title_sr stringlengths 11 267 | title_en stringlengths 0 918 | abstract_sr stringlengths 36 21.4k | abstract_en stringlengths 43 16.7k | full_abstract bool 2
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Strukturna i funkcionalna analiza gena za alfa-1-antitripsin u bolestima pluća čoveka | Structural and functional analysis of alpha-1-antitrypsin gene in human lung diseases | Alfa-1-antitripsin je inhibitor serin proteaza čija je osnovna biološka funkcija inhibicija
elastaze neutrofila – enzima koji učestvuje u degradaciji elastina i koji dovodi do oštećenja
tkiva pluća. Deficijencija i disfunkcija alfa-1-antitripsina leže u osnovi više oboljenja od
kojih su najčešći emfizem pluća i obol... | Alpha-1-antitrypsin is a serine protease inhibitor whose main biological function is
inhibition of neutrophil elastase – enzyme capable of digestion of elastin and involved in
lung tissue destruction. Deficiency and disfunction of alpha-1-antitrypsin is associated with
emphysema and liver disease, and can represent ... | true |
Uticaj delimičnog isušivanja korenova na ekspresiju NCED, TAO1 i EIL1 gena i rastenje divljeg tipa i flacca mutanta paradajza (Lycopersicon esculentum Mill.) | The effect of partial root-zone drying on expression of NCED, TAO1 and EIL1 genes and growth in tomato wild-type and flacca mutant (Lycopersicon esculentum Mill.) | Cilj ovog istraţivanja je bio karakterizacija fizioloških procesa koji su u osnovi
regulacije rastenja i razvića biljaka paradajza pod dejstvom delimiĉnog isušivanja
korenova (Partial root-zone drying -PRD), ali i regulisanog deficita navodnjavanja
(Regulated deficit irrigation - RDI). Cilj je bio i da se u ova ispi... | The aim of presented PhD thesis was to investigate the physiological mechanisms that
are in the base of tomato growth and development under partial root-zone drying (PRD)
and regulated deficit irrigation (RDI). Investigations included plant growth, water
regime, gas exchange, abscisic acid (ABA) content in the leave... | true |
Studija asocijacije genetičkih varijanti u regionima 7q36, 8q24 i 17q12 sa rizikom za razvoj i progresiju karcinoma prostate | Association study of common genetic variants in regions 7q36, 8q24 and 17q12 with prostate cancer | Karcinom prostate je drugi najčešće dijagnostikovan maligni tumor muškaraca u svetu, i
šesti po broju smrtnih slučajeva. Standardni dijagnostički i prognostički parametri KP
su serumska vrednost prostata specifičnog antigena (PSA), Glison gradus sistem (GGS),
i klinički stadijum KP. Studije asocijacije na čitavom ge... | Prostate cancer (PCa) is the second most frequently diagnosed malignant tumor, and the
sixth leading cause of cancer-related deaths among men worldwide. Standard diagnostic
and prognostic parameters are serum PSA level, Gleason gradus score, and the clinical
stage of PCa. Genome-wide association studies (GWAS) have ... | true |
Promena boje cveta perunike (Iris germanica L.) genetičkom modifikacijom biosinteze karotenoida | Alteration of flower color of Iris germanica L. through genetic modification of carotenoid biosynthetic pathway | Boja cveta perunike (Iris germanica L.) je određena na osnovu dva odvojena
biohemijska puta sinteze biljnih pigmenata. Na osnovu biosinteze karotenoida dobijaju
se cvetovi žute, narandžaste i ružičaste boje, dok biosinteza antocijanina dovodi do
plave, ljubičaste i bordo boje cvetova. Crvene perunike ne postoje u pr... | Flower color in irises (Iris germanica L.) is determined by two distinct
biochemical pathways. The carotenoid biosynthetic pathway generates yellow, orange
and pink flowers, while the anthocyanin biosynthetic pathway produces blue, violet and
purple flowers. Red iris flowers do not exist naturally, and conventional ... | true |
Ekološka istraživanja juvenilnog inćuna, Engraulis encrasicolus (Linnaeus, 1758) u Kotorskom zalivu | Ecological study of the juvenile anchovy, Engraulis encrasicolus (Linnaeus, 1758) in the Bay of Kotor | U ovoj disertaciji prikazani su rezultati dvogodišnjeg istraživanja ekoloških
karakteristika juvenilnog inćuna, Engraulis encrasicolus (L.), na području Kotorskog
zaliva. S obzirom da se ribolov ove vrste na području Kotorskog zaliva obavlja
tradicionalnom metodom, korišćenjem mreža potegača sa vrlo malim okom na mr... | This thesis presents the results of a two-year research of ecological parameters
of juvenile European anchovy, Engraulis encrasicolus (L.), in the Bay of Kotor.
Considering that the anchovy fisheries in this region have been for centuries
performed using beach seines with very small mesh size (6 mm), one of the main... | true |
Procena angiogenih i anti-inflamatornih efekata ekstrakorporealne terapije zvučnim udarnim talasima na animalnom modelu ishemije kožnih režnjeva | Evaluation of angiogenic and anti-inflammatory effects of extracorporeal shockwave therapy in animal model of ischemic skin flaps | Skoro 30 godina terapija zvučnim udarnim talasima (engl. Extracorporeal Shock
Wave Therapy, ESWT) je u upotrebi u kliničkoj praksi kao efikasan tretman za razbijanje
kamena u urinarnom traktu. Ova tehnologija je kasnije razvijena i kao efikasan
neinvazivan tretman za različite indikacije u ortopediji i traumatologij... | For almost 30 years, extracorporeal shock wave therapy (ESWT) has been
implemented clinically and has proven to be an effective treatment for urinary stones.
This technology has also emerged as an efficacious non-invasive treatment modality for
several orthopedic and traumatic indications including problematic soft ... | true |
Ekološka i toksikološka istraživanja crnomorske haringe (Alosa immaculata Bennett, 1835) u Dunavu u Srbiji | Ecological and toxicological study of the Pontic shad (Alosa immaculata Bennett, 1835) in the Danube River in Serbia | Crnomorska haringa (Alosa immaculata, Bennett 1835) je anadromna vrsta koja
veći deo života provodi u jako zagađenom severoistočnom delu Crnog mora, a radi
mresta migrira u Dunav. Populacije crnomorske haringe imaju opadajući trend
brojnosti, tako da se prema IUCN Crvenoj listi ugroženih vrsta tretira kao ranjiva vr... | The Pontic shad (Alosa immaculata Bennett 1835) is an anadromous species that
spends most of its life cycle in the heavily polluted northwestern part of the Black Sea
and migrates into the Danube River to spawn. Populations of the Pontic shad have a
declining trend, and according to the IUCN Red List of Threatened S... | true |
Fitohemijska i genetička varijabilnost vrsta iz sekcije Serpyllum (Mill.) Benth. roda Thymus L. (Lamiaceae) u Srbiji | Phytochemical and genetical variability of species from section Serpyllum (Mill.) Benth. genus Thymus L. (Lamiaceae) in Serbia | Rod Thymus je po broju vrsta jedan od najznaĉajnijih u okviru familije
Lamiaceae. U zavisnosti od pristupa autora broj vrsta unutar roda varira, meĊutim
ukoliko se izabere pristup minimalne varijabilnosti, prema raspoloţivim podacima
opisano je 215 vrsta ovog roda. Vrste ovog roda podeljene su u osam sekcija. U flor... | In terms of the number of species, the genus Thymus is one of the most
important genera within the Lamiaceae family. The number of species may vary
depending on the approach of the author, but if the concept of minimal variability is
chosen 215 species have been described. This genus is divided into 8 sections. In F... | true |
Uticaj promenljivog magnetnog polja na motorno ponašanje pacova u laboratorijskim uslovima | Effect of an alternating magnetic field on motor behaviour of rats in laboratory conditions | Brojne studije su pokazale da promenljiva magnetna polja ekstremno niskih frekvencija (ENF-MP) utiču na motorno ponašanje eksperimentalnih životinja i ljudi, ali još uvek nisu u potpunosti razjašnjene veze između promena u neurotransmiterskim sistemima odgovornim za kontrolu motorne aktivnosti i promena u ponašanju. Ci... | Numerous studies have shown that alternating magnetic fields of extremely low frequency (ELF-MF) affect motor behaviour of experimental animals and humans, but the connections between changes in neurotransmitter systems involved in motor control and changes in behaviour are not yet completely explained. The purpose of ... | false |
Fiziološki i biohemijski aspekti regeneracije košutice (Fritillaria meleagris L.) in vitro | Physiological and biochemical aspects of regeneration snake's head fritillary (Fritillaria meleargis L.) in vitro | Proučavana je in vitro regeneracijia košutice (Fritillaria meleagris), višegodišnje
lukovičaste geofite. Indukcija morfogeneze in vitro košutice postignuta je u kulturi zrelih
zigotskih embriona, segmenata lukovica kao i bazalnih delova listova in vitro formiranih
lukovica. U kulturi zrelih zigotskih embriona regene... | We have investigated in vitro regeneration of snake’head fritillary (Fritillaria
meleagris L.), a perennial bulbous geophyte. The induction of morphogenesis in vitro of
snake’head fritillary was achieved in mature zygotic embryo culture, scale segment and leaf
base culture of in vitro formed bulbs. Plant regeneratio... | true |
Floristička, taksonomska i ekološka istraživanja dezmidnih algi Srbije | Floristical, taxonomical and ecological study of desmid algae in Serbia | Doktorska disertacija obuhvata istraživanja dezmidnih algi na teritoriji Srbije. Algološki
uzorci (299) za ovo istraživanje sakupljeni su u periodu od 2007. do 2011. godine sa 37
lokaliteta.
Istraživanje je obuhvatilo različite tipove vodenih staništa: tresave, veštačke
akumulacije, slane bare i ribnjake. Sa najveć... | The work compements and develops investigations on the desmid algae of Serbia.
Algological samples (299) for this study were collected from 37 localities during the
years 2007-2011.
The samples of phytoplankton, benthos and epiphyte were collected from pit bogs,
reservoirs, salt marshes and fish ponds.
Detailed de... | true |
Uticaj elektromagnetnog polja (2 mT, 50 Hz) na spontanu bioelektričnu aktivnost neurona antenalnog lobusa adulta Morimus funereus (Insecta, Coleoptera) | The influence of electromagnetic field (2 mT, 50 Hz) on spontaneous bioelectrical activity of antennal lobe neurons of adult Morimus funereus (Insecta, Coleoptera) | Spoljašnja magnetna polja (MP) narušavaju ravnotežu bioloških sistema, čak i
tokom kraćeg vremena izlaganja, što za posledicu ima poremećaje na različitim nivoima
organizacije. Na ovaj način nastali poremaćaji akumuliraju se u organizmima, što je jedan
od razloga za traženje objašnjenja bioloških efekata MP. S druge... | External magnetic fields (MF) disturb the equilibrium of biological systems, even
during short-term exposure, resulting in disturbances at different levels of organization.
These changes accumulate in organisms, which is one of the reasons for testing biological
effects of MF. On the other hand, the fact that modern... | true |
Adaptivan ili stabilan odgovor Amy-genotipova Drosophila subobscura u uslovima diskretnih i naglih promena sredine | Adaptive or stable response of Amy - genotypes of Drosophila subobscura in the conditions of discrete and abrupt changes of environment | U savremenoj biologiji opšte je prihvaćen stav da se organizmi i populacije ne mogu posmatrati izvan svojih sredina. U dinamici genofonda populacije značajan je stepen uspešnosti odgovora različitih genotipova na promene uslova sredine. Stoga je sagledavanje mogućih vidova interakcije različitih genotipova i sredina zn... | In modern biology, it is the generally accepted that organisms and populations can not be observed separately from their environments. Effectiveness of responses of different genotypes to environmental changes is essential for the dynamics of population gene pool. Therefore, consideration of the possible forms of inter... | false |
Spektralna analiza elektrokortikalne aktivnosti mozga pacova u modelu intoksikacije aluminijumom | Spectral analysis of electrocortical brain activity in rat model of aluminium intoxication | Cilj ove teze je prikaz metoda za kvalitativnu i kvantitativnu analizu moždane aktivnosti. Ujedno je matematički urađena biomedicinska aproksimacija rezultata. Animalni model intoksikacije aluminijumom je korišćen zbog rasprostranjenosti aluminijuma u prirodi i okruženju. Aluminijum ima selektivno neurotoksično dejstvo... | The aim of the study was quantitative and qualitative analysis of electrocortical brain activity in rat model of aluminium intoxication. We used animal model of aluminium intoxication becouse aluminium toxicity is widespread in nature. Aluminium has selective effects on different brain regiones. Animal model included d... | false |
Zaštitni efekat probiotika na modelu toksičnosti kadmiuma kod pacova | Protective effects of probiotics in the model of cadmium toxicity in rats | Kadmijum je široko prisutni toksikant životne sredine, koji izaziva različite poremećaje
u biološkim sistemima, uključujući tu i bubrežnu disfunkciju i degeneraciju tkiva jetre. Sa
druge strane, pretpostavlja se da su pozitivne osobine probiotskih bakterija u vezi sa njihovom
sposobnošću da vezuju različite ligande,... | Cadmium is a ubiquitous environmental toxicant that causes a variety of disturbances
in biological systems, including renal dysfunction and liver tissue degeneration. On the other
hand, it is supposed that beneficial properties of probiotic bacteria are related to their capacity
to adhere or bind different targets, ... | true |
Fiziološki i morfološki efekti ekspresije AtCKX gena u transformisanim biljkama krompira (Solanum tuberosum L.) gajenim in vitro | Physiological and morphological effects of expression of AtcKX genes in transformed potato (Solanum tuberosum l.) plants grown in vitro | Krompir (Solanum tuberosum L.) je po značaju četvrta poljoprivredna kultura
na svetu gajena za potrebe ljudske ishrane. Ekonomski značaj krompira potiče od
krtola, jestivih podzemnih modifikacija bočnih izdanaka koji omogućavaju
nakupljanje rezervi skroba. Brojna istraživanja potvrdila su da biljni hormoni
citokini... | Potato (Solanum tuberosum L.) is the world's fourth most important food
crop. Its economical importance arises from its potential to develop tubers, edible
storage organs derived from modified underground lateral shoots, which
accumulate starch. Extensive research has provided evidence that plant hormones
cytokinin... | true |
Uticaj B vitaminskih kompleksa i ribavirina na odgovor nervnih i glijskih ćelija i oporavak motornih funkcija nakon povrede mozga pacova | The effect of vitamin B complexes and ribavirin on response of neuronal and glial cells and recovery of motor function after injury to the rat brain | Traumatska povreda mozga (TPM) predstavlja veliki zdravstveni problem
savremenog društva jer je vodeći uzrok smrti i invaliditeta kod mlađih osoba. Uprkos
znatnim istraživačkim i kliničkim naporima, još uvek ne postoji ni jedan dovoljno
uspešan terapijski pristup koji utiče na sve patofiziološke procese koji prate m... | Traumatic brain injury (TBI) is a major health problem in modern society, being
a leading cause of death and disability among young people. Despite huge basic
research and clinical efforts an effective treatment for TBI has not been established yet,
that will counteract all of pathophysiological processes accompanyi... | true |
Evoluciona ekofiziologija stresa : uloga enzimskih i neenzimskih antioksidanata u prirodnim populacijama Iris pumila L. (Iridaceae) | Evolutionary ecophysiology of stress: the role of enzymatic and non-enzymatic antioxidants in natural populations of Iris pumila L. (Iridaceae) | U evolucionoj biologiji sredinski stres se definiše kao mehanizam koji
dovodi do adaptacija i evolucije u promenljivoj sredini, i istovremeno uključuje
svojstva stresora, kao sredinsku komponentu i stresiranih, kao biološku
komponentu. Više biljke, kao modularni i sesilni organizmi, razvile su tokom
evolucije velik... | In evolutionary biology, environmental stress is defined as a mechanism
that leads to adaptation and evolution in a variable environment and includes
properties of stress, as an environmental component, and stressed, as the
biological component. During the evolution higher plants, as sessile and
modular organisms, ... | true |
Uticaj propofola na signalni put neurotrofina u prednjem mozgu pacova starih 14 dana | Propofol-induced changes in neurotrophic signaling in 14-day-old rat forebrain | Neurotrofini čine familiju signalnih molekula sa brojnim uticajima na rast,
preživljavanje, diferencijaciju i sinaptičku plastičnost postmitotskih neurona, kako u
adultnom mozgu, tako i u mozgu tokom razvića. Neurotrofini (BDNF, NGF) se sa
određenim afinitetom vezuju za Trk receptore, iniciraju njihovu dimerizaciju ... | The neurotrophins are a family of secreted proteins that mediate numerous
functions in both the developing and mature nervous system, including growth, survival,
differentiation and synaptic plasticity of postmitotic neurons. The binding of
neurotrophins (BDNF, NGF) to Trk receptors induces their dimerization which ... | true |
Invazivnost alohtonih vrsta makroinvertebrata i riba Dunava | Invasiveness of allochthonous macroinvertebrate and fish species of the Danube river | Istraživanje alohtone faune makroinvertebrata i riba Dunava rađeno je na osnovu
uzoraka prikupljenih tokom avgusta i septembra 2007. i 2013. godine. U radu je dat
detaljan pregled alohtone komponente sa tri aspekta: taksonomska i zoogeografska
analiza, testiranje indeksa za ocenu pritisaka i procena invazibilnosti p... | Investigation of allochthonous macroinvertebrates and fish species of the
Danube River was based on samples collected during August and September 2007 and
2013. Detailed overview of allochthonous species was presented regarding: taxonomic
and zoogeographic analyses, testing of indices and risk assessment procedure a... | true |
Imunofenotipska karakterizacija ćelija akutne mijeloidne leukemije kod odraslih i njena uloga u dijagnozi, praćenju i prognozi bolesti | Immunophenotypic characterization of acute myeloid leukemia in adults and its role in the diagnosis,monitoring, and prognosis of the disease | U tezi su ispitivani savremeni aspekti primene imunofenotipizacije
multiparametarskom protočnom citofluorimetrijom (IMPC) u dijagnostici i
praćenju AML. Ispitivanjem je obuhvaćeno 320 odraslih bolesnika sa de novo
AML, od kojih je 294 uključeno u retrospektivno ispitivanje (dijagnoza,
klasifikacija i prognoza), dok... | In
the
thesis
are
examined
modern
aspects
of
application
immunophenotyping and multiparameter flow cytometry (IMPC) in the
diagnosis and monitoring of AML. The study included 320 adult patients
with de novo AML, of which 294 included in the retrospective study
(diagnosis, classification and prognosis), whil... | true |
Izgradnja računovodstvenog sistema entiteta sektora Republike Srbije | Designing the accounting system of the public sector's entities in the Republic of Serbia | U savremenim uslovima, kada uloga javnog sektora postaje sve značajnija u
funkcionisanju nacionalnog sistema, neophodno je raspolagati pouzdanim
informacijama o njegovom poslovanju. S obzirom na veliku zainteresovanost
javnosti, a posebno poreskih obveznika, za upravljanje javnim poslovima i
upotrebu javnih resursa... | In contemporary conditions, when the public sector is becoming more important
in the functioning of the national system, accessing to reliable information is extremely
important for its business. Due to the great interest of the public, especially taxpayers, for
managing of public affairs and using of available reso... | true |
Holistički pristup oceni zdravstvenog stanja školske dece i omladine | Holistic approach to the evaluation of the health status of school children and adolescents | Istraživanje predstavlja studiju preseka na reprezentativnom uzorku od 672 deteta starosti od 7 do 19 godina u Vojvodini. Kao instrument istraživanja korišćeni su upitnici kojima su dobijeni podaci o demografskim i socijalno-ekonomskim karakteristikama, samoproceni zdravlja, zadovoljstvu životom, higijenskim navikama, ... | The research represents a cross-sectional study of the representative sample of 672 schoolchildren 7-19 of age in Vojvodina. Instrument was specially constructed questionnaire providing data about demographic and socio-economic characteristics, self assessment of the health, life satisfaction, hygiene, nutrition, physi... | false |
Analiza velikog konjugabilnog plazmida bakterije Lactococcus lactis subsp. lactis biovar. diacetylactis S50 | Analysis of large conjugative plasmid of Lactococcus lactis subsp. lactis biovar. diacetylactis S50 | Lactococcus lactis subsp. lactis biovar. diacetylactis S50 je prirodni izolat iz maslacne maje. Soj S50 sintetise bakteriocin uskog spektra delovanja i proteinazu PI tipa. Soj S50 poseduje tri vidijiva plazmida koji se mogu izolovati (pS50-7, pS50-10a i pS50-10b). Ciscenjem plazmida iz soja S50 istovremenim tretmanom s... | Lactococcus lactis subsp. lactis biovar. diacetylactis S50 was isolated from butter starter culture. Strain S50 produced bacteriocin which has narrow antibacterial spectrum, In addition, strain S50 synthesized extracellular cell wall-associated proteinase of Pl-type. The strain S50 has three plasmids detectable by conv... | false |
Izolacija i funkcionalna karakterizacija gena uključenih u sintezu karnozinske kiseline | Isolation and functional characterization of the genes involved in the synthesis of carnosic acid. | Karnozinska kiselina, fenolni diterpen, poseduje brojne biološke
aktivnosti zbog čega je potencijalno veoma značajna za farmaceutsku
industriju. Grčka žalfija (Salvia fruticosa Mill.) i ruzmarin (Rosmarinus
officinalis L.) bogati su prirodni izvori ovog jedinjenja. Iako je mnogo toga
poznato u vezi strukture i biol... | Carnosic acid is a phenolic diterpene potentially highly significant for the
pharmaceutical industry, due to its numerous biological activities. Cretan sage
(Salvia fruticosa Mill.) and Rosemary (Rosmarinus officinalis L.) are rich natural
sources of this compound. Although the structure and biological activities of... | true |
Detekcija i karakterizacija genomske nestabilnosti tumora mozga glijalnog porekla | Detection and characterization of genomic instability in patients with malignant glioma | Glioblastomi (GBM) predstavljaju najčešći i najmaligniji tip tumora mozga. Iako imaju istu
histopatološku sliku, primarni i sekundarni glioblastomi se razlikuju po mehanizmu nastanka
i setu karakterističnih genetičkih promena. Iako je tokom poslednjih godina došlo do
određenog poboljšanja u sagledavanju njihove komp... | Glioblastoma is the most frequent and the most malignant human brain tumor. Despite a similar
histological appearance, primary and secondary glioblastomas are distinct tumor entities with
different genetic alterations but none being specific enough to distinguish them. Despite better
insight in its complex genetic n... | true |
Regulacija ekspresije gena za metalotionein tipa 3 heljde i uloga proteina MT3 u odbrani biljnih tkiva od stresa izazvanog teškim metalima | Regulation of gene expression of metallothionein type 3 and buckwheat protein MT3 role in defending the plant tissues from stress induced by heavy metals | Iz biblioteke cDNK semena heljde u srednjoj fazi sazrevanja prethodno su izolovana dva klona cDNK koja kodiraju metalotioneinu-sličan protein. Izolovan je i odgovarajući genomski klon koji obuhvata deo kodirajućeg regiona kao i 71 bp 5`UTR i 569 bp promotorskog regiona. U ovom radu, izolovani promotorski region gena Fe... | Two cDNA clones coding for metallothionein-like protein (FeMT3) were isolated previously from the cDNA library of developing buckwheat seeds. The corresponding genomic clone, containing part of the coding region, as well as 71 bp of the 5' UTR and 569 bp of the promoter region, was also isolated. To shed light on expre... | false |
Nosivost zavrtnjeva kao sredstva za sprezanje u prefabrikovanim spregnutim konstrukcijama od čelika i betona | Resistance of bolted shear connectors in prefabricated steel-concrete composite decks | Primenom prefabrikovanih betonskih ploča vreme izgradnje spregnutih
nosača mostova ili u zgradarstvu se značajno smanjuje. Ukoliko se kao sredstva za
sprezanje koriste zavrnjevi ubetonirani u prefabrikovanu betonsku ploču,
moguće je postići veći stepen prefabrikacije u poređenju sa rešenjem sa
grupisanim moždanicim... | Prefabrication of concrete slabs reduces construction time for composite steel-
concrete buildings and bridge decks. Casting of bolted shear connectors in prefabricated
concrete slabs offers the higher level of prefabrication when compared to a technique
with grouped headed studs in envisaged pockets of concrete slab... | true |
Karakterizacija osmotski aktiviranih jonskih struja u membrani citoplazmatskih kapi izolovanih iz sporangiofora gljive Phycomyces blakesleeanus Burgeff | Characterization of osmotically activated ion currents in the membrane of cytoplasmic droplets from Phycomyces blakesleeanus Burgeff sporangiophores. | Membrana citoplazmatskih kapi dobijenih iz rastućih sporangiofora gljive Phycomyces
blakesleeanus Burgeff je jedan od samo dva za sada poznata model sistema u kojima se mogu
ispitivati elektrofiziološka svojstva plazma membrane filamentoznih gljiva (drugi model
sistem je sluzavi mutant gljive Neurospora crassa). Pok... | Cytoplasmic droplet membrane obtained from growing sporangiophore of fungus
Phycomyces blakesleeanus Burgeff is one out of two known exerimental models for
electrophysiological exploration of plasma membrane properties of filamentous fungi (the
other being Neurospora crassa slime mutant). At least 20 % of cytoplasmi... | true |
Biološka aktivnost fermentisanih mlečnih napitaka dobijenih primenom kombuhe i konvencionalnih starter kultura | Biological activity of fermented milk beverages obtained using kombucha and conventional starter culture | Proizvodnja fermentisanih mliječnih napitaka unapreijeđenih funkcionalnih karakteristika postala je jedan od glavnih fokusa u industriji prerade mlijeka. Cilj doktorske disertacije je ispitivanje biološke aktivnosti fermentisanih mliječnih napitaka dobijenih primjenom nekonvencionalne starter kulture, kombuhe (kultivis... | Nowadays, production of fermented dairy products with elevated benefits on human health has become one of the major focuse in dairy industry. The aim of the PhD thesis is to examine the biological activity of fermented milk products obtained using non-conventional starter culture kombucha (cultivated on black tea with ... | false |
Diferencijacija vrsta iz sekcije Juniperus roda Juniperus L. (Cupressaceae) sa Balkanskog poluostrva, korišćenjem fitohemijskih i molekularnih karaktera | Differentation of species within Section Juniperus of Genus Juniperus L. (Cupressaceae) from the Balkan peninsula using phytochemical & molecular characters | U ovom radu analizirana je fitohemijska i molekularna varijabilnost i diferencijacija prirodnih populacija taksona sekcije Juniperus roda Juniperus (Cupressaceae) sa Balkanskog poluostrva... | This thesis deals with phytochemical & molecular variability variability & differentation of natural population of taxa belonging to section Juniperus of the genus Juniperus (Cupressaceae) from the Balkan peninsula... | false |
Effects of anthocyanins and their metabolites on the function of human endothelial cells and platelets in vitro | Uticaj antocijana i njihovih metabolita na funkciju endotelnih ćelija i trombocita čoveka in vitro | Kardiovaskularne bolesti predstavljaju oboljenja koja zahvataju srce i krvne sudove i najčešći su uzrok obolevanja i umiranja u svetu. Prema mestu javljanja mogu se podeliti na bolesti srca, cerebrovaskularne bolesti i bolesti perifernih krvnih sudova. Osnovni uzročnik kardiovaskularnih bolesti je ateroskleroza, hronič... | Increasing number of scientific evidence suggests the beneficial role of dietary anthocyanins, phytochemicals mainly present in berries and derived products, in cardiovascular health. These anthocyanin health benefits may be attributed to their effect on endothelial cells or platelets that represent the key players in ... | false |
Uklanjanje fenola iz otpadnih voda sortama zelene salate (Lactuca sativa L.) | Removal of phenol from wastewater using different verieties of lettuce (Lactuca sativa L.) | U ovoj doktorskoj disertaciji ispitivana je mogućnost uklanjanja fenola iz rastvora,
korišćenjem različitih sorti zelene salate, sa ciljem njihove upotrebe u procesu
fitoremedijacije. Ispitivano je 11 različitih sorti zelene salate, čija semena su klijala na
podlogama sa različitim koncentracijama fenola (0-400 mgL-... | In this doctoral dissertation, the possibilities of use of various cultivars of lettuce have been
investigated for removal of dissolved phenol in the process of phytoremediation. Seeds of 11
different cultivars of lettuce germinated on media with different phenol concentrations (0-400
mgL-1) over 20 days. It has bee... | true |
Fiziološki i biohemijski aspekti propagacije endemičnih vrsta Micromeria pulegium (Rochel) Benth. i Micromeria croatica (Pers.) Schott in vitro | Physiological and biochemical aspects of propagation in endemic species Micromeria pulegium (Rochel) Benth. and Micromeria croatica (Pers.) Schoot in vitro | aromatičnih biljaka koje se koriste u tradicionalnoj medicini, hortikulturi, hemijskoj,
prehrambenoj i kozmetičkoj industriji. Retke, endemične i/ili ugrožene vrste familije
Lamiaceae predstavljaju poseban izazov za proučavanje, prevashodno u cilju očuvanja
specijskog diverziteta i njihovih populacija u prirodi, ali... | Plants from Lamiaceae family are prominent representatives of the edible, medicinal
or aromatic herbs used in traditional medicine, horticulture, chemical, cosmetic and food
industry. The rare, endemic and/or threatened species from family Lamiaceae pose a special
challenge for studying, primarily in order to preser... | true |
Molekularni markeri poremećaja koagulacije, inflamacije, apoptoze, formiranja i remodelovanja koštanog tkiva kod Leg-Kalve-Pertesove bolesti | Molecular markers of impaired coagulation, inflammation, apoptosis, formation and bone remodeling processes in Legg-Calve-Perthes disease | Leg-Kalve-Pertesova (LKP) bolest je idiopatska avaskularna osteonekroza epifize femura. Etiologija ove bolesti je nepoznata. Uprkos 100 godina istraživanja mehanizma njene patofiziologije i detaljnog opisivanja kliniĉkih i radioloških karakteristika, LKP bolest i dalje predstavlja jednu od najkontroverznijih bolesti u ... | Legg-Calve-Perthes (LCP) disease is the idiopathic avascular osteonecrosis of the hip in children, with an unknown etiology. Despite nearly 100 years of detailed characterization of its clinical and radiological features, as well as a research devoted to the pathophysiology of this disease, LCP disease still remains on... | false |
Unapređenje bezbednosti saobraćaja na putno-pružnim prelazima | Safety improvement of traffic at railway crossings | U ovom radu su istraženi statistički modeli za procenu frekvencije nesreća, težine
posledica
nesreća
i
empirijskog
rizika
koji
najviše
odgovaraju
lokalnim
karakteristikama putnih prelaza Srbiji u cilju identifikacije mesta visokog rizika na
mreži. Uzorak putnih prelaza lociranih na železničkoj mreži u Srbiji... | In this paper there were developed statistical models for estimation of accident
frequency, accident severity and empirical risk, that correspond to local characteristics
of crossings in Serbia. The goal was to identify high risk locations. The data used were
from five year period. Several regression models were tri... | true |
Značaj polimorfizama u genima za glukokortikoidni i adrenokortikotropni receptor u nastanku adrenalnih incidentaloma | Importance of polymorphisms in glucocorticoid receptor and adrenocorticotropic receptor genes in development of adrenal incidentalomas | UVOD: Glukokortikoidni hormoni (GC) ostvaruju svoje efekte vezivanjem za
glukokortikoidni receptor (GR). Adrenokortikotropni hormon (ACTH) reguliše sintezu
GC vezivanjem za ACTH receptor (ACTHR). Prisustvo polimorfizama u genu za GR
(BclI, N363S, ER22/23EK and A3669G) i promotoru ACTHR može uticati na efekte
glukok... | INTRODUCTION: Glucocorticoid hormones (GCs) accomplish their effects through
binding to glucocorticoid receptor (GR). Adrenocorticotropic hormone (ACTH) regulates
synthesis of GCs through binding to ACTH receptor (ACTHR). Presence of common GR
gene (BclI, N363S, ER22/23EK and A3669G) and ACTHR promoter polymorphisms... | true |
Strukturirano učenje nad velikim podacima zasnovano na verovatnosnim grafovskim modelima | Structured learning from big data based on probabilistic graphical models. | Struktuirano ucenje je oblast koja se bavi ucenjem složenih objekata iz složenih (struktuiranih) podataka... | Structured learning is an area that deals with the learning of complex objects from complex (structured) data. Structured data, in this context, represent data that consists of several interdependent parts. Structured learning is an important segment of machine learning, and is an active research topic with numerous un... | false |
Odlike životne istorije i distribucije bele kanje Neophron percnopterus u Republici Makedoniji | Characteristics of the life history and distribution of the Egyptian vulture Neophron percnopterus in the Republic of Macedonia. | Bela kanja Neophron percnopterus (Aves: Accipitridae) je globalno
ugroženi, mali, oportunistički, monogamni, uglavnom solitarni i dugoživeći
lešinar, rasprostranjen u južnim delovima Evrope, Bliskog Istoka, Kavkaza,
centralne Azije, Indije, i severne Afrike, sa svetskom populacijom od 13000-
41000 adultnih jedinki. ... | The Egyptian Vulture Neophron percnopterus (Aves: Accipitridae) is a
globally endangered, small, opportunistic, monogamous, mostly solitary and long-lived
vulture, distributed in the southern parts of Europe, the Middle East, Caucasus, Central
Asia and north Africa, with global population of 13000-41000 adult indivi... | true |
Uloga glukokortikoidnih hormona u regulaciji energetskog metabolizma i inflamacije u jetri pacova nakon ishrane obogaćene fruktozom | The role of glucocorticoid hormones in regulation of energy metabolism and inflammation in the liver of fructose-fed rat | Jedan od najznaĉajnijih uzroka razvoja metaboliĉkog sindroma je moderan naĉin ishrane
bogate fruktozom koja u jetri pokreće de novo lipogenezu, glukoneogenezu i hroniĉnu
inflamaciju, što kumulativno vodi razvoju insulinske rezistencije. Glukokortikoidni hormoni su
vaţni regulatori energetskog metabolizma, koji deluj... | One of the major causes of metabolic syndrome development is modern diet rich in
fructose. Fructose-enriched diet initiates de novo lipogenesis, gluconeogenesis and chronic
inflammation in the liver, which cumulatively lead to progress of insulin resistance.
Glucocorticoid hormones are important regulators of energy... | true |
Efekat ekspresije gena za protein-kinazu 1 duvana (NPK1) kod transformisanih biljaka karfiola (Brassica oleracea L. var. botrytis) na razvoj tolerancije prema povišenim koncentracijama NaCI in vitro | Effect of tobacco protein kinase 1 (NPK1) gene expression in transformed cauliflower (Brassica oleracea L. var. botrytis) plants on the development of tolerance to increased concentrations of NaCl in vitro | Biljke su neprekidno izloţene razliĉitim vrstama stresa iz spoljašnje sredine, koji nepovoljno utiĉu na njihov rast i razviće. Povećan salinitet zemljišta je jedan od faktora spoljašnje sredine, koji u velikoj meri ograniĉava produktivnost gajenih biljaka. Karfiol (Brassica oleracea L. var. botrytis), je znaĉajna povrt... | Plants are continuously exposed to various types of stress from the environment that adversely affect their growth and development. The increased salinity of the soil is one of the environmetal factors that greatly limits the productivity of the cultivated plants. Cauliflower (Brassica oleracea L. var. botrytis), is an... | false |
Analiza ekspresije celokupnog genoma u cilju identifikacije ključnih gena i mikroRNK za nastanak urođenih anomalija bubrega i urinarnog trakta čoveka | Analysis of whole genome expression in order to indentify the key genes and microRNAs for the occurence of congenital anomalies of the kidney and urinary tract in humans | UNIVERZITET U BEOGRADU
BIOLOŠKI FAKULTET
Ivan G. Jovanović
Analiza ekspresije celokupnog genoma u
cilju identifikacije ključnih gena i mikro RNK
za nastanak urođenih anomalija bubrega i
urinarnog trakta čoveka
doktorska disertacija
Beograd, 2016
UNIVERSITY OF BELGRADE
FACULTY OF BIOLOGY
Iv... | Urođene anomalije bubrega i urinarnog trakta (engl. Congenital Anomalies
of the Kidney and Urinary Tract – CAKUT) su razlog nastanka čak polovine
slučajeva terminalne bubrežne insuficijencije ali patofiziološka osnova ove bolesti
još uvek nije poznata u potpunosti pa je samim tim otežana prevencija i terapija. U
ov... | true |
Prostorna distribucija i ekologija orhideja (Orchidaceae) zapadne Srbije | Spatial distribution and ecology of orchids (Orchidaceae) of western Serbia | Orhideje su poznate po bogatstvu taksona, kompleksnoj ekologiji i velikom broju
ugroženih vrsta. Osnovni ciljevi ove disertacije su utvrđivanje prostorne distribucije i
diverziteta orhideja zapadne Srbije, kao i utvrđivanje ekoloških preferencija i
konzervacionog statusa orhideja. Za svaki takson izrađene su karte r... | Orchids are known for their taxa richness, complex ecology and a large number of
endangered species. The main objectives of this dissertation are the determination of
spatial distribution and diversity of orchids in western Serbia, and the determination of
ecological preferences and conservation status of orchids. D... | true |
Studija genetičke osnove Parkinsonove bolesti kod stanovništva Srbije | Study of the genetic basis of Parkinson's disease in Serbian population | Parkinsonova bolest je drugo najčešće neurodegenerativno oboljenje koje pogaĎa od 1% do
2% stanovništva starijeg od 65 godina i više od 4% stanovništva starijeg od 85 godina.
Klinička prezentacija obuhvata četiri kardinalna znaka bolesti: bradikineziju, tremor u miru,
rigor i posturalnu nestabilnost, kao i druge mot... | Parkinson’s disease is the second most common neurodegenerative disorder that affects 1%
to 2% of the population older than 65 years and over 4% of the population older than 85
years. Clinical presentation includes four cardinal signs of disease: bradykinesia, resting
tremor, rigidity an postural instability, as wel... | true |
Filogenetski odnosi rodova subtribusa Lysiphlebina i taksonomski status vrsta roda Adialytus (Foerster) (Hymenoptera, Braconidae, Aphidiinae) | Phylogenetic relationships among genera of subtribe Lysiphlebina and taxonomic status of Adialytus (Foerster) species (Hymenoptera, Braconidae, Aphindiinae) | Rod Adialytus predstavlja jedan od tri roda subtribusa Lysiphlebina. Pored ovog,
ovde spadaju rodovi Lysiphlebus i Lysiphlebia. Ukupno je opisano sedam vrsta roda
Adialytus, koje su rasprostranjene širom Palearktika. Adialytus je dugo bio razmatran
kao podrod u okviru roda Lysiphlebus, sa kojim deli mnoge morfološke... | The genus Adialytus is a member of the subtribe Lysiphlebina. Beside this genus
the subtribe encompasses two more genera: Lysiphlebus and Lysiphlebia. So far, seven
valid Adialytus species have been recognized which can be found throughout the
Palaearctic. The genus Adialytus was previously considered as a subgenus ... | true |
Ispitivanje genetičke varijabilnosti lokalnih populacija kukuruza (Zea mays L.) molekularnim markerima | Genetic variability of maize landraces (zea mays l.) assessed by molecular markers | Agronomski biodiverzitet je širok pojam koji uključuje sve komponente
biološkog diverziteta od značaja za hranu i poljoprivredu. On predstavlja rezultat
interakcije između genetičkih resursa, životne sredine i upravljanja sistemima i prakse
koji čine poljoprivrednu proizvodnju. Biljni genetički resursi, smatraju se ... | Agricultural biodiversity is a broad term which includes all components of
biological diversity of relevance to food and agriculture. It represents the result of
interaction between genetic resources, environmental protection and both management
systems and practices that make agricultural production. Plant genetic ... | true |
Efekat mimetika superoksid dismutaze na mitohondrijalni i funkcioni status humanih spermatozoida | The effect of superoxide dismutase mimic on mitochondrial and functional state of human spermatozoa | Neplodnost je globalni problem u svetu. Uzroci i frekvenca različitih oblika
neplodnosti variraju, a novije studije pokazuju da reaktivne vrste kiseonika (ROS) i
azota (RNS), superoksid (O2•─) i azot oksid (NO) pre svega, igraju važnu ulogu, posebno
kod neplodnosti muškaraca. Pokazano je da su mitohondrije ne samo m... | Infertility is a global problem worldwide. The frequency and origin of different
forms of infertility vary, but recent studies showed that reactive oxygen species (ROS)
and reactive nitrogen species (RNS), first of all, superoxide (O2
•─) and nitric oxide
(NO), play an important role, especially in male infertility.... | true |
Efekti estradiola u srcu pacova sa insulinskom rezistencijom izazvanom ishranom bogatom fruktozom | Effects of estradiol in the heart of rats with fructose-rich diet-induced insulin resistance | Fruktoza je prirodni šećer, ĉiji se unos poslednjih decenija dramatiĉno povećao, najvećim delom zbog povećane upotrebe kukuruznog sirupa sa visokim sadrţajem fruktoze. Povećan unos fruktoze vodi ka razvoju metaboliĉkog sindroma kod ljudi i eksperimentalnih ţivotinja. Pored promena u jetri, adipoznom tkivu i skeletnim m... | Fructose is natural sugar whose intake has increased dramatically over the past decades, mostly due to increased consumption of high-fructose corn syrup. Increased intake of fructose initiates development of metabolic syndrome phenotype in humans and experimental animals. In addition to changes in liver, adippose tissu... | false |
Mehanizmi preživljavanja astrocita pacova u medijumu bez glukoze i u uslovima hipoksije in vitro | The mechanisms of rat astrocytes survival in the medium without glucose and in hypoxic conditions in vitro | Uvod. Poznato je da astrociti preživljavaju duže izlaganja deprivaciji kiseonika i
glukoze (OGD) i da preživljavaju danima bez nutrijenata u poređenju sa izrazito
osetljivim neuronima. Razlozi ovako smanjene osetljivosti astrocita i dalje nisu
dovoljno razjašnjeni. Šta više, promene membranskog potencijala mitohondrija... | Introduction. Astrocytes are known to tolerate long periods of oxygen-glucose deprivation
(OGD) and they survive nutrient deprivation (ND) for days as compared to rather vulnerable
neurons. The reasons for this reduced vulnerability of astrocytes are not well understood. In
fact, changes in mitochondrial membrane poten... | true |
The role of NO-synthetic pathway in structural remodeling of rat myocardium | Uloga NO-sintaznog puta u strukturnom remodeliranju miokarda pacova | Azot oksid (NO), endogeno sintetisan NO sintazama (NOS, engl. NO
synthases) ima važnu ulogu u optimizaciji adaptivnog odgovora srca. Poznato je da
NO pri fiziološkim koncentracijama ima pozitivno inotropno dejstvo, kao i da je
hronično redukovan fiziološki nivo NO spregnut sa izmenjenom funkcijom srca i da
stoga mo... | Nitric oxide (NO), endogenously synthesized by nitric oxide synthases (NOSs),
generally acts to fine tune and optimise cardiac pump function. Several experimental
studies have shown that low (submicromolar) doses of NO exert small positive
inotropic effects, while at higher, but still physiological levels, NO enhanc... | true |
Varijabilnost genotipa i fenotipske ekspresije spinalne mišićne atrofije kod pacijenata iz Srbije | Variability of genotype phenotypic expression of spinal muscular atrophy in patients from Serbia | Spinalna mišićna atrofija (SMA) je drugo najčešće autozomno recesivno oboljenje
kod ljudi. Prema uzrastu kada se pojavljuju prvi simptomi i težini kliničke slike SMA je
klasifikovana u tri tipa. Mutacije u telomernoj kopiji gena SMN1 (eng. survival of mo-
tor neuron), koji se nalazi u 5q13 regionu, dovode do nastanka... | Spinal muscular atrophy (SMA) is the second most frequent autosomal recessive
disease in humans. According to the age of onset and severity of clinical manifestations,
SMA is classified into three types. Mutations in the telomeric copy of the survival of
motor neuron gene (SMN1) cause the disease while other genes i... | true |
Molekularna osnova auto-inkompatibilnog sistema heljde (Fagopyrum esculentum Moench) | Molecular basis of self-incompatibility system in buckwheat (Fagopyrum esculentum Moench) | Heljda (fam. Polygonaceae) je heteromorfna biljna vrsta koja sadrži cvetove dve
morfologije: "pin" (dugačak stubić tučka, kratke antere, manja polenova zrna) i "tram"
(kratak stubić tučka, dugačke antere, veća polenova zrna). Oplođenje je dozvoljeno samo
između cvetova različite morfologije, dok je sprečeno između c... | Buckwheat (fam. Polygonaceae) is heteromorphic species with two flower morphs: "pin"
(long style, short anthers, and smaller pollen grains) and "thrum" (short style, long anthers,
and larger pollen grains). Fertilization is allowed only between flowers of different
morphology, while it is prevented between flowers o... | true |
Uticaj obrade hrane i interakcija komponenti matriksa hrane na strukturu i funkciju alergena hrane | Impact of food processing and interactions with other food components on the structure and function of food allergens | β-laktoglobulin (BLG) je glavni protein surutke mleka preživara, ali je prisutan i u
mleku mnogih drugih vrsta sisara. Poznato je da BLG poseduje niz funkcionalnih osobina
(npr. geliranje, stvaranje pene, emulzifikacija) važnih za industriju hrane kao i veliku
nutritivnu vrednost zbog visokog sadržaja esencijalnih a... | β-lactoglobulin (BLG) is the major whey protein of ruminant species, but is also
present in the milk of many other species. It is well known that BLG has many benefitial
functional properties such as gelling, foaming and emulsifying properties. Although, BLG
is considered to be a valuable protein in view of nutritio... | true |
Primena nelinearnih metoda u analizi promena EEG teta ritma pri formiranju kratkoročne auditivne memorije kod ljudi | Aplication of nonlinear methods in analysis of EEG theta rhythm changes during auditory short-term memory formation in human. | Kratkoročna auditivna memorija (KAM) predstavlja kratkotrajno zadržavanje auditivno
primljenih informacija u memoriji. Kratkoročna memorija, iako zaseban sistem, nije u potpunosti
nezavisna od dugoročne memorija. Memorija se ne nalazi na jednom području u mozgu, već
obuhvata široko - distribuiranu mrežu koja se sast... | Short-term auditory memory (STAM) is a short-term retention of auditory received
information in memory. Short-term memory, although a separate system, is not entirely
independent of long-term memory. Memory is not located in one area of the brain, but also
includes a wide - distributed network consisting mainly of n... | true |
Molekularno-citogenetička karakterizacija hromozomskih prekida u limfocitima periferne krvi pacijenata obolelih od Fankonijeve anemije u različitim fazama bolesti | Molecular-cytogenetic characterization of chromosomal breakages in peripheral blood lymphocytes of Fanconi anemia patients in different stages of the disease | Česta fragilna mesta (CFS) su hromozomski regioni skloni lezijama, suženjima i
prekidima u uslovima replikativnog stresa in vitro. Najčešće se mogu naći kod
sindroma hromozomskih nestabilnosti kao što je Fankonijeva anemija (FA), retka
nasledna bolest koju karakteriše sklonost ka razvoju maligniteta i progresivna
i... | Common fragile sites (CFSs) are chromosomal regions prone to gaps,
constrictions and breaks under conditions of replication stress in vitro. They are
mostly found in chromosomal instability syndromes such as Fanconi anemia (FA).
FA is rare inherited disease characterized by cancer predisposition, progressive bone
m... | true |
Diverzitet mekušaca Dunava (1260-863,5 rkm) i taksonomska analiza rodova Planorbarius, Radix, Physella, i Ferrissia (Pulmonata:Basommatophora) | Diversity of Molluscs in the Danube river (1269-863.5 rkm) and taxonomic analysis of the genera Planorbarius, Radix, Physella and Ferrissia (Pulmonata: Basommatophora) | Analiza slatkovodnih mekušaca razmatrana je kroz tri zone glavnog toka
Dunava (1260 - 863,5 rkm) kao i plavnoj zoni, na levoj obali reke, od 1082 do 1085
rkm. Uzorci su prikupljeni sezonski (april, jun, septembar i novembar), u tri
ponavljanja, uključujući uzorke za analizu fizičkih i hemijskih parametara kvaliteta ... | Fresh water molluscs analysis was performed through three zones of The
Danube main flow (1260-863.5 rkm) as well as flooding zone, on the left river bank
from 1080 to 1085 rkm. Samples were collected seasonally (April, June, September and
November), in three repetitions, along with samples for physical and chemical ... | true |
Struktura globalnih finansijskih mreža i transfer rizika na iskustvu bankarskih sistema zemalja zapadnog Balkana | The structure of global financial networks and risk transfer in the experience of the banking system of Western Balkan countries | U ovoj disertaciji je analizirana struktura globalne finansijske
mreže u periodu poslednje finansijske krize, od 2007-2013. godine. Osnovni
izvor podataka koji je u istraživanju korišćen jeste Konsolidovana bankarska
statistika Banke za međunarodna poravnanja (BIS). Posebno je analizirana
struktura jednog užeg segm... | The structure of the global financial network in the period of the last financial
crisis, from 2007 to 2013, was analyzed in this dissertation. The main data source used
in the research is the Consolidated banking statistics from the Bank for International
Settlements (BIS). The structure of the smaller part of the ... | true |
Uticaj varijanti u kodirajućim i nekodirajućim regionima gena uzročnika i gena modifikatora na fenotip pacijenata sa hiperfenilalaninemijom | Impact of variants in coding and noncoding regions of disease-causing and modifier genes on phenotype of patients with hyperphenylalaninemia | Hiperfenilalaninemija
(HPA)
predstavlja
najčešći
nasledni
poremećaj
metabolizma aminokiselina (učestalost 1:10 000) koji se karakteriše povišenim nivoom
fenilalanina u krvi. Višak fenilalanina ima toksičan efekat na razvoj mozga, i ukoliko se
pravovremeno ne uvede odgovarajuća terapija, dolazi do teške i irever... | Hyperphenylalaninemia (HPA) is the most frequent inborn error of amino acid
metabolism (incidence 1:10 000) and it is characterized by an increased level of blood
phenylalanine. Excessive phenylalanine has a toxic effect on brain development, and if
left untreated, leads to a severe and irreversible mental retardati... | true |
Ekofiziološke adaptacije odabranih vrsta zeljastih biljaka na deponiji pepela termoelektrane 'Nikola Tesla - A' u Obrenovcu | Ecophysiological adaptations of selected herbaceous plants growing on the fly ash deposits of thermoelectric plant 'Nikola Tesla - A' in Obrenovac | Zasnivanje biljnog pokrivača na odlagalištima pepela obezbeđuje fizičku i
hemijsku stabilizaciju pepela, sprečava eroziju vetrom i smanjuje disperziju toksičnih
hemijskih elemenata u životnu sredinu. Istraživanja u okviru ove disertacije su
obavljena na području deponije pepela termoelektrane 'Nikola Tesla – A' u Ob... | Establishment of plant cover on fly ash deposits provides the physical and
chemical stabilization of ash, prevents wind erosion and reduces dispersion of toxic
chemical elements in the environment. Research within this thesis was carried out in the
area of the fly ash deposits thermoelectric plant 'Nikola Tesla - A'... | true |
Biomarkeri oksidacionog stresa i koncentracija metala u odabranim tkivima belouške (Natrix natrix) i ribarice (Natrix tessellata) sa područja Obedske bare i Pančevačkog rita | Oxidative stress biomarkers and metal concentrations in selected tissues of grass snake (Natrix natrix) and dice snake (Natrix tessellata) from Obedska bara and Pančevački rit | Ekotoksikološka istraživanja su značajna zbog činjenice da mogu imati
praktičnu primenu u zaštiti životne sredine. Semiakvatične vrste zmija konstantno su
izložene dejstvu kompleksa različitih ekoloških faktora kako u vodenoj tako i u
terestričnoj sredini. Zmije su dugoživeći organizmi, nalaze se na vrhu lanca ishra... | Ecotoxicological studies are important due to the fact they can have a practical
application in environmental protection. Semiaquatic snakes are continuously exposed
to various complex environmental factors both in aquatic and terrestrial environment.
They are long-living organisms, on the top of the food chain, wit... | true |
Obavezna odbrana u krivičnom postupku | Mandatory legal aid in criminal proceedings | Obavezna odbrana je stručna odbrana, u zakonski određenim slučajevima obavezna u krivičnom postupku za okrivljene izloženim povećanim procesnim rizicima. Ti rizici uzrokovani su nekim ličnim hendikepima koji dovode do smanjene procesne kompetencije, težinom krivičnih dela, kao i nekim drugim procesnim okolnostima koje ... | Mandatory legal aid is defence by attorney, implemented in criminal proceedings in cases when defendants are exposed to high procedural risks, e.g. if charged for serious crimes, or when there are reasons of a personal nature which made them incompetent for personal defence or even to realise the need of having an atto... | false |
Bioakumulacija i biomagnifikacija toksičnih metala i elemenata u tragovima kod slatkovodnih riba različitog trofičkog nivoa iz Dunava kod Beograda | Bioaccumulation and biomagnifications of toxic metals and trace elements in freshwater fishes from different trophic levels in the Danube near Belgrade | Iako je i dalje u upotrebi, termin „teški metal“ različiti autori
definišu na različite načine brojnim parametrima. Izvori zagađenja teškim
metalima mogu biti prirodni, ali su najčešće antropogeni. Ova klasa
zagađivača predstavlja značajnu pretnju za životnu sredinu i vrste koje žive u
njoj, kao i potencijalnu pret... | Although still in use, the term “heavy metal” is defined in different ways, based
on a number of parameters, by different authors. Sources of heavy metal contamination
can be natural, yet they are mostly anthropogenic. This class of pollutants poses a
significant threat to environment and species living in it, as we... | true |
Detekcija elokventnih govornih moždanih zona funkcionalnom magnetnom rezonancom | FMRI identification of eloquent language brain areas | Funkcionalna magnetna rezonanca (fMR), u poslednjoj deceniji dala je
značajan doprinos u ispitivanju različitih aspekata moždanih funkcija
kako kod zdravog mozga tako i u različitim patološkim stanjima. Svrha ove
disertacije bila je da ispita mogućnosti fMR u detekciji elokventnih
govornih moždanih zona kako kod zd... | Functional magnetic resonance imaging (fMRI), in the last decade, has
made significant contributions in the study of various brain functions in the
healthy brain and in different pathological brain conditions as well. The purpose
of this thesis was to explore the possibilities of fMRI in detection of eloquent
langu... | true |
Uticaj LPS i IL-33 na adultne matične tkiva periodoncijuma: funkcijske promene i aktivirani molekulski mehanizmi | The influence of LPS and IL-33 on adult stem cells of periodontal ligament:functional changes and activated molecular mechanisms | Savremeni načini lečenja različitih oboljenja usne duplje, nastalih
usled urođenih deformiteta, mehaničkih oštećenja ili poremećaja
uzrokovanim
inflamatornim
ili
tumorskim
oboljenjima
mogu
predstavljati kompleksan klinički zadatak s obzirom da se nameće zahtev
obnove funkcije, ali i estetike orofacijalnog regi... | Contemporary methods for treating various diseases of the oral cavity, caused by
congenital deformities, mechanical damage or damage caused by inflammatory or
tumor diseases can be a complex clinical task, given that the requirement for restoration
of function and aesthetics of the orofacial region is imposed. The s... | true |
Solvotermalna sinteza cink-oksida sa kontrolisanom veličinom čestica na nano i mikro skali | Solvothermal synthesis of zinc oxide with controlled nano-and microsized particles | Cink-oksid je poluprovodni materijal koji je zbog svojih specifičnih fizičkih i
hemijskih svojstava (širok energijski procep, hemijska i fotohemijska stabilnost, optička
propustljivost, piezoelektricitet, netoksičnost, antibakterijska svojstva) našao primenu u
izradi optoelektronskih uređaja, uređaja na bazi površin... | Zinc oxide is a semiconductor material, which has been found useful in many
applications, such as optoelectronic devices, surface acoustic wave devices, field
emitters, piezoelectric devices, transparent conducting materials, sollar cells, cosmetics
etc., due to its interesting properties, especially wide band gap, ... | true |
Effect of salicylic acid on the expression of heat-shock proteins and morphology of potato (Solanum tuberosum L.) plants under heat stress in vitro | Uticaj salicilne kiseline na ekspresiju proteina toplotnog stresa i morfološke osobine biljaka krompira (Solanum Tuberosum L.) u uslovima toplotnog streasa in vitro | Krompir, Solanum tuberosum L., je četvrta po značaju kulturna biljka u svetu. Najveći
broj sorti krompira je razvijen za gajenje u umerenim klimatskim zonama i izuzetno su
osetljive na visoke temperature. Kao rezultat globalnog zagrevanja u narednih 60
godina, predvidja se značajan pad u prinosu krompira izmedju 18%... | The potato, Solanum tuberosum L., is the fourth most important crop in the world. Most
of the commercial potato cultivars were developed for growing in temperate climate
regions and they are highly sensitive to elevated temperatures. As a result of global
warming over next 60 years, significant potato yield losses i... | true |
Taksonomski status rodova i vrsta Euaphidius mackauer i Remaudierea starý (Hymenoptera, Braconidae, Aphidiinae) na osnovu morfoloških i molekularnih analiza 28S rRNK I COI gena | Taxonomic status of genera and species of Euaphidius mackauer and Remaudierea Starý (Hymenoptera, Braconidae, Aphidiinae) based on morphological and molecular analyses of 28s rRNA and COI genes | Taksonomski status roda Euaphidius Mackauer, sa dve opisane vrste E. cingulatus
(Ruthe) i E. setiger Mackauer, je poslednjih decenija pod znakom pitanja. Ove dve vrste su u
literaturi obično razmatrane u okviru roda Aphidius Nees. Međutim, na osnovu nekih
morfoloških karakteristika, pre svega, tentorijalnog indeksa ... | Taxonomic status of the genus Euaphidius Mackauer with two described species E.
cingulatus (Ruthe) and E. setiger Mackauer has been questionable over past few decades. In
the literature, these two species are considered within the genus Aphidius. However, based on
some morphological characteristics, such as tentoria... | true |
Ligninolitički potencijal i medicinska svojstva ekstrakata vrsta roda Trametes fr. | Ligninolytic potential and medicinal properties of extracrs of Trametes fr. species. | Rod Trametes Fr. obuhvata vrste širokog rasprostranjena sa dobro razvijenim ligninolitičkim enzimskim sistemom i značajnim kapacitetom u sintezi raznovrsnih biološki aktivnih jedinjenja, zbog čega sve više nalaze primenu u mnogobrojnim biotehnološkim procesima. Ciljevi ovog istraživanja bili su optimizacija uslova kult... | The genus Trametes Fr. encompasses widely distributed species with strongly developed ligninolytic enzyme system and significant capacity to synthesize diverse biologically active compounds, because of which are increasingly used in numerous biotechnological processes. The aims of this research were the optimization of... | false |
Fauna cikada (Hemiptera: Auchenorrhyncha) u vinogradima Makedonije i njihova uloga u epidemologiji ""Candidatus Phytoplasma solani"" | Auchenorrhyncha) in the vineyards of macedonia and their role in the epidemiology of 'Candidatus Phytoplasma solani' | Bois noir (BN), oboljenje koje izaziva stolbur fitoplazma, nanosi velike štete u
vinogradarskim regionima širom Evro-mediteranskog basena. Tokom 2012. i 2013. godine
preduzeta su epidemiološka istraživanja za određivanje potencijalnih insekata vektora i
najvažnijih biljaka rezervoara BN fitoplazme u makedonskim vino... | Bois noir (BN), induced by stolbur phytoplasma, is an important grapevine yellows disease
that causes severe damage in viticultural regions throughout the Euro-Mediterranean basin.
Epidemiological survey to determine potential insect vectors and the main reservoir plants
of BN phytoplasma in Macedonian vineyards was... | true |
Ekspresija i varijante gena za tumorski supresor VHL u papilarnim karcinomima štitaste žlezde | Expression and gene variants of VHL tumour supressor in papillary thyroid carcinoma | Papilarni karcinomi štitaste žlezde (PTC) predstavljaju najučestalije karcinome
endokrinog porekla. Poslednjih decenija, incidenca ovih karcinoma je u stalnom porastu
zbog čega je identifikacija molekularnih markera koji bi doprineli preciznijoj
klasifikaciji bolesnika sa rizikom za progresiju bolesti, a u cilju izb... | Papillary thyroid carcinomas (PTC) represent the most prevalent type of endocrine
malignancy. Over the last decades their incidence has been increasing, underlining the
significance of the identification of molecular markers which would improve the risk
stratification and help optimize the therapeutic approach to PT... | true |
Uticaj različitih ekstrakata krastavaca (Cucumis sativus L. cv. Chinese long) na encefalitogeni potencijal T limfocita pacova u eksperimentalnom autoimunskom encealomijelitisu | Effects of different Cucumber exstracts (Cucumis sativus L. cv. Chinese long) on the encephalitogenic potential of T lymphocytes in experimental autoimmune encephalomyelitis | Eksperimentalni autoimunski encefalomijelitis (EAE) je model multiple skleroze (MS),
hronične inflamatorne bolesti centralnog nervnog sistema (CNS). Osnovne patogene
populacije u EAE su efektorski T limfociti koji produkuju interferon-γ (Th1) ili
interleukin-17 (Th17) i aktivirani makrofagi koji dovode do oštećenja ... | Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple
sclerosis (MS), a chronic inflammatory disease of the central nervous system (CNS). T
lymphocytes, which produce interferon-γ (Th1) or interleukin-17 (Th17), and activated
macrophages, that lead to CNS damage, are the major pathogenic cel... | true |
Ispitivanje antitumorskog delovanja 6-[trifenilstanil]-1-heksanola vezanog za mezoporozni nanomaterijal SBA-15 u modelu mišjeg melanoma in vitro i in vivo | Evaluation of antitumor activity of 6-(triphenylstannyl)hexan-1-ol loaded in SBA-15 mesoporous nanostructured material in the mouse model of melanoma in vitro and in vivo | Uprkos razvoju imunoterapije i ciljanih terapija, globalna incidenca melanoma nastavlja
da raste. Konvencionalna hemoterapija, naţalost, pokazuje ograniĉenu efikasnost u
leĉenju metastatskog melanoma. Primenu najĉešće korišćenog hemoterapeutskog leka
cisplatine, ograniĉava uroĊena rezistencija ovog tipa tumora, što ... | Despite rapid development in immunotherapy and targeted therapies, the global
incidence of melanoma continues to increase. Besides, conventional chemotherapy
demonstrates only limited efficacy in the treatment of advanced melanoma. Clinical
application of widely used chemotherapeutic drug cisplatin, is hampered by t... | true |
Uloga Sonic Hedgehog signalnog puta u regulaciji ekspresije SOX18 gena u HeLa ćelijama, kao model sistemu karcinoma grlića materice | The role of Sonic Hedgehog signaling pathway in the regulation of SOX18 gene expression in HeLa cells, model system of cervical carcinoma | Sonic Hedgehog (SHH) signalni put ima važnu ulogu u procesima koji se
odvijaju tokom embrionalnog razvića u kojima kontroliše proliferaciju i diferencijaciju
ćelija i učestvuje u održavanju polarnosti tkiva. Poslednjih godina mnogobrojni
literaturni podaci pokazuju da promena u regulaciji SHH signalnog puta dovodi d... | The Sonic Hedgehog (SHH) signaling pathway plays important role in
embrionic development directing cell proliferation and diferentiation and maintaing
tissue polarity. In adults, this signaling pathway is rather suppressed. SHH signaling
pathway has been associated with medulloblastoma, leukemia, basal cell carcinom... | true |
Povezanost ekspresije PTEN proteina i prognoze bolesti kod žena obolelih od ranog karcinoma dojke lečenih ovarijalnom ablacijom | The relationship between PTEN protein expression and prognosis in women with early breast cancer treated with ovarian ablation | Sve pacijentkinje sa detektabilnom ekspresijom hormonskih receptora (HR) za
karcinom dojke (KD) trebalo bi da se leče endokrinom terapijom (ET). Za
premenopauzne pacijentkinje, tamoksifen i/ili ovarijalna supresija (OvS) su adekvatna
terapija. Promene u fosfataza i tenzin homolog (PTEN) signalnom putu bi mogle da
b... | All breast cancer (BC) patients with detectable hormone receptors (HR)
expression should be offered endocrine therapy (ET). For premenopausal patients,
tamoxifen and/or ovarian suppression (OvS)/ ablation (OA) may improve disease
outcome. Alteration of phosphatase and tensin homolog (PTEN) signaling pathway
could b... | true |
Efekti fluoksetina i klozapina na antioksidativni sistem i parametre inflamacije u mozgu i jetri pacova u uslovima hronične izolacije | The effects of fluoxetine and clozapine on antioxidative system and inflammation parameters in the brain and liver of chronically isolated rats | Depresija je visokoprevalentno, multifaktorijalno i heterogeno psihijatrijsko
oboljenje kompleksne neurobiološke osnove. S obzirom da veliki broj pacijenata (30–
40%) ne postiže remisiju bolesti uprkos antidepresivnoj terapiji, patofiziologija
depresije i mehanizmi delovanja antidepresiva i danas su aktuelne problema... | Depression is a highly prevalent, multifactorial and heterogeneous disorder with
complex neurobiology. Large numbers of patients (30–40%) do not achieve disease
remission despite receiving antidepressive therapy. Thus, despite the decades of
research, the pathophysiology of depression and mechanisms of antidepressan... | true |
Vijabilnost populacija tekunice Spermophilus citellus (L., 1766) na području Srbije | Viability of European ground squirrel Spermophilus citellus (L., 1766) populations in Serbia | Evropska tekunica (Spermophilus citellus, L. 1766) je endemična vrsta za područje
Centralne i Jugoistočne Evrope. Recentni areal je karpatskim masivom podeljen na dva
dela. Severni deo se karakteriše uniformnim stepskim staništima koja se javljaju na malim
nadmorskim visinama, dok se južni deo areala nalazi na Balka... | The European ground squirrel (Spermophilus citellus, L. 1766) is endemic species
to the Central and Southeastern Europe. Its recent range is divided in two main parts by
the Carpathian Mountains. The northern part of the range is characterized by uniform
steppe habitats at low altitudes, while the southern part is s... | true |
Uloga mTOR i MAPK signalnih puteva u rezistenciji karcinoma štitaste žlezde na hemioterapiju | The role of mTOR and MAPK signaling pathways in resistance of thyroid carcinoma to chemotherapy. | Karcinomi štitaste žlezde su najčešći maligniteti endokrinog sistema.
Klasifikacija ovih maligniteta je izvršena na osnovu njihovih histopatoloških
karakteristika na papilarni, folikularni medularni i anaplastični karcinom (ATC).
Većina karcinoma štitaste žlezde je dobro diferencirana i ima odličnu prognozu
(papila... | Thyroid carcinoma is the most common malignancy of the endocrine system.
Thyroid malignancies are classified according to their histopathological characteristic
as papillary, follicular, medullary and anaplastic thyroid carcinoma (ATC). Most
thyroid malignancies (papillary thyroid carcinoma and follicular thyroid ca... | true |
Efekat estradiola u modulaciji apoptotskih signala u moždanoj kori i hipokampusu pacova tokom hronične moždane hipoperfuzije | Effects of estradiol on modulation of apoptotic signals in cerebral cortex and hippocampus of rats during chronic cerebral hypoperfusion | Iako se ishemijske bolesti mozga, koje se karakterišu pogoršanjem motornih i
kognitivnih funkcija, uključujući smanjenje sposobnosti učenja i memorije, intenzivno
proučavaju poslednjih 20 godina malo je poznato o molekulskim mehanizmima
njihovog nastanka, kao i odgovarajućim terapijama. Osnovni cilj ove doktorske
d... | Although ischemic brain diseases, characterized by decline of motor and cognitive
functions, including reducing the ability of learning and memory, have been intensively
studied over the past 20 years, the molecular mechanisms of their generation, as well as
appropriate treatments are still matter of controversy. Th... | true |
Molekularna i biohemijska osnova dijapauze kukuruznog plamenca Ostrinia nubilalis (Hbn.) (Lepidoptera: Pyralidae) | Molecular and biochemical basis of diapause of European corn borer Ostrinia nubilalis (Hbn.) (Lepidoptera: Pyralidae) | Dijapauza je period zaustavljenog razvoja kod insekata, drugih zglavkara i
određenih vrsta riba, a koja se javlja na određenom, za svaku vrstu
karakterističnom, razvojnom stadijumu. Dijapauzu, kao dugotrajnu i „skupu“ fazu
mirovanja, karakteriše prilagođavanje organizma na molekularnom, fiziološkom,
morfološkom i b... | Diapause is a carefully regulated state of arrested development that occurs at a
species-specific life stage of insects, other arthropods and some fish species. It
engages a plethora of molecular, physiological, morphological and behavioral
changes that altogether increase stress tolerance and the ability to survive... | true |
Struktura segmentalne duplikacije 5q13.2 kao modifikator fenotipa spinalne mišićne atrofije i amiotrofične lateralne skleroze | Structure of the 5q13.2 segmental duplication as a modifier of the phenotype of spinal muscular atrophy and amyotrophic lateral sclerosis | Spinalna mišićna atrofija (SMA) i amiotrofična lateralna skleroza (ALS) su bolesti
motoneurona. SMA je najčešći monogenski uzročnik smrtnosti dece, dok je ALS adultna,
neizlečiva bolest sa vrlo progresivnim tokom. SMA je uzrokovana homozigotnim odsustvom
gena SMN1 u telomernom delu segmentalne duplikacije 5q13.2, do... | Spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS) are motor
neurone diseases. SMA is the most frequent monogenic cause of infant mortality, whereas
ALS is an incurable late-onset disease with an inexorably progressive course. SMA is caused
by homozygous absence of the SMN1 gene located in the tel... | true |
Adsorpciona i emulgujuća svojstva proteinskog izolata i hidrolizata semena tikve (Cucurbita pepo) | Adsorption and emulsifying properties of pumpkin (Cucurbita pepo) seed protein isolate and hydrolysate | Seme tikve (Cucurbita pepo) obiluje kako uljem
tako i proteinima. Nakon izdvajanja ulja, proteini se
koncentrišu u uljanoj pogači, sekundarnom proizvodu
procesa proizvodnje ulja, gde njihov sadrţaj dostiţe do
65%. Proteini semena tikve su primamljiv sastojak za
prehrambenu, farmaceutsku i kozmetičku industriju zbo... | Pumpkin (Cucurbita pepo) seed is rich source of
both, oil and proteins. Once the oil has been extracted,
proteins concentrate in oil cake, a by–product of the oil
extraction process, where their content can reach up to
65%. Pumpkin seed proteins are desirable ingredient in
food, pharmaceutical and cosmetic ... | true |
Bioinformatička analiza proteina uključenih u patogenezu mijeloidnih maligniteta | Bioinformatics analysis of proteins involved in pathogenesis of myeloid malignancies | Mijeloidni maligniteti su klonalne bolesti ćelija mijeloidne krvne loze, koje su, pre
svega, posledica poremećaja samoobnavljanja i diferencijacije hematopoetskih matičnih
ćelija. Godišnja incidenca u Evropi je 7,5-8,6/100 000, a prosečna petogodišnja stopa
preživljavanja pacijenata, uz primenu standardne terapije, ... | Myeloid malignancies are clonal diseases of myeloid cell line, which arise, primary, as a
consequence of aberrant self-renewal and differentiation of hematopoietic stem cells.
Annual incidence in Europe is 7.5-8.6/100 000 and the mean 5-year survival rate, with
standard therapy, is 37%. Since malignancies often carr... | true |
Diverzitet vaskularne flore nizijskih šuma ravnog Srema | Diversity of vascular flora of lowland forests of ravni Srem | Kako su plavne šume u Evropi vrlo fragilni ekosistemi i povećava se njihova ugroženost prevashodno antopopresijom, postoji rastuća potreba za povećanjem obima stavljanja sastojina ovih šuma pod specijalni režim zaštite. Upravo sprovdena, floristička i ekološka istraživanja u ovoj disertaciji obezbeđuju jednu širu ekolo... | As floodplains in Europe are very fragile ecosystems, increasingly threatened by anthropopression, there is a growing need for increase in number of forest stands of this type placed under a special protection regime. The most recent floristic and ecological studies presented in this dissertation provide a wider ecolog... | false |
Određivanje profila ekspresije i unutarćelijske lokalizacije proteina ANKRD2 u srcu i skeletnim mišićima čoveka | Determination of expression profile and localization of ANKRD2 protein in human cardiac and skeletal muscle | Protein Ankrd2 pripada familiji mišićnih proteina sa ankirinskim ponovcima (eng. Muscle Ankyrin Repeat Proteins – MARP). U sarkomeri ima ulogu strukturnog elementa i signalnog molekula u procesu mehanotransdukcije. Pod dejstvom fiziĉkih i hemijskih stresora migrira u jedro, gde ostvaruje ulogu regulatora transkripcije.... | Ankrd2 is a member MARP (Muscle Ankyrin Repeat Proteins) protein family. In sarcomere, it has a role of a structural element and signaling molecule in mechanotransduction. Ankrd2 is highly responsive to physical and chemical stress, which results in its translocation to the nucleus where it acts as a transcriptional re... | false |
Biološka aktivnost etarskih ulja odabranih aromatičnih biljaka na vrste rodova Staphylococcus, Streptococcus, Lactobacillus, Pseudomonas, Entercoccus i Candida izlovane iz usne duplje čoveka | Biological activity of essential oils of selected aromatic plants on species of the genera Staphylococcus, Streptococcus, Lactobacillus, Pseudomonas, Enterococcus and Candida isolated from the human oral cavity | Oralno zdravlje smatra se važnim delom opšteg zdravlja ljudi, ali je često zanemarena oblast,
a razlozi tome su raznovrsni i kompleksni. Visoka učestalost oralnih oboljenja ima veliki
socijalni i ekonomski uticaj. Najčešća oboljenja usne duplje su karijes, parodontalna oboljenja
i oralne infekcije, dok su glavni uzr... | Oral health is considered an important part of general health, but is often neglected area, and
the reasons for this are diverse and complex. The high incidence of oral disease has a huge
social and economic impact. The most common diseases of the oral cavity are dental caries,
periodontal disease, and oral infectio... | true |
Karakterizacija i in vitro biološke aktivnosti fenolnih jedinjenja graška (Pisum sativum L) | Characterization and in vitro biological activities of phenolic compounds from pea (Pisum sativum L.) | Porodica mahunarki (Fabaceae) obiluje ekonomski i poljoprivredno značajnim vrstama
među kojima se po zastupljenosti gajenja u Srbiji izdvaja grašak (Pisum sativum L.) sa udelom
od 4,5% u ukupnoj povrtarskoj proizvodnji. Semenjače graška, posebno genotipova sa izrazito
pigmentisanim tamnim semenima predstavljaju znač... | The family of legumes (Fabaceae) is rich in economicaly and agriculturally important
species among which the most abundant in Serbia stands peas (Pisum sativum L.) with a share of
4.5% of the total vegetable production. Pea seed coats, especially in genotypes with highly
pigmented dark seeds are an important source ... | true |
Populaciona dinamika i ekotoksikologija crnog američkog patuljastog soma (Ameiurus melas Rafinesque, 1820) u Savskom jezeru | Population dynamic and and ecotoxicology of the black bullhead (Ameiurus melas Rafinesque, 1820) in Sava Lake | Crni američki patuljasti som (Ameiurus melas Rafinesque, 1820) je
najzastupljenija i najuspešnija alohtona vrsta ribe koja naseljava kopnene vode Evrope.
Istraživanja koja su sprovedena u proteklih nekoliko godina ukazuju na to da je ovo
dominantna invazivna vrsta i u mnogim kopnenim vodama u Srbiji.
Cilj istraživa... | abundant and successful non-native fish species in European freshwaters. Recent studies
indicate that the black bullhead is one of the most dominant invasive fish species in
Serbian waters as well.
The aim of this research was to determine the population characteristics of this
species in Sava Lake, as well as bioa... | true |
Citokininska homeostaza i ekspresija gena uključenih u kontrolu ćelijskog ciklusa tokom procesa regeneracije kelerabe (Brassica oleracea L. var. gongylodes) in vitro | Cytokinin homeostasis and expression of the genes involved in cell cycle control during kohlrabi (Brassica oleracea L. var. gongylodes) regeneration in vitro | Regeneracija in vitro gajenog biljnog tkiva kontrolisana je regulatorima rastenja,
naročito citokininima i auksinima. Egzogeno primenjeni biljni regulatori rastenja mogu
interagovati sa endogenim biljnim hormonima i uticati na njihovu biosintezu ili
distribuciju, odnosno menjati hormonalnu homeostazu koja utiče na r... | vitro plant regeneration is under control of plant growth regulators (PGRs), especially
cytokinins and auxins. Exogenously applied PGRs can affect the homeostasis of
endogenous plant hormones by influencing their biosynthesis and distribution,
subsequently altering in vitro development. Intensive cell divisions repr... | true |
Karakterizacija molekulskih vrsta specifičnog antigena prostate čoveka primenom imunoafinitetne hromatografije na čipu | Characterization of molecular species of human prostate-specific antigen by on-chip immunoaffinity chromatography | KARAKTERIZACIJA MOLEKULSKIH VRSTA SPECIFIČNOG ANTIGENA
PROSTATE ČOVEKA PRIMENOM IMUNOAFINITETNE HROMATOGRAFIJE
NA ČIPU
REZIME
Specifičan antigen prostate (prostate-specific antigen; PSA) ili kalikrein 3 (hK3),
pripada grupi ekstracelularnih serin-zavisnih proteaza iz porodice kalikreina. PSA u
najvećoj meri e... | CHARACTERIZATION OF MOLECULAR SPECIES OF HUMAN
PROSTATE-SPECIFIC ANTIGEN BY ON-CHIP IMMUNOAFFINITY
CHROMATOGRAPHY
ABSTRACT
Prostate-specific antigen (PSA), also known as kallikrein-3 (hK3), is an extracellular
serine protease belonging to the human kallikrein family. PSA is primarily produced by
the epithelia... | true |
Mutacije u genima koji doprinose riziku za oboljevanje od karcinoma dojke i/ili jajnika kod BRCA1 i BRCA2 negativnih visokorizičnih porodica u Srbiji | Mutations in breast cancer susceptibility genes in BRCA1 and BRCA2 negative hereditary breast and ovarian cancer families in Serbia | Uvod: Nasledni karcinom čini 5-10% od svih slučajeva karcinoma dojke i prvenstveno je
povezan sa štetnim mutacijama u visoko penetrabilnim genima BRCA1 i BRCA2. I pored
intenzivnog istraživanja ostatka nasledne komponente, treći visoko penetrabilni gen u
karcinomu dojke (BRCA3) još uvek nije pronadjen. Pod okriljem pol... | Background: 5-10% of all breast cancer cases are hereditary, and are often caused by
deleterious mutations in high penetrance BRCA1 and BRCA2 genes. Despite significant
efforts in unraveling the rest of the familial component, BRCA3 could not be identified.
Under the polygenic model of inheritance, three groups of g... | true |
Analiza mikrometastatske limfogene propagacije karcinomskih ćelija jetre kolorektalnog porekla | Analysis of micrometastatic lymphogenic propagation of colorectal carcinoma metastases | Cilj: Ispitati učestalost i distribuciju mikrometastatskih limfnih nodusa hepatičnog sliva i
prognostički značaj rutinske regionalne limfadenektomije s posebnim osvrtom na pojavu recidiva
maligne bolesti.
Metod: Ukupno 50 bolesnika sa metastatskom bolesti jetre podvrgnuto je resekciji jetre sa
rutinskom limfadenekt... | Objective: To investigate the frequency and distribution of micrometastatic lymph nodus of the
hepatic basin and the prognostic significance of routine regional lymphadenectomy with
particular reference to the occurrence of relapse of malignant disease.
Methods: A total of 50 patients with metastatic liver disease u... | true |
Uticaj različitih vrsta hrane na parametre oksidativnog stresa i masnokiselinski profil fosfolipida jetre pacova | Effects of different types of diets on the parameters of oxidative stress and the fatty acid profile of rat liver phospholipids | Sastav masnih kiselina lipida, posebno fosfolipida (PL) glavnih konstituenata ćelijskih
membrana zavisi od brojnih faktora. U poslednje vreme povećano je interesovanje za
istraživanja novih antioksidanasa u ishrani, uključujući omega-3 masne kiseline i
bioaktivne proteine prisutne u mleku. Uticaj različitih vrsta hr... | The composition of fatty acids especially phospholipids (PL) as the main constituents of
cell membranes depends on many factors. Recently, there has been an increased interest
in novel dietary antioxidants, including omega-3 fatty acids and bioactive proteins
present in milk. There is limited data regarding the effe... | true |
Mehanizmi tolerancije slobodnoživećih bakterija i bakterija u biofilmovima na teške metale | Mechanisms of heavy metal tolerance in free living bacteria and bacterial biofilms | Teški metali, čija se koncentracija u sredini sve više povećava kao rezultat povećane
industrijske aktivnosti i tehnološkog razvoja, ubrajaju se u najčešće zagađivače životne
sredine. Kada su prisutni u većim koncentracijama toksični su i predstavljaju ozbiljnu
pretnju kako za životnu sredinu tako i za zdravlje ljud... | Heavy metals are one of the most common environmental pollutants due to increased
industrial activities and technological development. When present in excessive
concentrations, heavy metals are highly toxic and they pose a serious threat both to
environment and human health, due to their persistence in nature and ac... | true |
Ispitivanje mehanizma antitumorskog delovanja derivata antrahinona in vitro | An in vitro investigation of the mechanism of antitumor activity of anthraquinone derivatives | Prirodni antrahinoni, važna klasa hinonskih jedinjenja, se mogu naći u velikom
broju viših biljaka, mahovinama, lišajevima kao i drugim organizmima. Ova hinolna
jedinjenja poseduju laksativno, antibiotičko, antiinflamatorno i antipiretičko kao i
antiviralno dejstvo, a njihov potencijal u tretmanu kancera, i inhibici... | Naturally occuring anthraquinones, an important class of quinone compounds, are
numerous in plants, moss, lichen and other organizms. These quinol compounds posses
laxative, antibiotic, antiinflamatory, antipyretic and antiviral properties, and their potential
for cancer treatment and inhibition of proliferation and... | true |
Uticaj dugotrajne restrikcije hrane na ekspresiju glukokortikoidnog receptora u prednjem mozgu pacova tokom starenja | The effect of long-term food restriction on te expression of glucocorticoid receptor in the rat forebrain during aging | Dugotrajna restrikcija hrane produžava životni vek i odlaže pojavu mnogih bolesti koje se
javljaju sa starenjem. Brojni literaturni podaci ukazuju da kod životinja kojima je unos hrane
smanjen izostaje karakterističan starosno-zavistan pad u kognitivnim funkcijama, međutim,
mehanizam ovakvog neuroprotektivnog dejstv... | Moderate restriction in food intake (dietary restriction, DR) extends the life-span and
delays the onset of many age-related diseases. In addition, food-restricted animals exhibit
attenuated cognitive deficits during aging as they perform better in learning and memory tasks
than their ad libitum fed counterparts. At... | true |
Rasprostranjenje, horološka struktura i centri diverziteta balkanske endemične flore u Crnoj Gori | Distribution, chorological structure and centers od diversity of the balkan endemic flora in Montenegro | Glavni cilj ovog rada je utvrđivanje ukupnog broja balkanskih endemičnih
taksona ranga vrste i podvrste na teritoriji Crne Gore. Terenskim istraživanjima, i
pregledom obimne literaturne građe i herbarskih zbirki utvrđeno je da u Crnoj Gori rastu
372 balkanska endemična taksona. Podaci koji obuhvataju rasprostranjenj... | The main objective of this study is to determine the total number of the Balkan
endemic taxa of species and subspecies rank on the territory of Montenegro. Field
research and extensive literature and herbarium collection review has found that there are
372 Balkan endemic taxa in Montenegro. The data which include di... | true |
Spavanje i elektroencefalografski ritmovi kao indikatori poremećaja funkcionalno različitih holinergičkih inervacija velikog mozga pacova | Sleep and electroencephalographic rhythms as an indicators of the functionally distinct cholinergic innervation disorders in rat brain | Alchajmerova bolest (AB) i Parkinsonova bolest (PB) su najčešće neurodegenerativne bolesti starenja... | Alzheimer's disease (AD)and Parkinson's disease are the most common neurodegenerative diseases in elderly... | false |
Molekulski mehanizmi citotoksičnog delovanja trans-kompleksa platine(II) i platine(IV) sa piridinskim derivatima kao ligandima | Molecular mechanisms of the cytotoxicity of trans-platinum(II) and trans-platinum(IV) complexes with pyridine ligands | Uvod: Hemioterapija koja se zasniva na platinskim agensima je ključna u lečenju
solidnih tumora, a jedan od vodeći itostatika koji se koristi je isplatina. Međutim, i
pored visoke efikasnosti cisplatine, toksičnost i razvoj rezistentnosti ograničili su njenu
upotrebu. Stoga su pokrenuta brojna istraživanja sa iljem ... | Introduction: Platinum-based anticancer chemotherapy constitutes a cornerstone for the
treatment of various solid tumors. Cisplatin was one of the first chemotherapeutic
agents to exhibit broad efficacy and it remains among the most widely used agents in
the treatment of cancer. Its introduction inspired great effor... | true |
Utvrđivanje varijabilnosti i diferencijacije prirodnih populacija Pinus nigra Arnold u Srbiji korišćenjem fitohemijskih i molekularnih markera | Determination of variability and diferentiation of native populations of Pinus nigra Arnold in Serbia using phytochemical and molecular markers | U ovom radu analizirana je fitohemijska i genetiţka varijabilnost i diferencijacija sedam autohtonih populacija Pinus nigra u Srbiji koje pripadaju razliţitim infraspecijskim taksonima (ssp. nigra, var. gocensis, ssp. pallasiana i var. banatica). U dvogodišnjim ţetinama 195 jedinki iz sedam populacija odreŤen je sadrţa... | In this work phytochemical and genetic variability and differentiation of seven native populations belonging to different infraspecific taxa of Pinus nigra (ssp. nigra, var. gocensis, ssp. pallasiana i var. banatica) in Serbia were analyzed. In the needles of 195 trees from seven populations, composition and variabilit... | false |
Primena Higučijeve fraktalne dimenzije i metode nezavisnih komponenata u analizi spontane bioelektrične aktivnosti Br neurona vinogradskog puža pod delovanjem konstantnog magnetnog polja i uabaina | Application of Higuchi fractal dimension and indepenedent component method in analysis of garden snail Br neuron bursting activity modulated by static magnetic field and ouabain. | Nelinearne i napredne statističke metode, pored linearnih metoda, zauzimaju sve
značajnije mesto u analizi fizioloških signala, posebno u svetlu nelinearnog i haotičnog
ponašanja bioloških sistema. Stoga je zajednička upotreba Higučijeve fraktalne dimenzije i
analize nezavisnih komponentata (ICA), značajan i nov pri... | Nonlinear and advanced statistical methods, in addition to linear methods, occupy a
prominent place in the analysis of physiological signals, especially in light of the non-linear and
chaotic behavior of biological systems. Therefore, the use of Higuchi fractal dimension and
independent component analysis (ICA), rep... | true |
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