text stringlengths 7 742 | labels stringclasses 2 values | reason stringlengths 35 141 |
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We report a case of seizure associated with L-asparaginase therapy but no evidence of hemorrhagic or thrombotic cerebrovascular events. | ADE | ---
**Please provide the text you would like me to review.** |
Eighty-two patients with various malignancies who received imipenem/cilastatin 143 times for neutropenic fever between March 1994 and October 1999 in Department of Pediatric Oncology, Gazi University, were identified. | ADE | **Explanation:** This sentence is a direct and unambiguous statement of an adverse drug event. It clearly states |
Eighty-two patients with various malignancies who received imipenem/cilastatin 143 times for neutropenic fever between March 1994 and October 1999 in Department of Pediatric Oncology, Gazi University, were identified. | ADE | This is ADE because the patient was treated with a drug that is a toxic and harmful adverse reaction that |
Incidence of seizures in pediatric cancer patients treated with imipenem/cilastatin. | ADE | This is ADE because the sentence describes a specific adverse event, but it doesn't describe the potential |
Incidence of seizures in pediatric cancer patients treated with imipenem/cilastatin. | ADE | This is ADE because the sentence describes a specific adverse event, and the sentence is not directly related to |
Proconvulsive tendency of imipenem/cilastatin is one of its well-known side effects. | ADE | This is ADE because it is a side effect of the drug Proconvulsive tendency.
--- |
Proconvulsive tendency of imipenem/cilastatin is one of its well-known side effects. | ADE | This is ADE because it is a side effect of a drug that is not directly related to the drug |
Three of these patients had convulsions attributed to imipenem/cilastatin; 3.6% of the patients had seizure, or 2% of imipenem/cilastatin administrations was followed by a seizure attack. | ADE | This sentence is not ADE because it does not describe any harmful or unintended effects.
---
** |
Three of these patients had convulsions attributed to imipenem/cilastatin; 3.6% of the patients had seizure, or 2% of imipenem/cilastatin administrations was followed by a seizure attack. | ADE | This is an ADE because the statement describes a potential adverse reaction to a drug.
---
The |
Three of these patients had convulsions attributed to imipenem/cilastatin; 3.6% of the patients had seizure, or 2% of imipenem/cilastatin administrations was followed by a seizure attack. | ADE | ---
Explanation:
The sentence is related to an adverse drug event because the patient had convulsions attributed |
Three of these patients had convulsions attributed to imipenem/cilastatin; 3.6% of the patients had seizure, or 2% of imipenem/cilastatin administrations was followed by a seizure attack. | ADE | * **Specificity:** The sentence is specific and provides a clear and concise explanation of the adverse event |
Three of these patients had convulsions attributed to imipenem/cilastatin; 3.6% of the patients had seizure, or 2% of imipenem/cilastatin administrations was followed by a seizure attack. | ADE | This is ADE because the sentence describes the patient's condition and the medication, and it does not |
Three of these patients had convulsions attributed to imipenem/cilastatin; 3.6% of the patients had seizure, or 2% of imipenem/cilastatin administrations was followed by a seizure attack. | ADE | This is ADE because the patient is experiencing a significant and unexpected adverse reaction, which is a direct and |
Gabapentin-induced mood changes with hypomanic features in adults. | ADE | This is an ADE because it describes a significant and unexpected adverse reaction to a medication, which can be |
Gabapentin-induced mood changes with hypomanic features in adults. | ADE | This is ADE because it describes a specific adverse reaction to a medication.
---
The following sentence |
We report two adults who received gabapentin (GBP) and subsequently developed behavioural side effects. | ADE | This is ADE because the statement describes a potential adverse effect.
Explanation: The sentence is about the |
We report two adults who received gabapentin (GBP) and subsequently developed behavioural side effects. | ADE | This is ADE because the statement describes a specific adverse drug event.
---
Please provide the text |
Acute pancreatitis in a child with idiopathic ulcerative colitis on long-term 5-aminosalicylic acid therapy. | ADE | **Explanation:** This sentence is a valid ADE because it describes an acute pancreatitis, which is a serious |
We describe a 10-year-old boy with ulcerative colitis who developed acute pancreatitis while on long-term treatment with 5-aminosalicylic acid. | ADE | This is ADE because the statement describes an acute pancreatitis, which is a serious and potentially life-threatening |
CONCLUSION: Marked visual field constriction appears to be associated with vigabatrin therapy. | ADE | This is ADE because the statement describes a medical condition and the treatment is specifically related to the condition. |
Electro-oculography, electroretinography, visual evoked potentials, and multifocal electroretinography in patients with vigabatrin-attributed visual field constriction. | ADE | This is ADE because the sentence describes a medical procedure that is not a clinical intervention and is not a |
PURPOSE: Symptomatic visual field constriction thought to be associated with vigabatrin has been reported. | ADE | This is not ADE because the sentence only mentions the symptom, but does not describe any harmful or unintended |
The current study investigated the visual fields and visual electrophysiology of eight patients with known vigabatrin-attributed visual field loss, three of whom were reported previously. | ADE | This sentence is ADE because the study investigates the visual fields and visual electrophysiology of eight patients with known |
The field defects and some electrophysiological abnormalities persist when vigabatrin therapy is withdrawn. | ADE | This is ADE because the sentence describes a defect in the drug's effectiveness or safety.
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Depressive symptoms disappeared after interferon therapy was stopped. | ADE | This is ADE because the patient experienced symptoms of depression after a medication cessation.
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--- |
Treatment of chronic hepatitis C with interferon alpha (IFN-alpha) is relatively contraindicated in patients with psychiatric disorders because of possible severe psychiatric side effects. | ADE | ---
**Explanation:**
* **Reason:** The reason is a direct and clear explanation of |
Treatment of chronic hepatitis C with interferon alpha (IFN-alpha) is relatively contraindicated in patients with psychiatric disorders because of possible severe psychiatric side effects. | ADE | This is ADE because it is a potential adverse drug event.
---
Example 5: |
While for ribavirin antidepressant effects are not known, we suppose that antidepressants may prevent changes in serotonergic or noradrenergic neurotransmission caused by IFN-alpha. | ADE | This sentence is likely an ADE because it is not a direct adverse event.
---
**Please |
Intensive high-flux hemodiafiltration is often used in the management of vancomycin toxicity. | ADE | **Explanation:** This sentence is considered an ADE because it describes a specific treatment used to treat vancom |
Management of hypophosphatemia induced by high-flux hemodiafiltration for the treatment of vancomycin toxicity: intravenous phosphorus therapy versus use of a phosphorus-enriched dialysate. | ADE | ---
**Answer:**
Reason: The sentence describes a dangerous adverse reaction, which is an ADE |
We describe 2 children with cerebral palsy who suffered significant morbidity immediately after treatment with hyperbaric oxygen. | ADE | This is ADE because the statement describes a specific, identifiable, and significant adverse event.
**Explanation |
A 33-year-old male presented with brown discolouration of the fingernails following the application of 4% hydroquinone in sorbolene cream and 0.1% tretinoin cream to the face intermittently for 9 months. | ADE | This is an ADE because the statement describes a condition that is harmful and unintended, and the patient is |
A 33-year-old male presented with brown discolouration of the fingernails following the application of 4% hydroquinone in sorbolene cream and 0.1% tretinoin cream to the face intermittently for 9 months. | ADE | This is ADE because it describes a specific adverse reaction to a medication.
Explanation: The sentence describes |
Nail staining from hydroquinone cream. | ADE | This is ADE because the statement describes a condition that is harmful to the skin, but not a direct |
Gangrene of the fingertips after bleomycin and methotrexate. | ADE | This is ADE because the statement describes a condition that is caused by the use of a harmful substance ( |
Gangrene of the fingertips after bleomycin and methotrexate. | ADE | This is ADE because the sentence describes a condition that is caused by the use of a drug that is |
This supports the well-reported potential of bleomycin to trigger acral vascular toxicity. | ADE | This sentence is a valid ADE because it describes a potential adverse reaction that is directly linked to the drug |
We describe a 57-year-old man with acral erythrocyanosis progressing to acute digital ischemia and gangrene that developed after combined chemotherapy (bleomycin and methotrexate) used to treat a metastatic squamous cell carcinoma of the hypopharynx. | ADE | This sentence is a positive ADE because it describes a specific adverse event that has been observed.
--- |
We describe a 57-year-old man with acral erythrocyanosis progressing to acute digital ischemia and gangrene that developed after combined chemotherapy (bleomycin and methotrexate) used to treat a metastatic squamous cell carcinoma of the hypopharynx. | ADE | This is an ADE because it describes a specific adverse event, which is a harmful and unintended effect. |
We describe a 57-year-old man with acral erythrocyanosis progressing to acute digital ischemia and gangrene that developed after combined chemotherapy (bleomycin and methotrexate) used to treat a metastatic squamous cell carcinoma of the hypopharynx. | ADE | This is ADE because the sentence describes a serious and potentially life-threatening condition, and the statement is |
We describe a 57-year-old man with acral erythrocyanosis progressing to acute digital ischemia and gangrene that developed after combined chemotherapy (bleomycin and methotrexate) used to treat a metastatic squamous cell carcinoma of the hypopharynx. | ADE | * The sentence is a statement of fact.
* It is not a claim of fact |
Diarrhea-associated over-anticoagulation in a patient taking warfarin: therapeutic role of cholestyramine. | ADE | This is ADE because it involves the drug's therapeutic role in the patient's condition, which |
We present a case of significant over-anticoagulation temporally associated with a bout of protracted diarrhea in a patient on warfarin therapy. | ADE | This is ADE because the sentence is related to the patient's condition and the treatment.
--- |
We present a case of significant over-anticoagulation temporally associated with a bout of protracted diarrhea in a patient on warfarin therapy. | ADE | ---
Here are some examples of ADE:
---
Example 1:
Sentence: " |
MI related to the use of activated and non-activated PCCs predominantly affects young patients who often have no preceding history of, or risk factors for, MI and tends to be associated with large cumulative doses of concentrate. | ADE | * The sentence is generally safe and doesn't indicate any potential harm.
* The sentence does |
Recombinant VIIa concentrate in the management of bleeding following prothrombin complex concentrate-related myocardial infarction in patients with haemophilia and inhibitors. | ADE | This is ADE because it describes an adverse reaction to a specific drug.
Sentence: "The patient |
We have safely used recombinant factor VIIa to treat bleeding in the immediate and long-term period following PCC-related MI. | ADE | This is not ADE because the sentence only describes the use of recombinant factor VIIa, and it does |
Even after a strict warning, he took another quinine tablet that evening, which triggered his fifth episode of severe thrombocytopenia, and confirmed the etiology of quinine-induced thrombocytopenia. | ADE | This is ADE because the sentence describes an adverse drug event, and the statement does not mention any harmful |
Even after a strict warning, he took another quinine tablet that evening, which triggered his fifth episode of severe thrombocytopenia, and confirmed the etiology of quinine-induced thrombocytopenia. | ADE | This sentence is an ADE because it describes an adverse drug event, even though it is not directly related |
Even after a strict warning, he took another quinine tablet that evening, which triggered his fifth episode of severe thrombocytopenia, and confirmed the etiology of quinine-induced thrombocytopenia. | ADE | This is ADE because the statement describes a specific event that was not explicitly stated in the original text. |
Occult quinine-induced thrombocytopenia. | ADE | This is not ADE because the sentence only mentions the drug and its mechanism of action, not the potential |
Only after three subsequent episodes of severe, symptomatic thrombocytopenia over the next four weeks did he say, upon repeat questioning, that he had continued to take quinine for night leg cramps. | ADE | This sentence is ADE because it describes a clinical event that is not related to the drug.
--- |
An 8-year-old child with familial Mediterranean fever exhibited signs of colchicine intoxication while receiving prophylactic doses of the drug. | ADE | * **Reason:** This is ADE because colchicine is a non-selective sedative and can cause |
CONCLUSION: To the best of our knowledge, this is the first time colchicine intoxication in this age group has been described in the English literature. | ADE | ---
Explanation:
The sentence "To the best of our knowledge, this is the first time |
Near fatal acute colchicine intoxication in a child. | ADE | This is ADE because colchicine is a non-selective, potent, and non-toxic drug that |
Near fatal acute colchicine intoxication in a child. | ADE | This is ADE because the patient was exposed to colchicine, a drug that is known to cause severe |
Acute myeloid leukemia and lung cancer occurring in a chronic lymphocytic leukemia patient treated with fludarabine and autologous peripheral blood stem-cell transplantation. | ADE | **Explanation:**
The sentence is a direct example of an adverse drug event. It directly describes a |
Acute myeloid leukemia and lung cancer occurring in a chronic lymphocytic leukemia patient treated with fludarabine and autologous peripheral blood stem-cell transplantation. | ADE | This is ADE because the sentence describes a specific type of cancer, while the other sentences describe a general |
We describe the exceptional development of AML and lung cancer in a patient with previously diagnosed CLL in minimal residual disease status after fludarabine treatment followed by autologous peripheral blood stem-cell transplantation. | ADE | This sentence is an ADE because it describes a significant adverse event, and it is not an ADE because |
We describe the exceptional development of AML and lung cancer in a patient with previously diagnosed CLL in minimal residual disease status after fludarabine treatment followed by autologous peripheral blood stem-cell transplantation. | ADE | This is an ADE because the patient has previously diagnosed AML and lung cancer, and has undergone fludar |
In 2 of the 3 cases the patients were also taking lithium carbonate and beta-blockers, both of which could have contributed to the incontinence. | ADE | ---
This example demonstrates the use of the word "ADE" in a clinical context.
It |
In the present paper the authors describe 2 female patients who developed incontinence secondary to the selective serotonin reuptake inhibitors paroxetine and sertraline, as well as a third who developed this side effect on venlafaxine. | ADE | This is an ADE because the patient has a history of incontinence and is taking paroxetine and sert |
In the present paper the authors describe 2 female patients who developed incontinence secondary to the selective serotonin reuptake inhibitors paroxetine and sertraline, as well as a third who developed this side effect on venlafaxine. | ADE | This is ADE because the statement describes a side effect of the drug, but it does not describe any |
In the present paper the authors describe 2 female patients who developed incontinence secondary to the selective serotonin reuptake inhibitors paroxetine and sertraline, as well as a third who developed this side effect on venlafaxine. | ADE | **Explanation:**
This sentence is a type of ADE because it describes a side effect of a medication |
This concerns 2 male patients who experienced incontinence while taking venlafaxine. | ADE | This is ADE because it's a significant adverse event that is related to the drug venlafax |
Case studies in heparin-induced thrombocytopenia. | ADE | This is ADE because heparin (a drug used to stabilize blood clots) can cause significant and potentially serious |
Major points illustrated are, (1) occurrence of HIT with any dose or form of heparin; (2) misperceptions on the diagnostic criteria; (3) correct (thrombin inhibitors) and incorrect (platelet transfusions and warfarin) management; (4) influence of management strategy on clinical outcomes; (5) severity of the syndrome; and (6) potential for both anamnestic response to heparin and disappearance of HIT antibodies over time. | ADE | This sentence is a statement of fact, it is not an adverse drug event.
---
Final |
Type II heparin-induced thrombocytopenia (HIT) is an immunological disorder characterized by antibodies to heparin-platelet factor 4 complexes and a high risk of thrombotic complications. | ADE | This is an ADE because it describes a specific adverse reaction to a drug, which is a characteristic of |
After several unrevealing medical work-ups, he was found to have a high blood lead level (122 microg/dL); he has a history of scraping and sanding lead paint without adequate protective measures. | ADE | This is ADE because the statement describes a potential adverse reaction to a drug that is not explicitly mentioned in |
It also highlights a current major etiologic question, that is, whether and to what degree lead exposure contributes to the development of hypertension, and raises the issue of whether lead-induced hypertension constitutes a subset of hypertension that is especially amenable to therapy with dietary calcium. | ADE | The sentence is related to an adverse drug event because it describes a potential adverse reaction to a medication. |
It also highlights a current major etiologic question, that is, whether and to what degree lead exposure contributes to the development of hypertension, and raises the issue of whether lead-induced hypertension constitutes a subset of hypertension that is especially amenable to therapy with dietary calcium. | ADE | The sentence is relevant to an adverse drug event because it discusses a current major etiologic question, that |
Poorly controlled hypertension in a painter with chronic lead toxicity. | ADE | This is an ADE because the statement describes a medical condition that is harmful and undesirable, and the patient |
This case demonstrates an occupational activity (construction) that has now become the dominant source of lead exposure for U.S. adults, the importance of a good occupational history to suspecting and making a diagnosis, the possible outcomes of chronic lead toxicity, and the importance of preventing further exposure and using proper methods to treat acute toxicity. | ADE | - It is a case of an occupational activity.
- It is a significant health concern. |
Severe rash, including the Stevens-Johnson syndrome (SJS), is the major toxicity of nevirapine and is described in the package labeling with a prominent, boxed warning. | ADE | ---
Explanation:
The sentence is a statement of fact, and it is not a statement of |
Severe rash, including the Stevens-Johnson syndrome (SJS), is the major toxicity of nevirapine and is described in the package labeling with a prominent, boxed warning. | ADE | ---
Explanation:
* **Reason:** This is a direct and clear explanation of the sentence |
Severe rash, including the Stevens-Johnson syndrome (SJS), is the major toxicity of nevirapine and is described in the package labeling with a prominent, boxed warning. | ADE | This is ADE because nevirapine is a drug that can cause a severe rash, including the Stevens |
Stevens-Johnson syndrome caused by the antiretroviral drug nevirapine. | ADE | This is ADE because the statement describes a serious and potentially life-threatening adverse reaction to a drug. |
Though physicians treating large populations of patients with HIV are well aware of this complication, only one other report of nevirapine-associated SJS has been documented in the dermatology literature. | ADE | This is a serious adverse event because it is a significant and potentially life-threatening complication.
--- |
We describe 2 cases of SJS related to nevirapine use and review the literature on this newly recognized association. | ADE | The sentence is related to the drug nevirapine and is a clinical safety review.
--- |
Oral intake and acarbose were withheld and the ileus spontaneously resolved after 2 days. | ADE | This is not ADE because the sentence does not mention any harmful or unintended effects.
---
** |
There is evidence that the angiotensin II receptor antagonist, losartan, increases urate excretion by reducing reabsorption of urate in the renal proximal tubule. | ADE | The sentence is a valid ADE because it describes a harmful adverse reaction to a medication.
--- |
Atrial fibrillation occurring in a patient taking etanercept plus methotrexate for rheumatoid arthritis. | ADE | This is ADE because it involves a serious and potentially life-threatening condition.
---
**Explanation |
Atrial fibrillation occurring in a patient taking etanercept plus methotrexate for rheumatoid arthritis. | ADE | This is ADE because the sentence describes the side effect of etanercept plus methotrexate.
--- |
A review of the literature revealed two other cases of hepatic angiosarcoma in patients after long-term cyclophosphamide treatment. | ADE | This is ADE because the sentence only mentions the drug cyclophosphamide and does not describe any harmful or |
Hepatic angiosarcoma occurring after cyclophosphamide therapy: case report and review of the literature. | ADE | This is an ADE because the patient has a tumor that is causing liver damage.
---
Example |
We propose that cyclophosphamide be added to the list of exposures potentially associated with hepatic angiosarcoma. | ADE | This is an ADE because it is a potential harmful adverse reaction to an existing drug.
--- |
ARA-C is frequently associated with dermatologic toxicity, but this is only the second case of toxic epidermal necrolysis described in connection with this drug. | ADE | This is ADE because the drug is a toxic epidermal necrolysis (TEN) inhibitor.
--- |
ARA-C is frequently associated with dermatologic toxicity, but this is only the second case of toxic epidermal necrolysis described in connection with this drug. | ADE | This is ADE because the statement describes a specific drug and its potential toxicity, but it does not mention |
On the fifth day after administration of a high dose of ARA-C (2 g/m2 intravenously every 12 hours), she developed bullous lesions on the hands and soles that disseminated, evolving to necrosis, sepsis, and death on the 22nd day. | ADE | This is ADE because the statement describes a significant and unexpected adverse event that is linked to the drug. |
On the fifth day after administration of a high dose of ARA-C (2 g/m2 intravenously every 12 hours), she developed bullous lesions on the hands and soles that disseminated, evolving to necrosis, sepsis, and death on the 22nd day. | ADE | This is an ADE because it describes a significant adverse event that is not a direct result of the drug |
On the fifth day after administration of a high dose of ARA-C (2 g/m2 intravenously every 12 hours), she developed bullous lesions on the hands and soles that disseminated, evolving to necrosis, sepsis, and death on the 22nd day. | ADE | This is ADE because the patient experienced severe and debilitating side effects, including bullous lesions on the hands |
Toxic epidermal necrolysis after the use of high-dose cytosine arabinoside. | ADE | This is ADE because the patient experienced a severe and uncontrolled adverse reaction to the drug cytosine arabinos |
We report a fatal case of toxic epidermal necrolysis (TEN) resulting from a high dose of cytosine arabinoside (ARA-C). | ADE | This is ADE because the statement contains a critical information that could potentially cause harm.
---
Example |
We report a fatal case of toxic epidermal necrolysis (TEN) resulting from a high dose of cytosine arabinoside (ARA-C). | ADE | This is ADE because the drug is toxic and harmful to the body.
---
Example 5 |
We report a fatal case of toxic epidermal necrolysis (TEN) resulting from a high dose of cytosine arabinoside (ARA-C). | ADE | The sentence is a statement about a serious adverse event.
---
Final Answer:
The correct |
We report a fatal case of toxic epidermal necrolysis (TEN) resulting from a high dose of cytosine arabinoside (ARA-C). | ADE | This is ADE because the sentence describes a serious adverse event.
---
Example 5: |
Quetiapine and obsessive-compulsive symptoms (OCS): case report and review of atypical antipsychotic-induced OCS. | ADE | The sentence is related to an adverse drug event.
---
**Please provide the text you want |
Quetiapine and obsessive-compulsive symptoms (OCS): case report and review of atypical antipsychotic-induced OCS. | ADE | This is ADE because the sentence is a case report and review of an atypical antipsychotic-induced O |
Quetiapine and obsessive-compulsive symptoms (OCS): case report and review of atypical antipsychotic-induced OCS. | ADE | This is ADE because the patient experienced a severe adverse reaction to a medication, and the medication was used |
The first known report of quetiapine exacerbating OCS in a 43-year-old man with obsessive-compulsive disorder (OCD), trichotillomania, delusional disorder and bipolar II disorder is presented. | ADE | This is ADE because the sentence describes a serious adverse event, which is a harmful and unintended effect caused |
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