ht.jsxs("span",{className:"ml-2 font-mono",children:[i.volumeMl.toFixed(2)," mL"]})]}),ht.jsxs("div",{children:[ht.jsx("span",{className:"text-gray-400",children:"Time:"}),ht.jsxs("span",{className:"ml-2 font-mono",children:[i.elapsedSeconds.toFixed(1),"s"]})]})]}),i.warning&&ht.jsx("div",{className:"mt-3 p-2 bg-yellow-900/30 border border-yellow-600/50 rounded text-xs text-yellow-300",children:i.warning})]})}function Xv({progress:i,message:t,status:n,elapsedSeconds:s}){const r=n==="failed",c=n==="completed",l=n==="waking_up",d=r?"bg-red-500":c?"bg-green-500":l?"bg-yellow-500":"bg-blue-500",h=n==="running"||n==="pending"||n==="waking_up"?"animate-pulse":"";return ht.jsxs("div",{className:"bg-gray-800 rounded-lg p-4 space-y-3",children:[ht.jsxs("div",{className:"flex justify-between items-center text-sm",children:[ht.jsx("span",{className:"text-gray-300 font-medium",children:t}),ht.jsxs("span",{className:"text-gray-400 tabular-nums",children:[i,"%"]})]}),ht.jsx("div",{className:"w-full bg-gray-700 rounded-full h-2.5 overflow-hidden",children:ht.jsx("div",{className:`h-full rounded-full transition-all duration-500 ease-out ${d} ${h}`,style:{width:`${i}%`},role:"progressbar","aria-valuenow":i,"aria-valuemin":0,"aria-valuemax":100,"aria-label":t})}),ht.jsxs("div",{className:"flex justify-between items-center text-xs text-gray-500",children:[s!==void 0?ht.jsxs("span",{className:"tabular-nums",children:["Elapsed: ",s.toFixed(1),"s"]}):ht.jsx("span",{children:"Starting..."}),ht.jsx("span",{className:`capitalize ${r?"text-red-400":c?"text-green-400":l?"text-yellow-400":"text-blue-400"}`,children:n==="waking_up"?"waking up":n})]})]})}class Kv extends Lt.Component{constructor(t){super(t),this.state={hasError:!1,error:null}}static getDerivedStateFromError(t){return{hasError:!0,error:t}}componentDidCatch(t,n){console.error("ErrorBoundary caught an error")}handleRetry=()=>{this.setState({hasError:!1,error:null})};render(){return this.state.hasError?this.props.fallback?this.props.fallback:ht.jsx("div",{className:"min-h-screen bg-gray-900 flex items-center justify-center p-4",children:ht.jsxs("div",{className:"bg-gray-800 rounded-lg p-6 max-w-md w-full text-center space-y-4",children:[ht.jsx("div",{className:"text-red-400 text-4xl",children:"Something went wrong"}),ht.jsx("p",{className:"text-gray-300",children:"An unexpected error occurred while rendering the application."}),this.state.error&&this.props.showDetails&&ht.jsxs("details",{className:"text-left",children:[ht.jsx("summary",{className:"text-gray-400 cursor-pointer hover:text-gray-300",children:"Error details"}),ht.jsx("pre",{className:"mt-2 p-2 bg-gray-900 rounded text-xs text-red-300 overflow-auto max-h-32",children:this.state.error.message})]}),ht.jsx("button",{onClick:this.handleRetry,className:"bg-blue-600 hover:bg-blue-700 text-white font-medium py-2 px-4 rounded-lg transition-colors",children:"Try Again"})]})}):this.props.children}}const jv=2e3;function Qv(){const[i,t]=Lt.useState(null),[n,s]=Lt.useState(null),[r,c]=Lt.useState(null),[l,d]=Lt.useState(null),[h,u]=Lt.useState(0),[m,g]=Lt.useState(""),[A,v]=Lt.useState(void 0),[y,w]=Lt.useState(!1),b=Lt.useRef(null),C=Lt.useRef(null),S=Lt.useRef(null),E=Lt.useCallback(()=>{C.current&&(clearInterval(C.current),C.current=null)},[]),M=Lt.useCallback(async(T,F)=>{if(T!==b.current){E();return}try{const I=await Gh.getJobStatus(T,F);if(T!==b.current)return;d(I.status),u(I.progress),g(I.progressMessage),v(I.elapsedSeconds),I.status==="completed"&&I.result&&(E(),w(!1),t({dwiUrl:I.result.dwiUrl,predictionUrl:I.result.predictionUrl,metrics:{caseId:I.result.caseId,diceScore:I.result.diceScore,volumeMl:I.result.volumeMl,elapsedSeconds:I.result.elapsedSeconds,warning:I.result.warning}})),I.status==="failed"&&(E(),w(!1),s(I.error||"Job failed"),t(null))}catch(I){if(I instanceof Error&&I.name==="AbortError")return;if(I instanceof Kn&&I.status===404){E(),w(!1),d("failed"),s("Job expired or lost. This can happen if the backend restarted. Please try again."),t(null);return}console.warn("Polling error (will retry):",I)}},[E]),N=Lt.useCallback(async(T,F=!0)=>{E(),S.current?.abort();const I=new AbortController;S.current=I,s(null),t(null),u(0),g("Creating job..."),d("pending"),v(void 0),w(!0);let B=0;for(;B<=qs;)try{const V=await Gh.createSegmentJob(T,F,I.signal),R=V.jobId;c(R),b.current=R,d(V.status),g(V.message),C.current=window.setInterval(()=>{M(R,I.signal)},jv),await M(R,I.signal);return}catch(V){if(V instanceof Error&&V.name==="AbortError")return;const R=V instanceof Kn&&V.status===503,Y=V instanceof TypeError&&V.message.toLowerCase().includes("fetch");if((R||Y)&&B<qs){B++,d("waking_up"),g(`Backend is waking up... Please wait (~30-60s). Retry ${B}/${qs}`),u(0),await WA(w2(B));continue}const P=R||Y?"Backend failed to wake up. Please try again later.":V instanceof Error?V.message:"Failed to start job";s(P),w(!1),d("failed");return}},[M,E]),U=Lt.useCallback(()=>{E(),S.current?.abort(),b.current=null,w(!1),d(null),u(0),g("")},[E]);return Lt.useEffect(()=>()=>{E(),S.current?.abort()},[E]),{result:i,error:n,jobId:r,jobStatus:l,progress:h,progressMessage:m,elapsedSeconds:A,isLoading:y,runSegmentation:N,cancelJob:U}}function Zv(){const[i,t]=Lt.useState(null),{result:n,isLoading:s,error:r,jobStatus:c,progress:l,progressMessage:d,elapsedSeconds:h,runSegmentation:u,cancelJob:m}=Qv(),g=async()=>{i&&await u(i)},A=s&&c&&c!=="completed";return ht.jsx(qA,{children:ht.jsxs("div",{className:"grid grid-cols-1 lg:grid-cols-3 gap-6",children:[ht.jsxs("div",{className:"space-y-4",children:[ht.jsx(_A,{selectedCase:i,onSelectCase:t}),ht.jsx("button",{onClick:g,disabled:!i||s,className:`w-full bg-blue-600 hover:bg-blue-700 disabled:bg-gray-600
+                       disabled:cursor-not-allowed text-white font-medium
+                       py-3 px-4 rounded-lg transition-colors`,children:s?"Processing...":"Run Segmentation"}),s&&ht.jsx("button",{onClick:m,className:`w-full bg-gray-700 hover:bg-gray-600 text-gray-300
+                         font-medium py-2 px-4 rounded-lg transition-colors text-sm`,children:"Cancel"}),A&&ht.jsx(Xv,{progress:l,message:d,status:c,elapsedSeconds:h}),r&&!s&&ht.jsxs("div",{role:"alert",className:"bg-red-900/50 text-red-300 p-3 rounded-lg text-sm",children:[ht.jsx("p",{className:"font-medium",children:"Error"}),ht.jsx("p",{className:"mt-1",children:r})]}),n&&ht.jsx(qv,{metrics:n.metrics})]}),ht.jsx("div",{className:"lg:col-span-2",children:n?ht.jsx(Hv,{backgroundUrl:n.dwiUrl,overlayUrl:n.predictionUrl}):ht.jsx("div",{className:"bg-gray-900 rounded-lg h-[500px] flex items-center justify-center",children:ht.jsx("p",{className:"text-gray-400",children:s?"Processing segmentation...":"Select a case and run segmentation to view results"})})})]})})}function Wv(){return ht.jsx(Kv,{children:ht.jsx(Zv,{})})}HA.createRoot(document.getElementById("root")).render(ht.jsx(Lt.StrictMode,{children:ht.jsx(Wv,{})}));