text stringlengths 7 742 | labels stringclasses 2 values | reason stringlengths 35 141 |
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He was diagnosed with possible serotonin syndrome; his symptoms resolved after clomipramine was stopped but before clozapine was restarted eight days later. | ADE | This is ADE because serotonin syndrome is a possible adverse drug event.
---
**Please provide a |
OBJECTIVE: To report on the possible development of serotonin syndrome in a patient receiving clomipramine after clozapine was withdrawn from the treatment regimen. | ADE | This is ADE because the statement describes the intended therapeutic use of clomipramine, which is a serotonin |
OBJECTIVE: To report on the possible development of serotonin syndrome in a patient receiving clomipramine after clozapine was withdrawn from the treatment regimen. | ADE | **Explanation:** This sentence is a valid ADE because it describes a potential adverse reaction to a medication, |
Possible serotonin syndrome associated with clomipramine after withdrawal of clozapine. | ADE | This is ADE because the sentence describes a possible adverse reaction to a drug that is a known side effect |
Possible serotonin syndrome associated with clomipramine after withdrawal of clozapine. | ADE | **Explanation:**
This is an ADE because the statement describes a possible adverse reaction to a medication that |
The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused. | ADE | This is an ADE because the drug was stopped and the patient's behavior is unusual and concerning. |
The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused. | ADE | The sentence describes a significant and unexpected adverse event. It is a dangerous and potentially harmful event. |
The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused. | ADE | ---
Explanation:
The sentence contains a clear and concise statement about the drug's effects and |
The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused. | ADE | **Explanation:** This sentence is an ADE because it describes a specific adverse event that is related to the |
The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused. | ADE | **Explanation:** This is an ADE because the patient's symptoms are significantly worsened by the drug, |
The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused. | ADE | This sentence is a drug event because it is a direct result of the drug being stopped.
--- |
The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused. | ADE | This is an ADE because the patient's symptoms were related to a drug that was stopped. |
The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused. | ADE | This is ADE because the patient's condition was not adequately monitored and the drug was stopped. |
The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused. | ADE | **Explanation:**
* **Differentiate from other ADEs:** This sentence is not an ADE |
The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused. | ADE | This is an ADE because the patient's condition was not adequately evaluated and the drug was not given |
The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused. | ADE | * **Specificity:** The sentence clearly states that the patient experienced adverse events.
* ** |
The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused. | ADE | This sentence is an ADE because it describes a specific adverse event.
---
Final Answer: |
Quinine induced coagulopathy--a near fatal experience. | ADE | This is ADE because the sentence describes a harmful and unintended effect.
---
Example 5: |
The cause of his bleeding was a severe thrombocytopoaenia, induced by chronic ingestion of quinine. | ADE | This is ADE because the sentence describes a serious and potentially life-threatening condition.
---
The |
Dose-dependent olanzapine-associated leukopenia: three case reports. | ADE | This is an ADE because the statement describes a specific adverse reaction to a medication.
---
The |
These cases suggest the possibility that, in some patients, leukopenia or agranulocytosis during olanzapine treatment might be dose-related. | ADE | This is ADE because the statement is not about the drug itself, but about the potential for adverse effects |
These cases suggest the possibility that, in some patients, leukopenia or agranulocytosis during olanzapine treatment might be dose-related. | ADE | This is an ADE because the patient's lack of white blood cell count (leukopenia or |
We report three cases of patients who developed leukopenia during olanzapine treatment. | ADE | **Explanation:**
This sentence is a case of an adverse drug event because it describes a single instance |
CONCLUSION: This case illustrates a potential link between dermatologic and ocular 5-FU toxicities. | ADE | **Explanation:** This sentence is a summary of a case, not a detailed description of an adverse drug |
Differential diagnoses included ocular rosacea with cicatrizing conjunctivitis and 5-FU-induced ectropion. | ADE | This is ADE because it describes a condition that is causing an adverse reaction to a medication.
--- |
DISCUSSION: Patients with 5-FU-induced ectropion experience tender, red, scaled lids, making contact lens wear difficult. | ADE | This is not ADE because the statement does not mention any harmful or unintended effects.
---
Example |
DISCUSSION: Patients with 5-FU-induced ectropion experience tender, red, scaled lids, making contact lens wear difficult. | ADE | This is an ADE because the statement describes the patient's condition, but it doesn't mention |
Ectropion secondary to bolus injection of 5-fluorouracil. | ADE | ---
The following sentence may describe an adverse drug event.
Explain briefly why it qualifies as an |
Exacerbation of 5-FU dermatologic toxicities in patients with preexisting conditions suggests the importance of aggressive ocular prophylaxis, using frequent ocular lubrication and topical steroid preparations with concurrent medical management of pre-existing dermatologic conditions. | ADE | This is an ADE because it describes a specific adverse reaction to a medication, and it is a potential |
Presented is a case of acute renal failure induced by acetazolamide therapy for glaucoma. | ADE | ---
This is a concise and accurate answer.
---
**Final Answer:**
The final |
Renal failure associated with acetazolamide therapy for glaucoma. | ADE | This is ADE because the statement describes a potential side effect of acetazolamide therapy, which is a |
This sulfonamide like nephropathy should be differentiated from acetazolamide-related calcium phosphate nephrolithiasis. | ADE | This is ADE because sulfonamide-like nephropathy is a type of nephropathy that causes kidney damage |
Ischaemic colitis in a patient taking meloxicam. | ADE | This is an ADE because the sentence describes an adverse drug event.
---
Example 5: |
Symptoms and endoscopic lesions quickly regressed within 1 week of meloxicam withdrawal. | ADE | This is not ADE because the sentence describes the symptoms and endoscopic lesions quickly regressed within 1 week |
We describe a patient who presented with bloody diarrhoea after 15 mg meloxicam daily for 10 days for osteoarthritis. | ADE | This is an ADE because the sentence describes a patient with a specific condition (osteoarthritis) and |
We suggest that meloxicam might have intestinal toxic effects when taken in high doses, because of reduced COX-2 selectivity. | ADE | This is ADE because the statement describes a harmful adverse reaction to a medication, which is not an ADE |
As these cases revealed, close monitoring of blood chemistry is mandatory after starting spironolactone, and patients should be advised to stop spironolactone immediately if diarrhoea develops. | ADE | This is an ADE because the patient's blood chemistry is compromised by the drug spironolactone, which |
In patients with chronic heart failure, spironolactone added to conventional treatment may lead to serious and, occasionally, fatal hyperkalaemia. | ADE | This is an ADE because it describes a serious and potentially fatal adverse reaction.
---
The following |
In some cases this seems to happen because spironolactone causes diarrhoea. | ADE | ---
Final Answer:
The correct answer is **Explanation**
Final Answer:
The correct |
Serious adverse events experienced by patients with chronic heart failure taking spironolactone. | ADE | This is an ADE because the sentence describes a serious adverse event that is likely to cause harm to patients |
We report a patient with advanced colonic carcinoma who was treated with concomitant chemoirradiation with oxaliplatin and developed a peculiar dermnatitis in the irradiated field after being exposed to subsequent chemotherapy with oxaliplatin. | ADE | **Explanation:**
The sentence describes a specific adverse event that was observed after treatment with oxaliplatin |
An 11-year-old boy developed a severe enteropathy 2 years after initiation of clofazimine treatment for graft-versus-host disease. | ADE | The sentence is not ADE because the statement describes the drug's intended use, not the harmful or |
Clofazimine enteropathy caused by crystal deposition can be life-threatening. | ADE | This is ADE because it is a serious and potentially life-threatening condition.
---
Example |
Clofazimine enteropathy caused by crystal deposition can be life-threatening. | ADE | This is a serious adverse event because it is a serious condition that can cause serious organ damage. |
Clofazimine enteropathy in a pediatric bone marrow transplant recipient. | ADE | This is ADE because the sentence describes a specific adverse reaction to a drug that is intended to help a |
She developed a severe urticarial rash 3 weeks following initiation of therapy with Enoxaparin. | ADE | This is ADE because the patient's condition is severe, and the drug Enoxaparin is |
We cared for a patient with progressive renal impairment who presented with blurred vision, QRS broadening and cardiac failure due to chronic cibenzoline intoxication. | ADE | This is ADE because the patient has progressive renal impairment (i.e., kidney damage), and the |
We cared for a patient with progressive renal impairment who presented with blurred vision, QRS broadening and cardiac failure due to chronic cibenzoline intoxication. | ADE | This sentence is not ADE because it does not mention any harmful or unintended effects.
---
** |
We cared for a patient with progressive renal impairment who presented with blurred vision, QRS broadening and cardiac failure due to chronic cibenzoline intoxication. | ADE | This is an ADE because the patient's condition is severe and progressive, and the drug is a |
We cared for a patient with progressive renal impairment who presented with blurred vision, QRS broadening and cardiac failure due to chronic cibenzoline intoxication. | ADE | This is an ADE because it describes a condition that is harmful and unintended in the context of the patient |
Indolent aspergillus arthritis complicating fludarabine-based non-myeloablative stem cell transplantation. | ADE | ---
**Answer:**
The sentence is an ADE because it describes an adverse drug event, which |
We describe two patients with aspergillus arthritis of the knee joint following fludarabine-based non-myeloablative stem cell transplantation. | ADE | The sentence is a summary of the adverse drug event.
Explanation: The sentence describes the adverse drug |
CONCLUSION: The present findings suggest that fluvoxamine can cause increased libido in some patients. | ADE | This is ADE because fluvoxamine is a drug that is used to treat depression.
Explanation: |
Increased libido in a woman treated with fluvoxamine: a case report. | ADE | This is ADE because the patient has a history of depression and is taking fluvoxamine.
--- |
OBJECTIVE: The aim of this paper is to describe a case of increased libido during fluvoxamine therapy. | ADE | **Explanation:** This is an ADE because the sentence describes an objective, but it does not provide any |
RESULTS: The patient, a 27-year-old married Japanese woman with borderline personality disorder, developed an increased libido with the administration of fluvoxamine. | ADE | This is ADE because fluvoxamine is a medication that can cause side effects and may be harmful to |
The increased libido disappeared after fluvoxamine was discontinued. | ADE | This is ADE because the drug fluvoxamine was discontinued, and the increased libido was a harmful adverse |
An infant who developed pancreatitis during meglumine antimoniate treatment for visceral leishmaniasis and who was successfully treated with a combination of allopurinol and ketoconazole is reported. | ADE | ---
**Explanation:**
The sentence is a clinical statement that describes a potential adverse drug event. |
Successful treatment of visceral leishmaniasis with allopurinol plus ketoconazole in an infant who developed pancreatitis caused by meglumine antimoniate. | ADE | This is ADE because the statement describes a specific adverse reaction to a medication, and it is a positive |
CONCLUSIONS: This case report showed that the clinical appearance of Hashimoto's disease after IFN-alpha therapy for chronic C hepatitis in our patient was associated with a specific genetic predisposition (DR5) for this pathology. | ADE | This is an ADE because the patient's condition is specifically linked to the genetic predisposition (DR5 |
Further studies are necessary to evaluate whether the study of HLA antigens may be a very useful tool to detect the patients with a predisposition to develop autoimmune thyroiditis, in order to make a early diagnosis of thyroid disorders during the IFN-alpha treatment. | ADE | This is a clinical safety review.
Explanation:
The sentence is related to an adverse drug event |
Further studies are necessary to evaluate whether the study of HLA antigens may be a very useful tool to detect the patients with a predisposition to develop autoimmune thyroiditis, in order to make a early diagnosis of thyroid disorders during the IFN-alpha treatment. | ADE | This sentence is a statement of fact, it is not an ADE.
---
Example 5 |
Hashimoto's disease during interferon-alpha therapy in a patient with pre-treatment negative anti-thyroid autoantibodies and with the specific genetic susceptibility to the thyroid disease. | ADE | This sentence is an ADE because it involves a specific genetic susceptibility to the thyroid disease and a patient with |
OBJECTIVES: The authors described a case of Hashimoto's disease during interferon-alpha (IFN-alpha) treatment for chronic viral C hepatitis in a patient with the specific genetic susceptibility associated with the thyroid disease. | ADE | This sentence is ADE because the objective is to identify the specific genetic susceptibility associated with the thyroid disease. |
OBJECTIVES: The authors described a case of Hashimoto's disease during interferon-alpha (IFN-alpha) treatment for chronic viral C hepatitis in a patient with the specific genetic susceptibility associated with the thyroid disease. | ADE | This sentence is an ADE because it describes a specific disease, but it does not mention any harmful or |
During dose-finding studies for intravenous proton pump inhibitors omeprazole and pantoprazole, three of six young female volunteers receiving omeprazole and two young female volunteers receiving pantoprazole developed peripheral edema within 8 hr when high doses of the proton pump inhibitors were applied by continuous infusion together with large volumes of fluid. | ADE | This is ADE because the drug is a medication, and the drug is being used in a clinical setting |
During dose-finding studies for intravenous proton pump inhibitors omeprazole and pantoprazole, three of six young female volunteers receiving omeprazole and two young female volunteers receiving pantoprazole developed peripheral edema within 8 hr when high doses of the proton pump inhibitors were applied by continuous infusion together with large volumes of fluid. | ADE | This is ADE because the drug is a medication and is not a harmful or unintended effect.
--- |
Pheripheral edema was observed in five female patients after taking proton pump inhibitors omeprazole, lansoprazole, or pantoprazole for 7-15 days for peptic acid diseases in recommended standard doses. | ADE | This is ADE because proton pump inhibitors (PPIs) are used to reduce stomach acid, which can |
Pheripheral edema was observed in five female patients after taking proton pump inhibitors omeprazole, lansoprazole, or pantoprazole for 7-15 days for peptic acid diseases in recommended standard doses. | ADE | This is ADE because the sentence describes a side effect of a drug that is harmful and unexpected. |
Pheripheral edema was observed in five female patients after taking proton pump inhibitors omeprazole, lansoprazole, or pantoprazole for 7-15 days for peptic acid diseases in recommended standard doses. | ADE | This sentence is not ADE because it does not mention any harmful or unintended effects.
---
Final |
Motor fluctuations appear after 2-3 years of levodopa treatment, and affect at least 50% of patients after five years. | ADE | ---
This is an example of a good, clear, and concise reason for the drug's |
CONCLUSION: Significant weight loss is a potential adverse event in patients with rheumatoid arthritis treated with leflunomide. | ADE | This is an ADE because the statement describes a significant weight loss in a patient with rheumatoid arthritis treated with |
Leflunomide-associated weight loss in rheumatoid arthritis. | ADE | This is ADE because the drug is a class of medication that can cause weight loss.
--- |
METHODS: We queried 35 rheumatologists at the Robert Breck Brigham Arthritis Center to determine if weight loss had occurred as an adverse event in patients treated with leflunomide between November 1998 and January 2000. | ADE | This is an ADE because weight loss is a harmful adverse reaction to a drug that is used in the |
OBJECTIVE: To determine the frequency of weight loss in patients treated with leflunomide for rheumatoid arthritis at an arthritis referral center. | ADE | This is an ADE because the sentence describes a clinical condition that is not a typical adverse drug event. |
RESULTS: Five of 70 patients who had begun leflunomide therapy had significant weight loss that could not be linked to other identifiable etiologies. | ADE | This is not ADE because the sentence only mentions the drug and its use, and does not report any |
It is increasingly recognized that dose adjustment of oral valacyclovir in renal failure is necessary to avoid neurotoxicity. | ADE | This is an ADE because it is a significant and important concern for patients with renal failure.
--- |
Neurotoxicity of valacyclovir in peritoneal dialysis: a pharmacokinetic study. | ADE | This is ADE because the drug is a neurotoxic substance and the study is focused on the pharmacokinetic properties |
She developed neurotoxicity with an adjustment dosage of valacyclovir for a cutaneous zoster infection. | ADE | This is ADE because the drug is a toxic drug that can cause serious harm.
---
** |
Avascular necrosis of the femoral head in patients with prostate cancer treated with cyproterone acetate and radiotherapy. | ADE | This is ADE because the patient has a condition that is not a direct result of the treatment. |
We report the case histories of two patients with histologically confirmed adenocarcinoma of the prostate, both of whom had been treated with steroidal anti-androgen therapy in the form of cyproterone acetate prior to radical or palliative pelvic irradiation, and who subsequently developed femoral head avascular necrosis. | ADE | This sentence is likely an ADE because it describes a disease with a specific diagnosis, a specific treatment, |
Levofloxacin induced polymorphic ventricular tachycardia with normal QT interval. | ADE | This is not ADE because the sentence only mentions the drug's pharmacological activity.
---
The |
We report the first case of polymorphic ventricular tachycardia with normal QT interval associated with the oral use of levofloxacin in the absence of other etiologies known to cause these arrhythmias. | ADE | * The sentence is related to the drug levofloxacin and its use in the absence of other |
So far, few cases of pulmonary side effects caused by ticlopidine have been reported. | ADE | This is not ADE because the sentence only mentions the side effects of ticlopidine.
--- |
Special care should be taken when pulmonary symptoms appear in association with ticlopidine treatment. | ADE | This is ADE because ticlopidine is a medication that can cause side effects.
--- |
Ticlopidine-induced interstitial pulmonary disease: a case report. | ADE | This is ADE because the statement describes a specific adverse reaction to a drug, and it is not a |
We report a case of interstitial pulmonary disease that occurred together with lymphocytic colitis during treatment with ticlopidine. | ADE | This is ADE because the sentence describes the specific condition and the related adverse event.
---
Example |
We report a case of interstitial pulmonary disease that occurred together with lymphocytic colitis during treatment with ticlopidine. | ADE | This is an ADE because it describes a condition that is harmful to the patient and is not a typical |
A patient that received methadone for cancer-associated pain developed myoclonus as a side effect. | ADE | This is an ADE because the sentence describes a side effect of a medication.
---
The following |
Methadone-induced myoclonus in advanced cancer. | ADE | This is ADE because methadone is a synthetic opioid and its effects on the body are not fully understood |
OBJECTIVE: To report a case of fatal hyperkalemia owing to succinylcholine administration in a patient with mucositis secondary to chemotherapy. | ADE | This is ADE because the patient has a significant and debilitating condition.
---
The following sentence may |
Succinylcholine-induced hyperkalemia in a patient with mucositis secondary to chemotherapy. | ADE | This is ADE because succinylcholine is a potent and selective inhibitor of acetylcholine receptors. It is a |
We believe that mucositis was a contributing factor to this case of fatal hyperkalemia after administration of succinylcholine, with a mechanism similar to that reported with thermal injury. | ADE | This is ADE because the statement describes a specific adverse event, and the mechanism is similar to that reported |
Cutaneous seeding after ultrasound-guided percutaneous ethanol injection for treatment of hepatocellular carcinoma. | ADE | This is not ADE because the sentence describes a procedure, not an adverse event.
---
The |
We describe a case of needle-track cutaneous seeding of hepatocellular carcinoma (HCC) after sonographically guided percutaneous ethanol injection (PEI). | ADE | This sentence is not ADE because the sentence describes a procedure, and the statement does not mention any harmful |
Adenosine-induced ventricular fibrillation. | ADE | This is an ADE because it is a harmful adverse reaction to an adenosine-induced ventricular fibrillation. |
However, adenosine shortens the antegrade refractoriness of accessory atrioventricular connections and may cause acceleration of the ventricular rate during atrial fibrillation. | ADE | This sentence is not ADE because the statement describes the effect of adenosine, not the adverse effect of an |
We observed ventricular fibrillation in 2 patients who presented to the emergency department with pre-excited atrial fibrillation and were given 12 mg of adenosine. | ADE | This is ADE because the sentence describes a serious condition with a potential for serious harm, and the patient |
After the dose of methylprednisolone was reduced from 40 mg to 20 mg i.v. q6h and shifted to other anti-asthma treatment by procaterol metered dose inhaler via spacer, the psychotic reaction disappeared a few hours later. | ADE | This is an ADE because the medication was used for a specific condition, and the side effect was reported |
Continuous EEG monitoring is helpful in managing seizures that occur as a complication of CBZ OD, after the course of recovery or worsening, and in providing assistance with prognosis. | ADE | This is ADE because the sentence describes a condition that is a side effect of the drug, and it |
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